CO12: Neuroimaging and Psychophysiology

The group is a multidisciplinary group led by a Ramón y Cajal researcher and made up of different pre- and post-doctoral researchers and clinical researchers, including psychologists, biologists, specialists in clinical neuroscience, as well as a large group of neurologists and neurosurgeons. The general objective of the group is to study the biological bases and brain mechanisms responsible for pathological symptoms in different neurological diseases such as Parkinson's disease, Multiple Sclerosis or Chronic Migraine, among others. For this, the different researchers use innovative tools and cutting-edge methodologies that include high-density EEG recordings, intracranial recordings in patients, peripheral measurements such as eye-tracking, advanced analysis of structural or functional MRI, as well as various brain stimulation techniques. , including transcranial magnetic stimulation or deep brain stimulation.

• Javier J. González-Rosa:
  • E-mail: javier.rosa@uca.es.
  • ORCID: 0000-0002-5609-1103.
  • Research ID: http://www.researcherid.com/rid/K-1291-2014.

• Human cognition and cognitive decline:
  • - Evaluation through electrophysiological and neuroimaging techniques of the neural bases of cognitive processes (e.g., executive functions, attention); Design of new cognitive tasks.
  • - Study of the brain mechanisms that underlie cognitive function both in the healthy population and in patients with neurological and psychiatric disorders.
  • - Evaluation of brain activity patterns and their relationship with the presence of cognitive impairment and clinical alterations.
  • - Currently working with patients with Parkinson's disease, Multiple Sclerosis, dementia, obsessive-compulsive disorder, and chronic migraine.
• Brain imaging methods:
  • - EEG and ERP: Advanced use of electrophysiological analysis and techniques; Use of high-density EEG equipment to understand the spatiotemporal dynamics of activation of cortical networks at rest and during the performance of cognitive tasks, both in healthy and pathological populations.
  • - New analysis and methodological solutions for the localization of brain generators through toolboxes such as Analyzer, EEGLAb, SPM12, y Brainstorm.
  • - Analysis of structural (MR) and functional neuroimaging (fMRI) data.
  • - Multimodal fusion and integration of electrophysiological (EEG) and hemodynamic (fMRI) data acquired separately or simultaneously.
  • - Intracranial recordings (icEEG) in humans post-surgery.
  • - Biometric records through "iMotions": automatic recognition of facial emotions, peripheral activity, and eye-tracker.
• Neuromodulation:
  • - Use of different neuromodulation techniques such as transcranial magnetic stimulation (TMS), direct current (tDCS), and static magnetic fields (tSMS), in healthy subjects and with neurological disorders.
  • - Deep brain stimulation (DBS) in neurological and psychiatric patients.
  • - Simultaneous EEG co-recordings during TMS and DBS protocols.

Electroencephalography (EEG) Structural and Functional Magnetic Resonance Neurological disorders Cognitive decline Neuromodulation and Deep Brain Stimulation (DBS) Location Cortical Generators Functional Connectivity

• Principal Investigators:
  • Javier J. González Rosa (PI) (Ramón y Cajal Investigator).
• Assistance Researchers:
  • Juan Martínez Chinchilla (FEA Neurosurgery).
  • Jesús Riqué Dormido (FEA Neurosurgery).
  • Lucía Forero Díaz (FEA Neurology).
  • Raúl Espinosa-Rosso (FEA Neurology).
  • Raúl Rashid López (FEA Neurology).
• Postdoctoral Researchers:
  • Álvaro Javier Cruz Gómez (UCA).
  • Esteban Sarrias Arrabal.
  • Constantino Méndez Bértolo (UCA).
  • Jaime D. Gómez Ramírez (UCA).
• Predoctoral Researchers:
  • Fernando López Sosa (Bio-medical Engineer).
  • Florencia Sanmartino (PIF-UCA).
  • Elena Lozano Soto (PIF-UCA).
  • Fátima Cano Cano (INiBICA).
• Technical Support Staff:
  • Paloma Macías García (INiBICA).
• Youth Guarantee:
  • Francisco Luis Sánchez Fernández (Technician).

• Instituto de Salud Carlos III,Proyectos de Investigación Clínica Independiente (2019). [ICI20/00074];Co-investigador responsable Hoospital Puerta del Mar (4 hospitales en total): Javier J. González Rosa; J: “Amantadina y Estimulación Magnética Transcraneal para Fatiga en la Esclerosis Multiple: Ensayo Fase III, Controlado, Randomizado, Cruzado y Doble Ciego”.
• Subprograma Estatal de Infraestructuras de Investigación y Equipamiento Científico- Técnico, Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 [EQC2019-006401-P]; PI: Javier J. González Rosa: “Equipamiento científico para la implementación de una unidad clínica-experimental de Resonancia Magnética Funcional”.
• Subprograma Estatal de Infraestructuras de Investigación y Equipamiento Científico- Técnico, Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 [EQC2018-004728-P]; PI: Javier J. González Rosa: “Evaluación sistemática de la excitabilidad cortical y de la conectividad inter e intrahemisférica en pacientes neurológicos”.
• Ministerio de Ciencia, Innovación y Universidades: Proyectos de I+D de Retos Investigación 2018. RTI2018-096951-A-I00. PI: Álvaro Javier Cruz Gómez. Identificación de un índice de neurodegeneración temprana con valor pronóstico en pacientes con esclerosis múltiple de reciente diagnóstico.
• Ministerio de Economía y Competitividad (MINECO), Agencia Estatal de Investigación, Programa Estatal de I+D+i Orientada a los Retos de la Sociedad [PSI2017-85951-R]. PI: Javier J. González Rosa Segura Assessing the integrity of cortical–subcortical functional networks by nucleus accumbens and subthalamic deep brain stimulation.
• Ministerio de Economía y Competitividad (MINECO); Ayudas Subprograma Ramón y Cajal” (Programa Estatal de Promoción del Talento y su Empleabilidad en I+D+i) [RYC-2015-18467]; PI: Javier J. González Rosa.
• Ministerio de Economía y Competitividad (MINECO); Programa Estatal de I+D+i Orientada a los Retos de la Sociedad (Proyectos de I+D+i para jóvenes investigadores sin vinculación o con vinculación temporal), [PSI2014-58654-JIN]; PI: Javier J. González Rosa: Characterising the neural bases of Deep Brain Stimulation to alter symptoms and decision making in Obsessive-Compulsive Disorder: a multimodal integration study from scalp and intracranial EEG”.

• Iniciativa Territorial Integrada (ITI) 2014-2020 para la provincia de Cádiz, por la Consejería de Salud y por el Fondo Europeo de Desarrollo Regional PI-0034-2019. PI: Javier J. González Rosa: "Neuromodulacion intracraneal y transcortical en el control de síntomas refractarios en pacientes con trastornos del movimiento".
• Iniciativa Territorial Integrada (ITI) 2014-2020 para la provincia de Cádiz, por la Consejería de Salud y por el Fondo Europeo de Desarrollo Regional PI-0025-2017. PI: Esther Berrocoso Domínguez PI: Javier J. González Rosa: "Efectos de la estimulación cerebral profunda (DBS) sobre las redes cortico-subcorticales y su relación con la sintómatología patofisiológica en pacientes neurológicos".

1. Authors: Cruz-Gómez AJ, Forero L, Lozano-Soto E, Cano-Cano F, Sanmartino F, Rashid-López R, Paz J, Espinosa-Rosso R, González-Rosa JJ. Title: Cortical Thickness and Serum NfL Explain Cognitive Dysfunction in Newly Diagnosed Patients With Multiple Sclerosis. Journal: Neurology, Neuroimmunology & Neuroinflammation. Year, volume, first and last pages: 2021 Aug 31;8(6):e1074. doi: 10.1212/NXI.0000000000001074. Print 2021 Nov. Impact factor: 8.485. Quartile/Decile in the year of publication: D1.
2. Authors: López-Sosa F, Reneses B, Sanmartino F, Vallejo-Galarza A, García-Albea J, Cruz-Gómez AJ, Yebra M, Oliviero A, Barcia JA, Strange BA, González-Rosa JJ. Title: Nucleus Accumbens Stimulation Modulates Inhibitory Control by Right Prefrontal Cortex Activation in Obsessive Compulsive Disorder. Journal: Cerebral Cortex. Year, volume, first and last pages: 2021 Mar 31;31(5):2742-2758. doi: 10.1093/cercor/bhaa397. Impact factor: 5.357. Quartile/Decile in the year of publication: Q1.
3. Authors: Aguirre N, Cruz-Gómez AJ, Félix S, Miró-Padilla A, Bueichekú E, Broseta-Torres R, Ávila C, Sanchis-Segura C, Forn C. Title: Enhanced frontoparietal connectivity in multiple sclerosis patients and healthy controls in response to an intensive computerized training focused on working memory. Journal: Multiple Sclerosis and Related Disorders. Year, volume, first and last pages: 2021 Jul;52:102976. doi: 10.1016/j.msard.2021.102976. Epub 2021 Apr 24. Impact factor: 4.339. Quartile/Decile in the year of publication: Q2.
4. Authors: Treu S, Gonzalez-Rosa JJ, et al. Title: “A ventromedial prefrontal dysrhythmia in Obsessive-Compulsive Disorder is attenuated by Nucleus Accumbens deep brain stimulation”. Journal: Brain Stimulation. 2021; 14(4):761-70. Impact factor: IF: 8.955. Quartile/Decile in the year of publication: D1.
5. Authors: Gomez-Ramirez JD & Gonzalez-Rosa JJ. Title: “Intra- and interhemispheric symmetry of subcortical brain structures: a volumetric analysis in the aging human brain”. Journal Brain Structure & Function. 2021 (in press). Impact factor: IF: 3.270, (Q1). Quartile/Decile in the year of publication: Q1 (2021).
6. Authors: Carretié, L., Yadav, R., Méndez-Bértolo, C. Title: The Missing Link in Early Emotional Processing. Journal: Emotion Review. Year, volume, first and last pages: 2021; 13(3); 244:255. https://doi.org/10.1177/17540739211022821. Impact factor: 6,469 (2021). Quartile/Decile in the year of publication: Q1 (2021).
7. Authors: Gimenez-Fernandez, Tamara ;Fernández-Folgueiras, Uxía ;Fondevila, Sabela ;Méndez-Bértolo, Constantino ;García-Rubio, María José ;Hernández-Lorca, María ;Kessel, Dominique ;Carretié, Luis. Title: Enhanced N170 to outgroup faces: Perceptual novelty or prejudice? Journal: Social Neuroscience. Year, volume, first and last pages: 2021; 16(3); 252:264. https://doi.org/10.1080/17470919.2021.1889658. Impact factor: 2,941 (2021). Quartile/Decile in the year of publication: Q2 (2021).

1. Authors: E. Lozano-Soto, A.J. Cruz-López, R. Gutiérrez, M. González, F. Sanmartino, R. Rashid-Lopez, R. Espinosa-Rosso, L. Forero, J.J. González-Rosa. Title; “Predicting Neuropsychological Impairment in Relapsing Remitting Multiple Sclerosis: The Role of Clinical Measures, Treatment, and Neuropsychiatry Symptoms”. Journal: Archives of Clinical Neuropsychology. Year, volume, first and last pages: 2020 (in press) doi: 0.1093/arclin/acaa088. Impact factor: 2.666; Quartile/Decile in the year of publication: Q2.
2. Authors: Garrido-Palomino I, Fryer S, Giles D, González-Rosa JJ, España-Romero V. Title; “Attentional Differences as a Function of Rock Climbing Performance”. Journal: Frontiers in Psychology. Year, volume, first and last pages: 2020 Jul 23;11:1550. doi: 10.3389/fpsyg.2020.01550. Impact factor: 2.323; Quartile/Decile in the year of publication: Q2.
3. Authors: Vázquez-Marrufo M, Caballero-Díaz R, Martín-Clemente R, Galvao-Carmona A, González-Rosa JJ. Title; “Individual test-retest reliability of evoked and induced alpha activity in human EEG data”. Journal: PLoS One. Year, volume, first and last pages: 2020 Sep 23;15(9): e0239612. doi: 10.1371/journal.pone.0239612. Impact factor: 2.740; Quartile/Decile in the year of publication: Q1.
4. Authors: Barrero F, Mallada-Frechin J, Martínez-Ginés ML, Marzo ME, Meca-Lallana V, Izquierdo G, Ara JR, Oreja-Guevara C, Meca-Lallana J, Forero L, et al. Title; “Spanish real-world experience with fingolimod in relapsing-remitting multiple sclerosis patients: MS NEXT study”. Journal: PLoS One. Year, volume, first and last pages: 2020 Apr 2;15(4): e0230846. doi: 10.1371/journal.pone.0230846. Impact factor: 2.740; Quartile/Decile in the year of publication: Q1.

1. Authors: Matías-Guiu JA, Gómez-Pinedo U, Forero L, Pytel V, Cano F, Moreno-Ramos T, Cabrera-Martín MN, Matías-Guiu J, González-Rosa JJ. Title; “Plasma Neurofilament Light Chain in Primary Progressive Aphasia and Related Disorders: Clinical Significance and Metabolic Correlates”. Journal: Journal of Alzheimers Disease. Year, volume, first and last pages: 2019;72(3):773-782. doi: 10.3233/JAD-190838.; Impact factor: 3.909; Quartile/Decile in the year of publication: Q1.
2. Authors: Yebra M, Galarza A, Soto-Leon V, Gonzalez-Rosa JJ, et al. Title; “Action boosts episodic memory encoding in humans via engagement of a noradrenergic system”. Journal: Nature Communications; Year, volume, first and last pages: 2019 (in press). Impact factor: 11.88; Quartile/Decile in the year of publication: D1 /Q1.

1. Cruz-Gómez AJ, Aguirre Vidal N, Sanchis-Segura C, Ávila C, Forn C. Title: Subcortical gray matter structures in multiple sclerosis: what is their role in cognition? Journal: NeuroReport. Year, volume, first and last pages: 2018; 29(7): 547-552. Impact factor: 4.122. Quartile/Decile in the year of publication: Q2.
2. Authors: García-García R*, Cruz-Gómez AJ*, Urios A, Mangas-Losada A, Forn C, et al. Title: Learning and memory impairments in patients with minimal hepatic encephalopathy are associated with structural and functional connectivity alterations in hippocampus. Journal: Scientific Reports. Year, volume, first and last pages: 2018 8(1):9664. Impact factor: 4.122. Quartile/Decile in the year of publication: Q1.

1. García-García R*, Cruz-Gómez AJ*, Mangas-Losada A, Urios A, Forn C, Escudero D, Tosca J, Giner-Durán R, León J, Serra M, Ávila C, et al. Title: Reduced resting state connectivity and gray matter volume correlate with cognitive impairment in minimal hepatic encephalopathy. Journal: PloS One. Year, volume, first and last pages: 2017, doi: 10.1371/journal.pone.0186463. Impact factor: 3.54. Quartile/Decile in the year of publication: Q1.
2. Fittipaldi-Márquez MS, Cruz-Gómez AJ, Sanchis-Segura C, Belenguer A, Ávila C, Forn C. Title: Exploring Neural Efficiency in Multiple Sclerosis (MS) patients during the Symbol Digit Modalities Test (SDMT): a functional MRI study. Journal: Neurodegenerative Diseases. Year, volume, first and last pages: 2017; 17: 199-207. Impact factor: 2.78. Quartile/Decile in the year of publication: Q2.
3. González-Torre JA*, Cruz-Gómez AJ*, Belenguer A, Sanchis-Segura C, Ávila C, Forn C. Title: Hippocampal dysfunction is associated with memory impairment in multiple sclerosis: A volumetric and functional connectivity study. Journal: Multiple Sclerosis Journal. Year, volume, first and last pages: 2017; 23(14):1854-1863. Impact factor: 5.28. Quartile/Decile in the year of publication: Q1.

1. Authors: Chieffo R, Straffi L, Inuggi A, Gonzalez-Rosa JJ, Spagnolo F, Coppi E, Nuara A, Houdayer E, Comi G, Leocani L. Title; “Motor Cortical Plasticity to Training Started in Childhood: The Example of Piano Players”. Journal: PLoS One; Year, volume, first and last pages: 2016; 11(6). Impact factor: 3.54; Quartile/Decile in the year of publication: Q1.
2. Authors: J.J. González-Rosa. Title: “Integración Multimodal: Métodos para la fusión de datos electromagnéticos (M/EEG) y hemodinámicos (fMRI). Journal: Mente y Cerebro: De la Psicología Experimental a la Neurociencia Cognitiva (En MT Bajo, LJ Fuentes, J Lupiañez, y MR Rueda - Coords.). 1º Ed. (in press). Alianza Universidad Year, volume, first and last pages: 2016; Capítulo 7, pp. 38-50.
3. Sanchis-Segura C*, Cruz-Gómez AJ*, Belenguer A, Fittipaldi Márquez MS, Ávila C, Forn C. Title: Increased regional gray matter atrophy and enhanced functional connectivity in male multiple sclerosis patients. Journal: Neuroscience Letters. Year, volume, first and last pages: 2016; 630:154-7. Impact factor: 2.16. Quartile/Decile in the year of publication: Q2.

1. Authors: Nachev P, Lopez-Sosa F, Gonzalez-Rosa JJ, Galarza A, Avecillas J, Pineda-Pardo JA, Lopez-Ibor JJ, Reneses B, Barcia JA, Strange B. Title: “Dynamic risk control by human nucleus accumbens”; Journal: Brain; Year, volume, first and last pages: 2015, 138(12): 3496-502. Impact factor: 10.226; Quartile/Decile in the year of publication: D1 / Q1.
2. Authors: Gonzalez-Rosa JJ, Soto-Leon V, Real P, Carrasco C, Forfani G, Strange B, Oliviero A. Title: “Static magnetic field stimulation over the visual cortex increases alpha oscillations and slows visual search in humans”; Journal: Journal of Neuroscience; Year, volume, first and last pages: 2015; 5(24): 9182-93. Impact factor: 6.92; Quartile/Decile in the year of publication: D1.
3. Authors: Houdayer E, Teggi R, Velikova S, Gonzalez-Rosa JJ, Bussi M, Comi G, Leocani L. Title: “Involvement of cortico-subcortical circuits in normoacousic chronic tinnitus: A source localization EEG study”; Journal: Clinical Neurophysiology; Year, volume, first and last pages: 2015, 126(12): 2356-65. Impact factor: 3.534; Quartile/Decile in the year of publication: Q1.
4. Authors: Oliviero A, Carrasco-López MC, Campolo M, Perez-Borrego YA, Soto-León V, Gonzalez-Rosa JJ, Higuero AM, Strange BA, Abad-Rodriguez J, Foffani G. Title: “Safety study of transcranial static magnetic field stimulation (tSMS) of the human cortex”; Journal: Brain Stimulation; Year, volume, first and last pages: 2015, 8(3):481-5. Impact factor: 5.432; Quartile/Decile in the year of publication: Q1.
5. Authors: Gonzalez-Rosa JJ, Natali F, Tettamanti A, Velikova S, Gatti R, Comi G, Leocani L. Title: “Action observation and motor imagery in motor learning: evidence from EEG and kinematic analysis”; Journal: Behavioral Brain Reserch; Year, volume, first and last pages: 2015, 281: 290-300; Impact factor: 3.028; Quartile/Decile in the year of publication: Q1.
6. Authors: Kleindienst A, Marin-Laut, FM, Dodoo-Schittko F. Title: “Dysphagia Diagnosed by Fiberoptic Endoscopy Is Common and Transient in Critical Illness Polyneuropathy: Are There Any Clinical Implications?” Journal: Critical Care Medicine; Year, volume, first and last pages: 2015; 43(2): 492-93. Impact factor: 7.422; Quartile/Decile in the year of publication: Q1.
7. Authors: José Manuel Ortega Zufiría, Jesús Riqué Dormido, Raquel Sánchez García, Marta Calvo Alonso, Noemí Lomillos Prieto. Title: “Pseudomeningocele posterior causante de cuadriparesia después de la laminectomía cervical: reporte de caso”. Journal: Journal Cubana de Neurología y Neurocirugía; Year, volume, first and last pages: 2015; 5(1): 34-39. Impact factor: Quartile/Decile in the year of publication:
8. Baltruschat SA; Ventura-Campos N; Cruz-Gómez AJ; Belenguer A; Forn C. Title: Gray matter atrophy is associated with functional connectivity reorganization during the Paced Auditory Serial Addition Test (PASAT) execution in Multiple Sclerosis. Journal: Journal of Neuroradiology. Year, volume, first and last pages: 2015; 42 (3): 141-149. Impact factor: 2.171. Quartile/Decile in the year of publication: Q2.

1. Authors: Galvao-Carmona A, González-Rosa JJ, Hidalgo-Muñoz AR, Páramo D, Benítez ML, Izquierdo G, Vázquez-Marrufo M. Title: “Disentangling the attention network test: behavioral, event related potentials, and neural source analyses”; Journal: Frontiers Human Neuroscience; Year, volume, first and last pages: 2014, 13; 8:81300; Impact factor: 2.986; Quartile/Decile in the year of publication: Q2.
2. Authors: Vázquez-Marrufo M, Galvao-Carmona A, González-Rosa JJ, Hidalgo-Muñoz AR, Borges M, Ruiz-Peña JL, Izquierdo G. Title: “Neural correlates of alerting and orienting impairment in multiple sclerosis patients”; Journal: PLoS One; Year, volume, first and last pages: 2014; 9(5):e97226; Impact factor: 3.534; Quartile/Decile in the year of publication: Q1.
3. Authors: José Manuel Ortega, Marta Calvo, Jesús Riqué, Raquel Sánchez, Noemí Lomillos. Title: “Coexistencia de múltiples abscesos cerebrales y metástasis de calota en una paciente con adenocarcinoma de mama. Presentación de un caso clínico y revisión de la literatura”. Journal: Neurología Argentina; Year, volume, first and last pages: 2014; 7(1): 34-38. Impact factor: Quartile/Decile in the year of publication: Q4.