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CO17: Diabetes mellitus: Autoimmunity and chronic complications. Pathogenic, clinical, therapeutic and prognostic implications
Principal Investigator
Co-Principal Investigator
Lines of research
  • Diabetes and Autoimmunity. Study of the pathogenesis of type 1 diabetes mellitus (DMT1) focused on beta cells in an animal model (BB rat) and evaluation of different treatment models (continuous insulin infusion systems and multi-injections). Assessment of preventive proposals and predictive parameters (autoimmunity).
  • Diabetes Mellitus and Pregnancy. Implications of proinflammatory cytokines and oxidative stress in the pathogenesis of gestational DM. Predictive variables of metabolic syndrome and risk of cardiovascular disease. Role of the placenta in the pathogenic mechanisms involved. Analysis of the relationship between periodontal disease and gestational diabetes.
  • Diabetic retinopathy. Pathogenic mechanisms of diabetic retinopathy in animal and human models. Molecular biology and biochemistry of the mechanisms that modulate the process. Incidence of retinopathy in patients with T1DM. Population screening models using digital retinography.
  • Diabetic nephropathy. Study of the processes that trigger renal pathology associated with diabetes mellitus in animal and human models. Molecular biology and biochemistry of the modulation mechanisms of the process.
  • Diabetic foot and risk of amputation. Characterization of the population that suffers amputations due to diabetic foot. Census analysis. Study of socioeconomic variables. Qualitative analysis through interviews with patients and professionals.
Keywords
Diabetes Autoimmunity Retinopathy Gestation Amputation
Principal Investigator
Manuel Aguilar Diosdado
INiBICA Scientific Director.
Co-Principal Investigator
Ana Isabel Arroba Espinosa
Nicolás Monarde Contract.
Team members
  • Principal Investigators:
    • Manuel Aguilar Diosdado (PI).
    • Ana Isabel Arroba Espinosa (Co-PI).
  • Investigators:
    • Laura María Gómez Jaramillo.
    • María del Mar Roca Rodríguez.
    • Cristina López Tinoco.
    • Almudena Lara Barea.
    • Pedro Alemany Márquez.
    • Soledad Jiménez Carmona.
    • Marta Iturregui Guevara.
    • José Ortego Rojo.
    • Isabel María Torres Barea.
    • Rosa Márquez Pardo.
    • Ana Sáez-Benito Godino.
    • Alicia Abal Cruz.
    • Carlos Díaz López.
    • Laura Díaz López.
    • Fátima Cano Cano.
    • Lourdes García García-Doncel.
    • Ana Motero Galván.
    • Lorea Zubiaga Toro.
    • Mª Carmen González Montelongo.
    • Pablo Álvarez Ramos.
    • Francisco Vílchez.
    • Isabel Mateos.
    • Pablo Ramos.
    • Miguel A González Moles.
    • Ana Sáenz Benito.
  • Predoctoral Researchers:
    • Belén Cuevas Gómez.
    • Francisco Martín Loro.
International Calls
  • Participación en proyectos internacionales. 2-SRA-2019-837-S-B. PI: Benoit Gauthier (CABIMER). INiBICA Collaborators: Manuel Aguilar-Diosdado, Ana I. Arroba. Juvenile Diabetes Research Foundation (JDRF). LRH-1/NR5A2 agonism to stimulate immune coupled human islet beta cell regeneration.
National Calls
  • Instituto Nacional de Salud Carlos III, Acción Estratégica en Salud 2017-2020, PI18/01287 PI: Manuel Aguilar Diosdado / Ana I. Arroba Espinosa. Influencia de Exendina-4, Peptide-1 (GLP-1), y Papel de los Exosomas como Biomarcadores en la Patogenia de la Diabetes Mellitus Tipo 1 y de sus Complicaciones.
  • Instituto Nacional de Salud Carlos III, Acción Estratégica en Salud 2016, PI16/00370 PI: Cristina López Tinoco. Estado proinflamatorio y marcadores de daño endotelial en mujeres con Diabetes mellitus gestacional y su relación con el patrón diario de Presión arterial.
  • Instituto Nacional de Salud Carlos III, Acción Estratégica en Salud 2016, PI16/01543 PI: Soledad Jiménez Carmona. Validación de un sistema automático de cribado de retinopatía diabética mediante análisis informatizado de la retinografía digital.
  • Ministerio de Economía y Competitividad (MINECO), Agencia Estatal de Investigación, Programa Estatal de I+D+i Orientada a los Retos de la Sociedad SAF2016-76083R Colaboración. Inflammation associated with chronic metabolic damage in type 2 diabetes and its complications.
  • Instituto Nacional de Salud Carlos III, Acción Estratégica en Salud 2015, PI15/01106 PI: Manuel Aguilar Diosdado. Variables biológicas y determinantes sociales asociados a las amputaciones de miembros inferiores por diabetes en Andalucía (PERIODO 2005-2015.
Regional Calls
  • Consejería de Salud y Familias, Junta de Andalucía, PI-0036-2020 PI: Mª del Mar Roca Rodríguez y Manuel Aguilar Diosdado. RIdentificación del patrón de proteínas relacionada con la progresión de la diabetes mellitus tipo 1 y complicaciones asociadas: Diabetomics.
  • Consejería de Salud y Familias, Junta de Andalucía, ITI-0012-2019 PI: Ana I. Arroba Espinosa. Determinación de la inflamación temprana como una nueva diana terapeútica en el diagnóstico y tratamiento de la diabetes mellitus y sus complicaciones. el uso de productos naturales bioactivos de origen marino.
  • Consejería de Salud y Familias, Junta de Andalucía, PI-0123-2018 PI: Ana I. Arroba Espinosa. Retinopatía diabética: la inflamación como una nueva diana terapéutica. Papel de los exosomas.
  • Iniciativa Territorial Integrada (ITI) 2014-2020 para la provincia de Cádiz, por la Consejería de Salud y por el Fondo Europeo de Desarrollo Regional PI-0029-2017 PI: Manuel Aguilar Diosdado. Diabetes Mellitus: Autoinmunidad y Complicaciones Crónicas. Implicaciones Patogénicas, clínicas, Terapéuticas y Pronósticas.
Local Calls
  • Plan Propio INIBICA, LI19/09IN-CO17 PI: : Laura M. Gómez-Jaramila y M. Mar Roca-Rodríguez. Nefropatía diabética: la inflamación como una nueva diana terapéutica. El papel de los exosomas.
Non-Competitive Calls
  • Estudio del papel protector de los compuestos Esteve en la nocicepción y neurodegeneración retiniana inducida por la diabetes. PI: Ana I. Arroba/Esther Berrocoso.
Human Resources Calls
  • Instituto Nacional de Salud Carlos III, Contrato Río Hortega. PI: ALMUDENA LARA BAREA.
2021 Publications
  1. *AUTHORS: Cano-Cano F, Alcalde-Estévez E, Gómez-Jaramillo L, Iturregui M, Sánchez-Fernández EM, García Fernández JM, Ortiz Mellet C, Campos-Caro A, López-Tinoco C, Aguilar-Diosdado M, Valverde ÁM, Arroba AI. MANUSCRIPT TITLE: Anti-Inflammatory (M2) Response Is Induced by A Sp 2 -Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy. JOURNAL: Frontiers in Immunology (Front Immunol). YEAR, VOLUME, PAGE: 2021;12:632132. doi: 10.3389/fimmu.2021.632132. PMID: 33815384. POSITION OCCUPIED BY THE JOURNAL IN THE CATEGORY: 39 de 159. IMPACT INDEX: 5,085, TERCILE;QUARTIL: T1; Q1. INIBICA AFFILIATION: YES. COLLABORATIVE GROUPS: GRUPO INIBICA LIDERADO POR ANTONIO CAMPOS.
  2. *AUTHORS: Petra I. Lorenzo, Esther Fuente-Martín, José M. Mellado-Gil,José A. Guerrero Martínez, Nadia Cobo-Vuilleumier, Valentine Comaills, Eugenia Martin Vazquez, Silvana Y. Romero-Zerbo, Jaime Muñoz Franco, Sabrina Rivero Canalejo, Antonio Campos-Caro, Christian Lachaud, Manuel Aguilar-Diosdado, Eduardo García Fuentes, Alejandro Martin-Montalvo, Manuel Álvarez Dolado, Franz Martin, Gemma Rojo-Martinez, David Pozo, Francisco J. Bérmudez-Silva, José C. Reyes and Benoit R. TITLE: The Metabesity factor HMG20A Potentiates Astrocyte Survival and Reactivity Preserving Neuronal Integrity. JOURNAL: Theranostics. YEAR, VOLUME, PAGE: 2021. POSITION OCCUPIED BY THE JOURNAL IN THE CATEGORY: 10 de 139. IMPACT INDEX: 8.579, TERCILE; QUARTIL: T1; Q1. INIBICA AFFILIATION: YES.
  3. *AUTHORS: Mateo-Gavira I, Sánchez-Toscano E, Mayo-Ossorio MÁ, Pacheco-García JM, Prada-Oliveira JA, Vílchez-López FJ. TITLE: Evaluation of Clinical Factors Predictive of Diabetes Remission Following Bariatric Surgery. JOURNAL: Journal of Clinical Medicine. YEAR, VOLUME, PAGE: 2021, 10(9):1945 (in press). POSITION OCCUPIED BY THE JOURNAL IN THE CATEGORY: 36 de 167. DOI: 10.3390/jcm10091945. IMPACT INDEX: 4,242 ; QUARTIL: Q1. INIBICA AFFILIATION: YES.
  4. *AUTHORS: Sánchez-Fernández EM, García-Hernández R, Gamarro F, Arroba AI, Aguilar-Diosdado M, Padrón JM, García Fernández JM, Ortiz Mellet C. TITLE: Synthesis of sp2-Iminosugar Selenoglycolipids as Multitarget Drug Candidates with Antiproliferative, Leishmanicidal and Anti Inflammatory Properties. JOURNAL: Molecules. YEAR, VOLUME, PAGE: 2021, Dec 11;26(24):7501. POSITION OCCUPIED BY THE JOURNAL IN THE CATEGORY: 82 de 219. DOI: 10.3390/molecules26247501. IMPACT INDEX: 4,412; QUARTIL: Q2. INIBICA AFFILIATION: YES.
  5. *AUTHORS: Cuevas B, Arroba AI, de Los Reyes C, Gómez-Jaramillo L, González-Montelongo MC, Zubía E. TITLE: Diterpenoids from the Brown Alga Rugulopteryx okamurae and Their Anti-Inflammatory Activity. JOURNAL: Marine Drugs. YEAR, VOLUME, PAGE: 2021 Nov 27;19(12):677. POSITION OCCUPIED BY THE JOURNAL IN THE CATEGORY: 12 de 62. DOI: 10.3390/md19120677. IMPACT INDEX: 5,118; QUARTIL: Q1/D1. INIBICA AFFILIATION: YES.
  6. *AUTHORS: Jimenez-Carmona S, Alemany-Marquez P, Alvarez-Ramos P, Mayoral E, Aguilar-Diosdado M. TITLE: Validation of an Automated Screening System for Diabetic Retinopathy Operating under Real Clinical Conditions. JOURNAL: J Clin Med. YEAR, VOLUME, PAGE: 2021 Dec 21;11(1):14. POSITION OCCUPIED BY THE JOURNAL IN THE CATEGORY: 36 de 167. DOI: 10.3390/jcm11010014. IMPACT INDEX: 4,242; QUARTIL: Q1. INIBICA AFFILIATION: YES.
  7. AUTHORS: MC Gonzalez-Montelongo, Samuel J Fountain. TITLE: Neuropeptide Y facilitates P2X1 receptor-dependent vasoconstriction via Y1 receptor activation in small mesenteric arteries during sympathetic neurogenic responses. JOURNAL: Vascul Pharmacol. YEAR, VOLUME, PAGE: 2021 Feb;136:106810. POSITION OCCUPIED BY THE JOURNAL IN THE CATEGORY: 45 de 276. DOI: 10.1016/j.vph.2020.106810. IMPACT INDEX: 5,773; QUARTIL: Q1. INIBICA AFFILIATION: NO.
  • Publications in collaboration with clinical-basic groups:
    1. AUTHORS: Cano-Cano F, Alcalde-Estévez E, Gómez-Jaramillo L, Iturregui M, Sánchez-Fernández EM, García Fernández JM, Ortiz Mellet C, Campos-Caro A, López-Tinoco C, Aguilar-Diosdado M, Valverde ÁM, Arroba AI. MANUSCRIPT TITLE: Anti-Inflammatory (M2) Response Is Induced by A Sp 2 -Iminosugar Glycolipid Sulfoxide in Diabetic Retinopathy. JOURNAL: Frontiers in Immunology (Front Immunol). YEAR, VOLUME, PAGE: 2021;12:632132. doi: 10.3389/fimmu.2021.632132. PMID: 33815384. POSITION OCCUPIED BY THE JOURNAL IN THE CATEGORY: 39 de 159. IMPACT INDEX: 5,085, TERCILE;QUARTIL: T1; Q1. INIBICA AFFILIATION: YES. PARTICIPATING RESEARCH GROUPS: QUIMICA BIOORGANICA DE CARBOHIDRATOS UNIVERSIDAD DE SEVILLA.
    2. AUTHORS: Sánchez-Fernández EM, García-Hernández R, Gamarro F, Arroba AI, Aguilar-Diosdado M, Padrón JM, García Fernández JM, Ortiz Mellet C. TITLE: Synthesis of sp2-Iminosugar Selenoglycolipids as Multitarget Drug Candidates with Antiproliferative, Leishmanicidal and Anti Inflammatory Properties. JOURNAL: Molecules. YEAR, VOLUME, PAGE: 2021, Dec 11;26(24):7501. POSITION OCCUPIED BY THE JOURNAL IN THE CATEGORY: 82 de 219. DOI: 10.3390/molecules26247501. IMPACT INDEX: 4,412; QUARTIL: Q2. INIBICA AFFILIATION: YES. PARTICIPATING RESEARCH GROUPS: QUIMICA BIOORGANICA DE CARBOHIDRATOS UNIVERSIDAD DE SEVILLA.
    3. AUTHORS: Petra I. Lorenzo, Esther Fuente-Martín, José M. Mellado-Gil, José A. Guerrero Martínez, Nadia Cobo-Vuilleumier, Valentine Comaills, Eugenia Martin Vazquez, Silvana Y. Romero-Zerbo, Jaime Muñoz Franco, Sabrina Rivero Canalejo, Antonio Campos-Caro, Christian Lachaud, Manuel Aguilar-Diosdado, Eduardo García Fuentes, Alejandro Martin-Montalvo, Manuel Álvarez Dolado, Franz Martin, Gemma Rojo-Martinez, David Pozo, Francisco J. Bérmudez-Silva, José C. Reyes and Benoit R. TITLE: The Metabesity factor HMG20A Potentiates Astrocyte Survival and Reactivity Preserving Neuronal Integrity. JOURNAL: Theranostics. YEAR, VOLUME, PAGE: 2021. PARTICIPATING RESEARCH GROUPS: GRUPO CABIMER Pancreatic Islet Development & Regeneration.
    4. AUTHORS: Mateo-Gavira I, Sánchez-Toscano E, Mayo-Ossorio MÁ, Pacheco-García JM, Prada-Oliveira JA, Vílchez-López FJ. TITLE: Evaluation of Clinical Factors Predictive of Diabetes Remission Following Bariatric Surgery. JOURNAL: Journal of Clinical Medicine. YEAR, VOLUME, PAGE: 2021, 10(9):1945 (in press). POSITION OCCUPIED BY THE JOURNAL IN THE CATEGORY: 36 de 167. DOI: 10.3390/jcm10091945. IMPACT INDEX: 4,242 ; QUARTIL: Q1. INIBICA AFFILIATION: YES. PARTICIPATING RESEARCH GROUPS: EM7: Cirugía Bariátrica y Metabólica: Estudio Clínicos y Modelos Experimentales.
2020 Publications
  1. AUTHORS (by order of signature): Rodriguez-Acuña R, Mayoral Sánchez E, Martinez-Carriazo A, Aguilar-Diosdado M, Martinez-Brocca M. TITLE: The Andalusian Program for early detection of Diabetic Retinopathy: Implementation and 15-year follow-up of a population-based screening program in Andalusia, Southern Spain. JOURNAL: BMJ Open Diab. Res. Care BMJ Open Diabetes Research & Care. YEAR, VOLUME, PAGE: ID bmjdrc-2020-001622.R1 -PMID: in press. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 5,067 Q1.
  2. AUTHORS (by order of signature): Pablo Álvarez-Ramos, Soledad Jiménez-Carmona,Pedro Alemany-Márquez, Juan A Córdoba-Doña, Manuel Aguilar-Diosdado. TITLE: Socioeconomic deprivation and development of diabetic retinopathy in patients with type 1 diabetes mellitus.. JOURNAL: BMJ Open Diab. Res. Care BMJ Open Diabetes Research & Care. YEAR, VOLUME, PAGE: Manuscript ID bmjdrc-2020-001387.R2PMID: in press. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 5,067 Q1.
  3. AUTHORS: Maria S Ruiz de Adana, Maria Rosa Alhambra-Expósito , Araceli Muñoz-Garach , Inmaculada Gonzalez-Molero , Natalia Colomo , Isabel Torres-Barea, Manuel Aguilar-Diosdado, Florentino Carral, Manuel Serrano, Maria A Martínez-Brocca , Ana Duran, Rafael Palomares, Diabetes Group of SAEDYN (Andalusian Society of Endocrinology, Diabetes, and Nutrition) TITLE: Randomized Study to Evaluate the Impact of Telemedicine Care in Patients With Type 1 Diabetes With Multiple Doses of Insulin and Suboptimal HbA 1c in Andalusia (Spain): PLATEDIAN Study JOURNAL: Diabetes CarePMCID: 31831473 YEAR, VOLUME, FIRST AND LAST PAGES: 2020 Feb;43(2):337-342. doi: 10.2337/dc19-0739. Epub 2019 Dec 12. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 16,03 Q1/D1.
  4. AUTHORS: Pablo Ramos-Garcia, Maria Del Mar Roca-Rodriguez , Manuel Aguilar-Diosdado, Miguel Angel Gonzalez-Moles. TITLE: Diabetes mellitus and oral cancer/oral potentially malignant disorders: A systematic review and meta-analysis. JOURNAL: Oral Dis.PMCID: 31994293. YEAR, VOLUME, FIRST AND LAST PAGES: 2020 Jan 29. doi: 10.1111/odi.13289. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 2,613 Q1.
2019 Publications
  1. AUTHORS: Andrea Villar-Lorenzo, Patricia Rada, Esther Rey, Patricia Marañón, Ana I Arroba, Beatriz Santamaría, Jorge Sáiz, Francisco J Rupérez, Coral Barbas, Carmelo García-Monzón, Ángela M Valverde , Águeda González-Rodríguez. TITLE: Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury.. JOURNAL: Dis Model Mech.PMCID: 31262748. YEAR, VOLUME, FIRST AND LAST PAGES:2019Jul16;12(7):dmm03881. doi: 10.1242/dmm.038810.. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 4,651 Q1.
  2. AUTHORS: Elena M Sánchez-Fernández, Ma Isabel García-Moreno, Ana I Arroba, Manuel Aguilar-Diosdado, José M Padrón, Raquel García-Hernández, Francisco Gamarro, Santos Fustero, José-Emilio Sánchez-Aparicio, Laura Masgrau, José Manuel García Fernández, Carmen Ortiz Mellet. TITLE: Synthesis of polyfluoroalkyl sp 2-iminosugar glycolipids and evaluation of their immunomodulatory properties towards anti-tumor, anti-leishmanial and anti-inflammatory therapies.. JOURNAL: Eur J Med Chem.PMCID: 31425910. YEAR, VOLUME, FIRST AND LAST PAGES: 2019 Nov 15;182:111604.doi: 10.1016/j.ejmech.2019.111604. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 5,573 Q1/D1.
  3. AUTHORS: Roca-Rodríguez MM, El Bekay R, Garrido-Sanchez L, Gómez-Serrano M, Coin-Aragüez L, Oliva-Olivera W, Lhamyani S, Clemente-Postigo M, García-Santos E, de Luna Diaz R, Yubero-Serrano EM, Fernández Real JM, Peral B, Tinahones FJ. TITLE: Parathyroid Hormone-Related Protein, Human Adipose-Derived Stem Cells Adipogenic Capacity and Healthy Obesity. JOURNAL: J Clin Med.PMCID: 30987326. YEAR, VOLUME, FIRST AND LAST PAGES: 2019 Apr 4;8(4):451. doi: 10.3390/jcm8040451.. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 3,303 Q1.
2018 Publications
  1. AUTHORS: Gabriel Jesús Rodríguez, Juan Antonio Córdoba-Doña*, Antonio Escolar-Pujolar, Manuel Aguilar-Diosdado, Isabel Goicolea. TITLE: Family, socioeconomic status and health services: Clues to health care in diabetic patients with lower limb amputations in Andalusia. A qualitative study. JOURNAL: Aten Primaria.PMCID: 29150148. YEAR, VOLUME, FIRST AND LAST PAGES: 2018 Dec;50(10):611-620. doi: 10.1016/j.aprim.2017.06.011. . IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 1,148 Q3.
  2. AUTHORS: Jose M. Mellado-Gil, Esther Fuente-Martín, Petra I. Lorenzo, Nadia Cobo-Vuilleumier, Maria Ceballos-Chávez, Laura M. Gómez-Jaramillo, Antonio Campos-Caro, Julia Rodriguez-Comas, Joan M. Servitja, Gemma Rojo-Martinez, Javier Bérmudez-Silva, Jose C. Reyes, Manuel Aguilar-Diosdado and Benoit Gauthier. TITLE:The Type 2 Diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity. Cell Death & Disease 2018; 9:279 DOI 10.1038/s41419-018-0272-z POSITION OCCUPIED BY THE JOURNAL IN THE CATEGORY: 39 de 190 IMPACT INDEX: 6.14 TERCILE: T1; Q1.
  3. AUTHORS: Sánchez-Lechuga B, Lara-Barea A, Córdoba-Doña JA, Montero Galván A, Abal Cruz A, Aguilar-Diosdado M, López-Tinoco C. TITLE: Usefulness of blood pressure monitoring in patients with gestational diabetes mellitus. JOURNAL: Endocrinol Diabetes Nutr PMCID: 29680782 YEAR, VOLUME, FIRST AND LAST PAGES: 2018; 65:394-401doi: 10.1016/j.endinu.2018.02.005 IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 1.10 Q4.
  4. AUTHORS: Lecumberri E, Ortega M, Iturregui M, Quesada JA, Vázquez C, Orozco D. TITLE: Quality-of-life and treatment satisfaction in actual clinical practice of patients with Type 1 diabetes mellitus (T1DM) and hypoglycemia treated with insulin degludec. JOURNAL: Curr Med Res Opin. PMCID: 29300101 YEAR, VOLUME, FIRST AND LAST PAGES: 2018; 34(6):1053-1059 IMPACT FACTOR (JCR)– QUARTIL (JCR) FI: 2,372 Q1.
  5. AUTHORS: Beltramo E, Arroba AI, Mazzeo A, Valverde AM, Porta M. TITLE: Imbalance between pro-apoptotic and pro-survival factors in human retinal pericytes in diabetic-like conditions. JOURNAL Acta Ophthalmol. PMCID: 28127871 YEAR, VOLUME, FIRST AND LAST PAGES: 2018; 96(1):e19-e26. doi: 10.1111/aos.13377. Epub 2017 Jan 27. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 3,679 Q2
  6. AUTHORS: Alcalde-Estévez E, Arroba AI, Sánchez-Fernández EM, Mellet CO, García Fernández JM, Masgrau L, Valverde ÁM. TITLE: The sp 2 -iminosugar glycolipid 1-dodecylsulfonyl-5N,6O- oxomethylidenenojirimycin (DSO 2 -ONJ) as selective anti-inflammatory agent by modulation of hemeoxygenase-1 in Bv.2 microglial cells and retinal explants. JOURNAL: Food Chem Toxicol. PMCID: 29191728 YEAR, VOLUME, FIRST AND LAST PAGES: 2018. 111:454-466. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 2,610 Q1.
  7. AUTHORS: Arroba AI, Campos-Caro A, Aguilar-Diosdado M, Valverde ÁM. TITLE: IGF-1, Inflammation and Retinal Degeneration: A Close Network. JOURNAL: Front Aging Neurosci PMCID: 30026694 YEAR, VOLUME, FIRST AND LAST PAGES: 2018; 96 111:454-466. doi:10.1016/j.fct.2017.11.050. Epub 2017 Nov 27. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 2,843 Q2.
2017 Publications
  1. AUTHORS: Cristina López-Tinoco, Amparo Rodríguez-Mengual, Almudena Lara-Barea, Ana Saez-Benito, Manuel Aguilar-Diosdado. TITLE: Impacto de la autoinmunidad antitirodiea positiva en gestantes con hipotiroidismo subclínico. JOURNAL: Endocrinología, Diabetes y Nutrición. DOI: 10.1016/j.endinu.2017.11.013  IMPACT INDEX: 1.10 TERCILE: T3; Q4.
  2. AUTHORS: Antonio Escolar-Pujolar, Juan Antonio Córdoba Doña, Isabel Goicolea Julían, Gabriel Jesús Rodríguez, Vanesa Santos Sánchez, Eduardo Mayoral Sánchez, Manuel Aguilar Diosdado. TITLE: El efecto del estado civil sobre las desigualdades sociales y de género en la mortalidad por diabetes mellitus en Andalucía. JOURNAL: Endocrinol Diabetes Nutr. 2017. DOI: 10.1016/j.endinu.2017.10.006 IMPACT INDEX: 1.10 TERCILE: T3; Q4.
  3. AUTHORS: Alonso Camacho-Ramírez; Manuel Blandino-Rosano; M. Carmen Segundo-Iglesias; Alfonso M. Lechuga-Sancho; Manuel Aguilar-Diosdado; Gonzalo M. Pérez-Arana and J. Arturo Prada-Oliveira. TITLE: Bariatric Surgery lnfluences b-Cell Turnover in Non Obese Rats JOURNAL: Histol Histopathol 2017;32:1341-1350. DOI: 10.14670/HH-11-909 IMPACT INDEX: 2.02 TERCILE: T2; Q2.
  4. AUTHORS: Francisco Visiedo García, Celeste Santos-Rosendo, Rosa M Mateos-Bernal, Fernando Bugatto, Manuel Aguilar Diosdado, Carmen Segundo and Cristina López-Tinoco TITLE: Characterization of NO-induced nitrosative status in human placenta from pregnant women with gestational Diabetes Mellitus JOURNAL: Oxid Med Cell Longev 2017. DOI: 10.1155/2017/5629341 IMPACT INDEX: 4.87 TERCILE: T1; Q2.
  5. AUTHORS: Mateo-Gavira I, Vílchez-López FJ, García-Palacios MV, Carral-San Laureano F, Visiedo-García FM, Aguilar Diosdado M. TITLE: Early blood pressure alterations are associated with pro-inflammatory markers in type 1 Diabetes Mellitus. JOURNAL: J Hum Hypert 2017;31:151-156 DOI: 10.1038/jhh.2016.56 IMPACT INDEX: 2.79 TERCILE: T2; Q2.
  6. AUTHORS: Baena-Nieto G, Mateo R, Segundo C, Aguilar Diosdado M, Lechuga A. TITLE: Ghrelin mitigates β-cell mass loss during insulitis in an animal model of autoimmune diabetes mellitus, the BioBreeding/Worcester rat. JOURNAL: Diabetes/Metab Res Rev 2017;33(1). DOI: 10.1002/dmrr.2813. IMPACT INDEX: 4.42 TERCILE: T2; Q2.
  7. AUTHORS: María José Cabeza de Vaca Pedrosa, Manuel Aguilar Diosdado, Miguel Ángel Vizcaya Rojas, José Pedro Novalbos Ruiz, Antonio Lorenzo Peñuelas, José Antonio Valero Cabeza de Vaca. TITLE: Relevancia del soporte nutricional especializado en las declaraciones de voluntades anticipadas. Experiencia de un centro hospitalario de especialidades. JOURNAL: Nutr Hosp 2017; 34:6-14. DOI: 10.20960/nh.969 IMPACT INDEX: 0.96 TERCILE: T3; Q4.
  8. AUTHORS: MM Roca-Rodríguez, C López-Tinoco, Á Fernández-Deudero, M. Murri, MV García-Palacios, MA. García-Valero, FJ Tinahones, M Aguilar Diosdado. TITLE: Unfavorable cytokines and adhesion molecule profiles during and after pregnancy, in women with gestational Diabetes Mellitus JOURNAL: Endocrin Nutr 2017; 64:18-25. DOI: 10.1016/j.endinu.2016.10.003 IMPACT INDEX: 1.10 TERCILE: T3; Q4.
  9. AUTHORS: Rodríguez GJ, Córdoba-Doña JA, Escolar-Pujolar A, Aguilar-Diosdado M, Goicolea I. TITLE: Familia, economía y servicios sanitarios: claves de los cuidados en pacientes con diabetes y amputación de miembros inferiores. Estudio cualitativo en Andalucía. JOURNAL: Aten Prim DOI: 10.1016/j.aprim.2017.06.011 IMPACT INDEX: 1.04 TERCILE: T2; Q3.
  10. AUTHORS: Fernandez-Garcia JC, Alcaide J, Santiago-Fernandez C, Roca-Rodriguez MM, Aguera Z, Baños R, Botella C, de la Torre R, Fernandez-Real JM, Fruhbeck G, Gomez-Ambrosi J, Jimenez-Murcia S, Menchon JM, Casanueva FF, Fernandez-Aranda F, Tinahones FJ, Garrido-Sanchez L. TITLE: An increase in visceral fat is associated with a decrease in the taste and olfactory capacity. JOURNAL: PLoS One. doi: 10.1371/journal.pone.0171204. ECollection 2017. PMCID: PMC5291407. YEAR, VOLUME, FIRST AND LAST PAGES: 2017 Feb 3;12(2):e0171204. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 3,54 Q1.
  11. AUTHORS: (by order of signature): Valdecantos MP, Pardo V, Ruiz L, Castro-Sánchez L, Lanzón B, Fernández-Millán E, García-Monzón C, Arroba AI, González-Rodríguez Á, Escrivá F, Álvarez C, Rupérez FJ, Barbas C, Konkar A, Naylor J, Hornigold D, Santos AD, Bednarek M, Grimsby J, Rondinone CM, Valverde ÁM. TITLE: A novel glucagon-like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice. JOURNAL: Hepatology YEAR, VOLUME, PAGE:  2017 Mar;65(3):950-968. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 11.19 D1.
  12. AUTHORS: (by order of signature): Beltramo E, Arroba AI, Mazzeo A, Valverde AM, Porta M. TITLE: Imbalance between pro-apoptotic and pro-survival factors in human retinal pericytes in diabetic-like conditions. JOURNAL: Acta Ophthalmol. YEAR, VOLUME, PAGE: 2017 Jan 27. doi: 10.1111/aos.13377. [Epub ahead of print] IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 2.512 D1.
  13. AUTHORS: (by order of signature): Arroba AI, Valverde ÁM. TITLE: Modulation of microglia in the retina: new insights into diabetic retinopathy. JOURNAL: Acta Diabetol. YEAR, VOLUME, PAGE: 2017 Jun;54(6):527-533. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 3.679 Q2.
  14. AUTHORS: (by order of signature): Aurora Mazzeo; Ana I. Arroba; Elena Beltramo; Angela M Martinez Valverde; Masimo Porta. TITLE: Somatostatin protects human retinal pericytes from inflammation mediated by microglia. JOURNAL: Experimental Eye Research YEAR, VOLUME, PAGE: 2017 Jul 20;164:46-54. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 3.017 Q1.
  15. AUTHORS: Elena Milla, Maria José Gamundi, Susana Duch, Jose Rios, Miguel Carballo, and EMEIGG Study Group. TITLE: Phenotypic Description of the Spanish Multicenter Genetic Glaucoma Group Cohort JOURNAL: Journal of Ophthalmology YEAR, VOLUME, PAGE: Volume 2017, Article ID 1907454, 6 pages doi.org/10.1155/2017/1907454 IMPACT FACTOR: IF 1.7120 QUARTILE, DECILE: Q3.
  16. AUTHORS: Abbas Q, Fondon I, Sarmiento A, Jiménez S, Alemany P. TITLE: Automatic recognition of severity level for diagnosis of diabetic retinopathy using deep visual features. JOURNAL: Med Biol Eng Comput YEAR, VOLUME, PAGE: 2017 Mar 28. doi: 10.1007/s11517-017-1638-6. IMPACT FACTOR: 1.916 QUARTILE, DECILE: Q2.
2016 Publications
  1. AUTHORS: M. Mar Roca-Rodríguez, María Teresa Muros de Fuentes, Gonzalo Piédrola-Maroto, et al. TITLE: Lixisenatida en pacientes con diabetes tipo 2 y obesidad: más allá del control glucémico. JOURNAL: Atención Primaria. YEAR, VOLUME, PAGE: (Ref. APRIM-OA-13-927R1)Aceptado para publicar el 14.06.2016. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 1,098 Q3.
  2. AUTHORS: (by order of signature): Arroba AI, Mazzeo A, Cazzoni D, Beltramo E, Hernández C, Porta M, Simó R, Valverde ÁM. TITLE: Somatostatin protects photoreceptor cells against high glucose-induced apoptosis. JOURNAL: Mol Vis. YEAR, VOLUME, PAGE: 2016 Dec 30;22:1522-1531. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 2.245 Q2.
  3. AUTHORS: (by order of signature): Arroba AI, Alcalde-Estevez E, García-Ramírez M, Cazzoni D, de la Villa P, Sánchez-Fernández EM, Mellet CO, García Fernández JM, Hernández C, Simó R, Valverde ÁM. TITLE: Modulation of microglia polarization dynamics during diabetic retinopathy in db/db mice. JOURNAL: Biochim Biophys Acta Mol. Basis Dis. YEAR, VOLUME, PAGE: 2016 Sep;1862(9):1663-74. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 5.089 Q1.
  4. AUTHORS: (by order of signature): Arroba AI, Rodríguez-de la Rosa L, Murillo-Cuesta S, Vaquero-Villanueva L, Hurlé JM, Varela-Nieto I, Valverde ÁM. TITLE: Autophagy resolves early retinal inflammation in Igf1-deficient mice. JOURNAL: Dis Model Mech. YEAR, VOLUME, PAGE: 2016 Sep 1;9(9):965-74. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 5.537 D1.
  5. AUTHORS: (by order of signature): Beltramo E, Lopatina T, Mazzeo A, Arroba AI, Valverde AM, Hernández C, Simó R, Porta M. TITLE: Effects of the neuroprotective drugs somatostatin and brimonidine on retinal cell models of diabetic retinopathy. JOURNAL: Acta Diabetol. YEAR, VOLUME, PAGE: 2016 Dec;53(6):957-964. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 3.679 Q2.
  6. AUTHORS: (by order of signature): Villar-Lorenzo A, Ardiles AE, Arroba AI, Hernández-Jiménez E, Pardo V, López-Collazo E, Jiménez IA, Bazzocchi IL, González-Rodríguez Á, Valverde ÁM. TITLE: Friedelane-type triterpenoids as selective anti-inflammatory agents by regulation of differential signaling pathways in LPS-stimulated macrophages. JOURNAL: Toxicol Appl Pharmacol YEAR, VOLUME, PAGE:  2016 Dec 15;313:57-67. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 3.630 Q1.
  7. AUTHORS: (by order of signature): García-Casarrubios E*, de Moura C*, Arroba AI*, Pescador N, Calderon-Dominguez M, Garcia L, Herrero L, Serra D, Cadenas S, Reis F, Carvalho E, Obregon MJ, Valverde ÁM. TITLE: Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes. JOURNAL: Biochim Biophys Acta Biocell Research YEAR, VOLUME, PAGE:  2016 Dec;1861(12 Pt A):1929-1941 IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 5.297 Q1.
  8. AUTHORS: Laura Gómez-Jaramillo; et al. TITLE: VAMP-2 IS IMPLICATED IN THE SECRETION OF ANTIBODIES BY HUMAN PLASMA CELLS AND CAN BE REPLACED BY OTHER SYNAPTOBREVINS JOURNAL: Cellular and Molecular Immunology. Innate immunity and Inflammation. PMCID: 27616736 YEAR, VOLUME, FIRST AND LAST PAGES: 2016. 13, pp.1-14. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 4,185 Q2.
  9. AUTHORS: Coín-Aragüez, Leticia; El Bekay, Rajaa; Frenandez-García, Diego; Oliva-Olivera, Wilfredo; Bernal-Lopez, Rosa; Clemente-Postigo, Mercedes; Delgado-Lista, Javier; Díaz-Ruiz, Alberto; Guzman-Ruiz, Rocio; Vázquez-Martínez, Rafael; Lhamyani, Said; Roca-Rodríguez, María Mar; Vendrell, Joan; Malagón, María M; Tinahones, Francisco J. TITLE: Effects of GLP-1 on the differentiation and metabolism of human adipocytes. JOURNAL: Br J Pharmacol. YEAR, VOLUME, PAGE: 2016 Jun;173(11):1820-34. PMID: 26993859. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 4,842 Q1/D1.
  10. AUTHORS: (by order of signature): Roca-Rodríguez MM, Coín-Aragüez L, Cornejo Pareja I, Alcaide J, Clu-Fernández C, Muñoz-Garach A, Durán-Martín E, Mora-Navas L, Gómez-Pérez AM, Molina-Vega M, Díaz-Perdigones C, Mancha-Doblas I, Tinahones FJ. TITLE: Carbohydrate metabolism improvement after H. pylori eradication. JOURNAL: Diabetes & Metabolism YEAR, VOLUME, PAGE: 2016;42:130-4. PMID: 26712113 IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 3,267 Q2.
  11. AUTHORS: (by order of signature): María del Mar Roca-Rodríguez, Isabel Cornejo-Pareja, Isabel Mancha-Doblas, Francisco J. Tinahones. TITLE: Trastornos del calcio de baja prevalencia. Deleción en el gen stx16 asociada a pseudohipoparatiroidismo. JOURNAL: Med Clin (Barc) (Ref. MEDCLI-D-15-00806R2) YEAR, VOLUME, PAGE: 2016; 146(6):e33-e34. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 1,417 Q2.
  12. AUTHORS: (by order of signature): Larrán-Escandón L, Mateo-Gavira I, Vilchez-López F, Gómez-Cárdenas E, Aguilar-Diosdado M. TITLE: Pituitary apoplexy as presentation of atypical teratoid/rhabdoid tumor in an adult. JOURNAL: Endocrinol Nutr. YEAR, VOLUME, PAGE: 2016; 63:364-5 PMID: 27349334 IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 1,314, Q4.
  13. AUTHORS: Isabel Mateo-Gavira, Francisco J. Vílchez-López, María V. García-Palacios, Florentino Carral-San Laureano, Soledad Jiménez-Carmona, Manuel Aguilar-Diosdado. TITLE: Nocturnal Blood Pressure is Associated with the Progression of Microvascular Complications and Hypertension in Patients with Type 1 Diabetes Mellitus JOURNAL: Journal of Diabetes and its Complications. YEAR, VOLUME, PAGE: 2016 May 29. pii: S1056-8727(16)30174-X. doi: 10.1016/j.jdiacomp.2016.05.021. [Epub ahead of print] PMID: 27306509 IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 2,955 Q2.
  14. AUTHORS: Baena-Nieto G, Lomas-Romero IM, Mateos RM, Leal-Cosme N, Perez-Arana G, Aguilar-Diosdado M, Segundo C, Lechuga-Sancho AM TITLE: Ghrelin mitigates β-cell mass loss during insulitis in an animal model of autoimmune diabetes mellitus, the BioBreeding/Worcester rat. JOURNAL: Diabetes/Metabolism Research and Reviews. YEAR, VOLUME, PAGE: 2016 Apr 22. doi: 10.1002/dmrr.2813. PMID: 27103341 IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 3,553 Q2.
  15. AUTHORS: M. Aguilar Diosdado TITLE: Fisiología de la vitamina D. Fuentes, metabolismo y acciones biológicas JOURNAL: Medicina Clinica YEAR, VOLUME, PAGE: 2016;17:2-6 IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 1,417 Q2.
  16. AUTHORS: (by order of signature): Hernández C, Bogdanov P, Corraliza L, García-Ramírez M, Solà-Adell C, Arranz JA, Arroba AI, Valverde AM, Simó R. TITLE: Topical Administration of GLP-1 Receptor Agonists Prevents Retinal Neurodegeneration in Experimental Diabetes. JOURNAL: Diabetes. YEAR, VOLUME, PAGE: 2016 Jan;65(1):172-87 IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 8.474 D1.
2015 Publications
  1. AUTHORS: (by order of signature): Arroba AI, Valverde ÁM. TITLE: Inhibition of Protein Tyrosine Phosphatase 1B Improves IGF-I Receptor Signaling and Protects Against Inflammation-Induced Gliosis in the Retina. JOURNAL: Invest Ophthalmol Vis Sci YEAR, VOLUME, PAGE: 2015 Dec;56(13):8031-44 IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 3.661 D1.
  2. AUTHORS: R. J. Barranco, F. Gomez-Peralta , C. Abreu , M. Delgado, R. Palomares , F. Romero , C. Morales , M. A. de la Cal , J. M. Garcia-Almeida, F. Pasquel and G. E. Umpierrez. (Acknowledgments: Manuel Aguilar). TITLE: Incidence and care-related costs of severe hypoglycaemia requiring emergency treatment in Andalusia (Spain): the PAUEPAD Project. JOURNAL: Diabet Med. YEAR, VOLUME, PAGE: 2015;32(11):1520-6. PMID: 26118472 IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 3,115 Q2.
  3. AUTHORS: (by order of signature): Iglesias P, Pedro-Botet J, Arrieta F, Aguilar M, Escobar F C TITLE: Clinical significance of the new cardiovascular risk markers in diabetes mellitus JOURNAL: Curr Diabetes Rev YEAR, VOLUME, PAGE: 2015;11(4):273-80. PMID: 25808417 IMPACT FACTOR (JCR)– QUARTIL (JCR).
  4. AUTHORS: (by order of signature): María Asunción Martínez Brocca ,  Cristobal Morales ,  Pilar Rodríguez Ortega ,  Beatriz González Aguilera ,  Cristina Montes Castillo ,  Natalia Colomo Rodríguez ,  Gonzalo Piédrola Maroto ,  Mariola Méndez Muros ,  Isabel Serrano ,  María Soledad Ruiz de Adana Navas ,  Alberto Moreno ,  Ignacio Fernández López , Manuel Aguilar Diosdado,  Domingo Acosta Delgado ,  Rafael Palomares Ortega TITLE: Implementación del protocolo hospitalario de insulinización subcutánea para pacientes no críticos en hospitales andaluces de tercer nivel . JOURNAL: Endocrinol Nutr. YEAR, VOLUME, PAGE: 2015; 62 (2): 64-71. IMPACT FACTOR (JCR)– QUARTIL (JCR).
  5. AUTHORS: (by order of signature): Pérez-Arana G, Camacho-Ramírez A, Segundo-Iglesias MC, Lechuga-Sancho AM, Sancho-Maraver E, Aguilar-Diosdado M, Prada-Oliveira JA. TITLE: A surgical model of short bowel syndrome induces a long-lasting increase in pancreatic beta-cell mass. JOURNAL: Histol Histopathol. YEAR, VOLUME, PAGE: 2015; 30 (4): 479-87. PMID: 25396717 IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 2,48 Q2.
  6. AUTHORS: (by order of signature): I. Mateo, FJ. Vilchez, L. Larrán, MB Ojeda, C López, M. Aguilar. TITLE: Should the diagnostic and therapeutic protocols for adrenal incidentalomas be changed? JOURNAL: Cir Esp. YEAR, VOLUME, PAGE: 2015; 93 (1): 30-3. PMID: 25064523 IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 0,871 Q3.
  7. AUTHORS: (by order of signature): Mayo Ossorio MA, Pacheco Garcia JM, Pérez Gomar D, Bazán Hinojo Mdel C, Vilchez Lopez FJ, Aguilar Diosdad M, Fernández Serrano JL. TITLE: Long-term fulminant hepatic failure in patients undergoing gastric bypass for morbid obesity. JOURNAL: Nutr Hosp. YEAR, VOLUME, PAGE: 2015;32:430-4. PMID: 26262750 IMPACT FACTOR (JCR)– QUARTIL (JCR) FI: 1,04 Q4.
  8. AUTHORS: Irene Fondón, Jose Francisco Valverde, Auxiliadora Sarmiento, Qaisar Abbas, Soledad Jiménez, Pedro Alemany. TITLE: Automatic Optic Cup Segmentation Algorithm for Retinal Fundus Images based on Random Forest Classifier JOURNAL: IEEE. YEAR, VOLUME, PAGE: 2015, EUROCON, vol., no., pp.1-6 IMPACT FACTOR: IF 4.934 QUARTILE, DECILE:.
  9. AUTHORS: (by order of signature): María del Mar Roca-Rodríguez, María José Tapia-Guerrero, Silvia Maraver-Selfa, Francisco José Tinahones, Isabel Mancha-Doblas. TITLE: Experiencia clínica con lixisenatida en pacientes con diabetes tipo 2 y obesidad en consultas de atención especializada en Málaga. JOURNAL: Endocrinol Nutr. (1.10.2015) YEAR, VOLUME, PAGE: 2015; 62 (08): 512-514. doi: 10.1016/j.endonu.2015.07.004. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI.
  10. AUTHORS: (by order of signature): María del Mar Roca-Rodríguez, Lourdes Garrido-Sánchez, Jose Manuel García-Almeida, Josefina Ruiz-Nava, Juan Alcaide-Torres, Adela Gómez-González, Angel Montiel-Trujillo and Francisco Tinahones-Madueño. TITLE: Effects of exercise on inflammation in cardiac rehabilitation JOURNAL: Nutr Hosp. YEAR, VOLUME, PAGE: 2015;31(6):2633-2640. PMID: 26040375 IMPACT FACTOR (JCR)– QUARTIL (JCR) FI: 1,04 Q4.
  11. AUTHORS: (by order of signature): Roca-Rodríguez MM, Bekay RE, Garrido-Sanchez L, Gómez-Serrano M, Coin-Aragüez L, Oliva-Olivera W, Lhamyani S, Clemente-Postigo M, García-Santos E, Luna Diaz R, Yubero-Serrano EM, Real JF, Peral B, Tinahones FJ. TITLE: Parathyroid hormone-related protein, human adipose-derived Stem cells adipogenic capacity and healthy obesity. JOURNAL: J Clin Endocrinol Metab. YEAR, VOLUME, PAGE: 2015;100(6):E826-35. PMID: 25885945. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 6,209 Q1.
  12. AUTHORS: Ussa F, Fernandez I, Brion M, Carracedo A, Blazquez F, Garcia MT, Sanchez-Jara A, De Juan-Marcos L, Jimenez-Carmona S, Juberias JR, Martinez-de-la- Casa JM, Pastor JC. TITLE: Association between SNPs of Metalloproteinases and Prostaglandin F2α Receptor Genes and Latanoprost Response in Open-Angle Glaucoma. JOURNAL: Ophthalmology. YEAR, VOLUME, PAGE: 2015 Feb 19. pii: S0161-6420(15)00006-8. doi: 10.1016/j.ophtha.2014.12.038. IMPACT FACTOR: IF 6.17 QUARTILE, DECILE: D1.
  13. AUTHORS: (by order of signature): Clemente-Postigo M, Roca-Rodriguez M del M, Camargo A, Ocaña-Wilhelmi L, Cardona F, Tinahones FJ. TITLE: Lipopolysaccharide and lipopolysaccharide-binding protein levels and their relationship to early metabolic improvement after bariatric surgery JOURNAL: Surg Obes Relat Dis. YEAR, VOLUME, PAGE: 2015;11(4):933-9. PMID: 25737102. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 4,066 Q1/D1.
  14. AUTHORS: (by order of signature): María del Mar Roca-Rodríguez, Jose Manuel García-Almeida, Josefina Ruiz-Nava, Juan Alcaide, Yolanda Lupiañez-Pérez, Jose Manuel Rico-Pérez, María Dolores Toledo-Serrano, Fernando Cardona, Jose Antonio Medina-Carmona and Francisco J. Tinahones. TITLE: Long-term effects of varying consumption of o3 fatty acids in ear, nose and throat cancer patients: assessment 1 year after radiotherapy. JOURNAL: Int J Food Sci Nutr. YEAR, VOLUME, PAGE: 2015 Feb;66(1):108-13. PMID: 25265206 IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 1.206 Q3.
2014 Publications
  1. AUTHORS: Laura Gómez-Jaramillo; et al. TITLE: SYNTAXIN-4 IS IMPLICATED IN THE SECRETION OF ANTIBODIES BY HUMAN PLASMA CELLS JOURNAL: Journal of Leukocyte Biology. PMCID: YEAR, VOLUME, FIRST AND LAST PAGES: 2014; 95, pp.305-312. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 4,304 Q1.
  2. AUTHORS: (by order of signature): Álvarez-Ramos Pablo; Jiménez-Carmona Soledad; Alemany-Márquez Pedro; Mayoral Eduardo; Santos-Sánchez Vanessa, Aguilar- Diosdado Manuel. TITLE: Three years follow-up incidence of retinopathy, in type 1 diabetic patients, in a population-based screening program with digital retinal photographs. JOURNAL: Journal of Clinical & Experimental Ophthalmology. YEAR, VOLUME, PAGE: 2014, 5:382 DOI: 10.4172/2155-9570.1000382 IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 1,95 Q2.
  3. AUTHORS: Benítez-del-Castillo J, Regi T; Sicva Study Group. Study. JOURNAL: Eur J Ophthalmol. YEAR, VOLUME, PAGE: 2014 Jul-Aug;24(4):527-35. doi: 10.5301/ejo.5000402. Epub 2013 Dec 19. IMPACT FACTOR: Impact Factor: 1.068 QUARTILE, DECILE: Q4.
  4. AUTHORS: (by order of signature): Gutiérrez Manzanedo JV, Carral San Laureano F, García Domínguez G, Ayala Ortega C, Jiménez Carmona S, Aguilar Diosdado M. TITLE: High prevalence of inactivity among young patients with type 1 diabetes in south Spain. JOURNAL: Nutr Hosp. YEAR, VOLUME, PAGE: 2014; 29 (4): 922-8. PMID: 24679037 IMPACT FACTOR (JCR)– QUARTIL (JCR) FI: 1,04 Q4.
  5. AUTHORS: Santos-Bueso E, Fernández-Jacob MC, Asorey-García A, Sánchez-Jacob E, Cerván-López I, Jiménez-Carmona S, Rodríguez-Bermejo C, Gutiérrez-Ortiz C, García-Medina JJ, Arteaga-Sánchez A, Vinuesa-Silva I, Vinuesa-Silva JM, García-Sánchez J. TITLE: Ophthalmology, history and humanities. JOURNAL: Arch Soc Esp Oftalmol. YEAR, VOLUME, PAGE: 2014 Jun;89(6):213-215. doi: 10.1016/j.oftal.2014.04.025. IMPACT FACTOR: SJR 0.218. QUARTILE, DECILE: NO.
  6. AUTHORS: (by order of signature): I. Mateo Gavira, FJ. Vílchez López, M. Cayón Blanco, A. García Valero, L. Escobar Jiménez, MA. Mayo Ossorio, JM. Pacheco García, JM. Vázquez Gallego, M. Aguilar Diosdado. TITLE: Effect of gastric bypass on the cardiovascular risk and quality of life in morbid obese patients. JOURNAL: Nutr Hosp YEAR, VOLUME, PAGE: 2014; 29 (3): 508-12. PMID: 24558991 IMPACT FACTOR (JCR)– QUARTIL (JCR) FI: 1,04 Q4.
  7. AUTHORS: (by order of signature): M. M. Roca-Rodríguez, C. López-Tinoco, M. Murri, A. Fernández-Deudero, M.V. García-Palacios, M.A. García-Valero, F. J. Tinahones- Madueño, and M. Aguilar-Diosdado. TITLE: Postpartum development of endothelial dysfunction and oxidative stress markers in women with previous gestational diabetes mellitus. JOURNAL: J. Endocrinol Invest. YEAR, VOLUME, PAGE: 2014; 37 (6): 503-9. PMID: 24458829 IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 1,448 Q4.
  8. AUTHORS: (by order of signature): Arroba AI, Alvarez-Lindo N, van Rooijen N, de la Rosa EJ TITLE: Microglia-Müller glia crosstalk in the rd10 mouse model of retinitis pigmentosa. JOURNAL: Adv Exp Med Biol. YEAR, VOLUME, PAGE: 2014;801:373-9.  IMPACT FACTOR (JCR)– QUARTIL (JCR) FI 2.012 Q2.
  9. AUTHORS: (by order of signature): Roca-Rodríguez MM, García-Almeida JM, Ruiz-Nava J, Alcaide-Torres J, Saracho-Domínguez H, Rioja-Vázquez R, García-Fernández C, Gómez-González A, Montiel-Trujillo A, Tinahones-Madueño FJ. TITLE: Impact of an outpatient cardiac rehabilitation program on clinical and analytical variables in cardiovascular disease. JOURNAL: J Cardiopulm Rehabil Prev. YEAR, VOLUME, PAGE: 2014 Jan-Feb;34(1):43-8. PMID: 24280905. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI: 1,583 Q3.
  10. AUTHORS: (by order of signature): Garrido-Sánchez L, PhD, MM Roca-Rodríguez, PhD, D Fernández-García, PhD, J Alcaide, MD, M Rosa Bernal-López, PhD, Chacón MR, PhD, P Perez-Martinez, PhD, Vendrell J, PhD García-Fuentes E PhD, Tinahones FJ, PhD. TITLE: CCNG2 and CDK4 is associated with insulin resistance in adipose tissue. JOURNAL: Surg Obes Relat Dis. doi: 10.1016/j.soard.2013.12.011. Epub 2014 Jan 9. PubMed PMID: 24708911. YEAR, VOLUME, PAGE: 2014 Jul-Aug;10(4):691-6. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI: 4,066 Q1/D1.
  11. AUTHORS: : Roca-Rodríguez MM, García-Almeida JM, Lupiañez-Pérez Y, Rico JM, Toledo M, Alcaide-Torres J, Cardona F, Medina JA, Tinahones FJ. TITLE: Effect of a specific supplement enriched with n-3 polyunsaturated fatty acids on markers of inflammation, oxidative stress and metabolic status of ear, nose and throat cancer patients. JOURNAL: Oncol Rep. YEAR, VOLUME, PAGE: 2014 Jan;31(1):405-14. PMID: 24154820. IMPACT FACTOR (JCR)– QUARTIL (JCR) FI: 2.301 Q3.
Networks
  • TITLE: RED de Ensayos Clínicos en Metabolismo - Diabetes, Obesidad y Dislipemia:
    • FILE NUMBER: RIC-0539-2018.
    • PRINCIPAL INVESTIGATOR: FJ Tinahones Madueño.
    • RESEARCH COLLABORATOR: Manuel Aguilar Diosdado, Ana I. Arroba Espinosa, Cristina López Tinoco, José Ortego Rojo, Ana Montero Galván, Isabel María Torres Barea, Laura Gómez Jaramillo, Antonio Campos Caro et al.
    • FUNDING ENTITY/PROGRAM: Consejería de Salud. Junta de Andalucía.
    • CENTER: RED de UGC de Endocrinología y Nutrición de Andalucía. Hospital Puerta del Mar. INIBICA. Cádiz.
    • BUDGET: 404.972,40€.
    • PERIOD OF REALIZATION: 2019-2021.
Patents
  • TITLE: USO DE 3-ARILFTALIDAS Y SUS DERIVADOS COMO AGENTES ANTIINFLAMATORIOS:
    • AUTHORS: Eva Zubía, M. Jesús Ortega, Carolina Parrado, Laura Gómez Jaramillo, Ana I. Arroba, Manuel Aguilar-Diosdado.
    • REQUEST NUMBER: P202130739.
    • PRIORITY DATE: 29-07-2021.
    • OWNER ENTITY: UCA-SAS.
    • SITUATION: REQUESTED.
Consensus Guidelines / Clinical Practice / Protocol
  • José Manuel Quesada Gómez, Francisco Tinahones Madueño, Manuel Aguilar Diosdado, Pedro Pablo Garcia Luna, Jose Antonio Pérez Simón, Luis M Entrenas Costa, José López Miranda. Indicación del tratamiento con calcifediol en ancianos residentes en Residencias asistidas para minimizar su afectación por COVID-19Comité Técnico de expertos para estudios de suplemento e intervención nutricionalfrente a COVID-19. Consejeria de Salud. 2020.
  • M Aguilar Diosdado. MEDICINE (Coordinator). Enfermedades endocrinológicas y metabólicas. (VII). Patología suprarrenal. Volume 13, Issue 19, Pages 1049-1114 (October 2020). https://www.sciencedirect.com/journal/medicine-programa-de-formacion-medica-continuada-acreditado/vol/13/issue/19.
  • Cristina López Tinoco, Almudena Lara Barea, Manuel Aguilar Diosdado. Diabetes Mellitus y Gestacion. En: Manual de Endocrinología y Nutrición. Sociedad Española de Endocrinología y Nutrición. Madrid 2019; pp 1-39). https://manual.seen.es/article?id=55115000-5f3c-4afd-a3be-4b97ac18103c.
  • M Aguilar, Grupo de Trabajo. Evaluación del II Plan Integral de Diabetes de Andalucía. Actualización 2016. Ed: Junta de Andalucía. Consejería de Salud. Consejería de Salud: www.juntadeandalucia.es/salud. Repositorio Institucional SSPA: www.repositoriosalud.es.Sevilla2016.Pp1-137. http://www.juntadeandalucia.es/salud/sites/csalud/portal/index.jsp?idioma=es&perfil=org&opcion=listadoTematico&tema=/temas_es/P_2_ANDALUCIA_EN_SALUD_PLANES_Y_ESTRATEGIAS/&desplegar=/temas_es/P_2_ANDALUCIA_EN_SALUD_PLANES_Y_ESTRATEGIAS/&menu=S.