CO4: Neurodegeneration and Neurorepair

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CO4: Neurodegeneration and Neurorepair

This research group's main goal is to use a multidisciplinary approach to study the molecular, cellular and synaptic mechanisms underlying numerous neurodegenerative and psychiatric diseases. This multidisciplinary team of basic and clinical researchers looks to identify new predictive, diagnostic and/or prognostic biomarkers, therapeutic targets and possible treatments for various neurological conditions with neuronal degeneration and/or synaptic alterations. In order to do so, this research group has various cellular and animal models of different neuropathologies (mainly motor diseases such as ALS), and is equipped with the technology necessary to study from the level of sub-cellular organization to the whole organism. Using pharmacological and genetic tools, the group can identify and validate new therapeutic strategies at a preclinical level and subsequently apply them to patients. This research group also aims to develop and validate protocols for the determination of biomarkers with clinical validity.

Principal investigator
  • Bernardo Moreno López
  • e-mail: bernardo.moreno@uca.es
  • ORCID: 0000-0003-2897-6227
Co-principal investigator
  • David González Forero
  • e-mail: david.gonzalezforero@uca.es
  • ORCID: 0000-0001-5748-9546
Lines of research
  1. Neuronal vulnerability. Cellular and molecular mechanisms involved in the sensitization of neuronal degeneration.
  2. Intrinsic neuronal excitability. Ionic channels and modulating agents of active and passive neuronal membrane properties.
  3. Motor physiopathologies. Molecular and cellular mechanisms involved in motor neuron degeneration, with special focus on rare disease amyotrophic lateral sclerosis (ALS).
  4. Physiology, plasticity and pathology of the synapse. Molecular mechanisms involved in the normal functioning of synaptic transmission, in activity- or injury-induced synaptic remodelling and in synaptopathies related to neurological conditions.
  5. Identification of new biomarkers in patients with neurodegenerative diseases, with particular focus on motor neuron disease.
  6. Identification and development of new therapeutic tools at the preclinical level potentially translational to the clinical level.
  7. Identification and development of new tools that delay neuronal degeneration and/or repair damaged nerve tissue.
  8. Development and validation of new protocols for determining biomarkers in neurological and psychiatric diseases.
Key words
Motor neurons Amyotrophic lateral sclerosis Neurodegenerative diseases Electrophysiology Biomarkers Synapse Synaptopathies
Principal investigator
Bernardo Moreno López
  • University Professor
  • e-mail: bernardo.moreno@uca.es
  • ORCID: 0000‐0003-2897-6227
Co-principal investigator
David González Forero
  • University tenured professor
  • e-mail: david.gonzalezforero@uca.es
  • ORCID: 0000‐0001‐5748‐9546
Team members
  • Researchers:
    • Dr. Bernardo Moreno López
    • Dr. Federico Portillo Pacheco
    • Dr. David González Forero
    • Dr. José Juan Vallo de Castro
    • Dra. Victoria García Morales
    • Dra. Carmen Gómez Gómez
    • Dr. Germán Domínguez Vías
    • Dr. Jorge Carlos Morales Camino
    • Dr. Miguel Ángel Moya Molina
  • Predoctoral trainees: Ángela Gento Caro
  • Research support staff: Esther Vilches Herrando
National Funding Calls
  1. Spanish Ministry of Economy and Business Affairs. BFU2015‐71422‐R. Principal Investigator: Bernardo Moreno López. Role of membrane-derived phospholipids in synaptic plasticity and regulation of neuronal excitability. Involvement in neuronal death in an ALS model.
  2. Instituto de Salud Carlos III. PI11/00013. Principal Investigator: David González‐Forero. Role of imbalance in NMDA receptor NR2 subunit activity in synaptic input loss and neonatal motor neuron death following axonal injury.
  3. Spanish Ministry of Science and Innovation. SAF2011‐23633. Principal Investigator: Bernardo Moreno López. Mechanisms that sensitize motor neurons to death: the case of altered expression of K-1 by deregulation of the SP transcription factor.
Regional Funding Calls
  1. Department of Economy, Innovation & Science of the Junta de Andalucia. P11/CTS/7281. Principal Investigator: Bernardo Moreno López. Mechanisms that sensitize motor neurons to death: the case of altered expression of K-1 by deregulation of the SP-1 transcription factor.
Publications
Artículos originales
  • Victoria García Morales; Guillermo Rodríguez Bey; Laura Gómez Pérez; Germán Domínguez Vías; David González Forero; Federico Portillo Pacheco; Ángela Gento Caro; Antonio Campos Caro; Ana Garcera; Rosa María Soler; Bernardo Moreno López. Sp1‐regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1. Nature Communications. In press, 2019. ÍNDICE DE IMPACTO: 11.878 POSICIÓN QUE OCUPA LA REVISTA EN LA CATEGORÍA CIENCIAS MULTIDISCIPLINARES: 5 de 69, D1
  • Domínguez‐Vías G, Aretxaga‐Maza G, Prieto I, Luna JD, De Gasparo M, Ramírez‐Sánchez M. Diurnal opposite variation between angiotensinase activities in photo‐neuro‐endocrine tissues of rats. Chronobiol Int. 2017;34(9):1180‐1186. ÍNDICE DE IMPACTO: 2.643 POSICIÓN QUE OCUPA LA REVISTA EN LA CATEGORÍA BIOLOGIA: 22 de 85, Q1
  • Domínguez‐Vías G, Segarra AB, Martínez‐Cañamero M, Ramírez‐Sánchez M, Prieto I. Influence of a Virgin Olive Oil versus Butter Plus Cholesterol‐Enriched Diet on Testicular Enzymatic Activities in Adult Male Rats. Int J Mol Sci. 2017 Aug 4;18(8). pii: E1701. doi: 10.3390/ijms18081701. ÍNDICE DE IMPACTO: 3.687 POSICIÓN QUE OCUPA LA REVISTA EN LA CATEGORÍA BIOQUÍMICA Y BIOLOGIA MOLECULAR: 90 de 293, Q2
  • V. García‐Morales, F. Montero, D. González‐Forero, G. Rodríguez‐Bey, L. Gómez‐Pérez, M.J. Medialdea‐Wandossell, G. Domínguez‐Vías, J.M. García‐Verdugo, B. Moreno‐López. Membrane‐derived phospholipids control synaptic neurotransmission and plasticity. PLoS Biology 13(5): e1002153, 2015. ÍNDICE DE IMPACTO: 8.668 POSICIÓN QUE OCUPA LA REVISTA EN LA CATEGORÍA BIOLOGÍA: 2 de 86, D1 Trabajo destacado por Robinson R (2015) One Lipid, Two Synaptic Plasticity Pathways. PLoS Biol 13(5): e1002154. doi:10.1371/journal.pbio.1002154)
  • Cuenca‐López MD, Serrano‐Heras G, Montero JC, Corrales‐Sánchez V, Gomez‐Juarez M, Gascón‐Escribano MJ, Morales JC, Voisin V, Núñez LE, Morís F, Bader GD, Pandiella A, Ocaña A. Antitumor activity of the novel multi‐kinase inhibitor EC‐70124 in triple negative breast cancer. Oncotarget. 2015 Sep 29;6(29):27923‐37. ÍNDICE DE IMPACTO: 5.008 POSICIÓN QUE OCUPA LA REVISTA EN LA CATEGORÍA ONCOLOGÍA: 36 de 213, Q1
  • Serrano‐Heras G, Cuenca‐López MD, Montero JC, Corrales‐Sanchez V, Morales JC, Núñez LE, Morís F, Pandiella A, Ocaña A. Phospho‐kinase profile of colorectal tumors guides in the selection of multi‐kinase inhibitors. Oncotarget. 2015 Oct 13;6(31):31272‐83. ÍNDICE DE IMPACTO: 5.008 POSICIÓN QUE OCUPA LA REVISTA EN LA CATEGORÍA ONCOLOGIA: 36 de 213, Q1
  • V. García‐Morales, F. Montero, B. Moreno‐López. Cannabinoid agonists rearrange synaptic vesicles at excitatory synapses and depress motoneuron activity in vivo. Neuropharmacology 92:69‐79, 2015. ÍNDICE DE IMPACTO: 4.936 POSICIÓN QUE OCUPA LA REVISTA EN LA CATEGORÍA FARMACOLOGÍA: 19 de 255, D1
  • Cuenca‐López MD, Montero JC, Morales JC, Prat A, Pandiella A, Ocana A. Phospho‐kinase profile of triple negative breast cancer and androgen receptor signaling. BMC Cancer. 2014 Apr 30;14:302. ÍNDICE DE IMPACTO: 3.362 POSICIÓN QUE OCUPA LA REVISTA EN LA CATEGORÍA ONCOLOGÍA: 81 de 210, Q2
Artículos de revisión
  • González‐Forero, B. Moreno‐López. Retrograde response in axotomized motoneurons: Nitric oxide as a key player in triggering reversion toward a dedifferentiated phenotype. Neuroscience 283: 138‐65, 2014. ÍNDICE DE IMPACTO: 3.357 POSICIÓN QUE OCUPA LA REVISTA EN LA CATEGORÍA NEUROCIENCIAS: 96 de 252, Q2