EM29: Biomarkers

Research group made up of specialist physicians from the Puerto Real University Hospital, dedicated to the study of biomarkers in blood and biological fluids for the diagnosis and prognosis of diseases, with greater dedication in:

• Cancer biomarkers: the main objective is to identify biomarkers in blood or biological fluids to differentiate benign from malignant tumors. The researcher responsible for this line is Dr. José Diego Santotoribio Camacho, Head of the Clinical Biochemistry Laboratory of the Puerto Real University Hospital and member of the Committee of Experts on Biological Cancer Markers of the Spanish Society of Laboratory Medicine (SEQC-ML ) belonging to the International Federation of Clinical Chemistry (IFCC).
• Biomarkers of urological diseases: lead researcher Dr. Miguel Efren Jiménez Romero, specialist in urology at the Puerto Real University Hospital.
• Biomarkers of pain and brain damage: lead researcher Dr. Pablo Mesa Suarez, a specialist in anesthesiology at the Puerto Real University Hospital.
• Biomarkers of infectious diseases: lead researcher Dr. Carmen Martínez Rubio, Head of the Clinical Microbiology Section of the Puerto Real University Hospital.

• The group's line of research is the study of biomarkers in blood and biological fluids for the diagnosis and prognosis of diseases, with greater dedication to:
  • - Tumor markers.
  • - Inflammation markers.
  • - Infection markers.

Biomarkers Cancer Tumor markers Serology Antibodies

• Principal Investigators:
  • José Diego Santotoribio Camacho (PI).
  • Miguel Efrén Jiménez Romero (Co-PI).
• Investigators:
  • María Mayor Reyes.
  • Lourdes Diez Herrán.
  • Enrique Melguizo Madrid.
  • Rufino Mondéjar García.
  • Pablo Mesa Suárez.
  • Francisco Castro Lobo.
  • Miguel José Pulido Barba.
  • Elba Ysabel Canelón Castillo.
  • Miguel Ángel Sánchez Hurtado.
  • Isabel Bueno González.
  • José Carlos Rodríguez Bocanegra.
  • Carmen Martínez Rubio.
  • Carmen Cebada Romero.
  • Francisco Javier Casas Ciria.
  • Sofía García Martín.
  • Ianire Virto Peña.
  • Iván Fernando Revelo Cadena.

• Convenor organization: ISCIII. Call year: 2016. Start-end date: 01/01/2017 - 31/12/2019. Project name: Linfomas agresivos: Interacción entre el genoma tumoral y el microambiente como determinante de la progresión y respuesta a terapia (PI16/01294). Principal investigator: Miguel Ángel Piris Pinilla (Fundación Jiménez Díaz). Research group collaborators: Rufino Modéjar García. Economic amount: 189.365,00 €.

• Convenor organization: Junta de Andalucía. Consejería de Salud y familias. Call year: 2019. Start-end date: 01/11/2020 - 01/11/2023. Project name: Desarrollo y validación de un biosensor de lactato microinvasivo y en tiempo real para el control del bienestar fetal intraparto (ITI-0002-2019) Principal investigator: Juan Jesús Fernández Alba. Research group collaborators: José Diego Santotoribio Camacho. Economic amount: 310.224,89 €.
• Convenor organization: Comunidad de Madrid, Call year: 2017. Start-end date: 01/01/2018 - 31/12/2022. Project name: Linfomas agresivos, análisis clínico y genómico integrado para una medicina de precisión (B2017/BMD-3778). Principal investigator: Miguel Ángel Piris Pinilla (Fundación Jiménez Díaz). Research group collaborators: Rufino Modéjar García. Economic amount: 810.258,03 €.

• - Q2:
1. Authors: Jiménez-Romero ME (autor de correspondencia); Camacho-Gallego M; Navarro- Serrato JC; Sánchez-Hurtado MA; Santotoribio JD. Title: Treatment of Metastatic Castration- resistant Prostate Cancer Patients With Abiraterone Acetate and Prednisone and Corresponding Survival Prognostic Factors cancer: scientific evidence and sharing of our experience. Journal: Anticancer Research. Year, volume, first and last pages: 2021;41:3955-68. Impact factor in the year of publication: 2,480 (2020). Quartile/decile in the year of publication: Q2 (2020).

• - Q1:
1. Authors: Pérez C, Mondéjar R (C.P. and R.M.contributed equally to this work) García-Díaz N,Cereceda L, León A, Montes S, Durán Vian C, Pérez Paredes MG, González-Morán A, Alegre de MiguelV, Sanz Anquela JM, Frias J, Limeres MA, GonzálezLM, Martin Dávila F, Beltrán M, Mollejo M,Méndez JR, González MA, González García J, LópezR, Gómez A, Izquierdo F, Ramos R, Camacho C, Rodriguez-Pinilla SM, Martinez N, Vaqué JP, Ortiz- Romero PL, Piris MA. Title: Advanced-stage mycosis fungoides: role of the signal transducer and activator of transcription 3, nuclear factor-κB and nuclear factor of activated T cells pathways. Journal: British Journal of Dermatology. 2020;182:147-55. Impact factor in the year of publication: 9,302. Quartile/decile in the year of publication: Q1/D1.

• - Q2:
1. Authors: Lepe-Balsalobre E; Santotoribio JD (autor de correspondencia); Núñez Vázquez R; García-Morillo S; Jimenez-Arriscado P; Hernandez-Arévalo P; De la Rosa-Rodriguez R; Guerrero JM; Macher HC. Title: . Genotype/phenotype relationship in Gaucher disease patients. Novel mutation in glucocerebrosidase gene. Journal: Clinical Chemistry and Laboratory Medicine. Year, volume, first and last pages: 2020;58:2017-24. Impact factor in the year of publication: 3,694. Quartile/decile in the year of publication: Q2.

• - Q2:
1. Authors: Santotoribio JD (autor de correspondencia); Cañavate-Solano C; Quintero- Prado R; González-Macías C; Soto-Pazos E; Vilar- Sánchez A; Mesa-Suárez P; Ramos-Ramos V; Cuadros-Muñoz JF; Mayor-Reyes M; Pérez-Ramos S; Fernández-Alba JJ. Title: Neuroapoptosis in newborns with respiratory acidosis at birth. Journal: Clinical Biochemistry. Year, volume, first and last pages: 2019;74:69-72. Impact factor in the year of publication: 2,610 Quartile/decile in the year of publication: Q2.
2. Authors: Jimenez-Romero ME (autor decorrespondencia),Canelón-Castillo EY, Diéz- Farto S, Santotoribio JD. Title: Radium 223 combined with new hormone therapies for the treatment of castrate-resistant metastatic prostate cancer: scientific evidence and sharing of our experience. Journal: Translational Andrology and Urology Year, volume, first and last pages: 2019;8:567-73. Impact factor in the year of publication:2,445 Quartile/decile in the year of publication: Q2.
3. Authors: Santotoribio JD (autor de correspondencia), Del Valle-Vazquez L, García-de la Torre A, Del Castillo-Otero D, Lopez-Saez JB, Sanchez Del Pino MJ. Title: The diagnostic value of pleural fluid homocysteine in malignant pleural effusion. Journal: PloS One. Year, volume, first and last pages: 2019;14:e0222616. Impact factor in the year of publication: 2,740. Quartile/decile in the year of publication: Q2.

• - Q1:
1. Authors: Mondejar R, Pérez C, Onaindia A, Martinez N, González-Rincón J, Pisonero H, Vaqué JP, Cereceda L, Santibañez M, Sánchez- Beato M, Piris MA Title: Molecular basis of targeted therapy in T/ NK-cell lymphoma/leukemia: A comprehensive genomic and immunohistochemical analysis of a panel of 33 cell lines. Journal: PLoS One. Year, volume, first and last pages: 2017;12:e0177524. Impact factor in the year of publication: 3,240. Quartile/decile in the year of publication: Q1.

• - Q2:
1. Authors: Melguizo-Madrid E (autor de correspondencia), González-Rodríguez C, Ávila- García MG, Arrobas-Velilla T, Fernández-Riejos P. Title: Zenit RA evaluation, a solid-phase chemiluminescence immunoassay for detection of anti-cellular antibodies. Journal: Bioanalisys. Year, volume, first and last pages: 2017;9:435-45. Impact factor in the year of publication: 2,478. Quartile/decile in the year of publication: Q2.