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CO1: INMOX (Inflammation, Nutrition, Metabolism and Oxidative Stress)

Our research is mainly focused on the search for novel diagnostic methods and therapeutic strategies whose primary purpose is to treat and prevent obesity, diabetes and its complications from the gestational stage to adulthood, and the influence of nutrition on inflammation and oxidative stress. We are a multidisciplinary group, and with a marked translational character, from the research laboratory to the patient and to society as a whole.

The members of the research team are distributed between the IN-CO1 group of the Cádiz Biomedical Research and Innovation Institute (INiBICA) and the CTS-927 group of the Andalusian Research Plan (PAIDI), in the context of a mixed group made up of a care team made up of Specialist Physicians from the Pediatrics and Physiotherapy Area, Nurses and a team specialized in biomedical research from the Research Unit of the Puerta del Mar University Hospital (Biochemists and Biologists) and from the Department of Biomedicine, Biotechnology and Public Health (Area of Biochemistry and Molecular Biology) of the University of Cádiz. Biomedical research focuses on developing novel diagnostic methods and therapeutic strategies for the care and prevention of obesity, diabetes and their complications, from the gestation stage to adulthood. The group's experience in the analysis of oxidative stress, antioxidant response and energy metabolism is implemented in the identification of risk biomarkers for associated complications and inflammatory diseases.

Principal Investigator
Lines of research
  • Line 1: In vivo antioxidant activity of food. Development of biochemical techniques for the in vivo analysis of the real antioxidant activity of food after its ingestion. This line of work is proposed as a service to companies in the agri-food sector interested in clinically certifying the real antioxidant activity in the people who consume them. NutrOX Testing Project.
  • Line 2: Mechanisms and markers of oxidative and inflammatory damage induced by food in childhood obesity, Type 1 Diabetes and Cystic Fibrosis.
Keywords
Diabetes Obesity Pregnancy Oxidative stress Omics Nutrition Inflammation
Principal Investigator
Alfonso María Lechuga Sancho
Professor of the Maternal and Child Department and Radiology of the University of Cádiz, with care links to the SAS.
Team members
  • Principal Investigators:
    • Alfonso M. Lechuga Sancho (PI).
  • Emerging Researchers:
    • Raúl González Domínguez (Miguel Servet Investigator).
  • Investigators:
    • M. Carmen Segundo Iglesias.
    • Francisco Javier Caro Contreras.
    • Francisco Medina Prieto.
  • Postdoctoral Researchers:
    • María Ángeles Santos Mata.
    • María de la Paz Gómez Jiménez.
    • Pablo Ruiz Ocaña.
  • Predoctoral Researchers:
    • Álvaro González Domínguez.
    • Ana García Zarzuela.
    • Celia Morales Pérez.
    • Jesús Domínguez Riscart.
    • María Heredia Torrejón.
    • Nuria Buero Fernández.
  • Research Support Staff:
    • María de las Nieves Romero Cayetano (Technical staff).
    • Juan Jesús Cobacho de Alba (Nurse).
International Calls
  • Title: Inflammasome inhibition and polypill strategy in the treatment of HGPS. PRF80 2022. PI: Mario David Cordero. RC: Álvaro González-Domínguez. Progeria Research Foundation.
National Calls
  • Instituto Salud Carlos III. 2019. PI19/00257. Collaboration. Implicaciones fisiopatológicas y valor diagnóstico de los miRNAs candidatos involucrados en el Desarrollo temprano de obesidad y enfermedad metabólica. Estudio CHILDEM.
  • Instituto Salud Carlos III. 2018 PI18/01316. PI: Rosa Mª Mateos Bernal and Co-PI: Alfonso Lechuga Sancho. VALOR DIAGNÓSTICO DE LA DEPLECIÓN ANTIOXIDANTE DEL ERITROCITO EN OBESIDAD INFANTIL.
  • MINISTERIO DE ECONOMÍA, INDUSTRIA Y COMPETITIVIDAD CTQ2017-86661-R. Colaboración en IMPREGNACIÓN DE EXTRACTOS Y FUNCIONALIZACIÓN DE NANOPARTÍCULAS ANTIOXIDANTES OBTENIDOS DE HOJAS DE MANGO MEDIANTE PROCESOS A ALTA PRESIÓN Y SU APLICACIÓN EN BIOMEDICINA.
  • Instituto Salud Carlos III. PI16/00370 Collaboration. Estado proinflamatorio y marcadores de daño endotelial en mujeres con Diabetes Mellitus Gestacional y su relación con el patrón diario de presión arterial.
  • Instituto Salud Carlos III. PI14/00710 Collaboration. Incidencia de diabetes tipo 2 en el estudio di@bet.es: papel de los ácidos grasos y de sistema de transporte regulado por VEGFB.
  • Instituto Salud Carlos III. PI14/01779 Collaboration. Papel de la translocación bacteriana en las modificaciones numéricas y funcionales de los polimorfonucleares neutrófilos en enfermos infectados por VIH.
Regional Calls
  • Consejería de Salud y Familias 2019. Proyectos de Investigación. PI-0209-2019. PI: Francisco M. Visiedo García. Grupo Colaborador. Title of the project: ERIT-OX (Análisis de las defensas antioxidantes del eritrocito frente al estrés oxidativo inducido por la obesidad. Uma primera aproximación a la proteómica en la obesidad infantil como modelo de estudio.
  • Iniciativa Territorial Integrada (ITI) 2014-2020 para la provincia de Cádiz, por la Consejería de Salud y por el Fondo Europeo de Desarrollo Regiona PI-0052-2017 Colaboración en Proyecto Gadicor. Proyecto Matricial para potenciar la Investigación Cardiovascular (CV) en la provincia de Cádiz.
  • Iniciativa Territorial Integrada (ITI) 2014-2020 para la provincia de Cádiz, por la Consejería de Salud y por el Fondo Europeo de Desarrollo Regiona PI-0007-2017.Colaboración en Prevención del sobrepeso y la obesidad infantil en escolares de la provincia de Cádiz. Estudio cuasiexperimental de la efectividad de una intervención multicomponente.
Local Calls
  • Plan Propio INIBICA. Proyectos de Investigación. LI19/15IN-CO24. PI: Alfonso M. Lechuga Sancho and Francisco M. Visiedo García. Title of the project: ERIT-OX (Análisis de las defensas antioxidantes del eritrocito frente al estrés oxidativo inducido por la obesidad. Uma primera aproximación a la proteómica en la obesidad infantil como modelo de estudio.
Non-Competitive Calls
  • FUN-GENOME (Caracterización FUNcional de Variantes GENÓMicas de Significado Incierto en pacientes con Síndrome de Noonan y otras RASopatías). PI: Alfonso María Lechuga Sancho.
  • GLUCOTYPP (Glucotype-based personalized nutrition for the management of childhood obesity. PI: Alfonso María Lechuga Sancho.
2022 Publications
  1. Growth hormone treatment does not to lead to insulin resistance nor excessive rise in IGF-1 levels, while improving height in patients small for gestational age A long-term observational study.López-Siguero JP, Martínez-Aedo MJ, Bermúdez de la Vega JA, Bosch-Muñoz J, Lechuga-Sancho AM, Villalobos T; SGA Study Investigator Collaborative Group. Clin Endocrinol (Oxf). 2022 Apr;96(4):558-568. doi: 10.1111/cen.14626. Epub 2021 Dec 9. PMID: 34882803. FI 3.478. Q/D 3. INIBICA appears in Affiliation? NO.
  2. Gregorio Peron; Tomás Meroño; Giorgio Gargari; Nicole Hidalgo Liberona; Antonio Miñarro; Esteban Vegas Lozano; Pol Castellano Escuder; RAÚL GONZÁLEZ DOMÍNGUEZ; Cristian del Bo'; Stefano Bernardi; Paul A. Kroon; Antonio Cherubini; Patrizia Riso; Simone Guglielmetti; Cristina Andrés Lacueva. A polyphenol-rich diet increases the gut microbiota metabolite indole 3-propionic acid in older adults with preserved kidney function: implication of the gut-kidney axis in dietary interventions. Molecular Nutrition & Food Research. pp. e2100349. Wiley, 2022. DOI: 10.1002/mnfr.202100349; PMID: 35315592. FI 5.914. Q/D 1. INIBICA appears in Affiliation? NO.
  3. RAÚL GONZÁLEZ DOMÍNGUEZ; Pol Castellano Escuder; Sophie Lefèvre-Arbogast; Dorrain Yanwen Low; Andrea Du Preez; Silvie Ruigrok; Hyunah Lee; Catherine Helmer; Mercè Pallàs; Mireia Urpi Sarda; Alex Sánchez Pla; Aniko Korosi; Paul J Lucassen; Ludwig Aigner; Claudine Manach; Sandrine Thuret; Cécilia Samieri; Cristina Andrés Lacueva. Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline. Alzheimer's Research & Therapy. 14, pp. 1. BMC, 2022. DOI: 10.1186/s13195-021-00948-8; PMID: 34980257. FI 6.982. Q/D 1. INIBICA appears in Affiliation? NO.
  4. Teresa Cavaco; Ana Cristina Figueira; RAÚL GONZÁLEZ DOMÍNGUEZ; Ana Sayago; Ángeles Fernández Recamales. Evolution of physicochemical parameters during the thermal-based production of água-mel, a traditional Portuguese honey-related food product. Molecules. 27 - 1, pp. 57. MDPI, 2022. DOI: 10.3390/molecules27010057; PMID: 35011289. FI 4.412. Q/D 2. INIBICA appears in Affiliation? NO.
  5. Steven Saavedra; Ángeles Fernández Recamales; Ana Sayago; Antonio Cervera Barajas; RAÚL GONZÁLEZ DOMÍNGUEZ; Juan Diego González Sanz. Impact of dietary mercury intake during pregnancy on the health of neonates and children: a systematic review. Nutrition Reviews. 80 - 2, pp. 317 - 328. Oxford University Press, 2022. DOI: 10.1093/nutrit/nuab029; PMID: 33954792. FI 7.110. Q/D 1. INIBICA appears in Affiliation? NO.
2021 Publications
  1. Levels of lactic acid's concordance with pH in pediatric parapneumonic pleural effusion.Estalella-Mendoza A, Lechuga-Sancho AM, Flores-González JC. Clin Biochem. 2021 Oct;96:8-12. doi: 10.1016/j.clinbiochem.2021.06.006. Epub 2021 Jul 1. PMID: 34217698. FI 3.281. Q/D 2. INIBICA appears in Affiliation? YES.
  2. Hybrid Closed-Loop System Achieves Optimal Perioperative Glycemia in a Boy With Type 1 Diabetes: A Case Report. Dominguez-Riscart J, Buero-Fernandez N, Garcia-Zarzuela A, Marmolejo-Franco FA, Perez-Guerrero AC, Lechuga-Sancho AM. Front Pediatr. 2021 Apr 29;9:625390. doi: 10.3389/fped.2021.625390. eCollection 2021. PMID: 33996680 Free PMC article. FI 3.418. Q/D 1. INIBICA appears in Affiliation? YES.
  3. Toxicity Induced by Cytokines, Glucose, and Lipids Increase Apoptosis and Hamper Insulin Secretion in the 1.1E7 Beta Cell-Line. Diaz-Ganete A, Quiroga-de-Castro A, Mateos RM, Medina F, Segundo C, Lechuga-Sancho AM. Int J Mol Sci. 2021 Mar 4;22(5):2559. doi: 10.3390/ijms22052559. PMID: 33806355 Free PMC article. FI 5.923. Q/D 1. INIBICA appears in Affiliation? YES.
  4. Mechanistic Insights into Alzheimer's Disease Unveiled through the Investigation of Disturbances in Central Metabolites and Metabolic Pathways. González-Domínguez R, González-Domínguez Á, Sayago A, González-Sanz JD, Lechuga-Sancho AM, Fernández-Recamales Á. Biomedicines. 2021 Mar 14;9(3):298. doi: 10.3390/biomedicines9030298. PMID: 33799385 Free PMC article. Review. FI 6.081. Q/D 1. INIBICA appears in Affiliation? YES.
  5. Blunted Reducing Power Generation in Erythrocytes Contributes to Oxidative Stress in Prepubertal Obese Children with Insulin Resistance. González-Domínguez Á, Visiedo F, Domínguez-Riscart J, Ruiz-Mateos B, Saez-Benito A, Lechuga-Sancho AM, Mateos RM. Antioxidants (Basel). 2021 Feb 5;10(2):244. doi: 10.3390/antiox10020244. PMID: 33562490 Free PMC article. FI 6.312. Q/D 1/1. INIBICA appears in Affiliation? YES.
  6. Cristian del Bo'; Stefano Bernardi; Antonio Cherubini; Marisa Porrini; Giorgio Gargari; Nicole Hidalgo Liberona; RAÚL GONZÁLEZ DOMÍNGUEZ; Raúl Zamora Ros; Gregorio Peron; Mirko Marino; Letizia Gigliotti; Mark S. Winterbone; Benjamin Kirkup; Paul A. Kroon; Cristina Andrés Lacueva; Simone Guglielmetti; Patrizia Riso. A polyphenol-rich dietary pattern improves intestinal permeability, evaluated as serum zonulin levels, in older subjects: the MaPLE randomised controlled trial. Clinical Nutrition. 40 - 5, pp. 3006 - 3018. Elsevier, 2021. DOI: 10.1016/j.clnu.2020.12.014; PMID: 33388204. FI 7.324. Q/D 1. INIBICA appears in Affiliation? NO.
  7. Giorgio Gargari; Giacomo Mantegazza; Valentina Taverniti; Cristian del Bo'; Stefano Bernardi; Cristina Andrés Lacueva; RAÚL GONZÁLEZ DOMÍNGUEZ; Paul A. Kroon; Mark S. Winterbone; Antonio Cherubini; Patrizia Riso; Simone Guglielmetti. Bacterial DNAemia is associated with serum zonulin levels in older subjects. Scientific Reports. 11, pp. 11054. Nature Publishing Group, 2021. DOI: 10.1038/s41598-021-90476-0; PMID: 34040086. FI 4.379. Q/D 1. INIBICA appears in Affiliation? NO.
  8. Gregorio Peron; Giorgio Gargari; Tomás Meroño; Antonio Miñarro; Esteban Vegas Lozano; Pol Castellano Escuder; RAÚL GONZÁLEZ DOMÍNGUEZ; Nicole Hidalgo Liberona; Cristian del Bo'; Stefano Bernardi; Paul A. Kroon; Barbara Carrieri; Antonio Cherubini; Patrizia Riso; Simone Guglielmetti; Cristina Andrés Lacueva. Crosstalk among intestinal barrier, gut microbiota and serum metabolome after a polyphenol-rich diet in older subjects with “leaky gut”: The MaPLE trial. Clinical Nutrition. 40 - 10, pp. 5288 - 5297. Elsevier, 2021. DOI: 10.1016/j.clnu.2021.08.027; PMID: 34534897. FI 7.324. Q/D 1. INIBICA appears in Affiliation? NO.
  9. Dorrain Low; Pierre Micheau; Ville Mikael Koistinen; Kati Hanhineva; László Abrankó; Ana Rodriguez Mateos; Andreia Bento da Silva; Christof Van Poucke; Conceição Almeida; Cristina Andrés Lacueva; Dilip K Rai; Esra Capanoglu; Francisco Tomás Barberán; Fulvio Mattivi; Gesine Schmidt; Gözde Gürdeniz; Kateřina Valentová; Letizia Bresciani; Lucie Petrásková; Lars Ove Dragsted; Mark Philo; Marynka Ulaszewska; Pedro Mena; RAÚL GONZÁLEZ DOMÍNGUEZ; Rocio Garcia Villalba; Senem Kamiloglu; Sonia de Pascual Teresa; Stephanie Durand; Wiesław Wiczkowski; Maria Rosário Bronze; Jan Stanstrup; Claudine Manach. Data sharing in PredRet for accurate prediction of retention time: application to plant food bioactive compounds. Food Chemistry. 357, pp. 129757. Elsevier, 2021. DOI: 10.1016/j.foodchem.2021.129757; PMID: 33872868. FI 7.514. Q/D 1. INIBICA appears in Affiliation? NO.
  10. Sophie Lefèvre-Arbogast; Boris P Hejblum; Catherine Helmer; Christian Klose; Claudine Manach; Dorrain Yanwen Low; Mireia Urpi Sarda; Cristina Andrés Lacueva; RAÚL GONZÁLEZ DOMÍNGUEZ; Ludwig Aigner; Barbara Altendorfer; Paul J Lucassen; Silvie R Ruigrok; Chiara De Lucia; Andrea Du Preez; Cécile Proust-Lima; Sandrine Thuret; Aniko Korosi; Cécilia Samieri. Early signature in the blood lipidome associated with subsequent cognitive decline in the elderly: a case-control analysis nested within the Three-City cohort study. EBioMedicine. 64, pp. 103216. Elsevier, 2021. DOI: 10.1016/j.ebiom.2021.103216; PMID: 33508744. FI 8.143. Q/D 1. INIBICA appears in Affiliation? NO.
  11. RAÚL GONZÁLEZ DOMÍNGUEZ; Pol Castellano Escuder; Francisco Carmona; Sophie Lefèvre-Arbogast; Dorrain Yanwen Low; Andrea Du Preez; Silvie Ruigrok; Claudine Manach; Mireia Urpi Sarda; Aniko Korosi; Paul J Lucassen; Ludwig Aigner; Mercè Pallàs; Sandrine Thuret; Cécilia Samieri; Alex Sánchez Pla; Cristina Andrés Lacueva. Food and microbiota metabolites associate with cognitive decline in older subjects: A twelve-year prospective study. Molecular Nutrition & Food Research. 65 - 23, pp. e2100606. Wiley, 2021. DOI: 10.1002/mnfr.202100606; PMID: 34661340. FI 5.914. Q/D 1. INIBICA appears in Affiliation? NO.
  12. Pol Castellano Escuder; RAÚL GONZÁLEZ DOMÍNGUEZ; Francesc Carmona Pontaque; Cristina Andrés Lacueva; Alex Sánchez Pla. POMAShiny: a user-friendly web-based workflow for metabolomics and proteomics data analysis. PLoS Computational Biology. 17 - 7, pp. e1009148. Public Library of Science, 2021. DOI: 10.1371/journal.pcbi.1009148; PMID: 34197462. FI 4.475. Q/D 1. INIBICA appears in Affiliation? NO.
  13. RAÚL GONZÁLEZ DOMÍNGUEZ; Ana Sayago; Ángeles Fernández Recamales. Potential of Ultraviolet-Visible Spectroscopy for the Differentiation of Spanish Vinegars According to the Geographical Origin and the Prediction of their Functional Properties. Foods. 10 - 8, pp. 1830. MDPI, 2021. DOI: 10.3390/foods10081830; PMID: 34441606. FI 4.350. Q/D 2. INIBICA appears in Affiliation? NO.
  14. Andrea Du Preez; Sophie Lefèvre-Arbogast; Vikki Houghton; Chiara De Lucia; Dorrain Yanwen Low; Catherine Helmer; Catherine Feart; Cécile Delcourt; Cécile Proust-Lima; Mercè Pallàs; Silvie Ruigrok; Barbara Altendorfer; RAÚL GONZÁLEZ DOMÍNGUEZ; Alex Sánchez Pla; Mireia Urpi Sarda; Cristina Andrés Lacueva; Ludwig Aigner; Paul J Lucassen; Aniko Korosi; Claudine Manach; Cécilia Samieri; Sandrine Thuret. The serum metabolome mediates the concert of diet, exercise and neurogenesis, determining the risk for cognitive decline and dementia. Alzheimer's & Dementia. Wiley, 2021. DOI: 10.1002/alz.12428; PMID: 34402599. FI 21.56. Q/D 1. INIBICA appears in Affiliation? NO.
  15. High prevalence of variants in skeletal dysplasia associated genes in individuals with short stature and minor skeletal anomalies. Sentchordi-Montané L, Benito-Sanz S, Aza-Carmona M, Díaz-González F, Modamio-Høybjør S, de la Torre C, Nevado J, Ruiz-Ocaña P, Bezanilla-López C, Prieto P, Bahíllo-Curieses P, Carcavilla A, Mulero-Collantes I, Barreda-Bonis AC, Cruz-Rojo J, Ramírez-Fernández J, Bermúdez de la Vega JA, Travessa AM, González de Buitrago Amigo J, Del Pozo A, Vallespín E, Solís M, Goetz C, Campos-Barros Á, Santos-Simarro F, González-Casado I, Ros-Pérez P, Parrón-Pajares M, Heath KE. Eur J Endocrinol. 2021 Oct 11;185(5):691-705. doi: 10.1530/EJE-21-0557. PMID: 34516402. FI 6.664. Q/D 1. INIBICA appears in Affiliation? NO.
  16. [Study of the quality of life and adherence to treatment in patients from 2 to 16 years-old with type 1 diabetes mellitus in Andalusia, Spain]. Álvarez Casaño M, Alonso Montejo MDM, Leiva Gea I, Jiménez Hinojosa JM, Santos Mata MÁ, Macías F, Romero Pérez MDM, de Toro M, Martínez G, Munguira P, Vivas G, López Siguero JP. An Pediatr (Engl Ed). 2021 Feb;94(2):75-81. doi: 10.1016/j.anpedi.2020.03.016. Epub 2020 Jun 12. PMID: 32540137. FI 1.5. Q/D 4. INIBICA appears in Affiliation? NO.
  17. The Issue of Body Mass Index Increase in Adolescents Living With HIV on ART. Domínguez-Riscart J, Soria-Alcaide E, Mellado MJ, Sainz T. Pediatr Infect Dis J. 2021 Aug 1;40(8):e319-e321. doi: 10.1097/INF.0000000000003175. PMID: 34250982. FI 2.129. Q/D 3. INIBICA appears in Affiliation? NO.
  18. Technological Improvements in the Genetic Diagnosis of Rett Syndrome Spectrum Disorders. Xiol C, Heredia M, Pascual-Alonso A, Oyarzabal A, Armstrong J. Int J Mol Sci. 2021 Sep 26;22(19):10375. doi: 10.3390/ijms221910375. PMID: 34638716. FI 5.923. Q/D 1. INIBICA appears in Affiliation? NO.
  19. Álvaro González-Domínguez, Raúl Montañez, Beatriz Castejón-Vega, Jéssica Nuñez-Vasco, Débora Lendines-Cordero, Chun Wang, Gabriel Mbalaviele, José M Navarro-Pando, Elísabet Alcocer-Gómez, Mario D Cordero. Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson-Gilford Progeria. EMBO molecular medicine, 13(10), e14012. EMBOpress, 2021. doi: 10.15252/emmm.202114012. FI 12.137. Q/D 1. INIBICA appears in Affiliation? YES.
  20. A Multimodal Intervention for Prevention of Overweight and Obesity in Schoolchildren. A Protocol Study "PREVIENE-CADIZ". Aragón-Martín R, Gómez-Sánchez MDM, Jiménez-Pavón D, Martínez-Nieto JM, Schwarz-Rodríguez M, Segundo-Iglesias C, Novalbos-Ruiz JP, Santi-Cano MJ, Castro-Piñero J, Lineros-González C, Hernán-García M, Rodríguez-Martín A. Int J Environ Res Public Health. 2021 Feb 8;18(4):1622. doi: 10.3390/ijerph18041622.PMID: 33567730. FI 3.39. Q/D 1. INIBICA appears in Affiliation? YES.
2020 Publications
  1. Romero-García R, Gómez-Jaramillo L, Mateos RM, Jiménez-Gómez G, Pedreño-Horrillo N, Foncubierta E, Rodríguez-Gutiérrez JF, Garzón S, Mora-López F, Rodríguez C, Valor LM, Campos-Caro A. Differential epigenetic regulation between the alternative promoters, PRDM1α and PRDM1β, of the tumour suppressor gene PRDM1 in human multiple myeloma cells.Sci Rep. 2020 Sep 28;10(1):15899. Impact index: 3,998-Q1.
  2. Sentchordi-Montané L, Benito-Sanz S, Aza-Carmona M, Pereda A, Parrón-Pajares M, de la Torre C, Vasques GA, Funari MFA, Travessa AM, Dias P, Suarez-Ortega L, González-Buitrago J, Portillo-Najera NE, Llano-Rivas I, Martín-Frías M, Ramírez-Fernández J, Sánchez Del Pozo J, Garzón-Lorenzo L, Martos-Moreno GA, Alfaro-Iznaola C, Mulero-Collantes I, Ruiz-Ocaña P, Casano-Sancho P, Portela A, Ruiz-Pérez L, Del Pozo A, Vallespín E, Solís M, Lerario AM, González-Casado I, Ros-Pérez P, Pérez de Nanclares G, Jorge AAL, Heath KE.Clinical and Molecular Description of 16 Families With Heterozygous IHH Variants.J Clin Endocrinol Metab. 2020 Aug 1;105(8):dgaa218. Impact index: 5,399.Q1.
  3. Palma JM, Mateos RM, López-Jaramillo J, Rodríguez-Ruiz M, González-Gordo S, Lechuga-Sancho AM, Corpas FJ. Plant catalases as NO and H2S targets. Redox Biol. 2020 Jul;34:101525. Impact index: 9,986.Q1.
  4. González-Domínguez Á, Visiedo-García FM, Domínguez-Riscart J, González-Domínguez R, Mateos RM, Lechuga-Sancho AM.Iron Metabolism in Obesity and Metabolic Syndrome.Int J Mol Sci. 2020 Aug 1;21(15):5529. Impact index: 4,556.Q1.
  5. Santos-Rosendo C, Bugatto F, González-Domínguez A, Lechuga-Sancho AM, Mateos R, Visiedo F. Placental Adaptive Changes to Protect Function and Decrease Oxidative Damage in Metabolically Healthy Maternal Obesity. Antioxidants (Basel). 2020 Aug 26;9(9):794. Impact index: 5,014.Q1, D1.
  6. Álvarez Casaño M, Alonso Montejo MDM, Leiva Gea I, Jiménez Hinojosa JM, Santos Mata MÁ, Macías F, Romero Pérez MDM, de Toro M, Martínez G, Munguira P, Vivas G, López Siguero JP. Study of the quality of life and adherence to treatment in patients from 2 to 16 years-old with type 1 diabetes mellitus in Andalusia, Spain.An Pediatr (Barc). 2020 Jun 12:S1695-4033(20)30145-4. Impact index: 1,140.Q2.
  7. Alonso-Ojembarrena A, Lechuga-Sancho AM, Morales-Arandojo P, Acuñas-Soto S, López-de-Francisco R, Lubián-López SPPediatr Pulmonol. 2020 doi: 10.1002/ppul.25098. Impact index: 2,534.Q2.
  8. Alonso-Ojembarrena A, Lechuga-Sancho AM, Ruiz-González E, González-Haba-Martínez B, Lubián-López SP Pediatr Pulmonol. 2020 doi: 10.1002/ppul.24920. Impact index: 2,534.Q2.
2019 Publications
  1. Álvarez Casaño M, Alonso Montejo MDM, Leiva Gea I, Jiménez Hinojosa JM, Santos Mata MÁ, Macías F, Romero Pérez MDM, de Toro M, Martínez G, Munguira P, Vivas G, López Siguero JP. Study of direct costs of type 1 diabetes mellitus in Andalusian patients aged 2-16 years.Endocrinol Diabetes Nutr. 2019 Oct;66(8):480-486. Impact index: .Q2.
  2. Prada Oliveira JA., Camacho Ramirez A., Salas Alvarez J., Campos Martinez FJ., Lechuga Sancho AM., Almorza Gomar D., Blandino Rosano M., Perez Arana GM. GLP-1 mediated improvement of the glucose tolerance in the T2DM GK rat model after massive jejunal resection. Annals of anatomy. 2019;223:1-7. DOI 10.1016/j.aanat.2019.01.007 Impact index: 2,241 Q2.
  3. Rodriguez-Gonzalez M, Benavente-Fernandez I, CastellanoMartinez A, Lechuga-Sancho AM, Lubian Lopez SP NT-proBNP plasma levels as biomarkers for pulmonary hypertension in healthy infants with respiratory syncytial virus infection. Journal Biomarkers in Medicine 2019. 10.2217/bmm-2018-0348 Impact index: 2.268 Q2.
  4. Flores González JC., Estalella Mendoza A., Rodríguez Campoy P., Saldaña Valderas M., Lechuga Sancho AM. Topical Pharyngeal Lidocaine Reduces Respiratory Adverse Events During Upper Gastrointestinal Endoscopies Under Ketamine Sedation in Children. Journal Paediatric drug. 2019;21:25-31.DOI 10.1007/s40272-018-0320-2 Impact index: 1.760 Q2.
  5. Almudena Alonso Ojembarrena; José Vicente Martínez Díaz; Alfonso María Lechuga Sancho; Fátima Galán Sánchez; Simón Pedro Lubián López. Broad spectrum antibiotics in newborns increase multi-drug resistant infections. Journal of chemotherapy (Florence, Italy). pp. 1 - 5. 24/01/2019. ISSN 1973-9478. Impact index: Q3.
2018 Publications
  1. Lechuga-Sancho AM, Gallego-Andujar D, Ruiz-Ocaña P, Visiedo FM, Saez-Benito A, Schwarz M, Segundo C, Mateos RM. Obesity induced alterations in redox homeostasis and oxidative stress are present from an early age. PLoS One. 2018 Jan 25;13(1) Impact index: 2,766 Q1.
  2. Área MULTIDISCIPLINARY SCIENCES Rosa María Mateos-Bernal, Gema Jiménez, Carmen ÁlvarezGil, Francisco Visiedo García, Fátima Rivera Rodríguez, Celeste Santos-Rosendo, Antonia Rodríguez-Pareja, German Perdomo, and Alfonso Lechuga Sancho. Excess Hydrocortisone Hamper Placental Nutrient Uptake Disrupting Cellular Metabolism. BioMed Research International (Aceptado en Septiembre 2018) Impact index: 2,583 Q2.
  3. Gonzalez-Dominguez A, Lechuga-Sancho AM, GonzalezDominguez R. Intervention and Observational Trials are Complementary in Metabolomics: Diabetes and the Oral Glucose Tolerance Test. Curr Top Med Chem. 2018;18(11):896-900. Impact index 3,374 Q2 Área Chemistry, medicinal.
  4. Raúl González Domínguez; Álvaro González Domínguez; Ana Sayago; Ángeles Fernández Recamales. Mass spectrometrybased metabolomic multiplatform for Alzheimer's disease research. Biomarkers for Alzheimer's disease drug development. 1750, pp. 125 - 137. 2018 Impact index 3,374 Q2.
  5. Sentchordi-Montané L, Aza-Carmona M, Benito-Sanz S, Barreda-Bonis AC, Sánchez-Garre C, Prieto-Matos P, RuizOcaña P, Lechuga-Sancho A, Carcavilla-Urquí A, MuleroCollantes I10, Martos-Moreno GA, Del Pozo A, Vallespín E, Offiah A, Parrón-Pajares M, Dinis I, Sousa SB, Ros-Pérez P, González-Casado I, Heath KE. Heterozygous aggrecan variants are associated with short stature and brachydactyly: Description of 16 probands and a review of the literature. Clin Endocrinol (Oxf). 2018 Jun;88(6):820-829. Impact index: 3,077 Q2 Área Endocrinology and metabolism.
  6. Ruiz-Ocaña P, Espinoza Requena P, Alonso-Ojembarrena A, Alemany Márquez P, Jiménez Carmona S, Lechuga-Sancho AM. Decreased Retinal Thickness in Type 1 Diabetic Children with Signs of Nonproliferative Diabetic Retinopathy. Int J Endocrinol. 2018 Apr 26;2018 Impact index 2,340 Q3 Área Endocrinology and metabolism (18)30353-2. doi: 10.1016/j.jacl.2018.07.013. [Epub ahead of print].
  7. Molecular basis of the familial chylomicronemia syndrome in patients from the National Dyslipidemia Registry of the Spanish Atherosclerosis Society.J Clin Lipidol. 2018 Aug 1. pii: S1933-2874 Impact index 3,58 Q1.
  8. Benavente-Fernández I, Rodríguez-Zafra E, León-Martínez J, Jiménez-Gómez G, Ruiz-González E, Fernández-Colina RC, Lechuga-Sancho AM, Lubián-López SP. Normal Cerebellar Growth by Using Three-dimensional US in the Preterm Infant from Birth to Term-corrected Age. Radiology. 2018 Jul;288(1):254-261. Impact index 7,469 Q1 Área RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING.
  9. Benavente-Fernandez I, Ramos-Rodriguez JJ, Infante-Garcia C, Jimenez-Gomez G, Lechuga-Sancho A, Lubian-Lopez S, Garcia-Alloza M. Altered plasma-type gelsolin and amyloid-β in neonates with hypoxic-ischaemic encephalopathy under therapeutic hypothermia. J Cereb Blood Flow Metab. 2018 Feb 21 Impact index Q1 Área.
  10. Bugatto F, Quintero-Prado R, Visiedo FM, Vilar-Sánchez JM, Figueroa-Quiñones A, López-Tinoco C, Torrejón R, Bartha JL. The Influence of Lipid and Proinflammatory Status on Maternal Uterine Blood Flow in Women With Late Onset Gestational Diabetes. Reprod Sci. 2018 Jun;25(6):837-843. Impact index 2,548 Q2 Área OBSTETRICS & GYNECOLOGY.
2017 Publications
  1. Álvaro González Domínguez; Enrique Durán Guerrero; Ángeles Fernández Recamales; Alfonso María Lechuga Sancho; Ana Sayago; Mónica Schwarz; Carmen Segundo; Raúl González Domínguez. An overview on the importance of combining complementary analytical platforms in metabolomic research. Current Topics in Medicinal Chemistry. 17 - 30, pp. 3289 - 3295. Bentham Science, 2017. Impact index: 3,374 Q2.
  2. Mateo-Gavira I, Vílchez-López FJ, García-Palacios M2, CarralSan Laureano F, Visiedo-García FM, Aguilar-Diosdado M. Early blood pressure alterations are associated with proinflammatory markers in type 1 diabetes mellitus. J Hum Hypertens. 2017 Feb;31(2):151-156. Impact index: 2,433 Q3 Área PERIPHERAL VASCULAR DISEASE.
  3. Camacho-Ramírez A, Blandino-Rosano M, Segundo-Iglesias MC, Lechuga-Sancho AM, Aguilar-Diosdado M, Pérez-Arana GM, Prada-Oliveira JA. Bariatric surgery influences β-cell turnover in non obese rats. Histol Histopathol. 2017 Jun 1:11909. Impact index: 2,02 Q2 Área PATHOLOGY.
  4. González Domínguez R.; Mateos RM; Lechuga Sancho AM.; González Cortés JJ.; Corrales Cuevas M.; Rojas Cots JA.; Segundo C.; Schwarz M. Synergic effects of sugar and caffeine on insulin-mediated metabolomic alterations after an acute consumption of soft drinks. Electrophoresis. 2017, 38(18):2313-2322. Impact index: 2,74 Q2 Área BIOCHEMICAL RESEARCH METHODS.
  5. Visiedo F, Santos-Rosendo C, Mateos-Bernal RM, GilSánchez MD, Bugatto F, Aguilar-Diosdado M, Segundo C, López-Tinoco C. Characterization of NO-Induced Nitrosative Status in Human Placenta from Pregnant Women with Gestational Diabetes Mellitus. Oxid Med Cell Longev. 2017; Impact index: 4,936 Q2 Área CELL BIOLOGY.
  6. Baena Nieto G.; Lomas-Romero IM.; Mateos RM; Leal-Cosme N; Perez-Arana G; Aguilar-Diosdado M; Segundo C; LechugaSancho AM. Ghrelin mitigates β-cell mass loss during insulitis in an animal model of autoimmune diabetes mellitus, the BioBreeding/Worcester rat. Diabetes/Metabolism Research and Reviews. 2017 Jan;33(1) Impact index: 3,26 Q2 Área ENDOCRINOLOGY & METABOLISM.
  7. Lechuga Sancho A, Palomo Atance E, Rivero Martin MJ, GilCampos M, Leis Trabazo R, Bahíllo Curieses MP, Bueno Lozano G; en representación del Grupo de Trabajo sobre Obesidad de la Sociedad Española de Endocrinología. [Spanish collaborative study: Description of usual clinical practice in infant obesity]. An Pediatr (Barc). 2017 Sep 21. Impact index: 1,14 Q3 Área PEDIATRICS.
  8. Benavente-Fernández I, Lubián-López SP, Zafra-Rodríguez P, Alonso-Ojembarrena A, Segado-Arenas A, Lechuga-Sancho AM. Amplitude-Integrated EEG and Brain Sparing in Preterm Smallfor-Gestational-Age Infants. J Clin Neurophysiol. 2017 Sep;34(5):456-460. Impact index: 1,22 Q4 Área NEUROSCIENCES.
  9. Flores-González JC, Estalella-Mendoza A, Lechuga-Sancho AM, Hernández-González A, Rubio-Quiñones F, RodríguezCampoy P, Saldaña-Valderas M. Supraventricular tachycardia after withdrawal of prolonged dexmedetomidine infusion in a paediatric patient without heart disease. J Clin Pharm Ther. 2017 Oct;42(5):653-655. Impact index: 0,927 Q4 Área PHARMACOLOGY ANDPHARMACY.
  10. Flores-González JC, Lechuga Sancho AM, Saldaña Valderas M, Jimenez Gomez G, Cruzado Garcia MD, Perez Aragon C, Blanca Garcia JA. Respiratory adverse events during upper digestive endoscopies in children under Ketamine sedation. Minerva Pediatr. 2017 Feb 7. Impact index: 0,532 Q4 Área PEDIATRICS.
  11. Flores-González JC, Grujic B, Lechuga-Sancho AM. Thyroid hormone intoxication as a not yet described cause of Jwave syndrome in a pediatric patient. Endocrine. 2017 Mar;55(3):989-991. Impact index:3,279 Q2 Área ENDOCRINOLOGY & METABOLISM.
  12. Benavente-Fernandez I, Lubián-Gutierrez M, Jimenez-Gomez G, Lechuga-Sancho AM, Lubián-López SP; Neonatal Neurology Foundation (Fundación Nene). Ultrasound lineal measurements predict ventricular volume in posthaemorrhagic ventricular dilatation in preterm infants. Acta Paediatr. 2017 Feb;106(2):211-217. Impact index:1,647 Q2 Área PEDIATRICS.
  13. Ramos-Rodriguez JJ, Spires-Jones T, Pooler AM, LechugaSancho AM, Bacskai BJ, Garcia-Alloza M. Progressive Neuronal Pathology and Synaptic Loss Induced by Prediabetes and Type 2 Diabetes in a Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2017 Jul;54(5):3428-3438. Impact index: 5,397 Q1 Área NEUROSCIENCES.
  14. Rodríguez-Ruiz M*, Mateos RM*, Codesido V, Corpas FJ, Palma JM. Characterization of the galactono-1,4-lactone dehydrogenase from pepper fruits and its modulation in the ascorbate biosynthesis. Role of nitric oxide. Redox Biology. 2017, 12:171-181. IF(JRC): 6,235; 1st Quartile (JRC) *Equal contribution at work.
2016 Publications
  1. Flores-González JC, Estalella-Mendoza A, Lechuga-Sancho AM, Quintero-Otero S, Rubio-Quiñones F, HernándezGonzález A, Saldaña-Valderas M. Severe pneumonia by Mycoplasma as an adverse event of everolimus therapy in patients with tuberous sclerosis complex. Eur J Paediatr Neurol. 2016 Sep;20(5):758-60. Impact index: 1,923 Q2 Área PEDIATRICS.
  2. Pinto-Souza AR, Firetto C, Pérez-Arana G, Lechuga-Sancho AM, Prada-Oliveira JA. Differences in the estrous cycles of Goto-Kakizaki and Wistar rats. Lab Anim (NY). 2016 Apr;45(4):143-8. Impact index: 0,681 Q4 Área VETERINARY SCIENCES.
  3. Palomo Atance E, Bahíllo Curieses P, Bueno Lozano G, Feliu Rovira A, Gil-Campos M, Lechuga-Sancho AM, Ruiz Cano R,Vela Desojo A. [Recommendations of the Spanish Paediatric Endocrinology Society Working Group on Obesity on eating habits for the prevention of obesity and cardiovascular risk factors in childhood]. An Pediatr (Barc). 2016 Mar; 84(3):178.e1-7. Impact index: 0,773 Q4 Área PEDIATRICS.
  4. Ramos-Rodriguez JJ, Infante-Garcia C, Galindo-Gonzalez L, Garcia-Molina Y, Lechuga-Sancho A, Garcia-Alloza M. Increased Spontaneous Central Bleeding and Cognition Impairment in APP/PS1 Mice with Poorly Controlled Diabetes Mellitus. Mol Neurobiol. 2016 May;53(4):2685-97. Impact index: 5,397 Q1 Área NEUROSCIENCES.
  5. Flores-González JC, Dominguez-Coronel MT, Matamala Morillo MA, Aragón Ramírez M, García Ortega RM, Dávila Corrales FJ, García Palacios MV, Perez Guerrero JJ, García García L, Lechuga Sancho AM. Does nebulized epinephrine improve the efficacy of hypertonic saline solution in the treatment of hospitalized moderate acute bronchiolitis? A double blind, randomized clinical trial. Minerva Pediatr. 2016 Apr;68(2):81-8. Impact index: 0,532 Q4 Área PEDIATRICS.
2015 Publications
  1. Visiedo F, Bugatto F, Quintero-Prado R, Cózar-Castellano I, Bartha JL, Perdomo G. Glucose and Fatty Acid Metabolism in Placental Explants From Pregnancies Complicated With Gestational Diabetes Mellitus. Reprod Sci. 2015 Jul;22(7):798-801. Impact index: 2,548 Q2 Área OBSTETRICS & GYNECOLOGY.
  2. Pérez Arana G.; Camacho Ramirez A.; Segundo Iglesias C.; Lechuga Sancho AM.; Aguilar Diosdado M.; Prada Oliveira JA. A surgical model of short bowel syndrome induces a longlasting increase in pancreatic beta-cell mass. Histology And Histopathology. 2015, 30 - 4, pp. 479 - 487. Impact index: 2,42 Q2 Área PATHOLOGY.
  3. Diaz-Ganete A, Baena-Nieto G, Lomas-Romero IM, LopezAcosta JF, Cozar-Castellano I, Medina F, Segundo C, LechugaSancho AM. Ghrelin's Effects on Proinflammatory Cytokine Mediated Apoptosis and Their Impact on ß-Cell Functionality. International Journal of Endocrinology. 2015: 235727. Impact index: 2,37 Q2 Área ENDOCRINOLOGY & METABOLISM.
  4. Flores-González JC, Matamala-Morillo MA, RodríguezCampoy P, Pérez-Guerrero JJ, Serrano-Moyano B, CominoVazquez P, Palma-Zambrano E, Bulo-Concellón R, SantosSánchez V, Lechuga-Sancho AM; Bronchiolitis of Cadiz Study group (BronCaS). Epinephrine Improves the Efficacy of Nebulized Hypertonic Saline in Moderate Bronchiolitis: A Randomised Clinical Trial. PLoS One. 2015 Nov 17;10(11):e0142847 Impact index: 3,057 Q1 Área MULTIDISCIPLINARY SCIENCES.
  5. Rodríguez-González M, Matamala-Morillo MÁ, SegadoArenas A, Marín-Iglesias M del R, Lechuga-Sancho AM. Chest Pain in Children With Suspected Type I Fibrillinopathy: A Case Report. Pediatrics. 2015 Oct;136(4):e1035-8. Impact index: 5,196 D1 Área PEDIATRICS.
  6. Ramos-Rodriguez JJ, Jimenez-Palomares M, MurilloCarretero MI, Infante-Garcia C, Berrocoso E, Hernandez Pacho F, Lechuga Sancho AM, Cozar-Castellano I, GarciaAlloza M. Central vascular disease and exacerbated pathology in a mixed model of type 2 diabetes and Alzheimer's disease. Psychoneuroendocrinology. 2015 Dec; 62:69-79. Impact index: 4,704 Q1 Área ENDOCRINOLOGY & METABOLISM.
  7. Gutiérrez-Fernández D, Moreno-Ancillo Á, Foncubierta Fernández A, López-Martínez I, Lechuga-Sancho A, Fernández Anguita MJ. Desensitization to mecasermin in an insulin-like growth factor 1-deficient patient. Ann Allergy Asthma Immunol. 2015 Jun;114(6):523-5. Impact index: 0,532 Q4 Área PEDIATRICS.
  8. Benavente-Fernández I, Lubián-López SP, Jiménez-Gómez G, Lechuga-Sancho AM, Garcia-Alloza M. Low-voltage pattern and absence of sleep-wake cycles are associated with severe hemorrhage and death in very preterm infants. Eur J Pediatr. 2015 Jan;174(1):85-90. Impact index: 1,791 Q2 Área PEDIATRICS.
  9. Visiedo F; Bugatto F; Carrasco-Fernandez C; Sáez-Benito A; Mateos RM; Cózar-Castellano I; Bartha JL; Perdomo G. Hepatocyte growth factor is elevated in amniotic fluid from obese women and regulates placental glucose and fatty acid metabolism. Placenta. 2015, 36, pp. 381 - 388. IF(JRC): 3,531. 1st Quartile (JRC)/1er decil.
  10. Cobos R*, Mateos RM*, Álvarez-Pérez JM, Olego MA, Sevillano S, González-García S, Garzón E, Rubio-Coque JJ Effectiveness of natural antifungal compounds to control infection through pruning wounds by grapevine trunk disease pathogens. Applied and Environmental Microbiology. 2015, 81(18). IF(JRC): 3,952 1st Quartile. *Equal contribution at work.
2014 Publications
  1. Ramos-Rodriguez JJ, Molina-Gil S, Ortiz-Barajas O, Jimenez Palomares M, Perdomo G, Cozar-Castellano I, Lechuga-Sancho AM, Garcia-Alloza M. Central proliferation and neurogenesis is impaired in type 2 diabetes and prediabetes animal models. PLoS One. 2014 Feb 20;9(2):e89229. Impact index: 3,234 Q1 Área MULTIDISCIPLINARY SCIENCES.
  2. Martos-Moreno GÁ, Gil-Campos M, Bueno G, Bahillo P, Bernal S, Feliu A, Lechuga-Sancho AM, Palomo E, Ruiz R, Vela A; Grupo de Trabajo de Obesidad de la Sociedad Española de Endocrinología Pediátrica (SEEP). [Obesity associated metabolic impairment is evident at early ages: Spanish collaborative study]. Nutr Hosp. 2014 Oct 1;30(4):787-93. Impact index: 1,818 Q4 Área NUTRITION & DIETETICS.
  3. Rodríguez-González M, Benavente Fernández I, Zafra Rodríguez P, Lechuga-Sancho AM, Lubián López S. Toxicity of remedies for infantile colic. Arch Dis Child. 2014 Dec;99(12):1147-8. Impact index: 2,889 Q1 Área PEDIATRICS.
  4. Flores-González JC, Rubio-Quiñones F, Hernández-González A, Rodríguez-González M, Blanca-García JA, Lechuga-Sancho AM, Quintero-Otero S. Pneumonia and purulent pericarditis caused by Streptococcus pneumoniae: an uncommon association in the antibiotic era. Pediatr Emerg Care. 2014 Aug;30(8):552-4. Impact index: 1,406 Q3 Área EMERGENCY MEDICINE.
  5. Ramos-Rodriguez JJ, Ortiz-Barajas O, Gamero-Carrasco C, de la Rosa PR, Infante-Garcia C, Zopeque-Garcia N, LechugaSancho AM, Garcia-Alloza M. Prediabetes-induced vascular alterations exacerbate central pathology in APPswe/PS1dE9 mice. Psychoneuroendocrinology. 2014 Oct; 48:123-35. Impact index: 4,944 Q1 Área NEUROSCIENCES.
  6. Gómez-Jaramillo L, Delgado-Pérez L, Reales E, Mora-Lopez F, Mateos RM, García-Poley A, Brieva J.A and Campos-Caro A. Syntaxin-4 is implicated in the secretion of antibodies by human plasma cells. Journal of Leukocyte Biology. 2014, 95(2): 605-612 IF (JRC): 4,99. 1er Quartil.
Networks
  • NETWORK NAME: Metanetwork. AUTONOMOUS. PI: Francisco Tinahones. Collaborators: Jesús Domínguez Riscart and Alfonso María Lechuga Sancho.
  • NETWORK NAME: CoRISPe. NATIONAL. PI: Talía Sainz. Collaborators: Jesús Domínguez Riscart.
Patents
  • Title: Use of natural antifungal agents in order to prevent the infection of pruning wounds, grafts and lesions in woody plants by phytopathogenic fungi.
    • International patent granted.
    • Grant year: 27/05/2013.
    • Authors: Rosa María Mateos Bernal; Rebeca Cobos Román; Penélope García Angulo; Alberto Alonso Monroy; María Luisa Álvarez Rodríguez; Silvia Sevillano Nistal; José Manuel Álvarez Pérez; José Luis Acebes Arranz; Enrique Garzón Jimeno; Juan José Rubio Coque.
    • Code: EP2692232B1 Company Bodegas Vega Sicilia S.A. Spain.