CO3: Respiratory Diseases and Allergies

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CO3: Respiratory Diseases and Allergies

This research group is made up of pneumologists, thoracic surgeons and allergists whose objective is to develop research in their respective areas, specifically on processes such as COPD, lung cancer, occupational respiratory diseases (such as silicosis) and allergic processes.

Principal investigator
  • Antonio León Jiménez
  • e-mail: antonio.leon.sspa@juntadeandalucia.es
  • ORCID: 0000-0002-0238-9588
Co-principal investigator
  • Aurelio Arnedillo Muñoz
  • e-mail: arnedillo@comcadiz.es
  • ORCID: 0000-0002-2267-057x
Lines of research
  1. Obstructive airway diseases (COPD and asthma): Optimization of exercise capacity and health-related quality of life.
  2. Telemedicine and chronic respiratory disease: Controlled self-management of the disease and diagnosis of exacerbations through the integration of automated biological signals. Remote monitoring of patients with chronic respiratory diseases.
  3. Respiratory pathology during sleep: Simplified diagnostic and monitoring systems for night-time respiratory therapies.
  4. Desensitization to biological agents: design of action protocols. Markers of in vitro techniques to assess effectiveness and efficiency.
  5. Hymenoptera poisoning: Design of new guidelines for administration. Design of activity markers and in vitro diagnostics.
  6. Oral immunotherapy techniques for food: shellfish.
  7. Interstitial and occupational lung diseases: Biomarkers of disease evolution. Cellular study and response to drugs.
Key words
TelemedicineChronic Respiratory DiseasesRespiratory pathology during sleepArtificial Stone SilicosisInflammatory DiseasesMyelomaExosomesOccupational lung diseasesInterstitial lung diseasesDesensitization to biological drugs
Principal investigator

Antonio León Jiménez
  • Director of the Department of Pneumology, Allergology and Thoracic Surgery. University Hospital “Puerta del Mar” (Cadiz).
  • e-mail: antonio.leon.sspa@juntadeandalucia.es
  • ORCID: 0000-0002-0238-9588
Co-principal investigator
Aurelio Arnedillo Muñoz
  • e-mail: arnedillo@comcadiz.es
  • ORCID: 0000-0002-2267-057x
Team members
  • Diego Gutiérrez Fernández
  • Cayo García Polo
  • Jose Enrique González-Moya Rodríguez
  • Dionisio Espinosa Jiménez
  • Daniel del Castillo Otero
  • Eva Vázquez Gandullo
  • Mercedes Merino Sánchez
  • Antonio Hidalgo Molina
  • Aurelio Arnedillo Muñoz
  • Antonio León Jiménez
National Funding Calls
  1. Instituto de Salud Carlos III. 2019 PI19/01064. Principal Investigator: Antonio León Jiménez. SILICOSIS CAUSED BY ARTIFICIAL QUARTZ AGGLOMERATES; SEARCH FOR DIAGNOSTIC/PREDICTIVE BIOMARKERS OF THE DISEASE, USE OF PET/CT AS A DISEASE MONITORING TECHNIQUE AND CLINICAL TRIAL WITH PYRFENIDONE.
  2. Spanish Society of Respiratory System Pathology. 2016. Principal Investigator: Aurelio Arnedillo Muñoz: Evaluation of a respiratory muscle training program using Feelbreathe® nasal ventilatory restriction device in COPD patients.
Regional Funding Calls
  1. Department of Health of the Junta de Andalucia. 2018. Principal Investigator: Antonio León Jiménez. CLINICAL FACTORS ASSOCIATED WITH THE RAPID EVOLUTION OF SILICOSIS CAUSED BY ARTIFICIAL QUARTZ AGGLOMERATES: IDENTIFICATION OF MOLECULAR AND CELLULAR MARKERS OF INFLAMMATION AND PULMONARY FIBROSIS AND THEIR PHARMACOLOGICAL INHIBITION IN CELLULAR AND ANIMAL MODELS.
Publications
  • Pérez-Alonso A, Córdoba-Doña JA, León-Jiménez A. Silicosis Caused by Artificial Quartz Conglomerates: Keys to Controlling an Emerging Disease. Arch Bronconeumol. 2019 Jul;55(7):394-395. doi: 10.1016/j.arbres.2019.01.015. FI 2018: 4,214, Q1.
  • Sanchez-Morillo D, O Osama , Fernandez-Granero MA, Leon-Jimenez A. Physiological Closed-Loop Control in Intelligent Oxygen Therapy: a review. Comput Methods Programs Biomed 2017: 146: 101-108. https://doi.org/10.1016/j.cmpb.2017.05.013 . FI JCR: 2,674 Q2
  • ernandez-Granero MA, Sanchez-Morillo D, Leon-Jimenez A. An artificial intelligence approach to early predict symptom-based exacerbations of COPD. Biotechnology & Biotechnological Equipment 2018: 32:3, 778-784, FI 1,092.
  • Arnedillo Muñoz A. THE RATIONALE FOR GESEPOC IN OUR ENVIRONMENT. Arch Bronconeumol. 2017 Jun;53(6): 293-294. IF: 2,979.
  • Calle Rubio M, Alcázar B, Soriano JB, Soler-Cataluña JJ, Rodríguez González-Moro JM, Fuentes M, López-Campos JL, On behalf of the EPOCONSUL Study. CLINICAL AUDIT OF COPD IN OUTPATIENT RESPIRATORY CLINICS IN SPAIN: THE EPOCONSUL STUDY. International Journal of COPD 2017:12 417-26. IF: 3,157-Q1.
  • Miravitlles M, Cosío BG, Arnedillo A, Calle M, Alcázar-Navarrete B, González C, Esteban C, Trigueros JA, Rodríguez González-Moro JM, Quintano Jiménez JA, Baloira A. PROPOSAL FOR THE WITHDRAWAL OF INHALED CORTICOSTEROIDS IN THE CLINICAL PRACTICE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE. Respir Res. 2017; 18(1): 198. doi: 10.1186/s12931-017-0682. FI: 3,841- Q1.
  • Calle M, Lopez-Campos JL, Soler-Cataluña JJ, et al. VARIABILITY IN ADHERENCE TO CLINICAL PRACTICE GUIDELINES AND RECOMMENDATIONS IN COPD OUTPATIENTS: A MULTI-LEVEL, CROSS-SECTIONAL ANALYSIS OF THE EPOCONSUL STUDY. Respiratory Research (2017) 18:200. DOI 10.1186/s12931-017-0685-8. IF: 3,751.
  • Crespo-Lessmann A, Plaza V, González-Barcala FJ et al. CONCORDANCE OF OPINIONS BETWEEN PATIENTS AND PHYSICIANS AND THEIR RELATIONSHIP WITH SYMPTOMATIC CONTROL AND FUTURE RISK IN PATIENTS WITH MODERATE-SEVERE ASTHMA. BMJ Open Respir Res. 2017 Sep 13;4(1):e000189. doi: 10.1136/bmjresp-2017-000189. IF: 1,19 Q1
  • Sánchez-Morillo, Daniel; Fernández-Granero, Miguel Ángel; León-Jiménez, Antonio. Use of predictive algorithms in-home monitoring of chronic obstructive pulmonary disease and asthma: A systematic review. CHRONIC RESPIRATORY DISEASES. 2016; 13(3): 264-283. FI: 1,646. Respiratory System (Q3)
  • Sanchez-Morillo, Daniel; Crespo-Miguel, Mario; León-Jiménez, Antonio; Crespo-Foix, Luis Felipe; León-Jiménez, Antonio. A novel multimodal tool for telemonitoring patients with COPD. Informatics for Health and Social Care. 2015; 40(1): 1-22. IF: 0,87. Health Care Sciences & Services (Q4);Medical Informatics (Q4)
  • Fernández-Granero, Miguel Angel; Sanchez-Morillo, Daniel; León-Jiménez, Antonio. Título: Computerised Analysis of Telemonitored Respiratory Sounds for Predicting Acute Exacerbations of COPD. Sensors 2015; 15(10):26978-26996. IF: 2,033. Instruments & Instrumentation (Q1)
  • Sanchez-Morillo, Daniel; Fernández-Granero, Miguel Angel; León-Jiménez, Antonio. Título: Detecting COPD exacerbations early using daily telemonitoring of symptoms and k-means clustering: a pilot study. Medical and Biological Engineering and Computing 2015;53(5):441-451 FI 1,797. Computer Science, Interdisciplinary Applications (Q2);
  • Velazquez-Peña, Francisco De Borja; Sanchez-Morillo, Daniel; Crespo-Miguel, Mario; Astorga-Moreno, Sonia; Santi-Cano, María José; Fernández-Granero, Miguel Angel; León-Jiménez, Antonio. Development and Evaluation of an Automated, Home-Based, Electronic Questionnaire for Detecting COPD Exacerbations. Journal of Healthcare Engineering 2015;6(4):705-716 FI: 0,925. Health Care Sciences & Services (Q4)
  • Fernández-Granero, Miguel Angel; Sanchez-Morillo, Daniel; León-Jiménez, Antonio; Crespo-Foix,Luis Felipe. Automatic prediction of chronic obstructive pulmonary disease exacerbations through home telemonitoring of symptoms. Bio-medical Materials and Engineering 2014;24 (6 ): 3825-3832. FI: 1.091. Engineering, Biomedical (Q3)
  • Sanchez-Morillo, Daniel; Lopez-Gordo, Miguel Angel; León-Jiménez, Antonio. Novel multiclass classification for home-based diagnosis of sleep apnea hypopnea syndrome Expert Systems with Applications 2014;41:4(2): 1654-1662. Computer Science, Artificial Intelligence (Q1); Engineering, Electrical & Electronic (Q1); FI: 2.240. Operations Research & Management Science (Q1).