EM4: Inflamación y metabolismo durante el envejecimiento

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EM4: Inflamación y metabolismo durante el envejecimiento

El envejecimiento es el principal factor de riesgo de las enfermedades metabólicas, cardiovasculares y neurodegenerativas. Durante este proceso natural, ocurren muchas alteraciones en el organismo que están asociadas al deterioro progresivo de varias vías metabólicas relacionadas con la composición corporal, resistencia a la insulina, disfunción mitocondrial, autofagia y respuesta inflamatoria. Durante los últimos años, se ha demostrado que la inflamación crónica de bajo grado impulsa el deterioro funcional asociado con la edad a través del agravamiento de la senescencia celular, y que la inhibición de la inflamación puede proporcionar beneficios para la salud. Nuestro grupo se centra en dilucidar los mecanismos e implicaciones de los complejos inflamasomas durante el proceso de envejecimiento, así como las enfermedades asociadas al mismo. Nuestro objetivo es averiguar el mecanismo por el cual, los inflamasomas aceleran el envejecimiento y como su modulación podría mostrar terapias antienvejecimiento de tal forma que consigamos un envejecimiento más saludable.

Además, pretendemos estudiar el papel que cumplen en modelos de envejecimiento acelerado tanto patológicos (síndromes progerorides) como biológico en aquellos tejidos que envejecen antes como es el caso de los ovarios.

Investigador responsable
  • Mario David Cordero Morales
  • Investigador Miguel Servet Tipo I
  • e-mail: mario.cordero@inibica.es
  • ORCID: 0000-0003-0151-3644
Líneas de investigación
  1. Papel de los inflamasomas durante el envejecimiento y sus alteraciones metabólicas.
  2. Implicaciones de los inflamasomas en el envejecimiento ovárico.
  3. Búsqueda de estrategias anti-envejecimiento.
  4. La autofagia y los inflamasomas en las enfermedades raras.
Palabras clave
envejecimiento inflamasomas senescencia autofagia mitocondria enfermedades raras
Investigador responsable
Mario David Cordero Morales
  • Investigador Miguel Servet Tipo I
  • e-mail: mario.cordero@inibica.es
  • ORCID: 0000-0003-0151-3644
Miembros del Equipo
  • Técnico: Debora Lendines Cordero
Convocatorias Nacionales
  • Ministerio de Economía y Competitividad MAT2015-67183-R. (2016-2018). José María Manero Panella (PI). Recubrimientos osteoinductivos y microbianos avanzados para mejorar la osteointegración de biomateriales en patologías osteoporóticas y diabéticas. Role: Associate Investigator. Grant: €121000.
  • Fundación Progreso y Salud (2015-2017), Andalusian Health Service, Junta de Andalucía. Role: PI. Mitochondrial dysfunction and activation of the NLRP3-inflammasome complex as etiological factors of major depression. Role: Principal Investigator. Grant: €35000.
  • Ministry of Health Social Services and Equality (2012). Saldaña Valderas M (PI). Randomized clinical trial, controlled with placebo and doublé blind to evaluate the effectiveness of coenzyme Q10 in diagnosed patients with fibromyalgia. Role: Co-Investigator. Grant: €95000.
Convocatorias Regionales
  • ALBA Andalucía (2013-2015). Andalusian Foundation of Fibromyalgia and Chronic fatigue Syndrome. Role: PI. The role of AMPK gene in the pathophysiology of Fibromyalgia. Role: Principal Investigator. Grant: €10000.
  • ALBA Andalucía (2011-2012). Andalusian Foundation of Fibromyalgia and Chronic fatigue Syndrome. Role: PI. Randomized, double-blind, placebo-controlled study of Coenzyme Q10 therapy in Fibromyalgia patients. Role: Principal Investigator. Grant: €12000.
Convocatorias Internacionales
  • COST association-EU. (2016-2020). Caty Casas Louzao (PI). TRANSAUTOPHAGY: European network for multidisciplinary research and translation of autophagy knowledge. Role: Associate Investigator. Grant: €277000.
Publicaciones
  • Fabiola Marín-Aguilar, Beatriz Castejón-Vega, Elísabet Alcocer-Gómez, Macarena López-Sánchez, Matthew A. Cooper, Eloísa Andújar-Pulido, Mónica Pérez-Alegre, Jordi Muntané, Bernhard Ryffel, Antonio J. Pérez-Pulido, Avril A. B. Robertson, Jesús Ruiz-Cabello, Pedro Bullón, Mario D. Cordero. Inhibition of the NLRP3-inflammasome by MCC950 improves healthspan in aged mice by autophagy and Pparα induction. J Gerontol A Biol Sci. 2020 75(8):1457-1464. IF: 5.4 Q1
  • Fabiola Marín-Aguilar, Ana V. Lechuga-Vieco, Diego Cañadas-Lozano, Elísabet Alcocer-Gómez, Beatriz Castejón-Vega, Alejandro Peralta Garcia, Antonio J. Pérez-Pulido, Alfonso Varela-López, José L. Quiles, Avril A. B. Robertson, Matthew A. Cooper, Bernhard Ryffel, Pedro Bullón, Jesús Ruiz-Cabello, Mario D. Cordero. NLRP3 inflammasome suppresion improves longevity and prevents cardiac aging. Aging Cell 2020 Jan;19(1):e13050. IF: 7.4. D1
  • Cañadas-Lozano D, Marín-Aguilar F, Castejón-Vega B, Ryffel B, Navarro-Pando JM, Ruiz-Cabello J, Alcocer-Gómez E, Bullón P, Cordero MD. Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice. Geroscience. 2020 Apr;42(2):715-725. doi: 10.1007/s11357-019-00151-6. IF: 6.4, D1
  • Sánchez-Díaz M, Nicolás-Ávila JÁ, Cordero MD,Hidalgo A. Mitochondrial Adaptations in the Growing Heart. Trends Endocrinol Metab. 2020 Apr;31(4):308-319. IF: 9.7, D1
  • Garnacho-Montero J, Palacios-García I, Díaz-Martín A, Gutiérrez-Pizarraya A, López-Sánchez JM, Gómez EA, Cordero MD. Sequential Changes of NLRP3 Inflammasome Activation in Sepsis and its Relationship With Death. Shock. 2020 Sep;54(3):294-300. IF: 2.9, Q1
  • Navarro-Pando JM, Bullón P, Cordero MD, Alcocer-Gómez E. Is AMP-Activated Protein Kinase Associated to the Metabolic Changes in Primary Ovarian Insufficiency? Antioxid Redox Signal. 2020 Nov 20;33(15):1115-1121. IF: 7, Q1
  • Nicolás-Ávila JA, Lechuga-Vieco AV, Esteban-Martínez L, Sánchez-Díaz M, Díaz-García E, Santiago DJ, Rubio-Ponce A, Li JL, Balachander A, Quintana JA, Martínez-de-Mena R, Castejón-Vega B, Pun-García A, Través PG, Bonzón-Kulichenko E, García-Marqués F, Cussó L, A-González N, González-Guerra A, Roche-Molina M, Martin-Salamanca S, Crainiciuc G, Guzmán G, Larrazabal J, Herrero-Galán E, Alegre-Cebollada J, Lemke G, Rothlin CV, Jimenez-Borreguero LJ, Reyes G, Castrillo A, Desco M, Muñoz-Cánoves P, Ibáñez B, Torres M, Ng LG, Priori SG, Bueno H, Vázquez J, Cordero MD, Bernal JA, Enríquez JA, Hidalgo A.A Network of Macrophages Supports mitochondrial Homeostasis in the Heart. Cell. 2020 Oct 1;183(1):94-109.e23. IF: 38, D1
  • Gallego P, Castejón-Vega B, Del Campo JA, Cordero MD. The Absence of NLRP3-inflammasome Modulates Hepatic Fibrosis Progression, Lipid Metabolism, and Inflammation in KO NLRP3 Mice during Aging. Cells. 2020 Sep 23;9(10):E2148. IF: 4.3, Q1
  • Cordero MD, Ruiz-Cabello J. Inflamm-ageing or inflammasom-ageing as independent events. Aging (Albany NY). 2020 Sep 28;12(18):17759-17760. IF: 4.8, Q1
  • Navarro-Pando JM, Alcocer-Gómez E, Castejón-Vega B, Navarro-Villarán E, Condés-Hervás M, Mundi-Roldan M, Muntané J, Pérez-Pulido AJ, Bullon P, Wang C, Hoffman HM, Sanz A, Mbalaviele G, Ryffel B, Cordero MD. Inhibition of the NLRP3 inflammasome prevents ovarian aging. Science Advances. 2020. IN PRESS. IF: 13.3, D1.
  • Bullón P, Castejón-Vega B, Román-Malo L, Jimenez-Guerrero MP, Cotán D, Forbes-Hernandez TY, Varela-López A, Pérez-Pulido AJ, Giampieri F, Quiles JL, Battino M, Sánchez-Alcázar JA, Cordero MD. Autophagic dysfunction in patients with Papillon-Lefèvre syndrome is restored by recombinant cathepsin C treatment. J Allergy Clin Immunol. 2018 Feb 2. pii: S0091-6749(18)30144-1. IF: 15.2 D1
  • Pavillard LE, Marín-Aguilar F, Bullon P, Cordero MD. Cardiovascular diseases, NLRP3 inflammasome, and western dietary patterns. Pharmacol Res. 2018 May;131:44-50. IF: 4.8 Q1
  • Cordero MD, Alcocer-Gómez E, Ryffel B. Gain of function mutation and inflammasome driven diseases in human and mouse models. J Autoimmun. 2018 Jul;91:13-22. IF: 7.6 Q1
  • Erdei J, Tóth A, Balogh E, Nyakundi BB, Bányai E, Ryffel B, Paragh G, Cordero MD, Jeney V. Induction of NLRP3 Inflammasome Activation by Heme in Human Endothelial Cells. Oxid Med Cell Longev. 2018 Mar 20;2018:4310816. IF: 4.9 Q1
  • Nyakundi BB, Tóth A, Balogh E, Nagy B, Erdei J, Ryffel B, Paragh G, Cordero MD, Jeney V. Oxidized hemoglobin forms contribute to NLRP3 inflammasome-driven IL-1β production upon intravascular hemolysis. Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):464-475. IF: 4.3 Q1
  • Cordero MD, Williams MR, Ryffel B. AMP-Activated Protein Kinase Regulation of the NLRP3 Inflammasome during Aging. Trends Endocrinol Metab. 2018 Jan;29(1):8-17. IF: 10.7 D1
  • Garcia-Rubira JC, Cano-Garcia FJ, Bullon B, Seoane T, Villar PV, Cordero MD, Bullon P. Body fat and metabolic age as indicators of inflammation and cardiovascular risk. Eur J Prev Cardiol. 2018 Feb;25(3):233-234. IF: 4.5 Q1
  • Pavillard LE, Cañadas-Lozano D, Alcocer-Gómez E, Marín-Aguilar F, Pereira S, Robertson AAB, Muntané J, Ryffel B, Cooper MA, Quiles JL, Bullón P, Ruiz-Cabello J, Cordero MD. NLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy induction. Oncotarget. 2017 Sep. 8;8(59):99740-99756. IF: 5.1 Q1
  • Alcocer-Gómez E, Cordero MD. NLRP3 inflammasome: common nexus between depression and cardiovascular diseases. Nat Rev Cardiol. 2017. 14(2):124. IF: 10.5 D1
  • Marín-Aguilar F, Pavillard LE, Giampieri F, Bullón P, Cordero MD. Adenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compounds. Int J Mol Sci. 2017 Jan 29;18(2). pii: E288. IF: 3.6 Q1
  • Alcocer-Gómez E, Castejón-Vega B, Cordero MD. Stress-Induced NLRP3 Inflammasome in Human Diseases. Adv Protein Chem Struct Biol. 2017;108:127-162.
  • Alcocer-Gómez E, Casas-Barquero N, Williams MR, Romero-Guillena SL, Cañadas-Lozano D, Bullón P, Sánchez-Alcazar JA, Navarro-Pando JM, Cordero MD. Antidepressants induce autophagy dependent-NLRP3-inflammasome inhibition in Major depressive disorder. Pharmacol Res. 2017 Jul;121:114-121. IF: 4.8 Q1
  • Giampieri F, Alvarez-Suarez JM, Cordero MD, Gasparrini M, Forbes-Hernandez TY, Afrin S, Santos-Buelga C, González-Paramás AM, Astolfi P, Rubini C, Zizzi A, Tulipani S, Quiles JL, Mezzetti B, Battino M. Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-activated protein kinase signaling cascade. Food Chem. 2017 Nov 1;234:464-471. IF: 4.9 Q1
  • Forbes-Hernández TY, Giampieri F, Gasparrini M, Afrin S, Mazzoni L, Cordero MD, Mezzetti B, Quiles JL, Battino M. Lipid Accumulation in HepG2 Cells Is Attenuated by Strawberry Extract through AMPK Activation. Nutrients. 2017 Jun 16;9(6). pii: E621. IF: 4.1 Q1
  • Danyels J. Klionsky………………….Mario D. Cordero…………….SM Zughaier. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222. IF: 11,7 D1
  • Zhiyu W, Wang N, Wang Q, Peng C, Zhang J, Liu P, Ou A, Zhong S, Cordero MD, Lin Y. The inflammasome: an emerging therapeutic oncotarget for cancer prevention. Oncotarget. 2016 Aug 2;7(31):50766-50780. IF: 5 Q1
  • Alcocer-Gómez E, Núñez-Vasco J, Casas-Barquero N, Williams MR, Navarro-Pando JM, Bullón P, Cordero MD. Gene Expression Profile in Major Depressive Disorder Shows Reduced Mitochondrial Biogenesis. CNS Neurosci Ther. 2016 Jul;22(7):636-8. IF: 4 Q1
  • Cordero MD, Alcocer-Gómez E. Editorial: Inflammasome Complex in Health and Disease: New Pharmacological Perspectives. Curr Drug Targets. 2016, 18(9):996. IF: 3 Q2
  • Oropesa-Ávila M, de la Cruz-Ojeda P, Porcuna J, Villanueva-Paz M, Fernández-Vega A, de la Mata M, de Lavera I, Rivero JM, Luzón-Hidalgo R, Álvarez-Córdoba M, Cotán D, Zaderenko AP, Cordero MD, Sánchez-Alcázar JA. Two coffins and a funeral: early or late caspase activation determines two types of apoptosis induced by DNA damaging agents. Apoptosis. 2016. 22(3):421-436. IF: 3.5 Q2
  • Bullon P, Cano-García FJ, Alcocer-Gómez E, Varela-Lopez A, Román-Malo L, Ruiz-Salmerón RJ,Quiles JL, Navarro-Pando JM, Battino M, Ruiz-Cabello J, Jiménez-Borreguero LJ, Cordero MD. Could NLRP3-inflammasome be a cardiovascular risk biomarkers in Acute Myocardial Infarction Patients? Antioxid Redox Signal. 2016, 27(5):269-275. IF: 7 D1
  • Oropesa Ávila M, Fernández Vega A, Garrido Maraver J, Villanueva Paz M, De Lavera I, De La Mata M, Cordero MD, Alcocer Gómez E, Delgado Pavón A, Álvarez Córdoba M, Cotán D, Sánchez-Alcázar JA. Emerging Roles of Apoptotic Microtubules During the Execution Phase of Apoptosis. Cytoskeleton (Hoboken)., 2015, In Press. IF: 3,1 Q1
  • Mario D. Cordero. The inflammasome in fibromyalgia and CRPS: a microglial hypothesis?. Nature Reviews Rheumatology, 2015, In Press. IF: 9,8 D1
  • Mario D. Cordero, Elísabet Alcocer-Gómez, Fabiola Marín-Aguilar, Tatyana Rybkina, David Cotán, Antonio Pérez-Pulido, José Miguel Alvarez-Suarez, Maurizio Battino, José Antonio Sánchez-Alcazar, Angel M. Carrión, Ognjen Culic, José M Navarro-Pando, Pedro Bullón. Mutation in Cytochrome b gene of mitochondrial DNA in a family with Fibromyalgia is associated with NLRP3-Inflammasome activation. J Med Genet. 2015. In Press. IF: 6,3 Q1
  • Villanueva Paz M, Cotán D, Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, de La Mata M, Delgado Pavón A, de Lavera I, Alcocer-Gómez E, Sánchez-Alcázar JA. Targeting autophagy and mitophagy for mitochondrial diseases treatment. Expert Opin Ther Targets. 2015 Nov 2:1-14. IF: 5,1 Q1
  • Alcocer-Gómez E, Garrido-Maraver J, Bullón P, Marín-Aguilar F, Cotán D, Carrión AM, Alvarez-Suarez JM, Giampieri F, Sánchez-Alcazar JA, Battino M, Cordero MD. Metformin and caloric restriction induce an AMPK-dependent restoration of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients. Biochim Biophys Acta-Molecular Basis of Diseases. 2015. pii: S0925-4439(15)00069-1. IF: 4,8 Q1
  • Mario D. Cordero, Benoit Viollet. Editorial: AMPK: New frontiers in human diseases. Current Drug Target, 2016, 17(8):852. IF: 3 Q2
  • de la Mata M, Cotán D, Oropesa-Ávila M, Garrido-Maraver J, Cordero MD, Villanueva Paz M, Delgado Pavón A, Alcocer-Gómez E, de Lavera I, Ybot-González P, Paula Zaderenko A, Ortiz Mellet C, Fernández JM, Sánchez-Alcázar JA. Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease. Sci Rep, 2015, 5:10903. IF: 5,8 Q1
  • Pedro Bullón, Elísabet Alcocer-Gómez, Angel M. Carrión, Fabiola Marín-Aguilar, Juan Garrido-Maraver, Lourdes Román-Malo, Jesus Ruiz-Cabello, Ognjen Culic, Bernhard Ryffel, Lionel Apetoh, François Ghiringhelli, Maurizio Battino, José Antonio Sánchez-Alcazar, Mario D. Cordero. AMPK phosphorylation modulates pain by activation of NLRP3-inflammasome. Antioxid Redox Signal, 2015, In Press. IF: 7,4 D1
  • Varela-Lopez A, Bullon P, Battino M, Ramirez-Tortosa M, Ochoa JJ, Cordero MD, Ramirez-Tortosa CL, Rubini C, Zizzi A, Quiles JL. Coenzyme Q Protects Against Age-Related Alveolar Bone Loss Associated to n-6 Polyunsaturated Fatty Acid Rich-Diets by Modulating Mitochondrial Mechanisms. J Gerontol A Biol Sci Med Sci, 2015, In Press. IF: 5,4 Q1
  • Garrido-Maraver J, Paz MV, Cordero MD, Bautista-Lorite J, Oropesa-Ávila M, de la Mata M, Pavón AD, de Lavera I, Alcocer-Gómez E, Galán F, Ybot González P, Cotán D, Jackson S, Sánchez-Alcázar JA. Critical role of AMP-activated protein kinase in the balance between mitophagy and mitochondrial biogenesis in MELAS disease. BBA-Molecular Bases of Diseases, 2015, In Press. IF: 4,8 Q1
  • Alcocer-Gómez E, Ulecia-Morón C, Marín-Aguilar F, Rybkina T, Casas-Barquero N, Ruiz-Cabello J, Ryffel B, Apetoh L, Ghiringhelli F, Bullón P, Sánchez-Alcazar JA, Carrión AM, Mario D. Cordero. Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome. Mol Neurobiol, 2015, In Press. IF: 5,1 Q1
  • Sánchez-Domínguez B, Bullón P, Román-Malo L, Marín-Aguilar F, Alcocer-Gómez E, Carrión AM, Sánchez-Alcazar JA, Cordero MD. Oxidative stress, mitochondrial dysfunction and, inflammation common events in skin of patients with Fibromyalgia. Mitochondrion. 2015. pii: S1567-7249(15)00021-5. IF: 3,2 Q1
  • Pagano G, Aiello Talamanca A, Castello G, Cordero MD, d'Ischia M, Gadaleta MN, Pallardó FV, Petrović S, Tiano L, Zatterale A. Current Experience in Testing Mitochondrial Nutrients in Disorders Featuring Oxidative Stress and Mitochondrial Dysfunction: Rational Design of Chemoprevention Trials.a: International journal of molecular sciences. 2015;15(11):20169-20208. IF: 2,9 Q2
  • Castro-Marrero J, Cordero MD, Segundo MJ, Saez-Francas N, Calvo N, Román-Malo L, Aliste L, Fernandez de Sevilla T, Alegre-Martin J. Does oral Coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in Chronic Fatigue Syndrome? Antioxid Redox Signal. 2015; 22(8):679-85. IF: 7,4 D1
  • Pedro Bullón, Lourdes Román-Malo, Fabiola Marín-Aguilar, José Miguel Alvarez-Suarez, Francesca Giampieri, Maurizio Battino, Mario D. Cordero. Lipophilic antioxidants prevent lipopolysaccharide-induced mitochondrial dysfunction through mitochondrial biogenesis improvement. Pharmacological Research. 2015;91:1-8. IF: 4,4 Q1
  • Elisabet Alcocer-Gómez, Mario D. Cordero. NLRP3 inflammasome: a new target in Major Depressive Disorder. CNS: Neuroscience and Therapeutics. 2014, 20(3):294-5. IF: 3,7 Q1
  • Elísabet Alcocer-Gómez, Jose A. Sanchez-Alcazar, Maurizio Battino, Pedro Bullón, Mario D. Cordero. Aging-related changes in inflammatory and LKB1/AMPK gene expression in Fibromyalgia patients. CNS: Neuroscience and Therapeutics.
  • Josè M Alvarez-Suarez; Francesca Giampieri; Sara Tulipani; Tiziana Casoli; Giuseppina Di Stefano; Ana M Gonzalez-Paramas; Celestino Santos-Buelga; Franco Busco; Josè L Quiles; Mario D Cordero; Stefano Bompadre; Bruno Mezzetti, Maurizio Battino. One-month strawberry-rich anthocyanins supplementation ameliorates cardiovascular risk, oxidative stress markers and platelets activation in humans. J Nutr Biochem. 2014, S0955-2863(13)00249-0. IF: 4,5 Q1
  • Pedro Bullon, Maurizio Battino, Alfonso Varela-Lopez, Patricia Perez-Lopez, Sergio Granados-Principal, Maria C. Ramirez-Tortosa, Julio J. Ochoa, Mario D. Cordero, Adrian Gonzalez-Alonso, César L. Ramirez-Tortosa, Corrado Rubini, Antonio Zizzi, José L. Quiles. Diets based on virgin olive oil or fish oil but not on sunflower oil prevent age-related alveolar bone resorption by mitochondrial-related mechanisms. PLOS One. 2013, 8(9):e74234. IF: 3,5 Q2
  • Elísabet Alcocer-Gómez, Francisco J. Cano García, Mario D. Cordero. Effect of Coenzyme Q10 evaluated by 1990 and 2010 ACR Diagnostic Criteria for Fibromyalgia and SCL-90-R: four case report and literature review. Nutrition, 2013; 29(11-12):1422-5. IF: 3 Q2
  • Mario D. Cordero*, Elísabet Alcocer-Gómez*, Ognjen Culic, Angel M. Carrión, Manuel de Miguel, Eduardo Díaz-Parrado, Eva M. Pérez-Villegas, Pedro Bullón, Maurizio Battino, José Antonio Sánchez-Alcazar. NLRP3 Inflammasome is activated in Fibromyalgia: the effect of Coenzyme Q10. Antioxidants & Redox Signaling, 2013; 20(8):1169-80. IF: 7,6 D1
  • Elísabet Alcocer-Gómez, Manuel De Miguel, Nieves Casas-Barquero, Jéssica Núñez-Vasco, José A. Sánchez-Alcázar, Ana Fernández-Rodríguez, Mario D. Cordero. NLRP3 inflammasome activated in mononuclear blood cells from patients with Major Depressive Disorder. Brain, Behavior and Immunity, 2014; S0889-1591(13)00516-3. IF: 6,1 Q1
  • Elísabet Alcocer-Gómez, José A. Sánchez-Alcázar, Mario D. Cordero. Coenzyme Q10 regulates serotonin levels and depressive symptoms in Fibromyalgia patients: results of a small clinical trial. The Journal of Clinical Psychopharmacology, 2014; 34(2):277-8. IF: 3,7 Q2
  • Juan Garrido Maraver, Mario D. Cordero, Manuel Oropesa-Avila, Alejandro Fernandez Vega, Mario de la Mata, Ana Delgado Pavon, Elisabet Alcocer-Gomez, Carmen Perez Calero, Marina Villanueva Paz, Macarena Alanis, Isabel de Lavera, David Cotan, Jose A. Sanchez-Alcazar. Clinical applications of coenzyme Q10. Frontiers in Biosciences. 2013, 19:619-33. IF: 4,2 Q1
  • Jesus Castro-Marrero, Mario D. Cordero, Naia Sáez-Francas, Conxita Jimenez-Gutierrez, Francisco J. Aguilar-Montilla, Luisa Aliste, Jose Alegre-Martin. Could Mitochondrial Dysfunction Be a Differentiating Marker Between Chronic Fatigue Syndrome and Fibromyalgia? Antioxidants & Redox Signaling, 2013; 19(15):1855-60. IF: 7,6 D1
  • Mario D. Cordero, Elísabet Alcocer-Gómez, Manuel de Miguel, Ognjen Culic, Angel M. Carrión, Jose M. Alvarez Suarez, Pedro Bullon, Maurizio Battino, Ana Fernández-Rodríguez, José A. Sánchez-Alcázar. Can Coenzyme Q10 Improve Clinical and Molecular Parameters in Fibromyalgia?. Antioxidants & Redox Signaling, 2013; 19(12):1356-61. IF: 7,6 D1
  • Manuel Oropesa-Ávila, Ana Fernández-Vega, Mario de la Mata, Juan Garrido Maraver, Mario D. Cordero, David Cotán, Manuel de Miguel, Calero CP, Paz MV, Pavón AD, Sánchez MA, Zaderenko AP, Ybot-González P, Sánchez-Alcázar JA. Apoptotic microtubules delimit an active caspase free area in the cellular cortex during the execution phase of apoptosis. Cell Death & Diseases, 2013; 4:e527. IF: 5,1 Q1
  • Mario D. Cordero, Eduardo Díaz-Parrado, Angel M. Carrión, Simona Alfonsi, José A. Sánchez-Alcázar, Pedro Bullon, Maurizio Battino, Manuel de Miguel. Is inflammation a mitochondrial dysfunction-dependent event in Fibromyalgia? Antioxidants & Redox Signaling, 2012; 18(7):800-7. IF: 8 D1
  • Pedro Bullon, Mario D. Cordero, José L. Quiles, Mari Carmen Ramirez-Tortosa, Adrian Gonzalez-Alonso, Simona Alfonsi, Rocio Garcia-Marin, Manuel de Miguel, Maurizio Battino. Autophagy in periodontitis patients and gingival fibroblasts: unraveling the link between chronic diseases and inflammation. BMC Medicine, 2012; 10(1):122. IF: 6,6 D1
  • Mario D. Cordero, Elísabet Alcocer-Gómez, Francisco Javier Cano-García, Benito Sánchez-Domínguez, Patrícia Fernández Riejo, Ana M. Moreno Fernández, Ana Fernández Rodríguez, Manuel De Miguel. Clinical symptoms in fibromyalgia are associated to overweight and lipid profile. Rheumatology International, 2012; 34(3):419-22. IF: 2,2 Q2
  • Juan Garrido-Maraver, Mario D. Cordero, Irene Domínguez Moñino, Sheila Pereira-Arenas, Ana V. Lechuga-Vieco, David Cotán, Mario De la Mata, Manuel Oropesa-Ávila, Manuel De Miguel, Juan Bautista Lorite, Eloy Rivas Infante, Manuel Alvarez-Dolado, Plácido Navas, Sandra Jackson, Silvia Francisci, José A. Sánchez-Alcázar. Screening of effective pharmacological treatments for MELAS syndrome using yeasts, fibroblasts and cybrids models of the disease. British Journal of Pharmacology, 2012; 167(6):1311-1328. IF: 5 Q1
  • Mario D. Cordero, David Cotán, Yaiza del-Pozo-Martín, Angel M. Carrión, Manuel de Miguel, Pedro Bullón, José Antonio Sánchez-Alcazar. Oral Coenzyme Q10 supplementation improves clinical symptoms and recovers pathological alterations in BMCs in a fibromyalgia patient. Nutrition, 2012; 28(11-12):1200-3. IF: 2,8 Q2
  • Mario D. Cordero; Rocio Santos-García; David Bermejo-Jover; Benito Sánchez-Domínguez; María Reyes Jaramillo-Santos; Pedro Bullón. Coenzyme Q10 in salivary cells correlate with blood cells in Fibromyalgia: improvement in clinical and biochemical parameter after oral treatment. Clinical Biochemistry, 2012; 45(6):509-11. IF: 2,1 Q2
  • Mario De la Mata, Juan Garrido-Maraver, David Cotán, Mario D. Cordero, Manuel Oropesa-Ávila, Lourdes Gómez Izquierdo, Manuel De Miguel, Juan Bautista Lorite, Eloy Rivas Infante, Patricia Ybot, Sandra Jackson and José A. Sánchez-Alcázar. Recovery of MERRF fibroblasts and cybrids pathophysiology by coenzyme Q10. Neurotherapeutics, 2012; 9(2):446-63. IF: 5,9 Q1
  • Mario D. Cordero, Francisco Javier Cano-García, Elísabet Alcocer-Gómez, Manuel De Miguel, José Antonio Sánchez-Alcázar. Oxidative stress correlates with headache symptoms in fibromyalgia: Coenzyme Q10 effect on clinical improvement. Plos One, 2012; 7(4):e35677. IF: 4 Q1
  • Ana María Moreno Fernández; Mario D. Cordero; Juan Garrido-Maraver; Elísabet Alcocer-Gómez; Nieves Casas-Barquero; María I. Carmona-López ; José Antonio Sánchez Alcázar; Manuel De Miguel. Oral treatment with amitriptyline induces Coenzyme Q deficiency and oxidative stress in psychiatric patients. Journal of Psychiatric Research, 2012; 46(3):341-5. IF: 4,6 Q1
  • David Cotán, Mario D. Cordero, Juan Garrido-Maraver, Manuel OropesaÁvila, Ángeles Rodríguez-Hernández, Lourdes Gómez Izquierdo, Mario De la Mata, Manuel De Miguel, Juan Bautista Lorite, Eloy Rivas Infante, Sandra Jackson, Plácido Navas, and José A. Sánchez-Alcázar. Secondary coenzyme Q10 deficiency triggers mitochondria degradation by mitophagy in MELAS fibroblasts. FASEB J, 2011; 25(8):2669-87. IF: 5,7 Q1
  • Mario D. Cordero, Elísabet Alcocer-Gómez, Francisco J. Cano-García, Manuel De Miguel, Angel M. Carrión, Plácido Navas, and José A. Sánchez Alcázar. Clinical symptoms in fibromyalgia are better associated to lipid peroxidation
  • Manuel Oropesa; Mario de la Mata; Juan Garrido Maraver; Mario D Cordero; David Cotán; Ángeles Rodríguez-Hernández; Irene Domínguez-Moñino; Manuel De Miguel; Plácido Navas; Jose A. Sanchez-Alcazar. Apoptotic microtubule network organization and maintenance depend on high cellular ATP levels and energized mitochondria. Apoptosis, 2011; 16(4):404-24. IF: 4,7 Q1
  • Pedro Bullon, Mario D. Cordero, Josè L Quiles, Juan M Morillo, Maria C Ramirez-Tortosa, Maurizio Battino. Mitochondrial dysfunction promoted by Porphyromonas gingivalis lipopolysaccharide as a possible link between cardiovascular disease and periodontitis. Free Radical Biology and Medicine, 2011; 50(10):1336-43. IF: 5,4 Q1
  • Mario D. Cordero; Elísabet Alcocer-Gómez; Manuel de Miguel; Francisco Javier Cano-García; Carlos M. Luque; Patricia Fernández-Riejo; Ana María Moreno Fernández; José Antonio Sánchez-Alcazar. Coenzyme Q10: a novel therapeutic approach for Fibromyalgia? Case series with 5 patients. Mitochondrion, 2011; 11(4):623-5. IF: 3,6 Q2
  • María Rosa Bautista-Ferrufino, Mario D. Cordero, José Antonio Sánchez-Alcázar, Matilde Illanes, Ana Fernández-Rodríguez, Plácido Navas, Manuel de Miguel. Amitriptyline induces coenzyme Q deficiency and oxidative damage in mouse lung and liver. Toxicology Letters, 2011; 204(1):32-7. IF: 3,2 Q1 levels in bloodvmononuclear cells rather than in plasma. PLOS One, 2011; 6(10):e26915. IF: 4 Q1
  • Mario D. Cordero, Manuel De Miguel, Ana M. Moreno-Fernández, Inés M. Carmona-López, Juan Garrido-Maraver, David Cotán, Lourdes Gómez Izquierdo, Pablo Bonal, Francisco Campa, Pedro Bullon, Plácido Navas, and José A. Sánchez-Alcázar. Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implication in the pathogenesis of the disease. Arthritis Research and Therapy, 2010; 12(1):R17. IF: 4,3, D1
  • Mario D. Cordero, A. M. Moreno Fernández, María I. Carmona-López , J. A. Sánchez Alcázar, Ana Fernández Rodríguez, P. Navas and Manuel de Miguel. Mitochondrial dysfunction in skin biopsies and blood mononuclear cells from two cases of fibromyalgia patients. Clinical biochemistry, 2010; 43(13-14):1174-6. IF: 2 Q2
  • Mario D. Cordero, José Antonio Sánchez-Alcazar, María Rosa Bautista-Ferrufino, María Inés Carmona-López, Matilde Illanes, María José Rios, Juan Garrido-Maraver, Ana Alcudia, Placido Navas and Manuel de Miguel. Acute oxidant damage promoted on cancer cells by amitriptyline in comparison with some common chemotherapeutic drugs. Anticancer drugs, 2010; 21(10):932-944. IF: 2,3 Q2
Patentes
  • Inventors: Manuel de Miguel Rodriguez, Mario David Cordero Morales. Title: Use of amitriptyline as an antitumor agent for treating lung cancer. N. Application: P201000061 Priority country: Spain Priority date: 19/01/2010 Holder entity: University of Seville. Countries to which it has spread: Spain Business / s that are exploding: US
  • Inventors: Jose Antonio Sanchez Alcazar, Mario Cordero Morales, Mario De la Mata, David Cotán Marin, Manuel Oropesa Avila, Juan Garrido Maraver. Title: Method for screening and / or assessment of the efficacy of drugs for the treatment of mitochondrial diseases and MELAS syndrome. N. Application: P201230936 Priority country: Spain Priority date: 15/06/2012 Holder entity: University Pablo de Olavide. Countries to which it has spread: Spain Business / s that are exploding: UPO
  • Inventors: Jose Antonio Sanchez Alcazar, Manuel Oropesa Avila, Alejandro Fernandez Vega, Juan Garrido Maraver, Mario De la Mata, David Cotán Marin Pavon Ana Delgado, Carmen Perez Calero Marina Paz Villanueva, Mario Cordero Morales, Elizabeth of Lavera Calderon. Title: Stabilizing compounds of apoptotic cells. N. Application: P201331533 Priority country: Spain Priority date: 10/17/2013 Holder entity: University Pablo de Olavide. Countries to which it has spread: Spain Business / s that are exploding: US
  • Inventors: Mario Cordero Morales, Manuel Miguel Angel Carrion Rodriguez, Jose Antonio Sanchez Alcazar, Angela Fontan Lozano Title: Rodent model for fibromyalgia and chronic pain. N. Application: P201300574 Priority country: Spain Priority date: 06/14/2013 Holder entity: Universidad de Sevilla, University Pablo de Olavide. Countries to which it has spread: Spain Business / s that are exploding: UPO, US
  • Inventors: Mario Cordero Morales, Pedro Fernandez Bullón, Elizabeth Alcocer Gomez Title: Use of AMPK inductors and metformin for fibromyalgia treatment. N. Application: P201400296 Priority country: Spain Priority date: 27/03/2014 Holder entity: University of Seville Countries that has spread: Spain, USA Business / s that are exploding: US