CO1: INMOX (Inflammation, Nutrition, Metabolism and Oxidative Stress)

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CO1: INMOX (Inflammation, Nutrition, Metabolism and Oxidative Stress)

The members of this research group are distributed between the IN-CO1 group belonging to the Biomedical Research and Innovation Institute of Cadiz (INiBICA) and the CTS-927 group belonging to the Andalusian Research Plan (PAIDI). This mixed group is made up of a healthcare team composed of specialist physicians from the paediatrics and physiotherapy departments, nurses and a team specialized in biomedical research from the Research Unit of the University Hospital "Puerta del Mar" (Biochemists and Biologists) and the Department of Biomedicine, Biotechnology and Public Health (Area of Biochemistry and Molecular Biology) of the University of Cadiz. Biomedical researches focus on developing novel diagnostic methods and therapeutic strategies for the management and prevention of obesity, diabetes and their related complications, from foetal stage to adulthood. The group's expertise in the analysis of oxidative stress, antioxidant response and energy metabolism is used to identify biomarkers of risk for associated complications and inflammatory diseases.

Principal investigator
  • Alfonso María Lechuga Sancho
  • e-mail: alfonso.lechuga@uca.es
  • ORCID: 0000-0001-5861-6041
Co-principal investigator
  • Rosa María Mateos Bernal
  • e-mail: rosa.mateos@uca.es
  • ORCID: 0000-0002-9853-1103
Lines of research
  1. Mechanisms of diet-induced oxidative and inflammatory damage in childhood obesity and other chronic inflammatory diseases (e.g., cystic fibrosis).
  2. Strategies for preserving beta cell function caused by cytotoxic, metabolic and oxidative stress in type 1 and type 2 diabetes.
  3. Study of the role of the placenta in complicated pregnancies with diabetes and/or gestational obesity caused by the action of factors such as hyperglycaemia, pro-inflammatory damage, oxidative and nitrosative stress.
  4. In vivo antioxidant activity of food. Development of biochemical techniques for the in vivo analysis of real antioxidant activity of foods after their ingestion. This line of work is proposed as a service to companies in the agri-food sector interested in checking whether their products have a real antioxidant response in healthy adult humans. "NutrOX Testing" Project.
Key words
DiabetesObesityPregnancyOxidative stressOmicsNutritionInflammation
Principal investigator

Alfonso María Lechuga Sancho
  • Professor of Maternal/Childhood and Radiology Departments of the University of Cadiz, providing healthcare in the Andalusian Health Service.
  • e-mail: alfonso.lechuga@uca.es
  • ORCID: 0000-0001-5861-6041
  • Research ID: M-2712-2015
  • Scopus ID: 10341314400
Co-principal investigator
Rosa María Mateos Bernal
  • Assistant Professor/Doctor of Biochemistry and Molecular Biology in the Department of Biomedicine, Biotechnology and Public Health. University of Cadiz.
  • e-mail: rosa.mateos@uca.es
  • ORCID: 0000-0002-9853-1103
  • Researcher ID: M-5213-2015
Team members
  • Alfonso M. Lechuga Sancho (Principal investigator)
  • Rosa M. Mateos Bernal (Co-principal investigator)
  • M. Carmen Segundo Iglesias (Researcher)
  • Pablo Ruiz Ocaña (Researcher)
  • Maria Ángeles Santos Mata (Researcher)
  • María de la Paz Gómez Jiménez (Researcher)
  • Juan Jesús Cobacho de Alba (Nurse)
  • Nuria Buero (Resident medical intern)
  • Francisco Medina Prieto (Researcher)
  • Francisco Manuel Visiedo García (Postdoctoral researcher)
  • Álvaro González Domínguez (Predoctoral researcher)
National Funding Calls
  1. Instituto de Salud Carlos III. 2018 PI18/01316. Principal Investigator: Alfonso Lechuga Sancho and Rosa Mª Mateos Bernal. DIAGNOSTIC VALUE OF ERYTHROCYTE ANTIOXIDANT DEPLETION IN CHILDHOOD OBESITY.
  2. SPANISH MINISTRY OF ECONOMY, INDUSTRY AND COMPETITIVENESS CTQ2017-86661-R (Collaboration). EXTRACTS IMPREGNATION AND FUNCTIONALIZATION OF ANTIOXIDANT NANOPARTICLES OBTAINED FROM MANGO LEAVES BY HIGH-PRESSURE PROCESSES AND ITS APPLICATION IN BIOMEDICINE.
  3. Instituto de Salud Carlos III. PI16/00370 (Collaboration). Proinflammatory state and markers of endothelial damage in women with gestational diabetes mellitus and its relationship with the daily pattern of blood pressure.
  4. Instituto de Salud Carlos III. PI14/00710 (Collaboration). Incidence of type 2 diabetes in the di@bet.es study: role of fatty acid transport system regulated by VEGFB.
  5. Instituto de Salud Carlos III. PI14/01779 (Collaboration). Role of bacterial translocation in numerical and functional modifications of neutrophil polymorphonuclears in HIV-infected patients.
Regional Funding Calls
  1. Department of Health and Family of the Junta de Andalucia 2019. Research projects. PI0209-2019. Principal Investigator: Francisco M. Visiedo García. Name of project: ERIT-OX (Analysis of the antioxidant defences of the erythrocyte against oxidative stress induced by obesity. A first approach to proteomics in childhood obesity as a model for study.
  2. Regional integration initiative (ITI) 2014-2020 for the province of Cadiz, by the Department of Health of the Junta de Andalucia and the European Regional Development Fund. PI-0052-2017 (Collaboration). Gadicor Project: Matrix project to promote cardiovascular (CV) researches in the Province of Cadiz.
  3. Regional Integrated Initiative (ITI) 2014-2020 for the province of Cadiz, by the Department of Health of the Junta de Andalucia and the European Regional Development Fund. PI-0052-2017 (Collaboration). Prevention of overweight and obesity in school children in the province of Cadiz: Quasi-experimental study on the effectiveness of a multicomponent intervention.
Publications
  • Prada Oliveira JA., Camacho Ramirez A., Salas Alvarez J., Campos Martinez FJ., Lechuga Sancho AM., Almorza Gomar D., Blandino Rosano M., Perez Arana GM. GLP-1 mediated improvement of the glucose tolerance in the T2DM GK rat model after massive jejunal resection. Annals of anatomy. 2019;223:1-7. DOI 10.1016/j.aanat.2019.01.007 Índice de Impacto: 2,241 Q2
  • Rodriguez-Gonzalez M, Benavente-Fernandez I, CastellanoMartinez A, Lechuga-Sancho AM, Lubian Lopez SP NT-proBNP plasma levels as biomarkers for pulmonary hypertension in healthy infants with respiratory syncytial virus infection. Journal Biomarkers in Medicine 2019. 10.2217/bmm-2018-0348 Índice de impacto: 2.268 Q2
  • Flores González JC., Estalella Mendoza A., Rodríguez Campoy P., Saldaña Valderas M., Lechuga Sancho AM. Topical Pharyngeal Lidocaine Reduces Respiratory Adverse Events During Upper Gastrointestinal Endoscopies Under Ketamine Sedation in Children. Journal Paediatric drug. 2019;21:25-31.DOI 10.1007/s40272-018-0320-2 Índice de impacto: 1.760 Q2
  • Almudena Alonso Ojembarrena; José Vicente Martínez Díaz; Alfonso María Lechuga Sancho; Fátima Galán Sánchez; Simón Pedro Lubián López. Broad spectrum antibiotics in newborns increase multi-drug resistant infections. Journal of chemotherapy (Florence, Italy). pp. 1 - 5. 24/01/2019. ISSN 1973-9478. Índice de impacto: Q3
  • Lechuga-Sancho AM, Gallego-Andujar D, Ruiz-Ocaña P, Visiedo FM, Saez-Benito A, Schwarz M, Segundo C, Mateos RM. Obesity induced alterations in redox homeostasis and oxidative stress are present from an early age. PLoS One. 2018 Jan 25;13(1) Índice de Impacto: 2,766 Q1
  • Área MULTIDISCIPLINARY SCIENCES Rosa María Mateos-Bernal, Gema Jiménez, Carmen ÁlvarezGil, Francisco Visiedo García, Fátima Rivera Rodríguez, Celeste Santos-Rosendo, Antonia Rodríguez-Pareja, German Perdomo, and Alfonso Lechuga Sancho. Excess Hydrocortisone Hamper Placental Nutrient Uptake Disrupting Cellular Metabolism. BioMed Research International (Aceptado en Septiembre 2018) Índice de impacto: 2,583 Q2
  • Gonzalez-Dominguez A, Lechuga-Sancho AM, GonzalezDominguez R. Intervention and Observational Trials are Complementary in Metabolomics: Diabetes and the Oral Glucose Tolerance Test. Curr Top Med Chem. 2018;18(11):896-900. Índice de impacto 3,374 Q2 Área Chemistry, medicinal
  • Raúl González Domínguez; Álvaro González Domínguez; Ana Sayago; Ángeles Fernández Recamales. Mass spectrometrybased metabolomic multiplatform for Alzheimer's disease research. Biomarkers for Alzheimer's disease drug development. 1750, pp. 125 - 137. 2018 Índice de impacto 3,374 Q2
  • Álvaro González Domínguez; Enrique Durán Guerrero; Ángeles Fernández Recamales; Alfonso María Lechuga Sancho; Ana Sayago; Mónica Schwarz; Carmen Segundo; Raúl González Domínguez. An overview on the importance of combining complementary analytical platforms in metabolomic research. Current Topics in Medicinal Chemistry. 17 - 30, pp. 3289 - 3295. Bentham Science, 2017. Índice de impacto 3,374 Q2
  • Sentchordi-Montané L, Aza-Carmona M, Benito-Sanz S, Barreda-Bonis AC, Sánchez-Garre C, Prieto-Matos P, RuizOcaña P, Lechuga-Sancho A, Carcavilla-Urquí A, MuleroCollantes I10, Martos-Moreno GA, Del Pozo A, Vallespín E, Offiah A, Parrón-Pajares M, Dinis I, Sousa SB, Ros-Pérez P, González-Casado I, Heath KE. Heterozygous aggrecan variants are associated with short stature and brachydactyly: Description of 16 probands and a review of the literature. Clin Endocrinol (Oxf). 2018 Jun;88(6):820-829. Índice de impacto: 3,077 Q2 Área Endocrinology and metabolism
  • Ruiz-Ocaña P, Espinoza Requena P, Alonso-Ojembarrena A, Alemany Márquez P, Jiménez Carmona S, Lechuga-Sancho AM. Decreased Retinal Thickness in Type 1 Diabetic Children with Signs of Nonproliferative Diabetic Retinopathy. Int J Endocrinol. 2018 Apr 26;2018 Índice de impacto 2,340 Q3 Área Endocrinology and metabolism (18)30353-2. doi: 10.1016/j.jacl.2018.07.013. [Epub ahead of print]
  • Molecular basis of the familial chylomicronemia syndrome in patients from the National Dyslipidemia Registry of the Spanish Atherosclerosis Society.J Clin Lipidol. 2018 Aug 1. pii: S1933-2874 Índice de impacto 3,58 Q1
  • Benavente-Fernández I, Rodríguez-Zafra E, León-Martínez J, Jiménez-Gómez G, Ruiz-González E, Fernández-Colina RC, Lechuga-Sancho AM, Lubián-López SP. Normal Cerebellar Growth by Using Three-dimensional US in the Preterm Infant from Birth to Term-corrected Age. Radiology. 2018 Jul;288(1):254-261. Índice de impacto 7,469 Q1 Área RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
  • Benavente-Fernandez I, Ramos-Rodriguez JJ, Infante-Garcia C, Jimenez-Gomez G, Lechuga-Sancho A, Lubian-Lopez S, Garcia-Alloza M. Altered plasma-type gelsolin and amyloid-β in neonates with hypoxic-ischaemic encephalopathy under therapeutic hypothermia. J Cereb Blood Flow Metab. 2018 Feb 21 Índice de impacto Q1 Área
  • Bugatto F, Quintero-Prado R, Visiedo FM, Vilar-Sánchez JM, Figueroa-Quiñones A, López-Tinoco C, Torrejón R, Bartha JL. The Influence of Lipid and Proinflammatory Status on Maternal Uterine Blood Flow in Women With Late Onset Gestational Diabetes. Reprod Sci. 2018 Jun;25(6):837-843. Índice de impacto 2,548 Q2 Área OBSTETRICS & GYNECOLOGY
  • Mateo-Gavira I, Vílchez-López FJ, García-Palacios M2, CarralSan Laureano F, Visiedo-García FM, Aguilar-Diosdado M. Early blood pressure alterations are associated with proinflammatory markers in type 1 diabetes mellitus. J Hum Hypertens. 2017 Feb;31(2):151-156. Índice de impacto 2,433 Q3 Área PERIPHERAL VASCULAR DISEASE
  • Camacho-Ramírez A, Blandino-Rosano M, Segundo-Iglesias MC, Lechuga-Sancho AM, Aguilar-Diosdado M, Pérez-Arana GM, Prada-Oliveira JA. Bariatric surgery influences β-cell turnover in non obese rats. Histol Histopathol. 2017 Jun 1:11909. Índice de impacto: 2,02 Q2 Área PATHOLOGY
  • González Domínguez R.; Mateos RM; Lechuga Sancho AM.; González Cortés JJ.; Corrales Cuevas M.; Rojas Cots JA.; Segundo C.; Schwarz M. Synergic effects of sugar and caffeine on insulin-mediated metabolomic alterations after an acute consumption of soft drinks. Electrophoresis. 2017, 38(18):2313-2322. Índice de impacto: 2,74 Q2 Área BIOCHEMICAL RESEARCH METHODS
  • Visiedo F, Santos-Rosendo C, Mateos-Bernal RM, GilSánchez MD, Bugatto F, Aguilar-Diosdado M, Segundo C, López-Tinoco C. Characterization of NO-Induced Nitrosative Status in Human Placenta from Pregnant Women with Gestational Diabetes Mellitus. Oxid Med Cell Longev. 2017; Índice de impacto: 4,936 Q2 Área CELL BIOLOGY
  • Baena Nieto G.; Lomas-Romero IM.; Mateos RM; Leal-Cosme N; Perez-Arana G; Aguilar-Diosdado M; Segundo C; LechugaSancho AM. Ghrelin mitigates β-cell mass loss during insulitis in an animal model of autoimmune diabetes mellitus, the BioBreeding/Worcester rat. Diabetes/Metabolism Research and Reviews. 2017 Jan;33(1) Índice de impacto: 3,26 Q2 Área ENDOCRINOLOGY & METABOLISM
  • Lechuga Sancho A, Palomo Atance E, Rivero Martin MJ, GilCampos M, Leis Trabazo R, Bahíllo Curieses MP, Bueno Lozano G; en representación del Grupo de Trabajo sobre Obesidad de la Sociedad Española de Endocrinología. [Spanish collaborative study: Description of usual clinical practice in infant obesity]. An Pediatr (Barc). 2017 Sep 21. Índice de impacto: 1,14 Q3 Área PEDIATRICS
  • Benavente-Fernández I, Lubián-López SP, Zafra-Rodríguez P, Alonso-Ojembarrena A, Segado-Arenas A, Lechuga-Sancho AM. Amplitude-Integrated EEG and Brain Sparing in Preterm Smallfor-Gestational-Age Infants. J Clin Neurophysiol. 2017 Sep;34(5):456-460. Índice de impacto: 1,22 Q4 Área NEUROSCIENCES
  • Flores-González JC, Estalella-Mendoza A, Lechuga-Sancho AM, Hernández-González A, Rubio-Quiñones F, RodríguezCampoy P, Saldaña-Valderas M. Supraventricular tachycardia after withdrawal of prolonged dexmedetomidine infusion in a paediatric patient without heart disease. J Clin Pharm Ther. 2017 Oct;42(5):653-655. Índice de impacto: 0,927 Q4 Área PHARMACOLOGY ANDPHARMACY
  • Flores-González JC, Lechuga Sancho AM, Saldaña Valderas M, Jimenez Gomez G, Cruzado Garcia MD, Perez Aragon C, Blanca Garcia JA. Respiratory adverse events during upper digestive endoscopies in children under Ketamine sedation. Minerva Pediatr. 2017 Feb 7. Índice de impacto: 0,532 Q4 Área PEDIATRICS
  • Flores-González JC, Grujic B, Lechuga-Sancho AM. Thyroid hormone intoxication as a not yet described cause of Jwave syndrome in a pediatric patient. Endocrine. 2017 Mar;55(3):989-991. Índice de impacto:3,279 Q2 Área ENDOCRINOLOGY & METABOLISM
  • Benavente-Fernandez I, Lubián-Gutierrez M, Jimenez-Gomez G, Lechuga-Sancho AM, Lubián-López SP; Neonatal Neurology Foundation (Fundación Nene). Ultrasound lineal measurements predict ventricular volume in posthaemorrhagic ventricular dilatation in preterm infants. Acta Paediatr. 2017 Feb;106(2):211-217. Índice de impacto:1,647 Q2 Área PEDIATRICS
  • Ramos-Rodriguez JJ, Spires-Jones T, Pooler AM, LechugaSancho AM, Bacskai BJ, Garcia-Alloza M. Progressive Neuronal Pathology and Synaptic Loss Induced by Prediabetes and Type 2 Diabetes in a Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2017 Jul;54(5):3428-3438. Índice de impacto: 5,397 Q1 Área NEUROSCIENCES
  • Rodríguez-Ruiz M*, Mateos RM*, Codesido V, Corpas FJ, Palma JM. Characterization of the galactono-1,4-lactone dehydrogenase from pepper fruits and its modulation in the ascorbate biosynthesis. Role of nitric oxide. Redox Biology. 2017, 12:171-181. IF(JRC): 6,235; 1er Quartil (JRC) *Igual contribución en el trabajo.
  • Flores-González JC, Estalella-Mendoza A, Lechuga-Sancho AM, Quintero-Otero S, Rubio-Quiñones F, HernándezGonzález A, Saldaña-Valderas M. Severe pneumonia by Mycoplasma as an adverse event of everolimus therapy in patients with tuberous sclerosis complex. Eur J Paediatr Neurol. 2016 Sep;20(5):758-60. Índice de impacto: 1,923 Q2 Área PEDIATRICS
  • Pinto-Souza AR, Firetto C, Pérez-Arana G, Lechuga-Sancho AM, Prada-Oliveira JA. Differences in the estrous cycles of Goto-Kakizaki and Wistar rats. Lab Anim (NY). 2016 Apr;45(4):143-8. Índice de impacto: 0,681 Q4 Área VETERINARY SCIENCES
  • Palomo Atance E, Bahíllo Curieses P, Bueno Lozano G, Feliu Rovira A, Gil-Campos M, Lechuga-Sancho AM, Ruiz Cano R,Vela Desojo A. [Recommendations of the Spanish Paediatric Endocrinology Society Working Group on Obesity on eating habits for the prevention of obesity and cardiovascular risk factors in childhood]. An Pediatr (Barc). 2016 Mar; 84(3):178.e1-7. Índice de impacto: 0,773 Q4 Área PEDIATRICS
  • Ramos-Rodriguez JJ, Infante-Garcia C, Galindo-Gonzalez L, Garcia-Molina Y, Lechuga-Sancho A, Garcia-Alloza M. Increased Spontaneous Central Bleeding and Cognition Impairment in APP/PS1 Mice with Poorly Controlled Diabetes Mellitus. Mol Neurobiol. 2016 May;53(4):2685-97. Índice de impacto: 5,397 Q1 Área NEUROSCIENCES
  • Flores-González JC, Dominguez-Coronel MT, Matamala Morillo MA, Aragón Ramírez M, García Ortega RM, Dávila Corrales FJ, García Palacios MV, Perez Guerrero JJ, García García L, Lechuga Sancho AM. Does nebulized epinephrine improve the efficacy of hypertonic saline solution in the treatment of hospitalized moderate acute bronchiolitis? A double blind, randomized clinical trial. Minerva Pediatr. 2016 Apr;68(2):81-8. Índice de impacto: 0,532 Q4 Área PEDIATRICS
  • Visiedo F, Bugatto F, Quintero-Prado R, Cózar-Castellano I, Bartha JL, Perdomo G. Glucose and Fatty Acid Metabolism in Placental Explants From Pregnancies Complicated With Gestational Diabetes Mellitus. Reprod Sci. 2015 Jul;22(7):798-801. Índice de impacto 2,548 Q2 Área OBSTETRICS & GYNECOLOGY
  • Pérez Arana G.; Camacho Ramirez A.; Segundo Iglesias C.; Lechuga Sancho AM.; Aguilar Diosdado M.; Prada Oliveira JA. A surgical model of short bowel syndrome induces a longlasting increase in pancreatic beta-cell mass. Histology And Histopathology. 2015, 30 - 4, pp. 479 - 487. Índice de impacto: 2,42 Q2 Área PATHOLOGY
  • Diaz-Ganete A, Baena-Nieto G, Lomas-Romero IM, LopezAcosta JF, Cozar-Castellano I, Medina F, Segundo C, LechugaSancho AM. Ghrelin's Effects on Proinflammatory Cytokine Mediated Apoptosis and Their Impact on ß-Cell Functionality. International Journal of Endocrinology. 2015: 235727. Índice de impacto: 2,37 Q2 Área ENDOCRINOLOGY & METABOLISM
  • Flores-González JC, Matamala-Morillo MA, RodríguezCampoy P, Pérez-Guerrero JJ, Serrano-Moyano B, CominoVazquez P, Palma-Zambrano E, Bulo-Concellón R, SantosSánchez V, Lechuga-Sancho AM; Bronchiolitis of Cadiz Study group (BronCaS). Epinephrine Improves the Efficacy of Nebulized Hypertonic Saline in Moderate Bronchiolitis: A Randomised Clinical Trial. PLoS One. 2015 Nov 17;10(11):e0142847 Índice de impacto: 3,057 Q1 Área MULTIDISCIPLINARY SCIENCES
  • Rodríguez-González M, Matamala-Morillo MÁ, SegadoArenas A, Marín-Iglesias M del R, Lechuga-Sancho AM. Chest Pain in Children With Suspected Type I Fibrillinopathy: A Case Report. Pediatrics. 2015 Oct;136(4):e1035-8. Índice de impacto: 5,196 D1 Área PEDIATRICS
  • Ramos-Rodriguez JJ, Jimenez-Palomares M, MurilloCarretero MI, Infante-Garcia C, Berrocoso E, Hernandez Pacho F, Lechuga Sancho AM, Cozar-Castellano I, GarciaAlloza M. Central vascular disease and exacerbated pathology in a mixed model of type 2 diabetes and Alzheimer's disease. Psychoneuroendocrinology. 2015 Dec; 62:69-79. Índice de impacto: 4,704 Q1 Área ENDOCRINOLOGY & METABOLISM
  • Gutiérrez-Fernández D, Moreno-Ancillo Á, Foncubierta Fernández A, López-Martínez I, Lechuga-Sancho A, Fernández Anguita MJ. Desensitization to mecasermin in an insulin-like growth factor 1-deficient patient. Ann Allergy Asthma Immunol. 2015 Jun;114(6):523-5. Índice de impacto: 0,532 Q4 Área PEDIATRICS
  • Benavente-Fernández I, Lubián-López SP, Jiménez-Gómez G, Lechuga-Sancho AM, Garcia-Alloza M. Low-voltage pattern and absence of sleep-wake cycles are associated with severe hemorrhage and death in very preterm infants. Eur J Pediatr. 2015 Jan;174(1):85-90. Índice de impacto: 1,791 Q2 Área PEDIATRICS
  • Visiedo F; Bugatto F; Carrasco-Fernandez C; Sáez-Benito A; Mateos RM; Cózar-Castellano I; Bartha JL; Perdomo G. Hepatocyte growth factor is elevated in amniotic fluid from obese women and regulates placental glucose and fatty acid metabolism. Placenta. 2015, 36, pp. 381 - 388. IF(JRC): 3,531. 1er Quartil (JRC)/1er decil.
  • Cobos R*, Mateos RM*, Álvarez-Pérez JM, Olego MA, Sevillano S, González-García S, Garzón E, Rubio-Coque JJ Effectiveness of natural antifungal compounds to control infection through pruning wounds by grapevine trunk disease pathogens. Applied and Environmental Microbiology. 2015, 81(18). IF(JRC): 3,952 1er Quartil. *Igual contribución en el trabajo.
  • Ramos-Rodriguez JJ, Molina-Gil S, Ortiz-Barajas O, Jimenez Palomares M, Perdomo G, Cozar-Castellano I, Lechuga-Sancho AM, Garcia-Alloza M. Central proliferation and neurogenesis is impaired in type 2 diabetes and prediabetes animal models. PLoS One. 2014 Feb 20;9(2):e89229. Índice de impacto: 3,234 Q1 Área MULTIDISCIPLINARY SCIENCES
  • Martos-Moreno GÁ, Gil-Campos M, Bueno G, Bahillo P, Bernal S, Feliu A, Lechuga-Sancho AM, Palomo E, Ruiz R, Vela A; Grupo de Trabajo de Obesidad de la Sociedad Española de Endocrinología Pediátrica (SEEP). [Obesity associated metabolic impairment is evident at early ages: Spanish collaborative study]. Nutr Hosp. 2014 Oct 1;30(4):787-93. Índice de impacto: 1,818 Q4 Área NUTRITION & DIETETICS
  • Rodríguez-González M, Benavente Fernández I, Zafra Rodríguez P, Lechuga-Sancho AM, Lubián López S. Toxicity of remedies for infantile colic. Arch Dis Child. 2014 Dec;99(12):1147-8. Índice de impacto: 2,889 Q1 Área PEDIATRICS
  • Flores-González JC, Rubio-Quiñones F, Hernández-González A, Rodríguez-González M, Blanca-García JA, Lechuga-Sancho AM, Quintero-Otero S. Pneumonia and purulent pericarditis caused by Streptococcus pneumoniae: an uncommon association in the antibiotic era. Pediatr Emerg Care. 2014 Aug;30(8):552-4. Índice de impacto: 1,406 Q3 Área EMERGENCY MEDICINE
  • Ramos-Rodriguez JJ, Ortiz-Barajas O, Gamero-Carrasco C, de la Rosa PR, Infante-Garcia C, Zopeque-Garcia N, LechugaSancho AM, Garcia-Alloza M. Prediabetes-induced vascular alterations exacerbate central pathology in APPswe/PS1dE9 mice. Psychoneuroendocrinology. 2014 Oct; 48:123-35. Índice de impacto: 4,944 Q1 Área NEUROSCIENCES
  • Gómez-Jaramillo L, Delgado-Pérez L, Reales E, Mora-Lopez F, Mateos RM, García-Poley A, Brieva J.A and Campos-Caro A. Syntaxin-4 is implicated in the secretion of antibodies by human plasma cells. Journal of Leukocyte Biology. 2014, 95(2): 605-612 IF (JRC): 4,99. 1er Quartil.