EM13: Clinical, epidemiological and translational research in Cancer

This is a research group made up of clinical oncologists and pharmacists who carry out their research activity mainly around clinical practice. The group participates in research projects, clinical trials and epidemiological studies, generating scientific production within cooperative groups.

• L1: Systemic cancer treatment: This is the line of research that includes phase I to IV clinical trials with antineoplastic drugs and other treatments in cancer patients.
• L2: Health literacy, communication with cancer patients: In English, health literacy includes a complex concept defined as "the social and cognitive skills that determine a person's level of motivation and ability to access, understand, and use information from manner that enables you to promote and maintain good health.
• L3: Safety in the cancer patient: Includes clinical research developed around the safety of people who are diagnosed and treated for cancer.
• L4: Translational and clinical research linked to care practice: Includes translational and clinical research developed around the care practice of people who are diagnosed and treated for cancer.
• L5: Radiotherapy in the treatment of cancer: Includes clinical research developed around the radiotherapy treatment of cancer.
• L6: Evidence-based medicine: evidence-based oncology procedures.

Breast cancer Chemotherapy Clinical Pharmacy Radiotherapy Screening mammograpy

• Clinical researchers, medical and radiation oncologists, and pharmacists.
• A research support nurse.

• Instituto de Salud Carlos III. Acción Estratégica en Salud 2018 - PI18/01476 Collaboration. Análisis integrado de las alteraciones en el número de copias, ADN Metilado y carga mutacional en pacientes con cáncer epidermoide de cabeza y cuello localmente avanzado. Importancia pronóstica y predictiva de respuesta al ensayo clínico TTCC-2007-01.

• Consejería de Salud y Familias, Junta de Andalucía, PIN-0109-2018 Collaboration. E-Health para la Promoción de la Salud y Calidad de Vida en Oncología Mamaria.
• Iniciativa Territorial Integrada (ITI) 2014-2020 para la provincia de Cádiz, por la Consejería de Salud y por el Fondo Europeo de Desarrollo Regional PI-0032-2017 Collaboration. Predicción del riesgo de metástasis a distancia del carcinoma de mama mediante la integración del datos morfológicos, inmunohistoquímicos y genéticos a través de tecnología Big-Data.
• Consejería de Salud., Junta de Andalucía, PI-0346-2017 PI: Jose Manuel Baena Cañada. Estudio del Sobrediagnóstico en Pacientes Con Cáncer de Mama.
• Consejería de Salud., Junta de Andalucía, PIN-0365-2016 Collaboration, Evaluación del Impacto de Una Aplicación Móvil para el Uso Apropiado de Pruebas Diagnósticas de Imagen en Cabeza y Cuello.
• Ayudas de la Fundación Pública Andaluza Progreso y Salud, para la financiación de Investigación Biomédica y en Ciencias de la Salud en Andalucía. Junta de Andalucía PI-0130-2014 PI: Jose Manuel Baena Cañada.. Estudio de democracia deliberativa en mujeres participantes en el programa de cribado mamográfico.

1. Virginia Lope, Miguel Martín, Adela Castelló, Amparo Ruiz, Ana Mª Casas, José Manuel Baena-Cañada, Silvia Antolín, Manuel Ramos-Vázquez, José Ángel García-Sáenz, Montserrat Muñoz, Ana Lluch, Ana de Juan-Ferré, Carlos Jara, Pedro Sánchez-Rovira, Antonio Antón, José Ignacio Chacón, Angels Arcusa, Mª Angeles Jimeno, Susana Bezares, Jesús Vioque, Eva Carrasco, Beatriz Pérez-Gómez, Marina Pollán. Overeating, caloric restriction and breast cancer risk by pathologic subtype: the EPIGEICAM study. Scientific Reports 2019; 9:3904 https://doi.org/10.1038/s41598-019-39346-4 1. Impact index (2018): 4,122. Quartile= Q1. Number in the group: (natural sciences) 12/64.
2. Ruíz-Borrego M, Guerrero-Zotano A, Bermejo B, Ramos M, Cruz J, Baena-Cañada JM, Cirauqui B, Rodríguez-Lescure A, Alba E, Martínez-Jáñez N, Muñoz M, Antolín S, Álvarez I, Del Barco S, Sevillano E, Chacón JI, Antón A, Escudero MJ, Ruiz V, Carrasco E, Martín M, on behalf of GEICAM. Phase III evaluating the addition of fulvestrant (F) to anastrozole (A) as adjuvant therapy in postmenopausal women with hormone receptor-positive HER2-negative (HR+/HER2−) early breast cancer (EBC): results from the GEICAM/2006–10 study. Breast Cancer Research and Treatment 2019. doi:10.1007/s10549-019-05296-8. Impact index (2018): 3,605. Quartile= Q2. Number in the group: 89/223.
3. Baena-Cañada JM, Campini-Bermejo A, Gámez-Casado S, Rodríguez L, Quílez A, Martínez MJ, Benítez E. Experiences with prescribing large quantities of systemic anticancer therapy near death. J Palliat Med 2019, doi: 10.1089/jpm.2019.0017. Impact index (2018): 2,490. Quartile= Q2. Number in the group: (Health care sciences and services) 29/94.
4. Beitia M, Solano-Iturri JD, Errarte P, Calvete-Candenas J, Loizate A, Etxezarraga MC, Sanz B, Larrinaga G. (Pro)renin Receptor Expression Increases throughout the Colorectal Adenoma-Adenocarcinoma Sequence and It Is Associated with Worse Colorectal Cancer Prognosis. Cancers (Basel) 2019;11(6). pii: E881. doi: 10.3390/cancers11060881. Impact index (2018): 6,162. Quartile= Q1. Number in the group: 31/229 (Oncology).
5. Morales-Conde M, López-Ibáñez N, Calvete-Candenas J, Mendonça FMI. Fulvestrant-induced toxic epidermal necrolysis. An Bras Dermatol 2019;94(2):218-220. doi: 10.1590/abd1806-4841.20197964. Impact index (2018): Quartile=.
6. López Torrecilla J, Marín I Borràs S, Ruiz-Alonso A, Jaen Olasolo J, Vázquez de la Torre ML, Bóveda Carro E, Rodríguez A, Ignacio García E, Caballero Martínez F, Campos Lucas FJ, Lara Jiménez PC, Martínez JC, Ferrer Albiach C. Quality indicators in radiation oncology: proposal of the Spanish Society of Radiation Oncology (SEOR) for a continuous improvement of the quality of care in oncology. Clin Transl Oncol 2019;21(4):519-533. doi: 10.1007/s12094-018-1943-z. Impact index (2018): 2,441. Quartile= 3. Decile= 7.

1. Rodríguez A, Algara M, Monge D, López-Torrecilla J, Caballero F, Morera R, Escó R, Pérez-Montero H, Ferrer C, Lara PC; Spanish Society of Oncology and Radiotherapy (SEOR) Analysis Group (Tisaire JL). Infrastructure and equipment for radiation oncology in the Spanish National Health System: analysis of external beam radiotherapy 2015-2020.Clin Transl Oncol. 2018;20(3):402-410. doi: 10.1007/s12094-017-1727-x. Impact index: 2.075. Quartile= 4. Decile= 8.
2. Irene Wapnir, Karen N. Price, Stewart J. Anderson, André Robidoux, Miguel Martin, Johan W.R. Nortier, Alexander H. G. Paterson, Mothaffar F. Rimawi, Istvan Lang, José Manuel Baena-Cañada, Beat Thurlimann, Eleftherios P. Mamounas, Charles E. Geyer, Jr., Shari Gelber, Alan S. Coates, Richard D. Gelber, Priya Rastogi, Meredith M. Regan, Norman Wolmark, Stefan P. Aebi; on behalf of International Breast Cancer Study Group, NRG Oncology, Breast International Group. Efficacy of Chemotherapy for ER-Negative and ER-Positive Isolated Locoregional Recurrence of Breast Cancer: Final Analysis of the CALOR Trial. J Clin Oncol 2018, doi: 10.1200/JCO.2017.76.5719. Impact index (2016): 24,008. Quartile= 1. Decile= 1.
3. Baena Cañada JM, Gámez Casado S, Rodríguez Pérez L, Quílez Cutillas A, Cortés Carmona C, Rosado Varela P, Estalella Mendoza S, Ramírez Daffós P, Benítez Rodríguez E. Evaluation of non-genomic, clinical risk and survival results in endocrine-sensitive, HER-2 negative, node negative breast cancer. Med Clin 2018, 10.1016/j.medcli.2018.01.020. Impact index (2016): 1,125. Quartile= 3. Decile= 5.
4. Baena Cañada JM, Rodríguez Pérez L, Gámez Casado S, Quílez Cutillas A, Cortés Carmona C, Rosado Varela P, Estalella Mendoza S, Ramírez Daffós P, Javier Jaén, Benítez Rodríguez E. Evaluation of waiting times for breast cancer diagnosis and surgical treatment. Clin Transl Oncol 2018. doi: 10.1007/s12094-018-1867-7. Impact index (2016): 2,353. Quartile= 3. Decile= 7.
5. José M Baena-Cañada, Violeta Luque- Ribelles, Alicia Quílez-Cutillas, Petra Rosado-Varela, Encarnación Benítez-Rodríguez, Soledad Márquez-Calderón, Juan Manuel Rivera-Bautista. How a deliberative approach includes women in the decisions of screening mammography: a citizens' jury feasibility study in Andalusia, Spain. BMJ Open 2018;8:e019852. doi: 10.1136/bmjopen-2017-019852. Impact index (2017): 2,413. Quartile= 2.

1. Virginia Lope, Miguel Martin, Adela Castelló, Soraya Casla, Amparo Ruiz, Jose Manuel Baena-Cañada, Ana Mª Casas, Lourdes Calvo, Begoña Bermejo, Montserrat Muñoz, Manuel Ramos, Ana de Juan-Ferré, Carlos Jara, Antonio Antón, Mª Ángeles Jimeno, Ana Lluch, Silvia Antolín, Jose Ángel García-Sáenz, Purificación Estévez, Esperanza Arriola-Arellano, Joaquín Gavilá, Beatriz Pérez-Gómez, Eva Carrasco, Marina Pollán. Physical activity and breast cancer risk by pathological subtype. Gynecologic Oncology 2017, 144 (3): 577–585. Impact index: 4.198. Quartile= 1. Decile= 1.
2. Huertas-Fernández María José, Martínez-Bautista María José, Rodríguez-Mateos María Eugenia, Zarzuela-Ramírez Manuel, Muñoz-Lucero Teresa, Baena-Cañada José Manuel. Implementation of safeguards to improve patient safety in chemotherapy. Clin Translat Oncol 2017; 19 (9): 1099-1106. doi: 10.1007/s12094-017-1645-y. Impact index: 2.075. Quartile= 4. Decile= 8.
3. Arroyo C, Rodríguez L, Rodríguez ME, Martínez MJ, Benítez E, Baena JM. Off-label antineoplastic drugs. An effectiveness and safety study. Farmacia Hospitalaria 2017; 41 (3): 382-390. Impact index: 0.20. Quartile= 4. Decile= 10.
4. Firmante de la publicacion (Baena-Cañada JM, miembro de ExteNET Study Group). Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol. Published Online November 13, 2017. http://dx.doi.org/10.1016/S1470-2045(17)30717-9. Impact index (2016): 33,900. Quartile= 1. Decile= 1.
5. Blancas I, Fontanillas M, Conde V, Lao J, Martínez E, Sotelo MJ, Jaen A, Bayo JL, Carabantes F, Illarramendi JJ, Gordon MM, Cruz J, García-Palomo A, Mendiola C, Pérez-Ruiz E, Bofill JS, Baena-Cañada JM, Jáñez NM, Esquerdo G, Ruiz-Borrego M. Efficacy of fulvestrant in the treatment of postmenopausal women with endocrine-resistant advanced breast cancer in routine clinical practice. Clin Transl Oncol. 2017 Nov 24. doi: 10.1007/s12094-017-1797-9. Impact index (2016): 2,353. Quartile= 3. Decile= 7.

1. Firmante de la publicación (Díaz L). Agreement in Metastatic Spinal Cord Compression. J Natl Compr Canc Netw 2016; 14 (1): 70-6. Impact index: 4.262. Quartile= 1. Decile= 3.
2. Firmante de la publicación (Díaz L). Spine Instability Neoplastic Score: agreement across different medical and surgical specialties. Spine J 2016; 16 (5): 591-9. doi: 10.1016/j.spinee.2015.10.006. Impact index: 2.660. Quartile= 1. Decile= 2.
3. Triana González-Carrascosa Vega, Jesús Francisco Sierra Sánchez, María Jose Martínez Bautista, Fatima Garcia Martin, Francisco Suarez Carrascosa, and Jose Manuel Baena Cañada. Medication reconciliation in oncological patients: a randomized clinical trial. Journal of Managed Care & Specialty Pharmacy 2016; 22 (6): 01-07. Impact index: 2.713. Quartile= 2. Decile= 3.
4. Adela Castelló, Brian Bujsse, Miguel Martín, Amparo Ruiz, Ana M. Casas, José M Baena-Cañada, Roberto Pastor, Silvia Antolín, Manuel Ramos, Montserrat Muñoz, Ana Lluch, Ana de Juan-Ferré, Carlos Jara, Virginia Lope, María A. Jimeno, Esperanza Arriola-Arellano, Elena Díaz, Vicente Guillem, Eva Carrasco, Beatriz Pérez-Gómez, Jesús Vioque, Marina Pollán. Evaluating the applicability of data-driven dietary patterns to independent samples with focus on measurement tools for pattern similarity. Journal of the Academy of Nutrition and Dietetics 2016; 116 (12): 1914-24.e6. doi: 10.1016/j.jand.2016.05.008. Impact index: 3.609. Quartile= 1. Decile= 3.

1. González-Haba Peña E, Agustín Ferrández MJ, Mangues Bafalluy I, Alfredo López N, Fraga Fuentes MD, Marín Gil R, Martínez Bautista MJ, Clopés Estela A. Off-label use of oncology drugs: national survey results. Farm Hosp 2015;39 (5): 275-87. doi: 10.7399/fh.2015.39.5.8979. Impact index: 0.20. Quartile= 4. Decile= 10.
2. Expósito J, Linares I, Castillo I, Martínez M, Vargas P, Herruzo I, Medina JA, Palacios A, Bayo E, Peracaula F, Jaén J, Sánchez JA, Ortiz MJ. Evaluation of the utilization of external radiotherapy in the treatment of localized prostate cancer in Andalusia, Spain. Radiat Oncol 2015; 10: 265. doi: 10.1186/s13014-015-0572-8. Impact index: 2.546. Quartile= 2. Decile= 4.
3. Adela Castelló, Miguel Martín, Amparo Ruiz, Ana M. Casas, Jose M Baena-Cañada, Virginia Lope, Silvia Antolín, Pedro Sánchez, Manuel Ramos, Antonio Antón, Montserrat Muñoz, Begoña Bermejo, Ana de Juan-Ferré, Carlos Jara, José Ignacio Chacón, María A. Jimeno, Petra Rosado, Elena Díaz, Vicente Guillem, Ana Lluch, Eva Carrasco, Beatriz Pérez-Gómez, Jesús Vioque, Marina Pollán on behalf of GEICAM researchers. Lower breast cancer risk among women following the World Cancer Research Fund and American Institute for Cancer Research lifestyle recommendations: EpiGEICAM case-control study. PLOS ONE 2015; 10 (5): e0126096 DOI: 10.1371/journal.pone.0126096. Impact index: 3,534. Quartile= 1. Decile= 2.
4. José M. Baena-Cañada, Petra Rosado-Varela, Inmaculada Expósito-Álvarez, Macarena González-Guerrero, Juan Nieto-Vera, Encarnación Benítez-Rodríguez. Using an informed consent in mammography screening: a randomized trial. Cancer Medicine 2015; 4 (12): 1923-32. doi: 10.1002/cam4.525. Impact index: 2.50. Quartile= 3. Decile= 6.
5. Miguel Martín, A. Ruiz, M. Ruiz Borrego, N. Ribelles, A. Rodriguez-Lescure, M. Muñoz-Mateu, S. González, M. Margelí Vila, A. Barnadas, M. Ramos, S. del Barco, C. Jara, L. Calvo, N. Martínez, C. Mendiola Fernández, C. A. Rodríguez, E. Martínez de Dueñas, R. Andrés, A. Plazaola, J. de la Haba, J. M. López-Vega, E. Adrover, A.I. Ballesteros, B. Munárriz, P. Sánchez-Rovira, J.M. Baena-Cañada, M. Casas, M.C. Cámara, E Carrasco, A. Lluch, on behalf of GEICAM (Spanish Breast Cancer Group). Epirubicin plus cyclophosphamide followed by docetaxel (EC-T) versus epirubicin plus docetaxel followed by capecitabine (ET-X) as adjuvant therapy for node-positive early breast cancer: Results from the GEICAM/2003-10 study. J Clin Oncol 2015; 33 (32): 3788-95. Doi: 10.1200/JCO.2015.61.9510. Impact index: 18.443. Quartile= 1. Decile= 1.
6. Garcia-Alfonso P, Chaves M, Muñoz A, Salud A, García-Gonzalez M, Grávalos C, Massuti B, González-Flores E, Queralt B, López-Ladrón A, Losa F, Gómez MJ, Oltra A, Aranda E; Spanish Cooperative Group for the Treatment of Digestive Tumors (TTD). Capecitabine and irinotecan with bevacizumab 2-weekly for metastatic colorectal cancer: the phase II AVAXIRI study. BMC Cancer 2015; 15: 327. doi: 10.1186/s12885-015-1293-y. Impact index: 3.288. Quartile= 1. Decile= 2.

1. López JL, Marrone I, Jaén J, Bruna M, Solé C, Sánchez-Reyes A, Rivin E, Ortiz MJ, Calvo F, Matute R. Outcome and toxicity using helical tomotherapy for craniospinal irradiadion in pediatric medulloblastoma. Clin Transl Oncol 2014;16 (1): 96-101. Impact index: 2.077. Quartile= 3. Decile= 8.
2. Tovar I, Expósito J, Jaén J, Alonso E, Martínez M, Guerrero R, Arrebola JP, Del Moral R. Pattern of use of radiotherapy for lung cancer: a descriptive study. BMC Cancer 2014; 14: 697. doi: 10.1186/1471-2407-14-697. Impact index: 3,362. Quartile= 2. Decile= 4.
3. Baena-Cañada JM. Reflections on the follow-up of long-term cancer survivors in Spain. Gac Sanit 2014; 28 (4): 524. http://dx.doi.org/10.1016/j.gaceta.2014.05.002. Impact index: 1,25. Quartile= 3. Decile= 7.
4. Aebi S, Gelber S, Anderson SJ, Láng I, Robidoux A, Martín M, Nortier JWR, Paterson AHG, Rimawi MF, Baena-Cañada JM, Thürlimann B, Murray E, Mamounas EP, Geyer CE, Price KN, Coates AS, Gelber RD, Rastogi P, Wolmark N, Wapnir IL. Chemotherapy for isolated locoregional recurrence of breast cancer (CALOR): a randomised trial. Lancet Oncol 2014; 15:156-63. Impact index: 25,12. Quartile= 1. Decile= 1.
5. Salvador J, Manso L, de la Haba J, Jaen A, Ciruelos E, de Villena MC, Gil M, Murias A, Galan A, Jara C, Bayo J, Baena JM, Casal J, Mel JR, Blancas I, Sanchez Rovira P. Final results of a phase II study of paclitaxel, bevacizumab, and gemcitabine as first-line therapy for patients with HER2-negative metastatic breast cancer. Clin Transl Oncol 2014; 17 (2): 160-6. doi: 10.1007/s12094-014-1210-x. Impact index: 1,600. Quartile= 4. Decile= 8.
6. José M. Baena-Cañada, Petra Rosado-Varela, Inmaculada Expósito-Álvarez, Macarena González-Guerrero, Juan Nieto-Vera, Encarnación Benítez-Rodríguez. Women’s perceptions of breast cancer screening. Spanish screening programme survey. The Breast 2014; 23: 883-8. doi: 10.1016/j.breast.2014.09.010. Impact index: 2,581. Quartile= 1. Decile= 3.
7. Adela Castelló, Marina Pollán, Brian Buijsse, Amparo Ruiz, Ana Casas, José M. Baena-Cañada, Virginia Lope Carvajal, Silvia Antolín, Manuel Ramos, Montserrat Muñoz, Ana Lluch, Ana de Juan Ferré, Carlos Jara Sanchez, Mª Angeles Jimeno, Petra Rosado, Elena Díaz, Vicente Guillem, Eva Carrasco, Beatriz Pérez-Gómez, Jesús Vioque, Heiner Boeing, and Miguel Martín. Spanish Mediterranean diet and other dietary patterns and breast cancer risk: case-control EpiGEICAM study. British Journal of Cancer 2014; 111 (7): 1454-62. doi: 10.1038/bjc.2014.434. Impact index: 4,817. Quartile= 1. Decile= 3.