CO6: Applied Cardiovascular and Proteomic Regenerative Therapy

The group is mainly made up of basic researchers, but also clinical researchers from primary care and internal medicine, all participating jointly in the projects that are being carried out.

In addition, we currently have several open lines of research in collaboration with the Angiology and Vascular Surgery Unit of the HUPM, researchers from various centers (IBIS, National Hospital for Paraplegics), as well as the company Rexgenero Biosciences.

Basically, our work focuses on studying the mechanisms of action of various cell types (progenitor endothelial cells, regulatory T cells, mesenchymal cells) in order to apply them as cell therapy in atherosclerosis and more in specifically in peripheral ischemia of the lower limbs (ICMI).

To this end, we carry out in vitro assays to characterize the molecular mechanisms by which these cells are activated in response to atherosclerotic environments, using proteomic tools, as well as to determine their behavior against said environment, using functional assays (proliferation, migration , angiogenesis), in order to modulate them and enhance their regenerative (endothelial) and anti-inflammatory (Tregs) role.

In turn, we performed in vivo assays, using an ICMI mouse model, to assess the vascular regenerative power of progenitor and mesenchymal endothelial cells. We use this same model with the Rex-001 cells of the company Rexgenero. At this point, we assess the changes that occur as a consequence of ischemia as well as in response to cell treatment (recovery of blood flow, neovascularization, arterogenesis). On the other hand, we are also carrying out biodistribution tests, to determine where the administered cells go, which is important in preclinical tests.

In parallel, we also apply proteomic tools to identify biomarkers related to cardiovascular diseases, mainly atherosclerosis, in order to define protein panels that allow detecting patients with thrombotic risks through routine analysis to prevent such events.

• Mª Carmen Durán Ruiz:
• E-mail: maricarmen.duran@gm.uca.es.
• ORCID: 0000-0003-3954-3734.
• Research ID: P-4175-2017.

• Regenerative cell therapy in cardiovascular diseases:
• - Evaluation of the regenerative role of human progenitor endothelial cells as cell therapy in atherosclerosis.
• - Evaluation of the role of regulatory T cells in atherosclerosis as an alternative cell therapy.
• - Cellular therapy applied in peripheral ischemia of the lower limbs (in murine models): Evaluation of the regenerative role of human endothelial progenitor cells.
• - Cellular therapy applied in peripheral ischemia of the lower limbs (in murine models): Evaluation of the regenerative role of cells derived from bone marrow (Collaboration with the company Rexgenero).
• - Assays of cell bio-distribution in animal models.

• Proteomics applied to cardiovascular diseases:
• - Proteomic analysis of markers associated with the atherosclerotic process. Identification and validation of associated markers.
• - Search for diagnostic markers in dyslipidemic patients.

• Cardiovascular disease prevention studies:
• - Socioeconomic level and early markers of dyslipidemia.
• - Primary Care in Basic Research of dyslipidemia and cardiovascular diseases.

Cellular therapy Cardiovascular Research Regenerative medicine Biomarkers Proteomics Atherosclerosis Peripheral artery disease

• Principal Investigators:
  • Mª Carmen Durán (PI).
• Postdoctoral Researchers:
  • Antonio Rosal Vela.
  • Margarita Jiménez.
  • Almudena González.
  • María Calderón Domínguez.
  • Lucía Beltrán Camacho.
  • Eva Lozano Loaiza.
  • Ismael Sánchez Gomar.
• Predoctoral Researchers:
  • Jose A. Alonso.
  • Mª Jesús Extremera.
  • Marta Rojas Torres.
• Youth Guarantee:
  • Sara Eslava Alcón.

• Instituto Nacional de Salud Carlos III 2016, PI16-00784 PI: MªCarmen Durán Ruiz. Validación de Biomarcadores y Terapia celular alternativa en Aterosclerosis basada en la modulación de células endoteliales progenitoras y células T reguladoras.

• Iniciativa Territorial Integrada (ITI) 2014-2020 para la provincia de Cádiz, por la Consejería de Salud y por el Fondo Europeo de Desarrollo Regional PI-0026-2017 PI: MªCarmen Durán Ruiz . Terapia celular en isquemia crítica periférica de miembros inferiores basada en la modulación de la capacidad regenerativa de células endoteliales progenitoras frente a un ambiente aterosclerótico.
• Iniciativa Territorial Integrada (ITI) 2014-2020 para la provincia de Cádiz, por la Consejería de Salud y por el Fondo Europeo de Desarrollo Regional PI-0002-2017 Colaboración . Influencia de una intervención con ejercicio físico sobre marcadores asociados al envejecimiento, perfil proteómico y fragilidad en personas mayores con deterioro cognitivo leve (INTERMAE).
• Iniciativa Territorial Integrada (ITI) 2014-2020 para la provincia de Cádiz, por la Consejería de Salud y por el Fondo Europeo de Desarrollo Regional PI-0009-2017 Colaboración Biomarcadores de respuesta terapéutica en el trastorno bipolar.

• IFondo supera-COVID19. Banco Santander y Crue Universidades.2020.Impacto del SARS-COV-2 en personal sanitario asintomático o con síntomas leves. Identificación de nuevos biomarcadores y mecanismos patogénicos.

1. AUTHORS: N Geribaldi-Doldán, C Fernández-Ponce, R Navarro Quiroz, I Sánchez-Gomar, L Gómez Escorcia, E Puentes Velásquez, E Navarro Quiroz. TITLE: The Role of Microglia in Glioblastoma. Journal: Frontiers in oncology. Year: 2021 Jan. Volume: 10, 603495. IF: 6.244; Quartile: Q1.
2. * AUTHORS: L Beltrán-Camacho; M Rojas-Torres; Mª Carmen Durán-Ruiz. TITLE: Current Status of Angiogenic Cell Therapy and Related Strategies to treat Critical Limb Ischemia. Journal: International Journal of Molecular Sciences. Year: 2021 Feb. Volume: 22(5):2335. PMID: 33652743. IF: 5.923; Quartile: Q1. Grupos investigación: CO-6 Terapia regenerativa Cardiovascular y proteómica aplicada (CTS-1076). Normativa de filiación del INiBICA: Sí.
3. * AUTHORS: Delgado-Sequera A, Hidalgo-Figueroa M, Barrera-Conde M, Duran-Ruiz MC, Castro C, Fernandez-Aviles C, de la Torre R, Sanchez-Gomar I, Perez V, Geribaldi-Doldan N, Robledo P, Berrocoso E. TITLE: Olfactory Neuroepithelium cells from cannabis users display alterations to the cytoskeleton and to markers of adhesión, proliferation and apoptosis. Journal: Molecular Neurobiology. Year: 2021 Apr. Volume: 58(4):1695-1710. PMID: 33237429. IF: 5.59; Quartile: Q1. Grupos investigación: CO-6 Terapia regenerativa Cardiovascular y proteómica aplicada (CTS-1076). CO-9 Neuropsicofarmacología y psicobiología. Normativa de filiación del INiBICA: Sí.
4. AUTHORS: Calderon-Dominguez M; Belmonte T; Quezada-Feijoo M; Ramos M; Calderon-Dominguez J; Campuzano O; Mangas A; Toro R. TITLE: Plasma microRNA expression profile for reduced ejection fraction in dilated cardiomyopathy. Journal: Scientific Reports. Year: 2021 Apr. Volume: 11(1):7517. PMID: 33824379. IF: 5.134; Quartile: Q1. Grupos investigación: CO-6 Terapia regenerativa Cardiovascular y proteómica aplicada (CTS-1076). CO-27 Diagnostico en Medicina Cardiovascular. Biomarcadores circulantes y herramientas de imagen. Normativa de filiación del INiBICA: Sí.
5. AUTHORS: C Fernández-Ponce, N Geribaldi-Doldán, I Sánchez-Gomar, R Navarro Quiroz, L Atencio Ibarra, L Gomez Escorcia, R Fernández-Cisnal, G Aroca Martinez, F García-Cózar, E Navarro Quiroz. TITLE: The Role of Glycosyltransferases in Colorectal Cancer. Journal: International Journal of Molecular Sciences. Year: 2021 Jun. Volume: 22(11):5811. PMID: 34070747. IF: 5.923; Quartile: Q1. Grupos investigación: CO-6 Terapia regenerativa Cardiovascular y proteómica aplicada (CTS-1076). CO-5 Neurogénesis y Neurorregeneración. CO-10 Inmunología Molecular e Inmunoterapia Génica y Celular. Normativa de filiación del INiBICA: Sí.
6. * AUTHORS: L Beltran-Camacho; M Jimenez-Palomares; I Sanchez-Gomar; A Rosal-Vela; M Rojas-Torres; S Eslava-Alcon; JA Alonso-Pineiro; A Gonzalez-Rovira; MJ Extremera-Garcia; E Doiz; M Rodriguez-Piñero; M Røssel Larsen; MC Duran-Ruiz. TITLE: Long term response to circulating angiogenic cells, unstimulated or atherosclerotic pre-conditioned, in critical limb ischemic mice. Journal: Biomedicines. Year: 2021 Sep. Volume: 9(9):1147. PMID: 34572333. IF: 6.081; Quartile: Q1. Grupos investigación: CO-6 Terapia regenerativa Cardiovascular y proteómica aplicada (CTS-1076). IN35 Investigación vascular aplicada a la medicina y el desarrollo. Normativa de filiación del INiBICA: Sí.
7. * AUTHORS: JA Alonso-Piñeiro, A Gonzalez-Rovira, I Sánchez-Gomar, JA Moreno, MC Durán-Ruiz. TITLE: Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress. Journal: Antioxidants. Year: 2021 Sep. Volume: 10(9):1463. PMID: 34573095. IF: 6.312; Quartile/Decile: D1. Grupos investigación: CO-6 Terapia regenerativa Cardiovascular y proteómica aplicada (CTS-1076). Normativa de filiación del INiBICA: Sí.
8. AUTHORS: Costa M; Calderon-Dominguez M; Mangas A; Campuzano O; Sarquella-Brugada G; Ramos M; Quezada-Feijoo M; García Pinilla JM; Robles-Mezcua A; Pacheco-Cruz GA; Belmonte T; Enguita FJ; Toro R. TITLE: Circulating circRNA as biomarkers for dilated cardiomyopathy etiology. Journal: Journal of Molecular Medicine. Year: 2021 Dec. Volume: 99(12):1711-1725. PMID: 34498126. IF: 6.029; Quartile: Q2. Grupos investigación: CO-6 Terapia regenerativa Cardiovascular y proteómica aplicada (CTS-1076). CO-27 Diagnostico en Medicina Cardiovascular. Biomarcadores circulantes y herramientas de imagen. Normativa de filiación del INiBICA: Sí.

1. (*): los artículos a destacar del 2021.

1. AUTHORS: Zumaquero E, Stone SL, Scharer CD, Jenks SA, Nellore A, Mousseau B, Rosal-Vela A, Botta D, Bradley JE, Wojciechowski W, Ptacek T, Danila MI, Edberg JC, Bridges L, Kimberly RP, Chatham WW, Schoeb TR, Rosenberg A, Boss JM, Sanz I, Lund FE TITLE: IFNγ induces epigenetic programming of human T-bet hi B cells and promotes TLR7/8 and IL-21 induced differentiation Journal: eLife Year: 2019 Volume, first and last pages: Published: 15 May 2019. Pages: 1-36, doi: 10.7554/eLife.41641 Impact factor: 7,616 Quartile/Decile in the year of publication: Q1/D1 (4/87).

1. AUTHORS: Arbulo-Echevarria M, Narbona-Sánchez I, FernandezPonce C, Rueda-Ygueravide D, Loran Dustin M, Miazek A, Durán-Ruiz MC, Garcia-Cozar F, Aguado E TITLE: A stretch of negatively charged amino acids of LAT adaptor has a dual role in TCR intracellular signaling Journal: Frontiers in Immunology, T-cell biology. Year: 2018 Volume: 9:115. Impact factor: 5.511 Quartile/Decile in the year of publication: Q1.
2. AUTHORS: Fernández-Ponce C, Duran-Ruiz MC, NarbonaSánchez I, Muñoz-Miranda JP, Arbulo-Echevarria M, Serna-Sanz A, Baumann C, Litran R, Aguado E, Bloch W, Garcia-Cózar F. TITLE: Ultrastrutural localization and molecular association of HCV capsid protein in Jurkat T cells. Journal: Frontiers in Microbiology Year: 2018 Volume: 8:2595. Impact factor: 4.076 Quartile/Decile in the year of publication: Q1.
3. AUTHORS: José Luis Trillo-Contreras, Reposo Ramírez-Lorca, Laura Hiraldo-González, Ismael Sánchez-Gomar, Ana GalánCobo, Nela Suárez-Luna, Eva Sánchez de Rojas-de Pedro, Juan José Toledo-Aral, Javier Villadiego, Miriam Echevarría. TITLE: Combined effects of aquaporin-4 and hypoxia produce age-related hydrocephalus Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Year: 2018 Volume: Volume 1864, Issue 10, 3515-3526 Impact factor: 5,476 Quartile/Decile in the year of publication: Q1 (45/290).
4. AUTHORS: García-Rodríguez S*, Rosal-Vela A*, Botta D, Cumba Garcia LM, Zumaquero E, Prados-Maniviesa V, Cerezo-Wallis D, Lo Buono N, Robles-Guirado JÁ, Guerrero S, González-Paredes E, Andrés-León E, Corbí Á, Mack M, KochNolte F, Merino R, Zubiaur M, Lund FE, Sancho TITLE: CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven TRPM2-dependent mechanism Journal: Scientific Reports Year: 2018 Volume: Feb 20;8(1):3357 Impact factor 2017: 4,122 Quartile/decile in 2017: Q1/D1 (12/64).

1. AUTHORS: De la Varga Martínez R, Gutierrez Fernández D, Añez GA, Foncubierta Fernández A, Andrés García JA, Medina Varo F TITLE: Use of basophil activation test in monitoring clinical tolerance after desensitization to brentoximab vedotin Journal: Ann Allergy Asthma Immunol Year: 2017 Volume: 118-6 (745-747) Impact factor: 3.728 Quartile/Decile in the year of publication: Q2 (9/26).
2. AUTHORS: Blandino-Rosano M, Barbaresso R, Jimenez Palomares M, Bozadjieva N, Werneck-Decastro J, Hatanaka M, Mirmira R, Sonenberg N, Liu M, Ruegg M, Hall M and Bernal-Mizrachi E TITLE: Loss of Mtorc1 Signaling in ß-Cells Identifies Downstream pathways controlling ß-Cell Mass and Insulin Processing Journal: Nature Communications Year: 2017 Volume, first and last pages: Vol 8, 2235-2248 Impact factor: 12,124 Quartile/Decile in the year of publication: D1 (3/64).
3. AUTHORS: Vega FM, Gautier V, Fernandez-Ponce C, Extremera MJ, Altelaar AFM, Millan J, Tellez JC, Hernandez-Campos JA, Conejero R, Bolivar J, Pardal R, Garcia-Cózar FJ, Aguado E, Heck A JR, Duran-Ruiz MC. TITLE: The atheroma plaque secretome stimulates the mobilization of endothelial progenitor cells ex vivo Journal: J Mol Cell Cardiol Corresponding autor: MªCarmen Durán Ruiz Year: 2017 Volume, first and last pages: vol 105: 12-2 Impact factor: 5.680 Quartile/Decile in the year of publication: Q1 (20/126).
4. AUTHORS: E. Ferrero, N. Lo Buono, S. Morone, R. Parrotta, C. Mancini, A. Brusco, A. Giacomino, S. Augeri, A. Rosal-Vela, S. García-Rodríguez, M. Zubiaur, J. Sancho, A. Fiorio Pla, A. Funaro. TITLE: Human canonical CD157/Bst1 is an alternatively spliced isoform masking a previously unidentified primatespecific exon included in a novel transcript Journal: Scientific Reports Year: 2017 Volume, first and last pages: Nov 21;7(1):15923 Impact factor: 4,122 Quartile/Decile in the year of publication: Q1/D1 (12/64).
5. AUTHORS: S García Rodríguez; S Arias Santiago; G Blasco Morente; J Orgaz Molina; A Rosal Vela; P Navarro; C Magro Checa; A Martínez López; J-C Ruiz; E Raya; R Naranjo Sintes; J Sancho; M Zubiaur. TITLE: Increased expression of MicroRNA-155 in peripheral blood mononuclear cells from psoriasis patients is related to disease activity Journal: Journal of the European Academy of Dermatology and Venereology Year: 2017 Volume, first and last pages: Feb;31(2):312-322 Impact factor: 4,287 Quartile/Decile in the year of publication: Q1/D1 (7/63).

1. AUTHORS: Sánchez Gomar I, Díaz Sánchez M, Uclés Sánchez AJ, Casado Chocán JL, Suárez-Luna N, Ramírez-Lorca R, Villadiego J, Toledo-Aral JJ, Echevarría M. TITLE: Comparative Analysis for the Presence of IgG AntiAquaporin-1 in Patients with NMO-Spectrum Disorders. Journal: International journal of molecular sciences. Year: 2016 Volume, first and last pages: 17(8), 1195 Impact factor: 3.226 Quartile/Decile in the year of publication: Q2 (54/166).
2. AUTHORS: Gutierrez-Fernández D, Moreno-Ancillo A, Foncubierta-Fernández A, Medina-Varo F, Andrés-García JA, Fernandez-Anguita MJ. TITLE: A protocol for induction of tolerance to apomorphine in patients with parkinson disease and Q to apomorphine Journal: Journal of investigational allergology&clinical immunology Year: 2016 Volume, first and last pages: 26-5 (324-325) Impact factor: 3.094 Quartile/Decile in the year of publication: Q3 (14/26).
3. AUTHORS: de la Varga Martínez R, Gutierrez Fernández D, Foncubierta Fernández A, Andrés García JA, Medina Varo F. TITLE: Rapid subcutaneous desensitization for treatment of hypersensitivity reactions to etanercept in two patients with positive basophil activation test. Journal: Allergology international: official journal of the Japanese Society of Allergology (ISSN: 1323-8930) Year: 2016 Volume, first and last pages: Impact factor: 3.194 Quartile/Decile in the year of publication: Q2 (13/26).
4. AUTHORS: Gutierrez Fernández D, de la Varga Martinez R, Lasa Luaces E, Foncubierta Fernández A, Andrés García JA, Medina Varo F. TITLE: Allergic contact conjunctivitis and cross-reaction between phenylephrine and epinephrine due to phenylephrine eye drops. Journal: Annals of allergy, asthma&Immunology Year: 2016 Volume, first and last pages: Vol 117-5 (564-565) Impact factor: 3.728 Quartile/Decile in the year of publication: Q2 (9/26).
5. AUTHORS: Blandino-Rosano M, Scheys JO, Jimenez-Palomares M, Barbaresso R, Bender As, Yanagiya A, Liu M, Rui L, Sonenberg N and Bernal-Mizrachi E TITLE: 4E-BP2/SH2B1/IRS2 are part of a Novel Feedback Loop that Controls ß-Cell Mass Journal: Diabetes Year: 2016 Volume, first and last pages: Vol 65(8), 2235-2248 Impact factor: 8,684 Quartile/Decile in the year of publication: Q1/D1 (9/138).
6. AUTHORS: Marcos-Ramiro B, García-Weber D, Barroso S, Feito J, Ortega MC, Cernuda-Morollón E, Reglero-Real N, Fernández-Martín L, Durán MC, Alonso MA, Correas I, Cox S, Ridley AJ, Millán J. TITLE: RhoB controls endothelial barrier recovery by inhibiting Rac1 trafficking to the cell border. Journal: J Cell Biol Year: 2016 Volume, first and last pages: 213(3):385-402 Impact factor: 7.995 Quartile/Decile in the year of publication: Q1 (27/189).
7. AUTHORS: Arbulo-Echevarria M, Muñoz-Miranda JP, CaballeroGarcía A, Poveda-Díaz JL, Fernández-Ponce C, Durán-Ruiz MC, Miazek A, García-Cózar F, Aguado E. TITLE: Non-T cell activation linker (NTAL) proteolytic cleavage as a terminator of activatory intracelular signals Journal: Journal of Leukocyte Biology Year: 2016 Volume, first and last pages: 100(2):351-60. doi: 10.1189/jlb.2A0715-318R Impact factor: 4.018 Quartile/Decile in the year of publication: Q2 (69/189).
8. AUTHORS: Antonio Rosal-Vela, Albert Barroso, Estela Giménez, Sonia García-Rodriguez, Victoria Longobardo, Jorge Postigo, Marcos Iglesias, Antonio Lario, Jesús Merino, Ramón Merino, Mercedes Zubiaur, Victoria Sanz-Nebot, Jaime Sancho. TITLE: Supporting data for the MS identification of distinct transferrin glycopeptide glycoforms and citrullinated peptides associated with inflammation or autoimmunity Journal: Data in Brief Year: 2016 Volume, first and last pages: Jan 11;6:587-602 Impact factor: 0,226 Quartile/Decile in the year of publication: Q2 (49/115).
9. AUTHORS: Antonio Rosal-Vela, Albert Barroso, Estela Giménez, Sonia García-Rodriguez, Victoria Longobardo, Jorge Postigo, Marcos Iglesias, Antonio Lario, Jesús Merino, Ramón Merino, Mercedes Zubiaur, Victoria Sanz-Nebot, Jaime Sancho. TITLE: Identification of multiple transferrin species in spleen and serum from mice with collagen-induced arthritis which may reflect changes in transferrin glycosylation associated with disease activity: the role of CD38 Journal: Journal of Proteomics Year: 2016 Volume, first and last pages: Feb 16;134:127-137 Impact factor: 3,914 Quartile/Decile in the year of publication: Q1 (17/78).

1. AUTHORS: Antonio Rosal-Vela, Jorge Postigo, Marcos Iglesias, Sonia García-Rodríguez, Maria Victoria Longobardo-Polanco, Antonio Lario, Ramón Merino Pérez, Jesús Merino Pérez, Mercedes Zubiaur, Jaime Sancho. TITLE: Distinct serum proteome profiles associated with collagen induced arthritis and complete Freund´s adjuvant induced inflammation in CD38-/- mice: the discriminative power of protein species or proteoforms Journal: Proteomics Year: 2015 Volume, first and last pages: Oct;15 (19):3382-93 Impact factor: 4,079 Quartile/Decile in the year of publication: Q1 (13/79).
2. AUTHORS: Antonio Rosal-Vela, Jorge Postigo, Marcos Iglesias, Sonia García-Rodríguez, Maria Victoria Longobardo-Polanco, Antonio Lario, Ramón Merino Pérez, Jesús Merino Pérez, Mercedes Zubiaur, Jaime Sancho. TITLE: Distinct serum proteome profiles associated with collagen induced arthritis and complete Freund´s adjuvant induced inflammation in CD38-/- mice: the discriminative power of protein species or proteoforms Journal: Proteomics Year: 2015 Volume, first and last pages: Oct;15 (19):3382-93 Impact factor: 4,079 Quartile/Decile in the year of publication: Q1 (13/79).
3. AUTHORS: Fernández-Gutierrez D, Cruz MJ, Foncubierta Fernández A, Moreno Ancillo A, Fernández-Anguita MJ TITLE: Monoclonal antibody desensitization in a patient with a generalized urticarial reaction following denosumab administration Journal: Allergy Asthma Clin Immunol. Biomed Central Year: 2015 Volume, first and last pages: Impact factor: 2.283 Quartile/Decile in the year of publication: Q3 (16/25).
4. AUTHORS: Fernández-Gutierrez D, Cruz MJ, Foncubierta Fernández A, Moreno Ancillo A, Fernández-Anguita MJ TITLE: Monoclonal antibody desensitization in a patient with a generalized urticarial reaction following denosumab administration Journal: Allergy Asthma Clin Immunol. Biomed Central Year: 2015 Volume, first and last pages: Impact factor: 2.283 Quartile/Decile in the year of publication: Q3 (16/25).
5. AUTHORS: Jimenez-Palomares M, Lopez-Acosta JF, Villa-Perez P; Moreno-Amador JL, Muñoz-Barrera J, Fernandez-Luis S, Heras-Pozas B, Perdomo G, Bernal-Mizrachi E and CozarCastellano I TITLE: Cyclin C Stimulates Beta-Cell Proliferation in Rat and Human Pancreatic Beta-Cells Journal: American Journal of Physiology, Endocrinology and Metabolism Year: 2015 Volume, first and last pages: Vol 308(6), E450-E459 Impact factor: 3,825 Quartile/Decile in the year of publication: Q2 (35/133).
6. AUTHORS: Durán-Ruiz MC. TITLE: Comportamiento del eje entero-insular en una población deportista; influencia de la dieta y el ejercicio Journal: Nutrición Hospitalaria Year: 2015 Volume, first and last pages: 32(5):2361-2362 ISSN 0212-1611 Impact factor: 1.497 Quartile/Decile in the year of publication: Q3 (60/80).
7. AUTHORS: Sanchez-De Melo, I, Grassi P, Ochoa F, Bolivar J, García-Cozar, FJ; Durán-Ruiz MC. TITLE: N_Glycosylation profile analysis of trastuzumab biosimilar candidates by Normal Phase Liquid Chromatography and MALDI-TOF MS approaches Journal: Journal of Proteomics Year: 2015 Volume, first and last pages: Vol 127 (Pt B):225-33; DOI:10.1016/j.jprot.2015.04.012 Impact factor: 3.867 Quartile/Decile in the year of publication: Q1 (15/77).

1. AUTHORS: Serna A1, Galán-Cobo A, Rodrigues C, SánchezGomar I, Toledo-Aral JJ, Moura TF, Casini A, Soveral G, Echevarría M. TITLE: Functional inhibition of aquaporin-3 with a gold-based compound induces blockage of cell proliferation. Year: 2014 Journal: Journal of cellular physiology Volume, first and last pages: 229(11):1787-801 Impact factor: 3.839 Quartile/Decile in the year of publication: Q1(15/83).
2. AUTHORS: Sánchez Gomar I, Díaz Sánchez M, Uclés Sánchez AJ, Casado Chocán JL, Ramírez-Lorca R, Serna A, Villadiego J, Toledo-Aral JJ, Echevarría M. TITLE: An immunoassay that distinguishes real neuromyelitis optica signals from a labeling detected in patients receiving natalizumab. Year: 2014 Journal: BMC Neurology Volume, first and last pages: 1471-2377-14-139 Impact factor: 2.04 Quartile/Decile in the year of publication: Q3(113/192).
3. AUTHORS: Gutierrez Fernández D, Foncubierta Fernández A, Anguita Carazo JL, Fernández-Melendez S, FernándezAnguita MJ, Medina-Varo F. TITLE: Adalimumab desensitization protocol in a patient with a generalized urticarial reaction and angioedema following adalimumab administration Year: 2014 Journal: J Investig Allergol Clin Immunol Volume, first and last pages: 24-4, pp. 267-285 Impact factor: 2.596 Quartile/Decile in the year of publication: Q2(12/24).
4. AUTHORS: Toro R, Mangas A, Quezada M, Rodriguez-Rosety M, Fournielles G, Rodriguez-Rosety I, Rodriguez-Rosety MA, Alonso JA, Garcia-Cozar F, Duran MC TITLE: Influencia de la dieta y el ejercicio en el perfil proteómico de una población deportista. Journal: Nutrición Hospitalaria Year: 2014 Volume, first and last pages: 30 (5):1110-1117. ISSN 0212-1611 Impact factor: 1.040 Quartile/Decile in the year of publication: Q4 (57/74).

• 2022:
  • Estudio de las vías de señalización implicadas en la sobreexpresión de la proteína hemooxigenasa-1 en células endoteliales progenitoras estimuladas con secretoma aterosclerótico.
    - Jose Angel Alonso Piñeiro.
    - Directed by MARIA CARMEN DURAN RUIZ and FRANCISCO JOSE GARCIA COZAR.

• 2021:
  • Evaluación in vivo del uso de células progenitoras endoteliales como terapia celular en la enfermedad periférica arterial en un ambiente aterosclerótico.
    - Lucía Beltrán Camacho.
    - Directed by MARIA CARMEN DURAN RUIZ.