EM11: UCInfectious

Research group made up of professionals with extensive experience in infectious diseases. Dr. Estella is currently coordinator of the Infectious Diseases Working Group of the Andalusian Society of Intensive Medicine and Coronary Units. The Drs. Cañadas y Recuerda are completing their doctoral theses and have extensive experience in the care of critically ill patients.

• Bacterial resistance:
• - The problem of bacterial resistance has become a global health problem. The group actively participates in action programs that have recently emerged to combat the inappropriate use of antibiotics (María Recuerda Núñez).
• Pneumonia and inflammatory response:
• - The SARS-CoV-2 epidemic has resurrected the concept of the cytokine-mediated inflammatory response. For more than a decade we have been investigating the inflammatory response in pneumonia, in fact it was the subject of Dr Estella's doctoral thesis and a line of research of the group.

Inflammatory answer Infections Cytokines Bacterial resistance Intensive care

• Principal Investigators:
  • Ángel Estella García (PI).
  • María Recuerda Núñez (Co-PI).
• Investigators:
  • Dolores Cañadas.
  • Mª del Carmen Gómez Sánchez.
  • Mª Paz Gómez Molinero.
  • Juan Carlos Alados Arboledas.

• Project funded by the European Union2015-Magicbullet. Jose Miguel Cisneros. Ángel Estella. 278232.

1. Authors: A Estella. Intensive Care Medicine: Quiet leadership versus protagonist in times of SARS-CoV-2 pandemic crisis. Med Intensiva. 2020 Sep 1. 1,982/Q3.
2. Authors: A Estella. Compassionate Communication and End-of-Life Care for Critically Ill Patients with SARS-CoV-2 Infection. J Clin Ethics. 2020 Summer;31(2). 0.252/Q3.
3. Authors: A Estella, J Garnacho-Montero.From empiricism to scientific evidence in antiviral treatment in severe cases of coronavirus infection in times of epidemic.Medicina Intensiva, 2020-Apr-22. 1,982/Q3.
4. Authors: Rubio O, Estella A, Cabre L, Saralegui-Reta I, Martin MC, Zapata L, Esquerda M, Ferrer R, Castellanos A, Trenado J, Amblas J. Ethical recommendations for a difficult decision-making in intensive care units due to the exceptional situation of crisis by the COVID-19 pandemia: A rapid review & consensus of experts. Medicina intensiva 2020-Apr-22. 1,982/Q3.
5. Authors: Ballesteros Sanz MÁ, Hernández-Tejedor A, Estella Á, et al. Recommendations of the Working Groups from the Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC) for the management of adult critically ill patients in the coronavirus disease (COVID-19). Medicina intensiva 2020-Apr-08. 1,982/Q3.
6. Authors: A Estella. Veteran or novice in end-of-life decision-making in intensive care medicine? Promote ethical deliberation. MEDICINA INTENSIVA Volume: ‏ 44 Number.: 3 APR 2020. 1,982/Q3.
7. Authors: Rodríguez-Baño J, Pérez-Moreno MA, Peñalva G, Garnacho-Montero J, Pinto C, Salcedo I, Fernández-Urrusuno R, Neth O, Gil-Navarro MV, Pérez-Milena A, Sierra R, Estella Á, et al. Outcomes of the PIRASOA programme, an antimicrobial stewardship programme implemented in hospitals of the Public Health System of Andalusia, Spain: an ecologic study of time-trend analysis. CLINICAL MICROBIOLOGY AND INFECTION Volume: 26 Number.: 3 MAR 2020. 6,425/Q1.
8. Authors: A Estella et al. Update and recommendations in decision making referred to limitation of advanced life support treatment. MEDICINA INTENSIVA Volume: ‏ 44 Number: ‏ 2 MAR 2020. 1,982/Q3.
9. Authors: Estella A. Reply to "The right to become an organ and tissue donor at the end of life of critically ill patient". MEDICINA INTENSIVA Volume: ‏ 44 Number: ‏ 1 JAN-FEB 2020. 1,982/Q3.
10. Authors: Martin-Loeches I, Torres A, Povoa P, Zampieri FG, Salluh J, Nseir S, Ferrer M, Rodriguez A; TAVeM study Group. The association of cardiovascular failure with treatment for ventilator-associated lower respiratory tract infection. INTENSIVE CARE MEDICINE Volume: ‏ 45 Number: ‏ 12 DEC 2019. 18,967/Q1.

1. Authors: Cisneros JM, Rosso-Fernández CM, Roca-Oporto C, De Pascale G, Jiménez-Jorge S, Fernández-Hinojosa E, Matthaiou DK, Ramírez P, Díaz-Miguel RO, Estella A, Antonelli M, Dimopoulos G, Garnacho-Montero J Colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia (Magic Bullet study): an investigator-driven, open-label, randomized, noninferiority controlled trial. CRITICAL CARE Volume: 23 Number.: 1 NOV 28 2019. 6,959/ Q1.
2. Authors: Sprung CL, Ricou B, Hartog CS, Maia P, Mentzelopoulos SD, Weiss M, Levin PD, Galarza L, de la Guardia V, Schefold JC, Baras M, Joynt GM, Bülow HH, Nakos G, Cerny V, Marsch S, Girbes AR, Ingels C, Miskolci O, Ledoux D, Mullick S, Bocci MG, Gjedsted J, Estébanez B, Nates JL, Lesieur O, Sreedharan R, Giannini AM, Fuciños LC, Danbury CM, Michalsen A, Soliman IW, Estella A, Avidan A. Changes in End-of-Life Practices in European Intensive Care Units From 1999 to 2016. JAMA Volume 322 Number.: 17 NOV 5 2019. 51,273/Q1.
3. Authors: ICON investigators. A worldwide perspective of sepsis epidemiology and survival according to age: Observational data from the ICON audit. JOURNAL OF CRITICAL CARE Volume: 51 JUN 2019. 2,783/Q2.
4. Authors: Francisco Valenzuela-Sánchez, Blanca Valenzuela-Méndez, Rafael Bohollo de Austria, Juan F Rodríguez-Gutiérrez, Ángel Estella-García, et al.Plasma levels of mid-regional pro-adrenomedullin in sepsis are associated with risk of death. MINERVA ANESTESIOLOGICA Volume: 85 Number.: 4 APR 2019. 2,840/Q2.
5. Authors: Estella Á, Velasco T, Saralegui I, Velasco Bueno JM, Rubio Sanchiz O, Del Barrio M, Martín Delgado MC. Multidisciplinary palliative care at the end of life of critically ill patient. MEDICINA INTENSIVA Volume: 43. Number.: 2 MAR 2019. 1,982/Q3.
6. Authors: Velasco-Sanz TR, Estella-García Á The importance of an interprofessional palliative approach for the critical patient. ENFERMERIA INTENSIVA Volume: 30 Number.: 1 JAN-MAR 2019. 0,16/Q3.
7. Authors: Moreno G, Rodríguez A, Reyes LF, Gomez J, Sole-Violan J, Díaz E, Bodí M, Trefler S, Guardiola J, Yébenes JC, Soriano A, Garnacho-Montero J, Socias L, Del Valle Ortíz M, Correig E, Marín-Corral J, Vallverdú-Vidal M, Restrepo MI, Torres A, Martín-Loeches I; GETGAG Study Group. Corticosteroid treatment in critically ill patients with severe influenza pneumonia: a propensity score matching study. Intensive Care Med. 2018 Sep;44(9). 14.34/Q1.

1. Authors: Estella A Team clinical decision making in end-of-life care. REVISTA CLINICA ESPANOLA Volume: 218 Number: 5 JUN-JUL 2018. 1,043/Q3.
2. Authors: Estella A Improvement opportunities for communication in the ICU. MEDICINA INTENSIVA Volume: 42 Number: 5 JUN-JUL 2018. 1,982/Q3.
3. Authors: Estella A Ethics research in critically ill patients. MEDICINA INTENSIVA Volume: 42 Number.: 4 MAY 2018. 1,982/Q3.
4. Authors: Estella A, Gamazo-Del Rio J, Álvarez-Manzanares J, Julián-Jiménez A, González Del Castillo J. Prognostic accuracy of qsofa according to the site of infection in older patient attended in Emergency Department. EUROPEAN JOURNAL OF INTERNAL MEDICINE Volume.: 50 APR 2018. 3,660/Q1.
5. Authors: Garnacho-Montero J, Díaz-Martín A, Cantón-Bulnes L, Ramírez P, Sierra R, Arias-Verdú D, Rodríguez-Delgado M, Loza-Vázquez A, Rodriguez-Gomez J, Gordón M, Estella Á, García-Garmendia JL.Initial Antifungal Strategy Reduces Mortality in Critically Ill Patients With Candidemia: A Propensity Score-Adjusted Analysis of a Multicenter Study. CRITICAL CARE MEDICINE Volume.: 46 Number.: 3 MAR 2018. 6.791/Q1.

1. Authors: Estella A From paper to new technologies in communication with our patients. REVISTA DE CALIDAD ASISTENCIAL Volume: 32 Number: 6 NOV-DEC 2017. 0,35/Q4.
2. Authors: Lobo SM, De Simoni FHB, Jakob SM, Estella A, et al Decision-Making on Withholding or Withdrawing Life Support in the ICU: A Worldwide Perspective. CHEST Volume: 152 Number: 2 AUG 2017. 7,652/Q1.

1. Authors: Francisco Valenzuela-Sánchez , Blanca Valenzuela-Méndez , Juan Francisco Rodríguez-Gutiérrez, Ángel Estella-García, María Ángela González-García New role of biomarkers: mid-regional pro-adrenomedullin, the biomarker of organ failure ANNALS OF TRANSLATIONAL MEDICINE Volume.: 4 Number.: 17 SEP 2016. 0,889/Q1.
2. Authors: Rodríguez AH, Avilés-Jurado FX, Díaz E, Schuetz P, Trefler SI, Solé-Violán J, Cordero L, Vidaur L, Estella Á, et al Procalcitonin (PCT) levels for ruling-out bacterial coinfection in ICU patients with influenza: A CHAID decision-tree analysis. JOURNAL OF INFECTION Volume.: 72 Number.: 2 FEB 2016. 4,201/Q1.

1. Authors: Estella A, Recuerda M, Moreno E , Pérez Fontaiña LRelación entre la procedencia de los enfermos sépticos ingresados en la unidad de cuidados intensivos y su pronóstico. EMERGENCIAS Volume.: 26 Number.: 4 AUG 2014. 2,895/Q1.
2. Authors: Almansa R, Justel M, Socias L, Ramírez P, Andaluz-Ojeda D, Estella A, et alIgA level in plasma as a differential factor for influenza infection in severe viral pneumonia. JOURNAL OF CLINICAL VIROLOGY Volume.: 59 Number.: 2 FEB 2014. 3,466/Q2.

1. Authors: Justel M, Socias L, Almansa R, Ramírez P, Gallegos MC, Fernandez V, Gordon M, Andaluz-Ojeda D, Nogales L, Rojo S, Vallés J, Estella A, et al IgM levels in plasma predict outcome in severe pandemic influenza. JOURNAL OF CLINICAL VIROLOGY Volume.: 58 Number.: 3 NOV 2013. 3,466/Q2.

1. Authors: Diaz E, Martin-Loeches I, Canadell L, Vidaur L, Suarez D, Socias L, Estella A, et al Corticosteroid therapy in patients with primary viral pneumonia due to pandemic (H1N1) 2009 influenza. JOURNAL OF INFECTION Volume.: 64 Number.: 3 MAR 2012. 4,073/Q1.

1. Authors: Estella A Dolor torácico no coronario con biomarcadores cardiacos elevados: presentación de 15 casos compatibles con miocarditis aguda. EMERGENCIAS Volume.: 23 Number.: 5 OCT 2011. 2,486/Q1.
2. Authors: Estella A Cytokine levels in bronchoalveolar lavage and serum in 3 patients with 2009 Influenza A(H1N1)v severe pneumonia. JOURNAL OF INFECTION IN DEVELOPING COUNTRIES Volume.: 5 Number.: 7 JUL 2011. 1,191/Q3.
3. Authors: Estella A. Emergency overcrowding: an incurable disease? CRITICAL CARE Volume.: 15 Number.: 3 2011. 4,607/Q1.
4. Authors: Díaz E, Rodríguez A, Martin-Loeches I, Lorente L, Del Mar Martín M, Pozo JC, Montejo JC, Estella A, et al. Impact of obesity in patients infected with 2009 influenza A(H1N1). CHEST Volume.: ‏ 139 Number.: ‏ 2 FEB 2011. 5,250/Q1.

1. Authors: Estella A Bronchoalveolar lavage for pandemic influenza A (H1N1)v pneumonia in critically ill patients INTENSIVE CARE MEDICINE Volume.: 36 Number.: 11 NOV 2010. 4,996/Q1.
2. Authors: Estella A . Effects on respiratory mechanics of bronchoalveolar lavage in mechanically ventilated patients JOURNAL OF BRONCHOLOGY & INTERVENTIONAL PULMONOLOGY Volume.: ‏ 17 Number.: ‏ 3 JUL 2010. 0,209/ Q3.

• Miembro Comité científico programa PIRASOA de la Comunidad Autónoma Andaluza.