CO5: Neurogenesis and Neuroregeneration

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CO5: Neurogenesis and Neuroregeneration

This research group studies the molecular and cellular mechanisms that regulate neurogenesis in the adult brain in order to promote the regeneration of traumatic, vascular or neurodegenerative brain injuries. Neuronal death caused by injuries of any etiology (such as trauma, ischemic strokes, neurodegenerative diseases etc.) is an irreversible process that still doesn't have an effective treatment. The discovery of neural stem cells in the adult brain has opened the possibility of developing new therapies in regenerative medicine based on neuronal replacement from neural stem cells (neurogenesis). Under physiological conditions, neurogenesis exists in two areas of the adult brain. However, very few new neurons are formed in injured areas. The problem is that there are signaling molecules around the injured areas that activate intracellular signaling pathways that prevent the formation of new neurons. Therefore, identifying which molecules and signaling pathways promote neurogenesis and trying to modulate their activity can help to regenerate the damaged nervous system. This research group’s lab work has recently shown that regulation of the ADAM17/TGFalpha/EGFR signaling pathway in mechanical injuries of the cerebral cortex can have a neurogenic effect. For this reason, the research group is looking for small molecules that, while acting on this signaling pathway, allow to generate functional neurons in damaged regions of the adult brain and integrate into pre-existing circuits. Such molecules may form the foundation for the development of drugs that facilitate the functional regeneration of brain injuries.

Principal investigator
  • Carmen Castro González
  • e-mail: carmen.castro@uca.es
  • ORCID: 0000-0001-6802-0572
Lines of research
  1. Hyperhomocysteinemia and dementia: effects of plasma homocysteine levels on neurogenesis in the adult brain.
  2. Regeneration of brain injuries: role of ADAM17 on the formation of neurons in cortical injuries.
  3. Search for non-tumourogenic PKC activators to facilitate the functional regeneration of brain injuries.
  4. Role of PKC in the development of Glioblastoma.
  5. Role of inflammation in neurodegeneration with brain iron accumulation (NBIA) pathologies.
Key words
Principal investigator

Carmen Castro González
  • University tenured professor
  • e-mail: carmen.castro@uca.es
  • ORCID / Research ID / Scopus ID: 0000‐0002-66802-0572 // http://www.researcherid.com/rid/C-7813-2009
Team members
  • Dra. Carmen Castro González (responsable)
  • Dra. Cristina Verástegui Escolano
  • Dra. Noelia Geribladi Doldán
  • Samuel Domínguez García
  • Ricardo Gómez Oliva
  • Investigadores asociados:
    • Dr. Pedro Nuñez Abades
    • Dra. Livia Carrascal
National Funding Calls
  1. Plan Nacional de I+D. Call Retos 2018. Spanish Ministry of Science and Innovation. RTI2018-099908-B-C21. Principal Investigator: Carmen Castro González. Neuronal replacement therapies in two animal models of brain damage: towards the search for new drugs (REMIND).
  2. Plan Nacional de I+D. Call Retos 2015. Spanish Ministry of Economy and Business Affairs. BFU2015-68652-R. Principal Investigator: Carmen Castro González. Regeneration of traumatic injuries to the cerebral cortex by means of PKC modulators.
Publications
  • Eugenia Flores-Giubi, Noelia Geribaldi-Doldán, Maribel Murillo-Carretero, Carmen Castro,* Rosa Durán-Patrón, Antonio J. Macías-Sánchez*, Rosario Hernández-Galán Lathyrane, premyrsinane and related diterpenesfrom Euphorbia boetica Boiss: effect on in vitro Tratamos la información que nos facilita con el fin de prestarles el servicio solicitado. Los datos proporcionados se conservarán hasta que el interesado no solicite su supresión; de esta manera estos datos se publicarán en la web del INIBICA con el fin de dar cumplimiento del principio de transparencia publicación. neural progenitor cell proliferation (* Corresponding authors). Journal of Natural Products. 2019. In press. Factor de impacto : 4.25 1er decil
  • Geribaldi-Doldán N., Gómez-Oliva R., Domínguez García S., Núnez-Abades P., and Castro C* Protein Kinase C: targets to regenerate brain injuries?. Frontiers in Cell and Developmental Biology.2019. 7, 39- Factor de Impacto 5.20 1er cuartil
  • Domínguez-García S, Castro C* and Geribaldi-Doldán N*. ADAM17/TACE a key molecule in brain injury regeneration. Neural Regen Res 2019, 14, 1378-79. Factor de Impacto: 2.7 3er cuartil
  • García-Bernal F, Geribaldi-Doldán N, Domínguez García, S., Díez-Salguero M., Carrasco M, MurilloCarretero M, Verástegui C, y Castro C*. Protein kinase C inhibition promotes neurogenesis in brain injuries Frontiers in Cellular Neuroscience 2018, 2018 Nov 27;12:462 Factor de Impacto: 3.9 2º cuartil
  • Geribaldi-Doldán N, Carrasco M, Murillo-Carretero M, Domínguez-García S, García-Cózar F, MuñozMiranda JP, Del Río-García V, Verástegui C, Castro C*. Specific inhibition of ADAM17/TACE promotes neurogenesis in the injured motor cortex. Cell Death Dis. 28;9(9):862 2018. Factor impacto: 5.9 1er cuartil.
  • Murillo-Carretero M, Geribaldi-Doldán N, FloresGiubi E, García-Bernal F, Navarro-Quiroz EA, Carrasco M, Macías-Sánchez AJ, HerreroFoncubierta P, Delgado-Ariza A, Verástegui C, Domínguez-Riscart J, Daoubi M, Hernández-Galán R, Castro C*. ELAC (3,12-di-O-acetyl-8-O-tigloilingol), a plant-derived lathyrane diterpene, induces subventricular zone neural progenitor cell proliferation through PKCβ activation. Br J Pharmacol. 2017 May 5. doi: 10.1111/bph.13846. Factor impacto: 6.8 1er decil
  • Rabaneda LG, Geribaldi-Doldán N, Murillo-Carretero M, Carrasco M, Martínez-Salas JM, Verástegui C, Castro C*. Altered regulation of the Spry2/Dyrk1A/PP2A triad by homocysteine impairs neural progenitor cell proliferation. Biochim Biophys Acta. 2016 Dec;1863(12):3015-3026. Factor Impacto 4.52 1er cuartil
  • Geribaldi-Doldán N, Flores-Giubi E, Murillo-Carretero M, García-Bernal FJ, Macías-Sánchez AJ, Carrasco M, Domínguez-Riscart J, Verástegui C, Hernández.-Galán R, and Castro C*. “12-Deoxiphorbols promote adult neurogenesis by inducing neural progenitor cell proliferation via PKC activation”. Int J Neuropsychopharmacol. 2015 19 (1). Factor Impacto: 4.72 1er cuartil
  • Carrasco M, Rabaneda L.G., Ortega-Martínez S., Tratamos la información que nos facilita con el fin de prestarles el servicio solicitado. Los datos proporcionados se conservarán hasta que el interesado no solicite su supresión; de esta manera estos datos se publicarán en la web del INIBICA con el fin de dar cumplimiento del principio de transparencia Murillo-Carretero M, Martinez-Chantar ML, Woodhoo A, Luka Z, Wagner C, Mato JM, Micó JA, and Castro C*. Glycine N-methyltransferase expression in mouse hippocampus and its role in neurogénesis and cognitive performance. 2014; Hippocampus 24 840-852. Factor Impacto: 5.49 1er cuartil
  • García-Bueno B, Bioque M, Mac-Dowell KS, Barcones MF, Martínez-Cengotitabengoa M, PinaCamacho L, Rodríguez-Jiménez R, Sáiz PA, Castro C, Lafuente A, Santabárbara J, González-Pinto A, Parellada M, Rubio G, García-Portilla MP, Micó JA, Bernardo M, Leza JC. Pro-/Anti-inflammatory Dysregulation in Patients With First Episode of Psychosis:Toward an Integrative Inflammatory Hypothesis of Schizophrenia. Schizophr Bull. 2014 Mar;40(2):376-87. Factor Impacto 8.8 1er Decil