CO9: Neuropsychopharmacology and Psychobiology

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CO9: Neuropsychopharmacology and Psychobiology

This research group from the University of Cadiz, led by Dr. Esther M. Berrocoso Domínguez, focuses its research activities on the area of neuropsychopharmacology. Specifically, in the R&D of new innovative drugs for the treatment of various diseases related with the central nervous system: antidepressants, analgesics, antipsychotics, pro-cognitive drugs, etc.

Moreover, the members of this research group also study the neurobiological mechanisms that underlie the interaction between opioids and monoamines in order to find new therapeutic targets and innovative drugs for the treatment of pain and depressive disorders. Another of the objectives of these researchers is the analysis of biomarkers related to chronic pain, depression and psychosis or schizophrenia, using transgenic animals.

This research group is highly experienced in researching natural products (including those derived from the marine environment) as possible narcotics, psychoactive drugs or analgesics. Similarly, the CTS-510 group is working on the effectiveness and mechanisms of action of antidepressants on pain as a symptom in depression and other diseases (such as neuropathic pain).

Principal investigator
  • Esther M. Berrocoso Domínguez
  • e-mail: esther.berrocoso@uca.es
  • ORCID: 0000-0003-0208-7242
Co-principal investigator
  • Juan Antonio Micó Segura
  • e-mail: juanantonio.mico@uca.es
  • ORCID: 0000-0001-8905-8484
Lines of research
  1. Biomarkers of therapeutic response in bipolar disorder.
  2. Neurobiology in the comorbidity of chronic pain and affective disorders.
  3. Mechanism of action of deep brain stimulation for the treatment of resistant affective disorders.
  4. Neurobiology and the search for biomarkers in mental diseases.
  5. Research on the mechanism of action of drugs and active substances on the central nervous system.
  6. Research and development of new molecules of natural, synthetic or semi-synthetic origin with potential activity on the central nervous system.
  7. Drug addiction and alcoholism.
Key words
pain depression schizophrenia deep brain stimulation neuropsychopharmacology antidepressants
Investigador responsable

Esther M. Berrocoso Domínguez
  • University tenured professor
  • e-mail: esther.berrocoso@uca.es
  • ORCID: 0000-0003-0208-7242
Co-principal investigator
Juan Antonio Micó Segura
  • University professor
  • e-mail: juanantonio.mico@uca.es
  • ORCID: 0000-0001-8905-8484
Team members
  • Esther M. Berrocoso Domínguez, University tenured professor, Head of research group – Principal Investigator.
  • Juan Antonio Micó Segura, University professor, Co-Principal Investigator)
  • Lidia Bravo García, Postdoctoral researcher
  • Sonia Torres Sánchez, Postdoctoral researcher
  • Meritxell Llorca Torralba, Postdoctoral researcher
  • Laura Pérez Caballero, Postdoctoral researcher
  • María Hidalgo Figueroa, Postdoctoral researcher
  • María del Carmen Romero Grimadi, Postdoctoral researcher
  • Irene Suárez Pereira, Postdoctoral researcher
  • María del Carmen Camarena Delgado, Predoctoral researcher
  • Alejandra María Delgado Sequera, Investigadora predoctoral.
  • Patricia Mariscal Ramírez, Predoctoral researcher
  • José Antonio García Partida, Administrative and service staff – Technician.
  • Santiago Muñoz Gutiérrez, Administrative and service staff – Technician
  • Elena Marín Álvarez, Technician.
  • Ana Luisa Pérez Morenilla, Predoctoral researcher
  • María Sancho García Serrano, Predoctoral researcher
  • Juan Gibert Rahola, Emeritus Professor
National Funding Calls
  1. Spanish Ministry of Science, Innovation and Universities: "Retos Investigación" R&D projects. RTI2018-099778-B- 100. Principal Investigator: Esther Berrocoso Domínguez. Sexual differences in comorbidity of chronic pain and anxiety: Focus on the Locus Coeruleus.
  2. Spanish Ministry of Science, Innovation and Universities. Health research projects (ISCIII) PI18/01691. Principal Investigator: Juan Antonio Micó Segura. Assessment of cognitive modulation capacity in depression and chronic pain as a consequence of changes in adult neurogenesis in the hippocampus and its correlation with Locus Coeruleus function.
  3. Spanish Ministry of Economy and Competitiveness. Plan Nacional I+D+i - Retos de la Sociedad. SAF2015-68647-R. Principal Investigator: Esther Berrocoso Domínguez. Study of the noradrenergic system in pain-depression comorbidity: A path to pharmacological innovation.
Regional Funding Calls
  1. Department of Health of the Junta de Andalucia. Year: 2018. PI-0134-2018. Principal Investigator: Lidia Bravo García. Indoleamine 2,3-dioxygenase (IDO) and kineurins as potential biomarkers predicting the development of major depression in patients with neuropathic pain.
  2. Regional integration initiative (ITI) 2014-2020 for the province of Cadiz, by the Department of Health of the Junta de Andalucia and the European Regional Development Fund. PI-0009-2017. Principal Investigator: Esther Berrocoso Domínguez. Biomarkers of therapeutic response in bipolar disorder.
  3. Regional integration initiative (ITI) 2014-2020 for the province of Cadiz, by the Department of Health of the Junta de Andalucia and the European Regional Development Fund. PI-0080-2017. Principal Investigator: Juan A. Mico Segura. The role of social cognition as a predictive factor in the psychosocial functioning of schizophrenic patients: Ecofun study.
  4. Regional integration initiative (ITI) 2014-2020 for the province of Cadiz, by the Department of Health of the Junta de Andalucia and the European Regional Development Fund. PI-0064-2017 (Collaboration). Search for biomarkers in the comorbidity of chronic pain and affective disorders.
Publications
  • Casquero-Veiga M, García-García D, MacDowell KS, Pérez-Caballero L, Torres-Sánchez S, Fraguas D, Berrocoso E, Leza JC, Arango C, Desco M, Soto-Montenegro ML. (2019). Risperidone administered during adolescence induced metabolic, anatomical and inflammatory/oxidative changes in adult brain: A PET and MRI study in the maternal immune stimulation animal model. Eur Neuropsychopharmacol.. FI (JCR): 4.468 - Rank: Q1 (Pharmacology & Pharmacy). Citas: 0. DOI: 10.1016/j.euroneuro.2019.05.002
  • Moreno C, Parellada M, MacDowell KS, García-Bueno B, Cabrera B, González-Pinto A, Saiz P, Lobo A, Rodriguez-Jimenez R, Berrocoso E, Bernardo M, Leza JC. (2019). Differences in the regulation of inflammatory pathways in adolescent- and adult-onset first-episode psychosis. Eur Child Adolesc Psychiatry. FI (JCR): 3.740 - Rank: D1 (Pediatrics). Citas: 0. DOI: 10.1007/s00787-019-01295-8
  • Llorca-Torralba M, Suárez-Pereira I, Bravo L, Camarena-Delgado C, Garcia-Partida JA, Mico JA, Berrocoso E. (2019). Chemogenetic Silencing of the Locus Coeruleus-Basolateral Amygdala Pathway Abolishes Pain-Induced Anxiety and Enhanced Aversive Learning in Rats. Biol Psychiatry. FI (JCR): 11.501 - Rank: D1 (Neurosciences). Citas: 1. DOI: 10.1016/j.biopsych.2019.02.018
  • Perez-Caballero L, Torres-Sanchez S, Romero-López-Alberca C, González-Saiz F, Mico JA, Berrocoso E. (2019). Monoaminergic system and depression. Cell Tissue Res. FI (JCR): 3.360 - Rank: Q3 (Cell Biology). Citas: 0. DOI: 10.1007/s00441-018-2978-8
  • Llorca-Torralba M, Pilar-Cuéllar F, Bravo L, Bruzos-Cidon C, Torrecilla M, Mico JA, Ugedo L, Garro-Martínez E, Berrocoso E. (2019). Opioid Activity in the Locus Coeruleus Is Modulated by Chronic Neuropathic Pain. Mol Neurobiol. FI (JCR): 4.586 - Rank: Q1 (Neurosciences). Citas: 0. DOI: 10.1007/s12035-018-1361-9
  • Llamosas N, Perez-Caballero L, Berrocoso E, Bruzos-Cidon C, Ugedo L, Torrecilla M. (2019). Ketamine promotes rapid and transient activation of AMPA receptor-mediated synaptic transmission in the dorsal raphe nucleus. Prog Neuropsychopharmacol Biol Psychiatry.FI (JCR): 4.315 - Rank: Q1 (Pharmacology & Pharmacy). Citas: 0. DOI: 10.1016/j.pnpbp.2018.07.022
  • Vázquez-Bourgon J, de la Foz VO, Suarez-Pereira I, Iruzubieta P, Arias-Loste MT, Setién-Suero E, Ayesa-Arriola R, Gómez-Revuelta M, Crespo J, Facorro BC. (2019). Cannabis consumption and non-alcoholic fatty liver disease. A three years longitudinal study in first episode non-affective psychosis patients. Prog Neuropsychopharmacol Biol Psychiatr. FI (JCR): 4.315 - Rank: Q1 (Pharmacology & Pharmacy). Citas: - . DOI: 10.1016/j.pnpbp.2019.109677
  • Harris A, Masgutova G, Collin A, Toch M, Hidalgo-Figueroa M, Jacob B, Corcoran LM, Francius C, Clotman F. (2019). Onecut Factors and Pou2f2 Regulate the Distribution of V2 Interneurons in the Mouse Developing Spinal Cord. Front Cell Neurosci. FI (JCR): 3.900 - Rank: Q2 (Neurosciences). Citas: - . DOI: 10.3389/fncel.2019.00184
  • Ojeda B, Salazar A, Calahorro MJ, Dueñas M, Mico JA, de Sola H, Failde I. (2018). Understanding the different relationships between mood and sleep disorders in several groups of non-oncological patients with chronic pain. J Curr Med Res Opin. FI (JCR): 2.665 - Rank: Q1 (Medicine, General & Internal). Citas: 1. DOI:10.1080/03007995.2017.1384372
  • Failde I, Dueñas M, Ribera MV, Gálvez R, Mico JA, Salazar A, de Sola H, Pérez C. (2018). Prevalence of central and peripheral neuropathic pain in patients attending pain clinics in Spain: factors related to intensity of pain and quality of life. J Pain Res. FI (JCR): 2.645 - Rank: Q3 (Clinical Neurology). Citas: 38. DOI: 10.2147/JPR.S159729
  • Perez-Caballero L, Soto-Montenegro ML, Hidalgo-Figueroa M, Mico JA, Desco M, Berrocoso E. (2018). Deep brain stimulation electrode insertion and depression: Patterns of activity and modulation by analgesics. Brain Stimulation. FI (JCR): 6.919 - Rank: D1 (Clinical Neurology). Citas: 0. DOI: 10.1016/j.brs.2018.06.010
  • Alba-Delgado C, Llorca-Torralba M, Mico JA, Berrocoso E. (2018). The Onset of Treatment with the Antidepressant desipramine is Critical for the Emotional Consequences of Neuropathic Pain. Pain.FI (JCR): 6.029 - Rank: D1 (Anesthesiology). Citas: 0. DOI: 10.1097/j.pain.0000000000001372
  • Torres-Sanchez, S; Borges GD; Mico, JA; Berrocoso, E. (2018). Opiod and noradrenergic contributions of tapentadol to the inhibition of locus coeruleus neurons in the streptozotocin rat model of polyneuropathic pain. Neuropharmacology.FI (JCR): 4.367 - Rank: Q1 (Pharmacology & Pharmacy). Citas: 0. DOI: 10.1016/j.neuropharm.2018.03.014
  • García S, Alberich S, Martínez-Cengotitabengoa M, Arango C, Castro-Fornieles J, Parellada M, Baeza I, Moreno C, Micó JA, Berrocoso E, Graell M, Otero S, Simal T, González-Pinto A. (2018). The complex association between the antioxidant defense system and clinical status in early psychosis. PLoS One.FI (JCR): 2.776 - Rank: Q2 (Multidisciplinary Sciences). Citas: 0. DOI: 10.1371/journal.pone.0194685
  • Perez-Palomar B, Mollinedo-Gajate I, Berrocoso E, Meana JJ, Ortega JE. (2018). Serotonin 5-HT3 receptor antagonism potentiates the antidepressant activity of citalopram. Neuropharmacology.FI (JCR): 4.367 - Rank: Q1 (Pharmacology & Pharmacy). Citas: 0. DOI: 10.1016/j.neuropharm.2018.02.020
  • Llorca-Torralba M, Mico JA, Berrocoso E. (2018). Behavioral effects of combined morphine and MK-801 administration to the locus coeruleus of a rat neuropathic pain model. Progress in Neuropsychopharmacol Biol Psychiatry. FI (JCR): 4.315 - Rank: Q1 (Pharmacology & Pharmacy). Citas: 0. DOI: 10.1016/j.pnpbp.2018.03.007
  • Torres-Sanchez S, Perez-Caballero L, Mico JA, Celada P, Berrocoso E. (2018). Effect of Deep Brain Stimulation of the ventromedial prefrontal cortex on the noradrenergic system in rats. Brain Stimulation. FI (JCR): 6.919 - Rank: D1 (Clinical Neurology). Citas: 1. DOI: 10.1016/j.brs.2017.10.003
  • Chaumette T., Chapuy E., Berrocoso E., Llorca-Torralba M., Bravo L., Mico J.A., Chalus M., Eschalier A., Ardid D., Marchand F., Sors A. (2018). Effects of S 38093, an antagonist/inverse agonist of histamine H3 receptors, in models of neuropathic pain in rats. Eur J Pain.FI (JCR): 3.188 - Rank: Q2 (Anesthesiology). Citas: 1. DOI: 10.1002/ejp.1097
  • Bravo L, Mico JA, Berrocoso E. (2017). Discovery and development of tramadol for the treatment of pain. Expert Opin Drug Discov. FI (JCR): 4.692 - Rank: D1 (Pharmacology & Pharmacy). Citas: 2. DOI: 10.1080/17460441.2017.1377697
  • Berrocoso E, Rey-Brea R, Fernández-Arévalo M, Micó JA, Martín-Banderas L. (2017). Single oral dose of cannabinoid derivate loaded PLGA nanocarriers relieves neuropathic pain for eleven days. Nanomedicine. FI (JCR): 6.500 - Rank: D1 (Medicine, Research & Experimental). Citas: 1. DOI: 10.1016/j.nano.2017.07.010
  • Borges G, Miguelez C, Neto F, Mico JA, Ugedo L, Berrocoso E. (2017). Activation of Extracellular Signal-Regulated Kinases (ERK 1/2) in the Locus Coeruleus Contributes to Pain-Related Anxiety in Arthritic Male Rats. Int J Neuropsychopharmacol. FI (JCR): 3.981 - Rank: Q1 (Pharmacology & Pharmacy). Citas: 1. DOI: 10.1093/ijnp/pyx005
  • Torres-Sanchez S, Perez-Caballero L, Berrocoso E. (2017). Cellular and molecular mechanisms triggered by Deep Brain Stimulation in depression: A preclinical and clinical approach. Prog Neuropsychopharmacol Biol Psychiatry. FI (JCR): 4.185 - Rank: Q1 (Pharmacology & Pharmacy). Citas: 1. DOI: 10.1016/j.pnpbp.2016.09.005
  • Dueñas M, Ojeda B, Salazar A, Fernández-Palacín F, Micó JA, Torres LM, Failde I. (2016). Use and satisfaction with the Healthcare System of the chronic pain patients in Spain: results from a nationwide study. Curr Med Res Opin. FI (JCR): 2.757 - Rank: Q1 (Medicine, General & Internal). Citas: 4. DOI: 10.1080/03007995.2016.1211519
  • MacDowell KS, Caso JR, Martín-Hernández D, Moreno BM, Madrigal JLM, Micó JA, Leza JC, García-Bueno B. (2016). The Atypical Antipsychotic Paliperidone Regulates Endogenous Antioxidant/Anti-Inflammatory Pathways in Rat Models of Acute and Chronic Restraint Stress. Neurotherapeutics. FI (JCR): 5.166 - Rank: D1 (Pharmacology & Pharmacy). Citas: 4. DOI: 10.1007/s13311-016-0438-2
  • Ojeda B, Salazar A, Dueñas M, Torres LM, Mico JA, Failde I. (2016). Assessing the Construct Validity and Internal Reliability of the Screening Tool Test Your Memory in Patients with Chronic Pain. PLoS One. FI (JCR): 2.806 - Rank: Q1 (Multidisciplinary Sciences). Citas: 2. DOI: 10.1371/journal.pone.0154240
  • Marchettini P, Wilhelm S, Petto H, Tesfaye S, Tölle T, Bouhassira D, Freynhagen R, Cruccu G, Lledó A, Choy E, Kosek E, Micó JA, Späth M, Skljarevski V, Lenox-Smith A, Perrot S. (2016). Are there different predictors of analgesic response between antidepressants and anticonvulsants in painful diabetic neuropathy?. Eur J Pain. FI (JCR): 3.019 - Rank: Q1 (Anesthesiology). Citas: 10. DOI: 10.1002/ejp.763
  • Francius C, Hidalgo-Figueroa M, Debrulle S, Pelosi B, Rucchin V, Ronellenfitch K, Panayiotou E, Makrides N, Misra K, Harris A, Hassani H, Schakman O, Parras C, Xiang M, Malas S, Chow RL, Clotman F. (2016). Vsx1 Transiently Defines an Early Intermediate V2 Interneuron Precursor Compartment in the Mouse Developing Spinal Cord. Front Mol Neurosci.FI (JCR): 5.076 - Rank: Q1 (Neurosciences). Citas: 2. DOI: 10.3389/fnmol.2016.00145
  • Bravo L, Mico JA, Rey-Brea R, Camarena-Delgado C, Berrocoso E. (2016). Effect of DSP4 and desipramine in the sensorial and affective component of neuropathic pain in rats. Prog Neuropsychopharmacol Biol Psychiatry. FI (JCR): 4.187 - Rank: Q1 (Pharmacology & Pharmacy). Citas: 4. DOI: 10.1016/j.pnpbp.2016.05.002
  • Jiménez-Sánchez L, Castañé A, Pérez-Caballero L, Grifoll-Escoda M, López-Gil X, Campa L, Galofré M, Berrocoso E, Adell A. (2016). Activation of AMPA Receptors Mediates the Antidepressant Action of Deep Brain Stimulation of the Infralimbic Prefrontal Cortex. Cereb Cortex. FI (JCR): 6.559 - Rank: D1 (Neurosciences). Citas: 18. DOI: 10.1093/cercor/bhv133
  • Alba-Delgado C, Cebada-Aleu A, Mico JA, Berrocoso E. (2016). Comorbid anxiety-like behavior and locus coeruleus impairment in diabetic peripheral neuropathy: A comparative study with the chronic constriction injury model. Prog Neuropsychopharmacol Biol Psychiatry. FI (JCR): 4.187 - Rank: Q1 (Pharmacology & Pharmacy). Citas: 4. DOI: 10.1016/j.pnpbp.2016.06.007
  • Llorca-Torralba M, Borges G, Neto F, Mico JA, Berrocoso E. (2016). Noradrenergic Locus Coeruleus pathways in pain modulation. Neuroscience. FI (JCR): 3.277 - Rank: Q2 (Neurosciences). Citas: 22. DOI: 10.1016/j.neuroscience.2016.05.057
  • Martinez-Cengotitabengoa M, MacDowell KS, Alberich S, Diaz FJ, Garcia-Bueno B, Rodriguez-Jimenez R, Bioque M, Berrocoso E, Parellada M, Lobo A, Saiz PA, Matute C, Bernardo M, Gonzalez-Pinto A, Leza JC; FLAMM-PEPs. (2016). BDNF and NGF Signalling in Early Phases of Psychosis: Relationship With Inflammation and Response to Antipsychotics After 1 Year. Schizophr Bull. FI (JCR): 7.575 - Rank: D1 (Psychiatry). Citas: 12. DOI: 10.1093/schbul/sbv078
  • Dueñas M, Salazar A, Ojeda B, Fernández-Palacín F, Micó JA, Torres LM, Failde I. (2015).A nationwide study of chronic pain prevalence in the general spanish population: identifying clinical subgroups through cluster analysis. Pain Med. FI (JCR): 2.324 - Rank: Q1 (Medicine, General & Internal). Citas: 15. DOI: 10.1111/pme.12640
  • Suárez-Pereira I, Canals S, Carrión AM. (2015). Adult newborn neurons are involved in learning acquisition and long-term memory formation: the distinct demands on temporal neurogenesis of different cognitive tasks. Hippocampus.FI (JCR): 4.074 - Rank: Q1 (Neurosciences). Citas: 26. DOI: 10.1002/hipo.22349
  • Suárez-Pereira I, Carrión ÁM. (2015). Updating stored memory requires adult hippocampal neurogenesis. Sci Rep.FI (JCR): 5.228 - Rank: Q1 (Multidisciplinary Sciences). Citas: 14. DOI: 10.1038/srep13993
  • Francius C, Ravassard P, Hidalgo-Figueroa M, Mallet J, Clotman F, Nardelli J. (2015). Genetic dissection of Gata2 selective functions during specification of V2 interneurons in the developing spinal cord. Dev Neurobiol.FI (JCR): 2.529 - Rank: Q2 (Developmental Biology). Citas: 6. DOI: 10.1002/dneu.22244
  • Romero-Grimaldi C, Berrocoso E, Alba-Delgado C, Madrigal JL, Perez-Nievas BG, Leza JC, Mico JA. (2015). Stress Increases the Negative Effects of Chronic Pain on Hippocampal Neurogenesis. Anesth Analg. FI (JCR): 3.827 - Rank: Q1 (Anesthesiology). Citas: 7. DOI: 10.1213/ANE.0000000000000838
  • Ramos-Rodriguez JJ, Jimenez-Palomares M, Murillo-Carretero MI, Infante-Garcia C, Berrocoso E, Hernandez-Pacho F, Lechuga-Sancho AM, Cozar-Castellano I, Garcia-Alloza M. (2015). Central vascular disease and exacerbated pathology in a mixed model of type 2 diabetes and Alzheimer's disease. Psychoneuroendocrinology. FI (JCR): 4.704 - Rank: Q1 (Psychiatry). Citas: 18. DOI: 10.1016/j.psyneuen.2015.07.606
  • Borges G, Berrocoso E, Mico JA, Neto F. (2015). ERK1/2: Function, signaling and implication in pain and pain-related anxio-depressive disorders. Prog Neuropsychopharmacol Biol Psychiatry. FI (JCR): 4.361 - Rank: Q1 (Pharmacology & Pharmacy). Citas: 11. DOI: 10.1016/j.pnpbp.2015.02.010
  • Borges GP, Micó JA, Neto FL, Berrocoso E. (2015). Corticotropin-Releasing Factor Mediates Pain-Induced Anxiety through the ERK1/2 Signaling Cascade in Locus Coeruleus Neurons. Int J Neuropsychopharmacol. FI (JCR): 4.333 - Rank: Q1 (Pharmacology & Pharmacy). Citas: 3. DOI: 10.1093/ijnp/pyv019
  • Rapado-Castro M, Pazos Á, Fañanás L, Bernardo M, Ayuso-Mateos JL, Leza JC, Berrocoso E, de Arriba J, Roldán L, Sanjuán J, Pérez V, Haro JM, Palomo T, Valdizan EM, Micó JA, Sánchez M, Arango C. (2015). Building up careers in translational neuroscience and mental health research: Education and training in the Centre for Biomedical Research in Mental Health. Rev Psiquiatr Salud Ment. FI (JCR): 1.650 - Rank: Q3 (Psychiatry). Citas: 0. DOI: 10.1016/j.rpsm.2014.09.003
  • García-Bueno B, Bioque M, MacDowell KS, Santabárbara J, Martínez-Cengotitabengoa M, Moreno C, Sáiz PA, Berrocoso E, Gassó P, Fe Barcones M, González-Pinto A, Parellada M, Bobes J, Micó JA, Bernardo M, Leza JC. (2015). Pro-/antiinflammatory dysregulation in early psychosis: results from a 1-year follow-up study. Int J Neuropsychopharmacol. FI (JCR): 4.333 - Rank: Q1 (Pharmacology & Pharmacy). Citas: 4. DOI: 10.1093/ijnp/pyu037
  • Ojeda B, Salazar A, Dueñas M, Torres LM, Micó JA, Failde I. (2014). The impact of chronic pain: the perspective of patients, relatives, and caregivers. Fam Syst Health. FI (JCR): 1.131 - Rank: Q3 (Public, Enviromental & Occupational Health). Citas: 7. DOI: 10.1037/fsh0000069
  • Bouhassira, D; Wilhelm, S; Schacht, A; Perrot, S; Kosek, E; Cruccu, G; Freynhagen, R; Tesfaye, S; Lledo, A; Choy, E; Marchettini, P; Mico, JA; Spaeth, M; Skljarevski, V; Tolle, T. (2014). Neuropathic pain phenotyping as a predictor of treatment response in painful diabetic neuropathy: Data from the randomized, double-blind, COMBO-DN study. Pain. FI (JCR): 5.213 - Rank: D1 (Anesthesiology). Citas: 41. DOI: 10.1016/j.pain.2014.08.020
  • Carrasco M, Rabaneda LG, Murillo-Carretero M, Ortega-Martínez S, Martínez-Chantar ML, Woodhoo A, Luka Z, Wagner C, Lu SC, Mato JM, Micó JA, Castro C. (2014).Glycine N-methyltransferase expression in the hippocampus and its role in neurogenesis and cognitive performance. Hippocampus. FI (JCR): 4.162 - Rank: Q1 (Neurosciences). Citas: 5. DOI: 10.1002/hipo.22274
  • Martínez-Cengotitabengoa M, Micó JA, Arango C, Castro-Fornieles J, Graell M, Payá B, Leza JC, Zorrilla I, Parellada M, López MP, Baeza I, Moreno C, Rapado-Castro M, González-Pinto A. (2014). Basal low antioxidant capacity correlates with cognitive deficits in early onset psychosis. A 2-year follow-up study. Schizophr Res..FI (JCR): 3.923 - Rank: Q1 (Psychiatry). Citas: 16. DOI: 10.1016/j.schres.2014.03.025
  • García-Bueno B, Bioque M, Mac-Dowell KS, Barcones MF, Martínez-Cengotitabengoa M, Pina-Camacho L, Rodríguez-Jiménez R, Sáiz PA, Castro C, Lafuente A, Santabárbara J, González-Pinto A, Parellada M, Rubio G, García-Portilla MP, Micó JA, Bernardo M, Leza JC. (2014). Pro-/anti-inflammatory dysregulation in patients with first episode of psychosis: toward an integrative inflammatory hypothesis of schizophrenia. Schizophr Bull.FI (JCR): 8.450 - Rank: D1 (Psychiatry). Citas: 42. DOI: 10.1093/schbul/sbt001
  • Berrocoso E. (2014). Gabapentin, a double-agent acting on cognition in pain?. Pain. FI (JCR): 5.213 - Rank: D1 (Anesthesiology). Citas: 1. DOI: 10.1016/j.pain.2014.06.012
  • Borges G, Neto F, Mico JA, Berrocoso E. (2014). Reversal of monoarthritis-induced affective disorders by diclofenac in rats. Anesthesiology. FI (JCR): 5.879 - Rank: D1 (Anesthesiology). Citas: 14. DOI: 10.1097/ALN.0000000000000177
  • Bravo L, Torres-Sanchez S, Alba-Delgado C, Mico JA, Berrocoso E. (2014). Pain exacerbates chronic mild stress-induced changes in noradrenergic transmission in rats. Eur Neuropsychopharmacol. FI (JCR): 4.369 - Rank: Q1 (Pharmacology & Pharmacy). Citas: 18. DOI: 10.1016/j.euroneuro.2014.01.011
  • Perez-Caballero L, Torres-Sanchez S, Bravo L, Mico JA, Berrocoso E. (2014). Fluoxetine: a case history of its discovery and preclinical development. Expert Opin Drug Discov. FI (JCR): 3.539 - Rank: Q1 (Pharmacology & Pharmacy). Citas: 22. DOI: 10.1517/17460441.2014.907790