CO10: Molecular Immunology and Gene and Cellular Immunotherapy

More infoTeamProjectsPublications
CO10: Molecular Immunology and Gene and Cellular Immunotherapyr

This research group, led by two specialists in clinical immunology, focuses on the research in immunology, with special emphasis on the development of chimeric antigen receptors (CAR) for cellular immunotherapy, as well as on the study of early signaling mechanisms and the mechanisms involved in the induction of immune tolerance.

Principal investigator
  • Francisco García-Cózar
  • e-mail: curro.garcia@uca.es
  • ORCID: 0000-0003-3720-259x
Co-principal investigator
  • Enrique Aguado Vidal
  • e-mail: enrique.aguado@uca.es
  • ORCID: 0000-0002-7232-2661
Líneas de investigación
  1. Molecular mechanisms of immune tolerance induction. Genomic and proteomic analysis of the mechanisms responsible for basic immune tolerance and the mechanisms responsible for the development of chronic infections.
  2. Gene and cellular immunotherapy. This line of research is based on the development of Chimeric Antigen Receptors (CAR), with application in oncological and inflammatory diseases (cardiovascular, digestive, neurological, etc.), as well as in the rejection of transplanted organs.
  3. Nanomedicine. In collaboration with the associated group led by Prof. Litrán, this research group develops nanoparticle-based contrasts for the specific identification of molecules in vivo, for applications in Diagnostic Imaging.
  4. Early intracellular signaling in T and B lymphocytes: implications in immune-based pathologies.
  5. Transmembrane adapter proteins and their role as activation regulators in lymphocytes.
Key words
T-lymphocytes immune tolerance intracellular signaling membrane adapter proteins cardiovascular disease gene immunotherapy cellular immunotherapy nanoparticles
Principal investigator

Francisco García-Cózar
  • University Professor
  • e-mail: curro.garcia@uca.es
  • ORCID: 0000-0003-720-259x
  • Research ID: A-6212-2013
Co-principal investigator
Enrique Aguado Vidal
  • University tenured professor
  • e-mail: enrique.aguado@uca.es
  • ORCID: 0000-0002-7232-2661
Team members
  • Francisco García Cózar (University professor)
  • Enrique Aguado Vidal (University tenured professor)
  • Cecilia Matilde Fernández Ponce (University tenured professor)
  • José Mª López-Cepero López-Cepero (University tenured professor)
  • Federico Rodriguez Rubio Cortadelas (University tenured professor)
  • Javier Alvarez Medialdea (Specialist)
  • Carmen María Pérez Alberca (Specialist)
  • Auxiliadora Mazuecas Blanca (Specialist)
  • Teresa Mª Garcia Alvarez (FSpecialistA)
  • Julia Wu (Specialist)
  • Encarnación García Domínguez (Specialist)
  • Cristina Montes Durán (Specialist)
  • Victoria de Lara Bendalián (Specialist)
  • Carmen Mínguez Mañanes (Specialist)
  • Carlos Bohorquez Sierra
  • María Isabel Moreno García (FEA)
  • Jesús García Serrano (FEA)
  • Ana Diez Núñez (FEA)
  • Juan Carlos Pérez Herrera (Specialist)
  • Jesús Navarro Navarro (Specialist)
  • Isaac Narbona Sánchez (Technician)
  • Mikel Arbulo Etxebarria (Postdoctoral researche)
  • Inmaculada Vico Barranco (Predoctoral researcher)
  • Juan Pedro Muñoz Miranda (Technician)
  • Ricardo Fernández Cisnal (Postdoctoral researcher)
  • Lucía Olvera Collantes (Predoctoral researcher)
  • Alicia Rodriguez Moreno (Predoctoral researcher)
National Funding Calls
  1. Health research projects from Instituto de Salud Carlos III. (2016) PI16/00784. Principal Investigator: Francisco García Cózar. Biomarker validation and alternative cell therapy in atherosclerosis based on modulation of progenitor endothelial cells and regulatory T cells.
Regional Funding Calls
  1. Regional integration initiative (ITI) 2014-2020 for the province of Cadiz, by the Department of Health of the Junta de Andalucia and the European Regional Development Fund. PI-0055-2017. Principal Investigator: Enrique Aguado Vidal. Molecular characterization of lymphocyte membrane adapters and their role as regulators of lymphocyte activation: Implications in rheumatoid arthritis.
  2. Regional integration initiative (ITI) 2014-2020 for the province of Cadiz, by the Department of Health of the Junta de Andalucia and the European Regional Development Fund. PI-0030-2017. Principal Investigator: Francisco García Cózar. Gene and cell immunotherapy monitored by nanoparticles for the clinical modulation of immune tolerance.
  3. Department of Health of the Junta de Andalucia. Year: 2013. PI-0365-2013. Principal Investigator: Enrique Aguado Vidal. Functional analysis of the proteolysis of molecules involved in the signaling mechanisms associated with immune receptors: Potential regulatory role of its activity and implications in allergy-based pathologies.
Publications
  • Autores: Geribaldi-Doldán N, Carrasco M, Murillo-Carretero M, DomínguezGarcía S, García-Cózar FJ, Muñoz-Miranda JP, Del Río-García V, Verástegui C, Castro C. Título: Specific inhibition of ADAM17/TACE promotes neurogenesis in the injured motor córtex. Revista: Cell Death Dis. Año, volumen, páginas primera y última: 2018 Aug 28;9(9):862. Factor de impacto: 5,638 Cuartil/decil en el año de publicación: Q1 (41/190)
  • Autores: Arbulo-Echevarria MM, Narbona-Sánchez I, Fernandez-Ponce CM, Vico-Barranco I, Rueda-Ygueravide MD, Dustin ML, Miazek A, Duran-Ruiz MC, García-Cózar F, Aguado E. Título: Stretch of Negatively Charged Amino Acids of Linker for Activation of T-Cell Adaptor Has a Dual Role in T-Cell Antigen Receptor Intracellular Signaling. Revista: Front Immunol. Año, volumen, páginas primera y última: 2018 Feb 2;9:115. Factor de impacto: 5. 511 Cuartil/decil en el año de publicación: Q1 (30/155 Immunology)
  • Autores: Fernández-Ponce C, Durán-Ruiz MC, Narbona-Sánchez I, MuñozMiranda JP, Arbulo-Echevarria MM, Serna-Sanz A, Baumann C, Litrán R, Aguado E, Bloch W, García-Cozar F. Título: Ultrastructural Localization and Molecular Associations of HCV Capsid Protein in Jurkat T Cells. Revista: Front Microbiol. Año, volumen, páginas primera y última: 2018 Jan 4;8:2595. doi: 10.3389/fmicb.2017.02595. eCollection 2017. Factor de impacto: 4.019 Cuartil/decil en el año de publicación: Q1 [18 de 80 (Microbiology)]
  • Autores: Vega FM, Gautier V, Fernandez-Ponce CM, Extremera MJ, Altelaar AFM, Millan J, Tellez JC, Hernandez-Campos JA, Conejero R, Bolivar J, Pardal R, García-Cózar FJ, Aguado E, Heck AJR, Duran-Ruiz MC Título: The atheroma plaque secretome stimulates the mobilization of endothelial progenitor cells ex vivo Revista: Journal of Molecular and Cellular Cardiology Año, volumen, páginas primera y última: 2017; 105:12-23 Factor de impacto: 5,680 Cuartil/decil en el año de publicación: Q1
  • Autores: Fernández-Ponce C, Dominguez-Villar M, Muñoz-Miranda JP, Arbulo-Echevarria MM, Litrán R, Aguado E, García-Cozar F. Título: Immune modulation by the hepatitis C virus core protein. Revista: J Viral Hepat. Año, volumen, páginas primera y última: 2017 May;24(5):350-356. Índice De Impacto (IP): 4,122 Cuartil/decil en el año de publicación: Q1 (17/84 Infectious Diseases)
  • Autores/as: Smith LE, Olszewski MA, Georgoudaki AM, Wagner AK, Hägglöf T, Karlsson MC, Dominguez-Villar M, García-Cózar F, Mueller S, Ravens I, Bernhardt G, Chambers BJ.Titulo: Sensitivity of dendritic cells to NK-mediated lysis depends on the inflammatory environment and is modulated by CD54/CD226-driven interactions. Revista: J Leukoc Biol. Año, volumen, páginas primera y última: 2016 Mar 31. pii: jlb.3A0615- 271RR. [Epub ahead of print] PMID: 27034402 Índice De Impacto (IP): 4,165 (año 2016) Cuartil/decil en el año de publicación: Q1 17/70 Haematology
  • Autores: Mikel M Arbulo-Echevarria; Juan P Muñoz-Miranda; Andrés Caballero-García; José L Poveda-Díaz; Cecilia Fernández-Ponce; Mª Carmen Durán-Ruiz; Arkadiusz Miazek; Francisco García-Cózar; Enrique Aguado Título: Non-T cell activation linker (NTAL) proteolytic cleavage as a terminator of activatory intracellular signals. Revista: Journal of Leukocyte Biology Año, volumen, páginas primera y última: 2016; 100: 351-360 Índice De Impacto (IP): 4,165 (año 2016) Cuartil/decil en el año de publicación: Q1 17/70 Haematology
  • Autores/as: Moreno Benítez F, Espinazo Romeu M, Letrán Camacho A, Mas S, García-Cózar FJ, Tabar AI Titulo: Variation in allergen content in sublingual allergen immunotherapy with house dust mites. Revista: Allergy. Año, volumen, páginas primera y última: 2015 Nov;70(11):1413-20. doi: 10.1111/all.12694. Epub 2015 Sep 11. PMID: 26185961 Índice De Impacto (IP): 6,335 (año 2014) Cuartil/decil en el año de publicación: D1 2/25 de ALLERGY
  • Autores/as: Sanchez-De Melo I, Grassi P, Ochoa F, Bolivar J, García-Cózar FJ, Durán-Ruiz MC. Titulo: N-glycosylation profile analysis of Trastuzumab biosimilar candidates by Normal Phase Liquid Chromatography and MALDI-TOF MS approaches Revista: J Proteomics. Año, volumen, páginas primera y última: 2015 Apr 21. pii: S1874- 3919(15)00193-1. doi: 10.1016/j.jprot.2015.04.012. PMID: 25907685 Índice De Impacto (IP): 3,888 (año 2014) Cuartil/decil en el año de publicación: Q1 16/79 BIOCHEMICAL RESEARCH METHODS
  • Autores/as: Toro R, Mangas A, Quezada M, Rodriguez-Rosety M, Fournielles G, Rodriguez-Rosety I, Rodriguez Rosety MA, Alonso JA, García-Cózar FJ, Duran MC. Titulo: Diet and exercise influence on the proteomic profile of an athlete population Revista: Nutr Hosp. Año, volumen, páginas primera y última: 2014 Nov 1;30(5):1110-7. doi: 10.3305/nh.2014.30.5.7697. PMID: 25365015 Índice De Impacto (IP): 1,04 (año 2014) 64/77 NUTRITION & DIETETICS
  • Autores/as: Fernandez-Ponce C, Dominguez-Villar M, Enrique Aguado, Francisco J. García-Cózar. Titulo: CD4+ primary T cells expressing HCV-core protein upregulate FOXP3 and IL-10, suppressing CD4 and CD8 T cells. Revista: PlosOne. Año, volumen, páginas primera y última: 2014 Jan 20;9(1):e85191 Índice De Impacto (IP): 3.234 (año 2014) Cuartil/decil en el año de publicación: Q1 9/57 de Multidisciplinary Sciences
  • Autores/as: Benítez FM, Camacho AL, del Cuvillo Bernal A, de Medina PL, García Cózar FJ, Romeu ME. Titulo: Determination of allergenic load and pollen count of Cupressus arizonica pollen by flow cytometry using Cup a1 polyclonal antibody. Revista: Cytometry B Clin Cytom. Año, volumen, páginas primera y última: 2014 Jan;86(1):63-9. Cuartil/decil en el año de publicación: Q1 10/32 de Medical Laboratory Technology