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CO27: Diagnosis in Cardiovascular Medicine. Circulating biomarkers and imaging tools

Our research group is specialized in the study of the pathophysiological processes of cardiovascular diseases, especially dilated cardiomyopathy and atherosclerosis. We are a group with a translational profile made up of clinical and basic researchers. Currently our lines of work are focused on the development of a tool based on the molecular signature of non-coding RNAs in combination with clinical and echocardiographic variables, which allows early identification of patients with dilated cardiomyopathy, the most common cause of heart failure. cardiac with a prevalence of 1 in 250. On the other hand, we address the clinical need to identify patients with intolerance to statins with high vascular risk. The main objective of this line is the characterization of the molecular mechanisms involved in muscle damage that occurs in these patients, and thus identify new therapeutic alternatives to reduce high cholesterol concentrations. For both lines, research strategies are combined in cell models (cardiomyocytes, muscle cells), studies in patients (with dilated cardiomyopathy of different etiologies, intolerant to statins and high cardiovascular risk) and development of ex-vivo tests with samples from them.

Principal Investigator
Co-Principal Investigator
Lines of research
  • Diagnosis in Cardiovascular Medicine: circulating biomarkers and imaging tools. The main objective is the development of a tool based on the molecular signature of circulating ncRNA in combination with clinical and echocardiographic variables, which allows early identification of patients with familial dilated cardiomyopathy (DCM) secondary to pathogenic mutations in the LMNA and BAG3 genes. and differentiate them from DCM of another etiology such as ischemic or idiopathic DCM.
  • Identification of new biomarkers of Statin Intolerance. There is a clinical need to find biomarkers that make it possible to identify potential patients with intolerance to statins (SI), with high vascular risk, who need to receive an alternative treatment to statins to reduce their LDLc concentrations. In this line, it is necessary to pathophysiologically define the underlying process in those patients with statin-associated muscular symptoms (SAMS). For this reason, we consider defining new biomarkers that will become novel diagnostic tools for the detection of the population with EI.
Keywords
Arteriosclerosis Noncoding RNA Biomarkers Statin intolerant Dilated cardiomyopathy miRNA
Principal Investigator
Rocío Toro Cebada
Assistant Professor.
Co-Principal Investigator
Alipio Mangas Rojas
Professor of Medicine associated with the Puerta del Mar University Hospital – University.
Team members
  • Principal Investigators:
    • Rocío Toro Cebada (PhD) (PI).
    • Alipio Mangas Rojas (PhD: Clinical Investigator) (Co-PI).
  • Investigators:
    • Carmen Rodríguez Leal (PhD: Clinical Investigator).
    • Aníbal Bermúdez (Clinical Investigator).
    • Fernando Bonet Martínez (PhD: Clinical Investigator).
  • Predoctoral Researchers:
    • Elena Alonso Villa.
Regional Calls
  • Iniciativa Territorial Integrada (ITI) 2014-2020 para la provincia de Cádiz, por la Consejería de Salud y por el Fondo Europeo de Desarrollo Regional IT-0017-2019. PI: Rocío Toro Cebada/ Alipio Mangas Roja. Avance hacia nuevas alternativas terapéuticas en la miocardiopatía dilatada idiopática a través de los RNA no codificados.
  • Iniciativa Territorial Integrada (ITI) 2014-2020 para la provincia de Cádiz, por la Consejería de Salud y por el Fondo Europeo de Desarrollo Regional PI-0048-2017 PI: Rocio Toro Cebada/ Alipio Mangas Roja. Aplicación de la transcriptómica en el abordaje Diagnostico-terapéutico de la miocardiopatía dilatada familiar: Aproximación a la medicina de precisión cardiovascular.
  • Iniciativa Territorial Integrada (ITI) 2014-2020 para la provincia de Cádiz, por la Consejería de Salud y por el Fondo Europeo de Desarrollo Regional 116200120019 PI: Alipio Mangas Roja. Aplicación de la biología de sistemas en la miocardiopatía arritmogénica para la caracterización de las redes de interacción Coding-Non coding RNA.
  • Ayudas de la Fundación Pública Andaluza Progreso y Salud, para la financiación de Investigación Biomédica y en Ciencias de la Salud en Andalucía. Junta de Andalucía. PI-0011-2014 PI: Rocio Toro Cebada. MicroRNAs circulantes: Alternativa diagnóstica y pronostica en la Miocardiopatía Dilatada de etiología familiar con alta incidencia de muerte súbita.
2021 Publications
  1. Sarquella-Brugada G, Fernandez-Falgueras A, Cesar S, Arbelo E, Coll M, Perez-Serra A, Puigmulé M, Iglesias A, Alcalde M, Vallverdú-Prats M, Fiol V, Ferrer-Costa C, Del Olmo B, Picó F, Lopez L, García-Alvarez A, Jordà P, Tiron de Llano C, Toro R, Grassi S, Oliva A, Brugada J, Brugada R, Campuzano O. Clinical impact of rare variants associated with inherited channelopathies: a 5-year update. Hum Genet. 2021 Sep 21. Impact factor: 4,132. Quartile/Decile: Q1.
  2. Ramos M, Quezada M, Ayala R, Gómez-Pavón FJ, Jaramillo J, Calderón-Domínguez M, Toro R. Asymptomatic aortic stenosis in a geriatric population. The role of frailty and comorbidity in mortality. Rev Esp Cardiol (Engl Ed). 2021 Feb;74(2):167-174. English, Spanish. Impact factor: 0,837. Quartile/Decile: Q1.
  3. Jordà P, Toro R, Diez C, Salazar-Mendiguchía J, Fernandez-Falgueras A, Perez-Serra A, Coll M, Puigmulé M, Arbelo E, García-Álvarez A, Sarquella-Brugada G, Cesar S, Tiron C, Iglesias A, Brugada J, Brugada R, Campuzano O. Malignant Arrhythmogenic Role Associated with RBM20: A Comprehensive Interpretation Focused on a Personalized Approach. J Pers Med. 2021 Feb 15;11(2):130. Impact factor: 4,434. Quartile/Decile: Q1.
  4. Vallverdú-Prats M, Alcalde M, Sarquella-Brugada G, Cesar S, Arbelo E, Fernandez-Falgueras A, Coll M, Pérez-Serra A, Puigmulé M, Iglesias A, Fiol V, Ferrer-Costa C, Olmo BD, Picó F, Lopez L, Jordà P, García-Álvarez A, Llano CT, Toro R, Grassi S, Oliva A, Brugada J, Brugada R, Campuzano O. Rare Variants Associated with Arrhythmogenic Cardiomyopathy: Reclassification Five Years Later. J Pers Med. 2021 Feb 26;11(3):162. Impact factor: 4,434. Quartile/Decile: Q1.
  5. Diz OM, Toro R, Cesar S, Gomez O, Sarquella-Brugada G, Campuzano O. Personalized Genetic Diagnosis of Congenital Heart Defects in Newborns. J Pers Med. 2021 Jun 16;11(6):562. Impact factor: 4,434. Quartile/Decile: Q1.
  6. Quezada-Feijoo M, Ramos M, Lozano-Montoya I, Toro R, Jaramillo-Hídalgo J, Fernández de la Puente E, Garmendia B, Carrillo P, Cristofori G, Goñi Rosón S, Ayala R, Sarro M, Gómez-Pavón FJ. Predictive Factors of Pulmonary Embolism in Older Patients with SARS-CoV-2: The OCTA-COVID-19 Study. J Clin Med. 2021 Jul 5;10(13):2998. Impact factor: 5,583. Quartile/Decile: Q1.
  7. Calderon-Dominguez M, Mangas A, Belmonte T, Quezada-Feijoo M, Ramos M, Toro R. Ischemic dilated cardiomyopathy pathophysiology through microRNA-16-5p. Rev Esp Cardiol (Engl Ed). 2021 Sep;74(9):740-749. English, Spanish. doi:10.1016/j.rec.2020.08.012. Epub 2020 Oct 10. PMID: 33051165. Impact factor: 0,837. Quartile/Decile: Q1.
  8. Gutiérrez-Barrios A, Mialdea-Salmerón D, Cañadas-Pruaño D, Garcia-Molinero D, Zayas-Rueda R, Calle-Pérez G, Vázquez-García R, Toro R, Gheorghe L. Electrocardiographic findings in true acute left main coronary total occlusion a subanalisys from ATOLMA registry. J Electrocardiol. 2021 Sep-Oct;68:48-52. Impact factor: 1,33. Quartile/Decile: Q1.
  9. Quezada-Feijoo M, Ramos M, Lozano-Montoya I, Sarró M, Cabo Muiños V, Ayala R, Gómez-Pavón FJ, Toro R. Elderly Population with COVID-19 and the Accuracy of Clinical Scales and D-Dimer for Pulmonary Embolism: The OCTA-COVID Study. J Clin Med. 2021 Nov 20;10(22):5433. Impact factor: 5,583. Quartile/Decile: Q1.
  10. Calderon-Dominguez M, Belmonte T, Quezada-Feijoo M, Ramos M, Calderon-Dominguez J, Campuzano O, Mangas A, Toro R. Plasma microrna expression profile for reduced ejection fraction in dilated cardiomyopathy. Sci Rep. 2021 Apr 6;11(1):7517. Impact factor: 4,379. Quartile/Decile: Q1.
  11. Costa MC, Calderon-Dominguez M, Mangas A, Campuzano O, Sarquella-Brugada G, Ramos M, Quezada-Feijoo M, Pinilla JMG, Robles-Mezcua A, Del Aguila Pacheco-Cruz G, Belmonte T, Enguita FJ, Toro R. Circulating circRNA as biomarkers for dilated cardiomyopathy etiology. J Mol Med (Berl). 2021 Dec;99(12):1711-1725. Impact factor: 4,599. Quartile/Decile: Q1.
  12. Authors: Jordà P, Toro R, Diez C, Salazar-Mendiguchía J, Fernandez-Falgueras A, Perez-Serra A, Coll M, Puigmulé M, Arbelo E, García-Álvarez A, Sarquella-Brugada G, Cesar S, Tiron C, Iglesias A, Brugada J, Brugada R, Campuzano O. Title: Malignant Arrhythmogenic Role Associated with RBM20: A Comprehensive Interpretation Focused on a Personalized Approach. Journal: J Pers Med. Year, volume, first and last pages: 2021 Feb 15;11(2):130 .. Impact factor: 4,433.. Quartile/Decile in the year of publication: Q1.
  13. Authors: Vallverdú-Prats M, Alcalde M, Sarquella-Brugada G, Cesar S, Arbelo E, Fernandez-Falgueras A, Coll M, Pérez-Serra A, Puigmulé M, Iglesias A, Fiol V, Ferrer-Costa C, Olmo BD, Picó F, Lopez L, Jordà P, García-Álvarez A, Llano CT, Toro R, Grassi S, Oliva A, Brugada J, Brugada R, Campuzano O. Title: Rare Variants Associated with Arrhythmogenic Cardiomyopathy: Reclassification Five Years Later. Journal: J Pers Med. Year, volume, first and last pages: 2021 Feb 26;11(3):162. Impact factor: 4,433. Quartile/Decile in the year of publication: Q1.
  • Publications in collaboration with clinical-basic groups:
    1. Sarquella-Brugada G, Fernandez-Falgueras A, Cesar S, Arbelo E, Coll M, Perez-Serra A, Puigmulé M, Iglesias A, Alcalde M, Vallverdú-Prats M, Fiol V, Ferrer-Costa C, Del Olmo B, Picó F, Lopez L, García-Alvarez A, Jordà P, Tiron de Llano C, Toro R, Grassi S, Oliva A, Brugada J, Brugada R, Campuzano O. Clinical impact of rare variants associated with inherited channelopathies: a 5-year update. Hum Genet. 2021 Sep 21. Impact factor: 4,132. Quartile/Decile: Q1.
    2. Jordà P, Toro R, Diez C, Salazar-Mendiguchía J, Fernandez-Falgueras A, Perez-Serra A, Coll M, Puigmulé M, Arbelo E, García-Álvarez A, Sarquella-Brugada G, Cesar S, Tiron C, Iglesias A, Brugada J, Brugada R, Campuzano O. Malignant Arrhythmogenic Role Associated with RBM20: A Comprehensive Interpretation Focused on a Personalized Approach. J Pers Med. 2021 Feb 15;11(2):130. Impact factor: 4,434. Quartile/Decile: Q1.
    3. Vallverdú-Prats M, Alcalde M, Sarquella-Brugada G, Cesar S, Arbelo E, Fernandez-Falgueras A, Coll M, Pérez-Serra A, Puigmulé M, Iglesias A, Fiol V, Ferrer-Costa C, Olmo BD, Picó F, Lopez L, Jordà P, García-Álvarez A, Llano CT, Toro R, Grassi S, Oliva A, Brugada J, Brugada R, Campuzano O. Rare Variants Associated with Arrhythmogenic Cardiomyopathy: Reclassification Five Years Later. J Pers Med. 2021 Feb 26;11(3):162. Impact factor: 4,434. Quartile/Decile: Q1.
    4. Diz OM, Toro R, Cesar S, Gomez O, Sarquella-Brugada G, Campuzano O. Personalized Genetic Diagnosis of Congenital Heart Defects in Newborns. J Pers Med. 2021 Jun 16;11(6):562. Impact factor: 4,434. Quartile/Decile: Q1.
    5. Quezada-Feijoo M, Ramos M, Lozano-Montoya I, Toro R, Jaramillo-Hídalgo J, Fernández de la Puente E, Garmendia B, Carrillo P, Cristofori G, Goñi Rosón S, Ayala R, Sarro M, Gómez-Pavón FJ. Predictive Factors of Pulmonary Embolism in Older Patients with SARS-CoV-2: The OCTA-COVID-19 Study. J Clin Med. 2021 Jul 5;10(13):2998. Impact factor: 5,583. Quartile/Decile: Q1.
    6. Gutiérrez-Barrios A, Mialdea-Salmerón D, Cañadas-Pruaño D, Garcia-Molinero D, Zayas-Rueda R, Calle-Pérez G, Vázquez-García R, Toro R, Gheorghe L. Electrocardiographic findings in true acute left main coronary total occlusion a subanalisys from ATOLMA registry. J Electrocardiol. 2021 Sep-Oct;68:48-52. Impact factor: 1,33. Quartile/Decile: Q1.
2020 Publications
  1. Authors: Calderon-Dominguez M, Mangas A, Belmonte T, Quezada-Feijoo M, Ramos M, Toro R. Title: Ischemic dilated cardiomyopathy pathophysiology through microRNA-16-5p. Journal: Rev. Esp. Cardiol. Year, volume, first and last pages: 2020 . Impact factor: 4,642. Quartile/Decile in the year of publication: Q1.
  2. Authors: Rioja J, Ariza MJ, García-Casares N, Coca-Prieto I, Arrobas T, Muñiz-Grijalvo O, Mangas A, Ibarretxe D, Sánchez-Chaparro MÁ, Valdivielso P. Title: Evaluation of the chylomicron-TG to VLDL-TG ratio for type I hyperlipoproteinemia diagnostic. Journal: Eur J Clin Inves. Year, volume, first and last pages: 2020 Jul 10; e13345. Impact factor: 3.481. Quartile/Decile in the year of publication: Q1.
  3. Authors: Campuzano O, Sarquella-Brugada G, Arbelo E, Cesar S, Jordà P, Pérez-Serra A, Toro R, Brugada J, Brugada R. Title: Genetic Variants as Sudden-Death Risk Markers in Inherited Arrhythmogenic Syndromes: Personalized Genetic Interpretation. Journal: J Clin Med. Year, volume, first and last pages: 2020 Jun 15;9(6):1866. Impact factor: 3.303 . Quartile/Decile in the year of publication: Q1.
  4. Authors: Campuzano O, Sarquella-Brugada G, Fernandez-Falgueras A, Coll M, Iglesias A, Ferrer-Costa C, Cesar S, Arbelo E, García-Álvarez A, Jordà P, Toro R, Tiron de Llano C, Grassi S, Oliva A, Brugada J, Brugada R. Title: Reanalysis and reclassification of rare genetic variants associated with inherited arrhythmogenic syndromes. Journal: EBioMedicine. Year, volume, first and last pages: 2020 Apr; 54:102732. Impact factor: 5.736. Quartile/Decile in the year of publication: Q1.
  5. Authors: Belmonte T, Mangas A, Calderon-Dominguez M, Quezada-Feijoo M, Ramos M, Campuzano O, Gomez S, Peña ML, Cubillos-Arango AM, Dominguez F, Llorente-Cortés V, de Gonzalo-Calvo D, Toro R. Title: Peripheral microRNA panels to guide the diagnosis of familial cardiomyopathy. Journal: Transl Res. Year, volume, first and last pages: 2020 Apr;218:1-15.. Impact factor: 5.411. Quartile/Decile in the year of publication: Q1.
  6. Authors: Calderón-Domínguez M*, Belmonte T*, Quezada-Feijoo M, Ramos-Sánchez M, Fernández-Armenta J, Pérez-Navarro A, Cesar S, Peña-Peña L, Vea À, Llorente-Cortés V, Mangas A, de Gonzalo-Calvo D, Toro R. Title: Emerging role of microRNAs in dilated cardiomyopathy: evidence regarding etiology. Journal: Transl Res Year, volume, first and last pages: 2020 Jan;215:86-101. Impact factor: 5.411. Quartile/Decile in the year of publication: Q1.
2019 Publications
  1. Authors: Ramos M, Quezada M, Ayala R, Gómez-Pavón FJ, Jaramillo J, Calderón-Domínguez M, Toro R. Title: Asymptomatic aortic stenosis in a geriatric population. The role of frailty and comorbidity in mortality. Journal: Rev Esp Cardiol (Engl Ed) Year, volume, first and last pages: 2019 Dec 24: S1885-5857(19)30398-6.. Impact factor: 4.642. Quartile/Decile in the year of publication: Q1.
  2. Authors: Rodríguez-Caulo EA, Macías D, Adsuar A, Ferreiro A, Arias-Dachary J, Parody G, Fernández F, Daroca T, Rodríguez-Mora F, Garrido JM, Muñoz-Carvajal I, Barquero JM, Valderrama JF, Melero JM. Title: Biological or mechanical prostheses for isolated aortic valve replacement in patients aged 50-65 years: the ANDALVALVE study. Journal: Eur J Cardiothorac Surg. Year, volume, first and last pages: 2019 Jun 1;55(6):1160-1167. Impact factor: 3.486. Quartile/Decile in the year of publication: Q2.
2018 Publications
  1. Authors: Zaragoza C, Saura M, Hernández I, Ramirez-Carracedo R, García-García F, Zamorano JL, Mangas A, Toro R. Title: Differential expression of circulating miRNAs as a novel tool to assess BAG3-associated familial dilated cardiomyopathy. Journal: Biosci Rep. Year, volume, first and last pages: 2018 Nov 13;72(20):2471-2481. Impact factor: 2.535. Quartile/Decile in the year of publication: Q3.
  2. Authors: Domínguez F, Cuenca S, Bilińska Z, Toro R, Villard E, Barriales-Villa R, Ochoa JP, Asselbergs F, Sammani A, Franaszczyk M, Akhtar M, Coronado-Albi MJ, Rangel-Sousa D, Rodriguez-Palomares JF, Jiménez-Jáimez J, Garcia-Pinilla JM, Ripoll-Vera T, Mogollón-Jiménez MV, Fontalba-Romero A, Garcia-Medina D, Palomino-Doza J, de Gonzalo-Calvo D, Cicerchia M, Salazar-Mendiguchia J, Salas C, Pankuweit S, Hey TM, Mogensen J, Barton PJ, Charron P, Elliott P, Garcia-Pavia P; European Genetic Cardiomyopathies Initiative Investigators. Title: Dilated Cardiomyopathy Due to BLC2-Associated Athanogene 3 (BAG3) Mutations. Journal: J Am Coll Cardiol. Year, volume, first and last pages: 2018 Nov 13;72(20):2471-2481. Impact factor: 18.639. Quartile/Decile in the year of publication: Q1.
  3. Authors: Ramirez-Carracedo R, Tesoro L, Hernandez I, Diez-Mata J, Filice M, Toro R, Rodriguez-Piñero M, Zamorano JL, Saura M, Zaragoza C. Title: Non-Invasive Detection of Extracellular Matrix Metalloproteinase Inducer EMMPRIN, a New Therapeutic Target against Atherosclerosis, Inhibited by Endothelial Nitric Oxide. Journal: Int J Mol Sci. Year, volume, first and last pages: 2018 Oct 19;19(10). Impact factor: 4.183. Quartile/Decile in the year of publication: Q2.
  4. Authors: Toro R, Blasco-Turrión S, Morales-Ponce FJ, Gonzalez P, Martínez-Camblor P, López-Granados A, Brugada R, Campuzano O, Pérez-Serra A, Rosa Longobardo F, Mangas A, Llorente-Cortes V, de Gonzalo-Calvo D. Title: Plasma microRNAs as biomarkers for Lamin A/C-related dilated cardiomyopathy. Journal: J Mol Med (Berl). Year, volume, first and last pages: 2018 Jul 14. Impact factor: 4.938. Quartile/Decile in the year of publication: Q1.
  5. Authors: Gomes CPC, de Gonzalo-Calvo D, Toro R, Fernandes T, Theisen D, Wang DZ, Devaux Y; Cardiolinc™ network. Title: Non-coding RNAs and exercise: pathophysiological role and clinical application in the cardiovascular system. Journal: Clin Sci (Lond). Year, volume, first and last pages: 2018 May 20;132(9):925-942. Impact factor: 5.220. Quartile/Decile in the year of publication: Q1.
  6. Authors: Botteri G, Salvadó L, Gumà A, Lee Hamilton D, Meakin PJ, Montagut G, Ashford MLJ, Ceperuelo-Mallafré V, Fernández-Veledo S, Vendrell J, Calderón-Dominguez M, Serra D, Herrero L, Pizarro J, Barroso E, Palomer X, Vázquez-Carrera M. Title: The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling. Journal: Metabolism. Year, volume, first and last pages: 2018 Aug;85:59-75. Impact factor: 5.777. Quartile/Decile in the year of publication: Q1.
  7. Authors: Agustín F. Fernandez†, Gustavo F. Bayón†, Marta I. Sierra, Rocío G. Urdinguio,Virginia López, Pablo Santamaría, María García, Antonella Carella, Estela G. Toraño, Thalía Belmonte, Isabel Cobo, Pablo Menéndez, Cristina Mangas, Cecilia Ferrero, Luís Rodrigo, Aurora Astudillo, Ignacio Ortea, Sergio Cueto Díaz, Pablo Rodríguez-Gonzalez, J. Ignacio García Alonso, Manuela Mollejo, Bárbara Meléndez, Gemma Dominguez, Felix Bonilla, and Mario F. Fraga*. Title: Loss of 5hmC identifies a new type of aberrant DNA hypermethylation in glioma. Journal: Human Molecular Genetics. Year, volume, first and last pages: . 2018 doi: 10.1093/hmg/ddy214. Impact factor: 5,34. Quartile/Decile in the year of publication: Q1.
2017 Publications
  1. Authors: David de-Gonzalo Calvo; Maribel Quezada Feijoo; Alexandra Perez-Serra; Jordi Broncano; Rocio Ayala; Monica Ramos; Sara Blasco-Turrion; Pablo Gonzalez; Francisco Javier Morales; Vicenta Llorente Cortes; Ramon Brugada; Alipio Mangas; Rocio Toro. Title: Familial dilated cardiomyopathy: A multidisciplinary entity, from basic screening to novel circulating biomarkers. Journal: International Journal of Cardiology. Year, volume, first and last pages: 2017, 228: 870 - 880. Impact factor: 6.189. Quartile/Decile in the year of publication: Q1.
  2. Authors: Paula Reventum; Matilde Alique; Irene Cuadrado; Susana Marquez; Rocio Toro; Carlos Zaragoza; Marta Saura. Title: iNOS derived Nitric Oxide induces integrinlinked kinase (ILK) endocytic lysosomemediated degradation in the vascular endothelium Arteriosclerosis. Journal: Thrombosis, and Vascular Biology. Year, volume, first and last pages: 2017, 37:1272-1281. Impact factor: 6.607. Quartile/Decile in the year of publication: Q1.
  3. Authors: Alcalá M, Calderon-Dominguez* M, Bustos E, Ramos P, Casals N, Serra D, Viana M, Herrero L. Title: Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice. Journal: Sci Rep. Year, volume, first and last pages: 2017 Nov 22;7(1):16082. Impact factor: 4.259. Quartile/Decile in the year of publication: Q1.
  4. Authors: Alcala M, Calderon-Dominguez M, Serra D, Herrero L, Ramos P, Viana M. Title: Reduction of ROS Below Physiological Levels Alters Insulin Sensitivity and Retroperitoneal Adipose Tissue Expansion in Obesity. Journal: Plos One. Year, volume, first and last pages: 2017; 13;12(10):e0186579. Impact factor: 2.806. Quartile/Decile in the year of publication: Q1.
  5. Authors: Gianchini F, Galaviz-Hernandez C, Damiano A, Viana M, Cadavid A, Asturizaga P, Teran E, Clapes S, Alcala M, Bueno J, Calderon-Dominguez M, Ramos MP, Lima VV, Sosa-Macias M, Martinez N, Roberts J, Escudero C. Title: Vascular dysfunction in mother and offspring during preeclampsia: Contributions from Latin American countries. Journal: Current Hypertension Reports. Year, volume, first and last pages: . 2017. 6;19(10):83. Impact factor: 3.036. Quartile/Decile in the year of publication: Q2.
2016 Publications
  1. Authors: Jesus Millan Nuñez-Cortes; Teresa Mantilla Morató; Rocío Toro Cebada; Joaquín Millán Pérez; Alipio Mangas Rojas. Title: Cardiometabolic risk related to the association of hypertrigliceridemia-lowHDL-c. Journal: Current Pharmacology Desing. Year, volume, first and last pages: 2016, 22: 365 – 371. Impact factor: 2.611. Quartile/Decile in the year of publication: Q2.
  2. Authors: David De Gonzalo; E Kenneweg; Rocio Toro; C Bang; RW Van Der Meer; LJ Rijzewijk; JW Smith; HJ Lamb;Concepcion LLorente-Cortes; Thomas Thum. Title: Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well controlled type 2 diabetes. Journal: Scientific Reports. Year, volume, first and last pages: 2016, 6:37354-37365. Impact factor: 4.259. Quartile/Decile in the year of publication: Q1.
  3. Authors: Rocío Toro; Alexandra Perez Serra; Oscar Campuzano; Javier Arlandi; Anna Iglesias; Catarina Allegue; Alipio Mangas; Ramón Brugada. Title: Familial dilated cardiomyopathy caused by a novel frameshift in the BAG3 gene. Journal: PLoS One. Year, volume, first and last pages: 2016,11(7):1-11. Impact factor: 2.806. Quartile/Decile in the year of publication: Q1.
  4. Authors: Alexandra Perez-Serra; Rocio Toro; Gerogia Sarquella-Brugada; David de-Gonzalo Calvo; Sandra Cesar;Elena Carro; Vicenta Llorente Cortes; Anna Iglesias; Josep Brugada; Ramon Brugada. Title: Genetic basis of dilated cardiomyopathy. Journal: International Journal of Cardiology. Year, volume, first and last pages: 2016, 224: 461 - 472. Impact factor: 6.189. Quartile/Decile in the year of publication: Q1.
  5. Authors: Irene Izquierdo; Ignacio Rosa; SBravo; E Guitian; Alexandra Perez-Serra; Oscar Campuzano; Ramon Brugada; Alipio Mangas; Angel Garcia; Rocío Toro. Title: Proteomic identification of putative biomarkers for early detection of sudden cardiac death in a family with a LMNA gene mutation causing dilated cardiomyopathy. Journal: Journal Proteomics. Year, volume, first and last pages: 2016,148: 75 – 84. Impact factor: 3.914. Quartile/Decile in the year of publication: Q1.
  6. Authors: Toro R, Cabeza-Letrán ML, Quezada M, Rodriguez-Puras MJ, Mangas A. Title: Impaired right and left ventricular mechanics in adults with pulmonary hypertension and congenital shunts. Journal: J Cardiovasc Med. Year, volume, first and last pages: 2016, 17:209-16. Impact factor: 1.613. Quartile/Decile in the year of publication: Q3.
  7. Authors: Calderon-Dominguez M*, Alcalá M*, Sebastián D, Zorzano A, Viana M, Serra D, Herrero L. Title: Brown adipose tissue bioenergetics: a new methodological approach. Journal: Advanced Sciences. Year, volume, first and last pages: 2016. 13;4(4):1600274. Impact factor: 9.034. Quartile/Decile in the year of publication: Q1.
  8. Authors: García-Casarrubios E, de Moura C, Arroba AI, Pescador N, Calderon-Dominguez M, Garcia L, Herrero L, Serra D, Cadenas S, Reis F, Carvalho E, Obregon MJ, Valverde ÁM. Title: Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes. Journal: Biochim Biophys Acta. Year, volume, first and last pages: 2016; 1861:1929-1941. Impact factor: 5.547. Quartile/Decile in the year of publication: Q1.
  9. Authors: Calderon-Dominguez M, Sebastián D, Fucho R, Weber M, Mir JF, García-Casarrubios E, Obregón MJ, Zorzano A, Valverde ÁM, Serra D, Herrero L. Title: Carnitine Palmitoyltransferase 1 Increases Lipolysis, UCP1 Protein Expression and Mitochondrial Activity in Brown Adipocytes. Journal: PLoS One. Year, volume, first and last pages: 2016; 11(7): e0159399. Impact factor: 2.806. Quartile/Decile in the year of publication: Q1.
  10. Authors: Toraño EG, Bayón GF, Del Real Á, Sierra MI, García MG, Carella A, Belmonte T, Urdinguio RG, Cubillo I, García-Castro J, Delgado-Calle J, Pérez-Campo FM, Riancho JA, Fraga MF, Fernández AF. Title: Age-associated hydroxymethylation in human bone-marrow mesenchymal stem cells. Journal: Journal Transl Med. Year, volume, first and last pages: 2016, 14. Impact factor: 3,786. Quartile/Decile in the year of publication: Q1.
2015 Publications
  1. Authors: Rocio Toro; Eduardo Segura; Jesús Millan Nuñez-Cortes; Juan Pedro-Botet; Maribel Quezada-Feijoo. Title: Relationship between lipoprotein (a) and micro/macro complications in type 2 diabetes mellitus: a forgotten target. Journal: Journal Geriatrics of Cardiolgy. Year, volume, first and last pages: 2015, 12: 93 - 99. Impact factor: 1.806. Quartile/Decile in the year of publication: Q3.
  2. Authors: Alexandra Perez-Serra; Rocio Toro (equally contributed); Oscar Campuzano; Georgia Sarquella-Brugada;Paola Berne; Anna Iglesias; Alipio Mangas; Josep Brugada; Ramon Brugada. Title: A Novel Mutation in Lamin A/C Causing Familial Dilated Cardiomyopathy Associated With Sudden Cardiac Death. Journal: Journal of Cardica Failure. Year, volume, first and last pages: 2015, 21:217-225. Impact factor: 3.765. Quartile/Decile in the year of publication: Q2.
  3. Authors: Núñez-cortés, Jesús Millán ; Mantilla -Morató, Teresa ; Toro Cebada Rocío, Millán Pérez, Joaquín ; Alipio Mangas Rojas. Title: : Metabolic syndrome in patients with clinical phenotype "hypertriglyceridemic waist". Journal: Nutrición Hospitalaria. Year, volume, first and last pages: 2015,32:1145-52. Impact factor: 0.74. Quartile/Decile in the year of publication: Q4.
  4. Authors: Gamaza-Chulián S, Camacho-Freire S, Toro-Cebada R, Giráldez-Valpuesta A, Benezet-Mazuecos J, Vargas-Machuca JC. Title: Ratio of Acceleration Time to Ejection Time for Assessing Aortic Stenosis Severity. Journal: Echocardiography. Year, volume, first and last pages: 2015, 32:1754-61. Impact factor: 1.314. Quartile/Decile in the year of publication: Q4.
  5. Authors: Rodriguez C, Quezada-Feijoo M, Toro C, Barón-Esquivias G, Segura E, Mangas A, Toro R. Title: Performance of entero-insular axis in an athletic population: diet and exercise influence. Journal: Nutrición Hospitalaria. Year, volume, first and last pages: 2015, 31:2187-94. Impact factor: 0.747. Quartile/Decile in the year of publication: Q4.
  6. Authors: Barón-Esquivias G1, Fernández-Avilés F, Atienza F, Pastor Pueyo P, Toro R, Sanmartín Fernández M. Title: Efficacy and safety of rivaroxaban in real-life patients with atrial fibrillation. Journal: Expert Rev Cardiovasc Ther. Year, volume, first and last pages: 2015, 4:341-53. Impact factor: 1.67. Quartile/Decile in the year of publication: Q3.
  7. Authors: Rosety MA, Pery MT, Rodriguez-Pareja MA, Diaz A, Rosety J, Garcia N, Brenes-Martin F, Rosety-Rodríguez M, Toro R, Ordoñez FJ, Rosety. Title: A short-term circuit resistance programme reduced epicardial fat in obese aged women. Journal: Nutrición Hospitalaria. Year, volume, first and last pages:2015,32:2193-7. Impact factor: 0.747. Quartile/Decile in the year of publication: Q4.
  8. Authors: Pedro-Botet J, Climent E, Chillarón JJ, Toro R, Benaiges D, Flores-Le Roux JA. Title: Statins for primary cardiovascular prevention in the elderly. Journal: J Geriatr Cardiol. Year, volume, first and last pages: 2015, 12:431-8. Impact factor: 1.806. Quartile/Decile in the year of publication: Q3.
  9. Authors: Calderon-Dominguez M, Mir JF, Fucho R, Weber M, Serra D, Herrero L. Title: Fatty acid metabolism and the basis of brown adipose tissue function. Journal: Adipocyte. Year, volume, first and last pages: 2015;5(2):98-118. Impact factor: 3.533. Quartile/Decile in the year of publication: Q2.
  10. Authors: Malandrino MI, Fucho R, Weber M, Calderon-Dominguez M, Mir JF, Valcarcel L, Escoté X, Gómez-Serrano M, Peral B, Salvadó L, Casals N, Villarroya F, Vázquez-Carrera M, Vendrell JJ, Serra D, Herrero L. Title: Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation. Journal: Am J Physiol Endocrinol Metab. Year, volume, first and last pages: 2015; 308 (9): E756-E769. Impact factor: 3.285. Quartile/Decile in the year of publication: Q1.
2014 Publications
  1. Authors: Q- Feijoo, M; Toro Cebada R ((equally contributed); Lopez Vazquez De La Torre , M; Lennie, V; Arce, Carmen; Moreno , V; Valencia, E; Vispo, E; Almeria, C; Mangas Rojas A; Carbonero , LM. Title: Relationship between endothelin-1 levels and pulmonary arterial hypertension in HIV+ patients. Journal: AIDS. Year, volume, first and last pages: 2014, 18:2693-2699. Impact factor: 5.019. Quartile/Decile in the year of publication: Q1.
  2. Authors: Toro R, Mangas A, Quezada M, Rodriguez-Rosety M, Fournielles G, Rodriguez-Rosety I, Rodriguez Rosety MA, Alonso JA, Garcia-Cozar FJ, Duran MC. Title: Diet and exercise influence on the proteomic profile of an athlete population. Journal: Nutr Hosp. Year, volume, first and last pages:2014, 30:110-7. Impact factor: 0.747. Quartile/Decile in the year of publication: Q4.
  3. Authors: Fornieles G, Rosety MA, Elosegui S, Rosety JM, Alvero-Cruz JR, Garcia N, Rosety M, Rodriguez-Pareja T, Toro R, Rosety-Rodriguez M, Ordonez FJ, Rosety I. Title: Salivary testosterone and immunoglobulin A were increased by resistance training in adults with Down syndrome. Journal: Braz J Med Biol Res. Year, volume, first and last pages: 2014, 47:345-8. Impact factor: 1.578. Quartile/Decile in the year of publication: Q2.
  4. Authors: Fornieles González G, Rosety Rodríguez MÁ, Rodríguez Pareja MA, Diaz Ordóñez A, Rosety Rodríguez J, Pery Bohorquez MT, Brenes Martin F, Escribano Ocon A, Rosety Rodríguez M, Ordóñez Muñoz FJ, Toro Cebada R, Rosety Rodríguez I. Title: A home-based treadmill training reduced epicardial and abdominal fat in postmenopausal women with metabolic syndrome. Journal: Nutr Hosp. Year, volume, first and last pages: 2014, 30:609-13. Impact factor: 0.747. Quartile/Decile in the year of publication: Q4.
  5. Authors: Calderon-Dominguez M, Gil G, Medina MA, Pandak WM, Rodriguez-Agudo D. Title: The StarD4 subfamily of steroidogenic acute regulatory-related lipid transfer (START) domain proteins: new players in cholesterol metabolism. Journal: The International Journal of Biochemistry & Cell Biology. Year, volume, first and last pages: 2014; 49:64-68. Impact factor: 4.152. Quartile/Decile in the year of publication: Q2.
Networks
  • NETWORK NAME: Sociedad Española de Cardiología (SEC). PRINCIPAL INVESTIGATOR: Rocío Toro.
Patents
  • Title: MARCADORES PARA LA MIOCARDIOPATIA DILATADA.
    • Application year: 2017.
    • Grant year: 2020.
    • Code: P201700749.