CO24: Nanotheranostics

The group arises from the interaction of three specialists in the application of nanotechnology to various medical disciplines, devoting their research to the design, preparation and characterization of biocompatible nanoparticles for theranostics in oncology and immunology, as well as the development of computational models for planning ( preclinical and clinical) of magnetic hyperthermia treatments.

• In silico magnetic hyperthermia assays (Daniel Ortega Ponce): Using virtual animal and human phantoms, we perform computer simulations of therapies and diagnostic techniques based on the interaction of electromagnetic fields and nanomaterials in the kHz frequency range.
• Development of a point-of-care (PoC) type test for monitoring cancer patients (Daniel Ortega Ponce): We are collaborating with researchers from other centers to design a nanotechnology that allows PoC testing to monitor cancer patients after treatment. Our main objective is the early detection of cancer relapse.
• Laser-induced nanomaterial manufacturing processes (Oscar Bomati Miguel): We synthesize and characterize biocompatible nanomaterials by laser ablation and laser pyrolysis, for their subsequent use in medicine.
• MRI contrast agents (Oscar Bomati Miguel): One of the main applications of the multifunctional nanomaterials that we develop are medical imaging contrasts, with special interest in magnetic resonance imaging, for the detection of tumors.
• Metallic, magnetic and fluorescent nanoparticles for detection of therapeutic cells through imaging techniques (Rocío Litrán Ramos): We design chemical synthesis processes for new nanoparticles with different physical properties that are later used in the detection and monitoring of therapeutic targets.

Nanoparticles In silico Theranostics Cancer Lasers Point-of-care

• Principal Investigators:
  • Daniel Ortega Ponce (PI).
  • Rocío Litrán Ramos (Co-PI).
• Investigators:
  • Oscar Bomati Miguel.
• Predoctoral Researchers:
  • Irene Rubia Rodríguez.
  • Antonio Santana Otero.
  • Javier Ortega Juliá.
  • Eduardo José Félix Ruiz.
  • José Carlos Frade González.

• Organizing body: M-ERA.NET Call 2018. Year: 2019-2022. Project name: Advanced magnetic nanoparticles for detection and quantification of biomarkers in biological fluids (BIOMAG). Principal investigator: Francisco José Terán Garcinuño. Group participants: Daniel Ortega Ponce.
• Organizing body: European Association of National Metrology Institutes (EURAMET). Year: 2019-2022. Project name: Radiotherapy Coupled with Hyperthermia -Adapting the Biological Equivalent Dose Concept (RaCHy). Principal investigator: Giovanni Durando. Group participants: Daniel Ortega Ponce.
• Organizing body: European Association of National Metrology Institutes (EURAMET). Year: 2017-2020. Project name: Towards an ISO standard for magnetic nanoparticles. Principal investigator: Uwe Steinhoff. Group participants: Daniel Ortega Ponce. Reference: 16NRM04.
• Organizing body: Comisión Europea. Year: 2016-2021. Project name: Nanomedicine upscaling for early clinical phases of multimodal cancer therapy (NoCanTher). Principal investigator: Rodolfo Miranda Soriano. Group participants: Daniel Ortega Ponce.
• Organizing body: Comisión Europea. Marie Curie Actions. Year: 2014. Project name: Laser Induced Synthesis of Biocompatible Multifunctional Inorganic Nanoparticles: A Novel Route to Produce Multifunctional Contrast Agents for Early Diagnosis of Breast Cancer (NIMBLIS). Principal investigator: Oscar Bomati Miguel. Reference or file (if known): 656908-NIMBLIS-ESR.
• Organizing body: Comisión Europea. AMAROUT-II Europe, Marie Curie Actions. Year: 2013-2016. Project name: Nanoscale magnetocalorics. Principal investigator: Daniel Ortega Ponce.
• Organizing body: Comisión Europea. Marie Curie Actions. Year: 2009-2011. Project name: Magnetic Biomaterials: Magnetically Loaded Stem Cells as Diagnostic and Therapeutic Vectors for Lung Cancer. Principal investigator: Daniel Ortega Ponce. Reference: 237695.

• Organizing body: Ministerio de Economía e Innovación. Ayudas para la adquisición de infraestructuras. Year: 2021-2024. Project name: Nanobomba termoforética dirigida y células CAR monitorizadas por nanopartículas como terapia inmunológica combinada (NaNoCAR). Principal investigator: Cecilia Fernández Ponce, Francisco José García Cozar. Group participants: Rocío Litrán Ramos, Jose Carlos Frade González, Antonio Santana Otero, Javier Ortega Juliá, Irene Rubia Rodríguez, Eduardo Félix Ruiz. Reference or file (if known): PID2020-117544RB-I00.
• Organizing body: Instituto de Salud Carlos III. Fondo COVID-19. Year: 2020-2021. Project name: Diagnóstico basado en nanosensores e Identificación rápida en solución de disruptores de la interacción del virus SARS-Cov-2 con su receptor celular (NANOCOMPETE). Principal investigator: Francisco José García Cozar. Group participants: Daniel Ortega Ponce, Rocío Litrán Ramos.
• Organizing body: Ministerio de Ciencia, Innovación y Universidades. Programa Ramón y Cajal. Year: 2019-2024. Project name: Nanotecnología aplicada a la salud. Principal investigator: Daniel Ortega Ponce. Reference: RYC2018-025253-I.
• Organizing body: Ministerio de Economía e Innovación. Ayudas para la adquisición de infraestructuras. Year: 2019. Project name: Mejora De Las Prestaciones Del Servicio Periférico De Investigación De Elipsometría Espectroscópica Del Imeymat. Principal investigator: Eduardo Blanco Ollero. Group participants: Oscar Bomati Miguel. Reference or file (if known): EQC2019005503-P.
• Organizing body: Ministerio de Economía e Innovación. Ayudas para la adquisición de infraestructuras. Call year: 2018. Project name: Sistema Láser de Generación de Nanomateriales (NANO-GLAS): Fabricación y procesado de materiales nanoestructurados y síntesis directa de dispersiones coloidales de nanopartículas funcionalizadas. Principal investigator: Oscar Bomati Miguel. Reference or file (if known): EQC2018-004979-P.
• Organizing body: Ministerio de Economía. Year: 2018-2020. Project name: Nanomateriales funcionales para la verificación de predicciones in silico de nanotermometria e hipertermia magnética (NANOLICO). Principal investigator: Francisco José Terán Garcinuño. Group participants: Daniel Ortega Ponce. Reference: MAT2017-85617-R.
• Organizing body: Ministerio de Ciencia e Innovación. Year: 2017. Project name: Síntesis Asistida por Láser de Nanopartículas Ternarias: Una Ruta Alternativa para la Fabricación de Nuevos Agentes de Contraste Multimodales para el Diagnóstico Temprano del Cáncer de Mama. Start-end date: 09/01/2017 - 31/12/2020. Principal investigator: Oscar Bomati Miguel. Other researchers in the group: Rocío Litrán. Reference: MAT2015-67354-R.
• Organizing body: Ministerio de Economía e Innovación: Programa Retos de la Sociedad. Year: 2017. Project name: Gestión eficiente y sostenible de efluentes en Acuicultura Marina mediante Tecnología Solar. Principal investigator: José Antonio Perales Vargas-Machuca. Other researchers in the group: Rocío Litrán Ramos. Reference: AGL2016-80507-R.
• Organizing body: Ministerio de Economía e Innovación. Programa Retos de la Sociedad. Year: 2015. Project name: Síntesis Asistida por Láser de Nanopartículas Ternarias: Una Ruta Alternativa para la Fabricación de Nuevos Agentes de Contraste Multimodales para el Diagnóstico Temprano del Cáncer de Mama. Principal investigator: Oscar Bomati Miguel. Other researchers in the group: Rocio Litrán Ramos. Reference or file (if known): MAT2015-67354-R.
• Organizing body: Ministerio de Economía y Competitividad. Year: 2014-2016. Project name: Multifunctional nanostructures for imaging and controlled therapy of cancer (NANOTER). Principal investigator: Daniel Ortega Ponce, Francisco José Terán Garcinuño.
• Organizing body: Royal Society of Chemistry (RSC). Year: 2014-2015. Project name: Magnetocaloric effect in nanostructured materials: applications in magnetic hyperthermia (MAGNACHYP). Principal investigator: Daniel Ortega Ponce.
• Organizing body: Ministerio de Ciencia e Innovación. Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia. Call year: 2013. Project name: Síntesis electroquímica y sonoelectroquímica de nanoestructuras para uso en biosensores e hipertermia. Principal investigator: Pilar Herrasti González. Group participants: Oscar Bomati Miguel.
• Organizing body: Ministerio de Ciencia e Innovación. Consolider Ingenio. Year: 2012. Project name: Surface Functionalization of Materials for High Added. Principal investigator: Carlos Palacio Orcajo. Group participants: Oscar Bomati Miguel. Reference or file (if known): CSD2008-00023.
• Organizing body: Engineering and Physical Sciencies Resarch Council (EPSRC). Year: 2011-2013. Project name: Magnetic Targeting of Stem Cells. Principal investigator: Mark Lythgoe. Group participants: Daniel Ortega Ponce. Subsidized amount: 300.000 €. Reference: EP/I014667/1.
• Organizing body: Comunidad de Madrid. Year: 2010-2012. Project name: Study of oxides and noble metal nanoparticles with exceptional magnetic properties. Principal investigator: José Javier Sáiz Garitaonandia. Group participants: Daniel Ortega Ponce. Reference: MAT2009-14398.
• Organizing body: Engineering and Physical Sciencies Resarch Council (EPSRC). Year: 2009-2012. Project name: Bio-functional Magnetic Nanoparticles: Novel High-Efficiency Targeting Agents for Localised Treatment of Metastatic Cancers. Principal investigator: Quentin A. Pankhurst. Group participants: Daniel Ortega Ponce. Reference: EP/G062072/1.
• Organizing body: Ministerio de Ciencia e Innovación. Year: 2008-2010. Project name: Desarrollo de Kit de marcaje celular múltiple con nanopartículas fluorescentes. Principal investigator: Rocío Litrán Ramos. Reference: PET2007_0203.
• Organizing body: Ministerio de Ciencia y Tecnología. Year: 2009-2012. Project name: Nanopartículas Magnéticas para Bioaplicaciones. Principal investigator: Manuel Domínguez de la Vega. Other researchers in the group: Rocío Litrán.
• Organizing body: Comunidad de Madrid. Year: 2019-2022. Project name: NANOMAGCOST “Soluciones del nanomagnetismo a los retos sociales". Principal investigator: Rodolfo Miranda Soriano. Group participants: Daniel Ortega Ponce. Reference: P2018/NMT-4321.

• Organizing body: Consejería de Salud y Familia. Convocatoria de subvenciones para la financiación de la Investigación, Desarrollo e Innovación (I+D+I) en Biomedicina y en Ciencias de la Salud en Andalucía- Modalidad Proyectos estratégicos de investigación en Terapia de células T con receptores. Year: 2021-2023. Project name: Nanobomba termoforética dirigida y células CAR monitorizadas por nanopartículas como terapia inmunológica combinada (NaNoCAR). Principal investigator: Daniel Ortega Ponce, Francisco José García Cozar. Group participants: RRocío Litrán Ramos, Daniel Ortega Ponce. Reference or file (if known): PECART- 0096-2020.
• Organizing body: Consejería de Salud y Familias / Ayudas a proyectos de I+D+i, destinadas a las universidades y entidades públicas de investigación calificadas como agentes del Sistema Andaluz del Conocimiento, en el ámbito del Plan Andaluz de Investigación, Desarrollo e Innovación (PAIDI 2020). Convocatoria 2020. Year: 2021-2023. Project name: Estrategias para mejorar el seguimiento de las células CAR. Seguimiento mediante nanopartículas. Principal investigator: Francisco José García Cozar. Group participants: RRocío Litrán Ramos, Daniel Ortega Ponce. Reference or file (if known): P20-01293.
• Organizing body: Consejería De Economía, Conocimiento, Empresas Y Universidad. Plan Andaluz De Investigación, Desarrollo E Innovación. Year: 2017. Project name: Adquisición de una instalación láser de pulsos ultracortos de alta potencia con cabezal galvanométrico de escáner integrado para el procesado y fabricación de materiales nanoestructurados y nanopartículas avanzados con potenciales aplicaciones en medicina, medioambiente, catálisis y/o energía. Principal investigator: Eduardo Blanco Ollero. Cuantía económica: 307.871 €. Reference or file (if known): 5763. Other researchers in the group: Oscar Bomati Miguel.
• Organizing body: Comunidad de Madrid. Year: 2014-2017. Project name: Nuevas fronteras del nanomagnetismo fundamental y aplicado. Principal investigator: Rodolfo Miranda Soriano. Group participants: Daniel Ortega Ponce. Reference: S2013/MIT-2850.
• Organizing body: FUNDACION AGENCIA ARAGONESA PARA LA INVESTIGACION Y EL DESARROLLO, ARAGON I+D. Year: 2010. Project name: Fabricación de Nanoplataformas Inorgánicas Multifuncionales Mediante Procesos Químicos Inducidos por Láser para su Aplicación como Sondas de Contraste Multimodales en Imagen Molecular. Principal investigator: Oscar Bomati Miguel.
• Organizing body: Junta de Andalucía. Year: 2009-2011. Project name: Evasión inmunológica del virus de la hepatitis C. Terapia celular con linfocitos T transgénicos apoyada en la monitorización mediante nanopartículas magnéticas. Principal investigator: Francisco J. García Cózar. Other researchers in the group: Rocío Litrán Ramos. Reference: P08-CTS-04348.
• Organizing body: Universidad de Cádiz. Year: 2016. Project name: Evaluación de fotobioreactores solares con nanomateriales para el tratamiento avanzado de aguas. Principal investigator: Milagrosa Ramírez del Solar. Other researchers in the group: Rocío Litrán Ramos. Reference: PR2016‐020.

1. J. Leliaert, J. Ortega-Julia and D. Ortega “Individual particle heating of interacting magnetic nanoparticles at nonzero temperature” Nanoscale 13 (2021) 14734 [F.I.: 7.790; Quartile: 1; Decile: 2].
2. Geoffrey Cotin, Cristina Blanco-Andujar, Francis Perton, Laura Asín, Jesus M. de la Fuente, Wilfried Reichardt, Denise Schaffner, Dinh-Vu Ngyen, Damien Mertz, Céline Kiefer, Florent Meyer, Simo Spassov, Ovidiu Ersen, Michael Chatzidakis, Gianluigi A. Botton, Céline Hénoumont, Sophie Laurent, Jean-Marc Greneche, Francisco J. Teran, Daniel Ortega, Delphine Felder-Flesch and Sylvie Begin-Colin “Unveiling the role of surface, size, shape and defects of iron oxide nanoparticles for theranostic applications” Nanoscale (2021) [F.I.: 7.790; Quartile: 1; Decile: 2].
3. Irene Rubia-Rodríguez, Luca Zilberti, Alessandro Arduino, Oriano Bottauscio, Mario Chiampi and Daniel Ortega “In silico assessment of collateral eddy current heating in biocompatible implants subjected to magnetic hyperthermia treatments” International Journal of Hyperthermia 38 (2021) 846-861 [F.I.: 3.914; Quartile: 2; Decile: 3].
4. José Lifante, Yingli Shen, Irene Zabala Gutierrez, Irene Rubia‐Rodríguez, Daniel Ortega, Nuria Fernandez, Sonia Melle, Miriam Granado, Jorge Rubio‐Retama, Daniel Jaque, Erving Ximendes “Reaching deeper: absolute in vivo thermal reading of liver by combining super-bright Ag2S nanothermometers and in silico simulations” Advanced Science 28 (2021) 2003838 [F.I.: 16.806; Quartile: 1; Decile: 1].
5. Irene Rubia-Rodríguez, Antonio Santana-Otero, Simo Spassov, Etelka Tombácz, Christer Johansson, Patricia De La Presa, Francisco J Teran, María Del Puerto Morales, Sabino Veintemillas-Verdaguer, Nguyen T K Thanh, Maximilian O Besenhard, Claire Wilhelm, Florence Gazeau, Quentin Harmer, Eric Mayes, Bella B Manshian, Stefaan J Soenen, Yuanyu Gu, Ángel Millán, Eleni K Efthimiadou, Jeff Gaudet, Patrick Goodwill, James Mansfield, Uwe Steinhoff, James Wells, Frank Wiekhorst, Daniel Ortega “Whither Magnetic Hyperthermia? A Tentative Roadmap” Materials 14 (2021) 706. [F.I.: 3.623; Quartile: 1; Decile: 3].
6. Espinosa, F. J. Teran and D. Ortega “Introduction to Nanomaterials Applied to Life Sciences” Nanoscale Advances 3 (2021) 1165-1166 [F.I.: 4.553; Quartile: 2; Decile: 4].
7. Irene Rubia-Rodríguez, Antonio Santana-Otero, Simo Spassov, Etelka Tombácz, Christer Johansson, Patricia De La Presa, Francisco J Teran, María Del Puerto Morales, Sabino Veintemillas-Verdaguer, Nguyen T K Thanh, Maximilian O Besenhard, Claire Wilhelm, Florence Gazeau, Quentin Harmer, Eric Mayes, Bella B Manshian, Stefaan J Soenen, Yuanyu Gu, Ángel Millán, Eleni K Efthimiadou, Jeff Gaudet, Patrick Goodwill, James Mansfield, Uwe Steinhoff, James Wells, Frank Wiekhorst, Daniel Ortega “Whither Magnetic Hyperthermia? A Tentative Roadmap” Materials 14 (2021) 706. [F.I.: 3.623; Quartile: 1; Decile: 3].
8. C. Fernández-Ponce, J.M. Mánuel, R. Fernández-Cisnal, E. Felix, J. Beato-López, J. P. Muñoz-Miranda, A. M. Beltran, A. J. Santos, F. M. Morales, M. P. Yeste, O. Bomati-Miguel, R. Litrán and F. García-Cózar “Superficial Characteristics and Functionalization Effectiveness of Non-Toxic Glutathione-Capped Magnetic, Fluorescent, Metallic and Hybrid Nanoparticles for Biomedical Applications”, Metals 11 (3) (2021) 383 F.I.:2.351 Quartile: 2, Decile: 3.
9. AidaNaghilou,* Oscar Bomati-Miguel,* AnaSubotic, Ruth Lahoz, Markus Kitzler-Zeiler, Christine Radtke, Miguel A. Rodríguez, Wolfgang Kautek. Femtosecond laser generation of bimetallic oxide nanoparticles with potential X-ray absorbing and magnetic functionalities for medical imaging applications. Ceramics International 47 (20) (2021) 15: 29363-29370. F.I.: 4.527. Cuarti:l 1. Decile: 1.

1. J. Wells, D. Ortega, U. Steinhoff, S. Dutz, E. Garaio, O. Sandre, E. Natividad, M.M. Cruz, F. Brero, P. Southern, Q. A. Pankhurst, S. Spassov and the RADIOMAG consortium “Challenges and Recommendations for Magnetic Hyperthermia Characterization Measurements” International Journal of Hyperthermia (2020) [F.I.: 3.914; Quartile: 2; Decile: 3].
2. M. Beltrán, J. M. Mánuel, R. Litrán, E. Félix, A. J. Santos, F. M. Morales, O. Bomatí-Miguel, “(S)TEM structural and compositional nanoanalyses of chemically synthesized glutathione-shelled nanoparticles”. Applied Nanoscience 10 (7) 2295–2301 (2020) IF: 3.80 Q3.
3. JJ Beato-López, M. Ramírez del Solar, M. Domínguez and R. Litrán “Glutathione-magnetite nanoparticles: synthesis and physical characterization for application as MRI contrast agent”, SN Applied. Science 2:1202 (2020).
4. Lahoz, Ruth ;Natividad, Eva ;Mayoral, Álvaro ;Rentenberger, Christian ;Díaz Fernández, Daniel ;Félix, Eduardo José ;Soriano, Leonardo ;Kautek, Wolfang ;Bomatí Miguel, Oscar ”Pursuit of optimal synthetic conditions for obtaining colloidal zero-valent iron nanoparticles by scanning pulsed laser ablation in liquids” Journal of Industrial and Engineering Chemistry 81 (2020) pp: 340 – 351 I.F.: 4,978 Q1.
5. Lahoz, Ruth ; Naghilou, Aida ;Kautek, Wolfgang ;Bomati Miguel, Oscar “Study of the physicochemical surface alterations and incubation phenomena induced on iron targets by nanosecond pulsed laser ablation in liquids: effect on productivity and characteristics of the synthesized nanoscale zero-valent iron (nZVI) particles” Applied Surface Science 511 (2020) pp: 145438-1 - 145438-13 I.F.:: 5,155 Q1.

1. Isabel Sánchez ;Mario Ramírez ;Marina Casas Angulo ;Raquel Vigil de la Villa ;Rosario García Jímenez ;Oscar Bomati-Miguel ;Antonio Zapardiel “Characterization of LDH (phyllosilicate/carbonate) type compounds formed in the pozzolanic reaction of phyllosilicate‐ rich industrial waste” Journal of the American Ceramic Society 102 (2019) pp: 4990 – 4998 I. F.: 3,094 Q1.

1. Cecilia Fernandez Ponce; Juan Pedro Muñoz Miranda; Enrique Aguado Vidal; Desire Martínez de los Santos; Francisco García Cózar; Rocío Litrán Ramos. “Influence of size and surface capping on photoluminescence and cytotoxicity of gold nanoparticles”. Journal of Nanoparticle Research. 20 - 11, pp. 305:1 - 305:20. Springer, 2018. IF: 2.127 Q2.
2. Fernández-Ponce, C. Durán-Ruiz, I. Narbona-Sánchez, J. P. Muñoz-Miranda, M. Arbulo-Echevarría, A. Serna-Sanz, C. Baumann, R. Litrán, E. Aguado, W. Bloch and F. García-Cózar, , “Ultrastructural localization and molecular associations of HCV capside protein in jurkat T cells” Frontiers in Microbiology 8 (2018) 2595 I.F.: 4.50 Q1.
3. H. Santos, E. Ximendes, M. C. Iglesias de la Cruz, I. Chaves-Coira, B. del Rosal, C. Jacinto, L. Monge, I. Rubia-Rodríguez, D. Ortega, S. Mateos, J. García Solé, D. Jaque and N. Fernández “In vivo early tumor detection by infrared luminescence transient nanothermometry”, Advanced Functional Materials 28 (2018) 1803924 I.F.: 15.621 Q1.
4. Niusha Lasemi; Oscar Bomatí Miguel; Ruth Lahoz; Vassili. V. Lennikov; Ulrich Pacher; Christian Rentenberger; Wolfgang Kautek “Laser‐Assisted Synthesis of Colloidal FeWxOy and Fe/FexOy Nanoparticles in Water and Ethanol” ChemPhysChem 2018, 19, pp. 1414 – 1419 I.F.: 2.947 Q1.

1. Bomati Miguel*; R. Lahoz ;V. Lennikov ;A. Naghilou ;A Subotic ;M.A. Rodríguez ;C Rentenberger ;W. Kautek “Liquid-assisted pulsed laser ablation: A novel route to produce multifunctional contrast agents for multimodal imaging diagnosis” Optics InfoBase Conference Papers 2017, F82-CLEO_Europe 2017 - CM_CL_1, 6-6.
2. N. Lasemi; U. Pacher; LV Zhigilei; O. Bomati Miguel; R. Lahoz; W. Kautek “Pulsed laser ablation and incubation of nickel, iron and tungsten in liquids and air” APPLIED SURFACE SCIENCE 2017, 433, pp. 772 - 779.I.F.: 4.439 Q1.
3. Lasemi Niusha; Pacher Ulrich; Rentenberger Christian; Bomati-Miguel Oscar; Kautek Wolfgang “Laser-Assisted Synthesis of Colloidal Ni/NiOx Core/Shell Nanoparticles in Water and Alcoholic Solvents” CHEMPHYSCHEM 2017, 18, pp. 1 – 8 I.F.: 2.947 Q1.
4. Cabrera, A. Lak, T. Yoshida, M. E. Materia, D. Ortega, F. Ludwig, P. Guardia, A. Sathya, T. Pellegrino, and F. J. Teran “Unravelling viscosity effects to tailor the dynamical magnetic response of magnetic nanocubes”, Nanoscale 9 (2017) 5094 I.F.: 7.233 Q1.
5. J. J. Beato-López, M. L. Espinazo, C. Fernández-Ponce, E. Blanco, M. Ramírez-del-Solar, M. Domínguez, F. García-Cózar, R. Litrán, “CdTe quantum dots linked to Glutathione as a bridge for protein crosslinking” J. of Luminiscence 187 (2017) 193-200 I.F.: 2.68 Q1.
6. Fernandez-Ponce, C , Dominguez-Villar, M, Munoz-Miranda, JP, ; Arbulo-Echevarria, MM; Litran, R Aguado, E] ; Garcia-Cozar, F , “Immune modulation by the hepatitis C virus core protein” J. of Viral Hepat.24 (2017) 350-356 I.F.: 4.12 Q1.

1. Blanco-Andújar,* D. Ortega,* P. Southern,* S. A. Nesbitt, N. T. K. Thanh and Q. A. Pankhurst “Real-time tracking of delayed-onset cellular apoptosis induced by intracellular magnetic hyperthermia”, Nanomedicine 11 (2016) 121 I.F.: 6,205 Q1 [(*) Co-first authors].

1. Périgo, G. Hemery, O. Sandre, D. Ortega, E. Garaio, F. Plazaola and F. J. Teran “Fundamentals and advances in magnetic hyperthermia” Applied Physics Reviews 2 (2015) 041302 I.F.: 14.310 Q1.
2. D. Cabrera, J. Camarero, D. Ortega and F. J. Terán “Influence of the aggregation, concentration and viscosity on the nanomagnetism of iron oxide nanoparticle colloids for magnetic hyperthermia” Journal of Nanoparticle Research 17 (2015) 1 I.F.: 2.101 Q2.
3. Iu. G. Morozov, O. V. Belousova, D. Ortega, M. K. Mafina and M. V. Kuznetzov “Structural, optical, XPS and magnetic properties of Zn particles capped by ZnO nanoparticles” Journal of Alloys and Compounds, 633 (2015) 237 I.F.: 3.014 Q1.
4. P. J. Ko, A. Abderrahmane, T. V. Thu, D. Ortega, T. Takamura and A. Sandhu “Laser power dependent optical properties of mono- and few-layer MoS2” Journal of Nanoscience and Nanotechnology, 15 (2015) 1 I.F.: 3.573 Q1.
5. C. Blanco-Andújar, D. Ortega, P. Southern, Q. A. Pankhurst and N. T. K. Thanh “High performance multi-core iron oxide nanoparticles for magnetic hyperthermia: microwave synthesis, and the role of core-to-core interactions” Nanoscale, 7 (2015) 1768 I.F.: 7.760 Q1.
6. Diaz-Fernandez D.; Mendez J.; del Campo A.; Mossanek R. J. O.; Abbate M.; Rodriguez M. A.; Dominguez-Canizares G.; Bomati-Miguel O.; Gutierrez A.; Soriano L. “Nanopatterning on highly oriented pyrolytic graphite surfaces promoted by cobalt oxides.” Carbon 2015, 85, pp. 89 – 98 I.F.: 6.198 Q1.

1. Galindo R.; Menendez N.; Crespo P.; Velasco V.; Bomati-Miguel O.; Diaz-Fernandez D.; Herrasti P. “Comparison of different methodologies for obtaining nickel nanoferrites.” JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS 2014, 361, pp. 118 – 125 I.F.: 1,97 Q1.
2. Diaz-Fernandez D.; Mendez J.; Bomati-Miguel O.; Yubero F.; Mossanek R. J. O.; Abbate M.; Dominguez-Canizares G.; Gutierrez A.; Tougaard S.; Soriano L “The growth of cobalt oxides on HOPG and SiO2 surfaces: A comparative study.” SURFACE SCIENCE 2014, 624, pp. 145 – 153 I.F.: 1,925 Q1.
3. L. Cortajarena, D. Ortega, S. Ocampo-Ocampo, A. Gonzalez-García, P. Couleaud, C. Belda-Iniesta and A. Ayuso-Sacido "Iron Oxide Nanoparticles: from basic design parameters towards current clinical applications" Nanobiomedicine, 1 (2014) 1.
4. M. V. Kuznetsov, O. V. Belousova, D. Ortega, Y. G. Morozov "Ferromagnetic SnO nanoparticles" Inorganic Materials, 50 (2014) 856 I.F.: 0.556 Q4.
5. M. V. Kuznetsov, Yu. G. Morozov, O. V. Belousova and D. Ortega "Ferromagnetic Zn/ZnO nanoparticles" Inorganic Materials, 50 (2014) 369 I.F.: 0.556 Q4.
6. Bomati-Miguel Oscar; Miguel-Sancho Nuria; Abasolo Ibane; Paula Candiota Ana; Roca Alejandro G.; Acosta Milena; Schwartz Simo Jr.; Arus Carles; Marquina Clara; Martinez Gema; Santamaria Jesus “Ex vivo assessment of polyol coated-iron oxide nanoparticles for MRI diagnosis applications: toxicological and MRI contrast enhancement effects” JOURNAL OF NANOPARTICLE RESEARCH 2014, 16, pp. 1 – 13 I.F.: 2.184 Q1.
7. Paula Candiota Ana; Acosta Milena; Vasco Simoes Rui; Delgado-Goni Teresa; Lope-Piedrafita Silvia; Irure Ainhoa; Marradi Marco; Bomati-Miguel Oscar; Miguel-Sancho Nuria; Abasolo Ibane; Schwartz Simo Jr.; Santamaria Jesus; Penades Soledad; Arus Carles “A new ex vivo method to evaluate the performance of candidate MRI contrast agents: a proof-of-concept study” JOURNAL OF NANOBIOTECHNOLOGY 2014, 12, pp. 1 – 14 I.F.: 4.115 Q1.

1. D. Ortega, J. C. Hernández-Garrido, C. Blanco-Andújar and J. S. Garitaonandia “Suppression and enhancement of the ferromagnetic response in Fe-doped ZnO nanoparticles by calcination of organic nitrogen, phosphorus and sulfur compounds” Journal of Nanoparticle Research, 15 (2013) 2120 I.F.: 2.278 Q1.
2. D. Ortega, M. V. Kuznetsov, Yu. G. Morozov, O. V. Belousova and I. P. Parkin “Thermal relaxation and collective dynamics in interacting NiFe2O4 hexagonal nanoparticles” Physical Chemistry Chemical Physics, 15 (2013) 20830 I.F.: 4.198 Q1.
3. H. Zhang, E. Goikolea, J. S. Garitaonandia, D. Ortega, K. Saito and K. Suzuki “A two-step process for preparation of dodecanethiol-capped Au nanoparticles with room-temperature spontaneous magnetization” New Journal of Chemistry, 37 (2013) 2628 I.F.: 3.159 Q2.
4. D. Ortega, M. V. Kuznetsov, Yu. G. Morozov, O. V. Belousova and I. P. Parkin “Phase, size and shape-controlled formation of aerosol generated nickel nanoparticles” Journal of Alloys and Compounds, 579 (2013) 495 I.F.: 2.726 Q1.
5. Yu. G. Morozov, D. Ortega, M. V. Kuznetsov, O. V. Belousova and I. P. Parkin “Some peculiarities in the magnetic behaviour of aerosol generated NiO nanoparticles” Journal of Alloys and Compounds, 572 (2013) 150 I.F.: 2.726 Q1.
6. D. Ortega, N. Pérez, J. L. Vilas, J. S. Garitaonandia, K. Suzuki, J. R. Marín and M. Rodriguez “Nonylphenol polyethoxylate coated BCC-iron nanocrystals for ferrofluids with technical applications” Journal of Applied Physics, 113 (2013) 17B505 I.F.: 2.185 Q2.
7. J. Riegler, A. Liew, S. O. Hynes, D. Ortega, T. O’Brien, R. Day, T. Richards, F. Sharif, Q. Pankhurst and M. Lythgoe “Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury” Biomaterials, 34 (2013) 1987 I.F.: 8.312 Q1.
8. Bomati-Miguel Oscar; Miguel-Sancho Nuria; Abasolo Ibane ;Paula Candiota Ana ;Roca Alejandro G. ;Acosta Milena ;Schwartz Simo Jr. ;Arus Carles ;Marquina Clara ;Martinez Gema ;Santamaria Jesus “Ex vivo assessment of polyol coated-iron oxide nanoparticles for MRI diagnosis applications: toxicological and MRI contrast enhancement effects” Journal of Nanoparticle Research: 2013, 16, pp: 2292-1 - 2292-13 I.F.: 2,184 Q2.
9. Malumbres A.; Martinez G. ;Mallada R. ;Hueso J. L. ;Bomati-Miguel O. ;Santamaria “Continuous production of iron-based nanocrystals by laser pyrolysis. Effect of operating variables on size, composition and magnetic response” NANOTECHNOLOGY 2013, 24(32), pp: 325613-1 - 325613-13 I.F.: 3,482 Q1.

1. Martinez G.; Malumbres A.; Mallada R. ; Hueso J. L.; Irusta S.; Bomati-Miguel O. ; Santamaria J. “ Use of a polyol liquid collection medium to obtain ultrasmall magnetic nanoparticles by laser pyrolysis NANOTECHNOLOGY 2012, 23 (42), pp: 425605-1 - 425605-9.
2. Miguel-Sancho Nuria; Bomati-Miguel Oscar; Roca Alejandro G.; Martinez Gema; Arruebo Manuel; Santamaria Jesus “Synthesis of Magnetic Nanocrystals by Thermal Decomposition in Glycol Media: Effect of Process Variables and Mechanistic Study”: INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 2012, 51(25), pp: 8348 – 8357 I.F.: 2,206 Q1.
3. Roca A. G.; Carmona D.; Miguel-Sancho N. ;Bomati-Miguel O. ;Balas F. ;Piquer C. ;Santamaria J. “Surface functionalization for tailoring the aggregation and magnetic behaviour of silica-coated iron oxide nanostructures” NANOTECHNOLOGY 2012, 23(15), pp: 155603-1-155603-10 I.F.: 3,482 Q1.
4. J.J. Beato-López, C. Fernández-Ponce, E. Blanco, C. Barrera-Solano,M. Ramírez del Solar, M. Domínguez, F. García-Cózar and R. Litrán, “Praparation and characterization of fluorescent CdS Quantum Dots used for the direct detection of GST Fusion Proteins”, J. of Nanomaterials and Nanotechnology, 2 (2012) 1-9 I.F.: 1.75 Q3.
5. J. González-Molina, J. Riegler, P. Southern, D. Ortega, C. C. Frangos, Y. Angelopoulos, S. Husain, M. F. Lythgoe, Q. A. Pankhurst and R. M. Day “Rapid magnetic cell delivery for large tubular bioengineered constructs”, Journal of The Royal Society Interface, 9 (2012) 3008 I.F.: 4.907 Q1.
6. Blanco-Andújar, D. Ortega, Q. A. Pankhurst and N. T. K. Thanh “Elucidating the morphological and structural evolution of iron oxide nanoparticles formed by sodium carbonate in aqueous medium”, Journal of Materials Chemistry, 22 (2012) 12498 I.F.: 6.108 Q1.
7. Yu. G. Morozov, O. V. Belousova, M. V. Kuznetsov, D. Ortega and I. P. Parkin “Electric field-assisted levitation-jet aerosol synthesis of Ni/NiO nanoparticles”, Journal of Materials Chemistry, 22 (2012) 11214 I.F.: 6.108 Q1.
8. D. Ortega, S. J. Chen, K. Suzuki and J. S. Garitaonandia “Room temperature spontaneous magnetization in calcined trioctylphosphine-ZnO nanoparticles”, Journal of Applied Physics, 111 (2012) 07C314 I.F.: 2.210 Q1.
9. S. J. Chen, J. S. Garitaonandia, D. Ortega and K. Suzuki “Room-temperature spontaneous magnetization in a nanostructured (TiO2)1-x/Alx system prepared by ball milling”, Journal of Alloys and Compounds, 536 (2012) S287 I.F.: 2.390 Q1.

1. Miguel-Sancho N.; Bomati-Miguel O.; Colom Gloria ;Salvador J. -Pablo ;Marco M. -Pilar ;Santamaria J “Development of Stable, Water-Dispersible, and Biofunctionalizable Superparamagnetic Iron Oxide Nanoparticle” CHEMISTRY OF MATERIALS 2011, 23 (11): pp: 2795 – 2802 I.F.: 7,286 Q1.

1. Bomati-Miguel O. ;Zhao X. Q. ;Martelli S. ;Di Nunzio P. E. ;Veintemillas-Verdaguer S. “ Modeling of the laser pyrolysis process by means of the aerosol theory: Case of iron nanoparticles“ APPLIED PHYSICS LETTERS 2010, 107 (1), pp: 014906-1 - 014906-7 I.F.: 3,481 Q1.
2. D. Ortega, E. Velez-Fort, D. A. García, R. García, R. Ltrán, C. Barrera-solano, M. Ramírez-del-solar, M. Domínguez , “Size and surface effects in the magnetic properties of maghemite and magnetite nanoparticles”, Philosophical transactions of the Royal Society A: Mathematical Physical and Engineering Sciences 386 (2010) 4407-4418 I.F.: 2.97 Q1.
3. Goikolea, J. S. Garitaonandia, M. Insausti, I. Gil del Muro, M. Suzuki, T. Uruga, H. Tanida, K. Suzuki, D. Ortega, F. Plazaola and T. Rojo “Magnetic and structural characterization of thiol-capped ferromagnetic Ag nanoparticles”, Journal of Applied Physics 107 (2010) 09E317 I.F.: 2.079 Q2.

• NETWORK NAME: Nanotecnología en hipertermia traslacional. NATIONAL/INTERNATIONAL/REGIONAL: National. PRINCIPAL INVESTIGATOR: Daniel Ortega Ponce. COLLABORATOR: Rocío Litrán Ramos, Oscar Bomati Miguel. FUNDING ENTITY/PROGRAM: Ministerio de Ciencia / Redes de Investigación. CENTER: IMDEA Nanociencia. BUDGET: 23.000 €. PERIOD OF REALIZATION: 2020-2022. Reference or file (if known): RED2018-102626-T.
• Call: COST Open call. Organizing body: COST (European Cooperation in Science and Technology). Year: 2018-2022. Title: European network for advancing Electromagnetic hyperthermic medical technologies (MyWAVE). Principal investigator: Lourdes Farugia. Other researchers in the group: Daniel Ortega Ponce. Reference: CA17115.
• Call: COST Open call. Organizing body: COST (European Cooperation in Science and Technology). Year: 2014-2018. Title: European network for innovative uses of EMFs in biomedical applications (EMF-MED). Principal investigator: Antonio Sarolic. Other researchers in the group: Daniel Ortega Ponce. Reference: BM1309.
• Call: COST Open call. Organizing body: COST (European Cooperation in Science and Technology). Year: 2014-2018. Title: Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy (RADIOMAG). Principal investigator: Daniel Ortega Ponce, Simo Spassov. Reference: TD1402.

• TITLE: Estudio clínico de factibilidad de la inyección intratumoral de nanopartículas magnéticas asociadas al tratamiento de hipertermia en el cáncer de páncreas localmente avanzado.
  • AUTHORS: Consorcio “NoCanTher” (https://cordis.europa.eu/article/id/435743-new-nanomedicine-therapy-joins-the-fight-against-pancreatic-cancer).
  • REQUEST NUMBER: 797/20/EC.
  • PRIORITY DATE: 03/07/2020.
  • OWNER ENTITY: Hospital Vall D’Hebron; PROMOTOR: BioKeralty Research Institute.
  • COUNTRIES OF APPLICATION: Europa.
  • SITUATION: EXTENSIÓN INTERNACIONAL.