More informationTeamPublications
IN42: Serious infections, sepsis and systemic and cerebral inflammatory response

Clinical studies on the inflammatory response and biological markers in severe infections in critically ill patients.

Principal Investigator
Lines of research
  • Severe infections.
  • Pneumonia.
  • Bacteremia.
  • Sepsis.
  • Infection prevention and control in the ICU.
  • Diagnosis of serious infections.
  • Diagnostic biomarkers.
  • Response to antimicrobial therapy.
Infections in the critical patient Pneumonia Bacteremias Sepsis Inflammatory answer
Principal Investigator
Rafael Sierra Camerino
Medical specialist in Intensive Medicine Puerta del MAr University Hospital, Cádiz. Associate Professor of Health Sciences-Medicine University of Cádiz.
Team members
  • Principal Investigators:
    • Rafael Sierra Camerino (PI).
  • Investigators:
    • Antonio Gordillo Brenes.
    • Mikel Celaya López.
    • Ángel Sánchez Rodríguez.
2018 Publications
  1. Garnacho-Montero J, Díaz-Martín A, Cantón-Bulnes L, Ramírez P, Sierra R, Arias-Verdú D, Rodríguez-Delgado M, Loza-Vázquez A, Rodriguez-Gomez J, Gordón M, Estella Á, García-Garmendia JL. Initial Antifungal Strategy Reduces Mortality in Critically Ill Patients With Candidemia: A Propensity Score-Adjusted Analysis of a Multicenter Study. Crit Care Med. 2018; 46:384-393.
  2. Pulido MR, Moreno-Martínez P, González-Galán V, Fernández Cuenca F, Pascual Á, Garnacho-Montero J, Antonelli M, Dimopoulos G, Lepe JA, McConnell MJ, Cisneros JM; MagicBullet Working Group. Application of BioFire FilmArray Blood Culture Identification panel for rapid identification of the causative agents of ventilator-associated pneumonia. Clin Microbiol Infect. 2018; 24:1213.
2017 Publications
  1. Tridente A, Bion J, Mills GH, Gordon AC, Clarke GM, Walden A, Hutton P, Holloway PAH, Chiche JD, Stuber F, Garrard C, Hinds C; GenOSept and GAinS Investigators. Derivation and validation of a prognostic model for postoperative risk stratification of critically ill patients with faecal peritonitis. Ann Intensive Care 2017;7:96.
  2. Rello J ,  Diaz E ,  Mañez R ,  Sole-Violan J ,  Valles J ,  Vidaur L ,  Zaragoza R ,  Gattarello S ;  CAPUCI II Consortium . Improved survival among ICU- hospitalized patients with community-acquired pneumonia by unidentified organisms: a multicenter case-control study. Eur J Clin Microbiol Infect Dis.  2017;36:123-130.
2016 Publications
  1. Álvarez-Lerma F ,  Marín-Corral J ,  Vila C ,  Masclans JR ,  González de Molina FJ ,  Martín Loeches I ,  Barbadillo S ,  Rodríguez A ;  H1N1 GETGAG/SEMICYUC Study Group . Delay in diagnosis of influenza A (H1N1)pdm09 virus infection in critically ill patients and impact on clinical outcome. Crit Care. 2016;20:337.
  2. Rodríguez AH ,  Avilés-Jurado FX ,  Díaz E ,  Schuetz P ,  Trefler SI ,  Solé-Violán J ,  Cordero L ,  Vidaur L ,  Estella Á ,  Pozo Laderas JC ,  Socias L ,  Vergara JC ,  Zaragoza R ,  Bonastre J ,  Guerrero JE ,  Suberviola B ,  Cilloniz C ,  Restrepo MI ,  Martín-Loeches I ;  SEMICYUC/GETGAG Working Group . Procalcitonin (PCT) levels for ruling-out bacterial coinfection in ICU patients with influenza: A CHAID decision-tree analysis. J Infect.  2016;72:143-51.
2015 Publications
  1. Rosso-Fernández C, Garnacho-Montero J, Antonelli M, Dimopoulos G, Cisneros JM; MagicBullet study group. Safety and efficacy of colistin versus meropenem in the empirical treatment of ventilator-associated pneumonia as part of a macro- project funded by the Seventh Framework Program of the European Commission studying off-patent antibiotics: study protocol for a randomized controlled trial. Trials. 2015; 16:102.
  2. Canadell L ,  Martín-Loeches I ,  Díaz E ,  Trefler S ,  Grau S ,  Yebenes JC ,  Almirall J ,  Olona M ,  Sureda F , Blanquer J ,  Rodriguez A ;  GETGAG . Degree of adherence to recommended antiviral treatment during the pandemic and post-pandemic periods of influenza A(H1N1)pdm09 in 148 intensive care units in Spain. Med Intensiva.  2015;39:222-33.
  3. Rautanen A, Mills TC, Gordon AC, Hutton P, Steffens M, Nuamah R, Chiche JD, Parks T, Chapman SJ, Davenport EE, Elliott KS, Bion J, Lichtner P, Meitinger T, Wienker TF, Caulfield MJ, Mein C, Bloos F, Bobek I, Cotogni P, Sramek V, Sarapuu S, Kobilay M, Ranieri VM, Rello J, Sirgo G, Weiss YG, Russwurm S, Schneider EM, Reinhart K, Holloway PA, Knight JC, Garrard CS, Russell JA, Walley KR, Stüber F, Hill AV, Hinds CJ; ESICM/ECCRN GenOSept Investigators. Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. Lancet Respir Med 2015;3:53-60.
  4. Gattarello S, Lagunes L, Vidaur L, Solé-Violán J, Zaragoza R, Vallés J, Torres A, Sierra R, Sebastian R, Rello J. Improvement of antibiotic therapy and ICU survival in severe non-pneumococcal community- acquired pneumonia: a matched case-control study. Crit Care. 2015; 19:335.
  5. Tridente A, Clarke GM, Walden A, Gordon AC, Hutton P, Chiche JD, Holloway PA, Mills GH, Bion J, Stüber F, Garrard C, Hinds C; GenOSept Investigators. Association between trends in clinical variables and outcome in intensive care patients with faecal peritonitis: analysis of the GenOSept cohort. Crit Care. 2015; 19:210.
  6. Mills TC, Chapman S, Hutton P, Gordon AC, Bion J, Chiche JD, Holloway PA, Stüber F, Garrard CS, Hinds CJ, Hill AV, Rautanen A; ESICM/ECCRN GenOSept Investigators. variants in the Mannose-binding Lectin Gene MBL2 do not associate with sepsis susceptibility or survival in a large.
  7. Martin-Loeches I ,  Povoa P ,  Rodríguez A ,  Curcio D ,  Suarez D ,  Mira JP ,  Cordero ML ,  Lepecq R ,  Girault C ,  Candeias C ,  Seguin P ,  Paulino C ,  Messika J ,  Castro AG ,  Valles J ,  Coelho L ,  Rabello L ,  Lisboa T ,  Collins D ,  Torres A ,  Salluh J ,  Nseir S ;  TAVeM study . Incidence and diagnosis of ventilator-associated tracheobronchitis in the intensive care unit: an international online survey. Lancet Respir Med.  2015;3:859-68. European cohort. Clin Infect Dis. 2015;61:695-703.
2014 Publications
  1. Tridente A, Clarke GM, Walden A, McKechnie S, Hutton P, Mills GH, Gordon AC, Holloway PA, Chiche JD, Bion J, Stuber F, Garrard C, Hinds CJ; GenOSept Investigators. Patients with faecal peritonitis admitted to European intensive care units: an epidemiological survey of the GenOSept cohort. Intensive Care Med. 2014;40:202-10.
  2. Walden AP, Clarke GM, McKechnie S, Hutton P, Gordon AC, Rello J, Chiche JD, Stueber F, Garrard CS, Hinds CJ; ESICM/ECCRN GenOSept Investigators. Patients with community acquired pneumonia admitted to European intensive care units: an epidemiological survey of the GenOSept cohort. Crit Care. 2014; 18:R58.
  3. Gattarello S ,  Borgatta B ,  Solé-Violán J ,  Vallés J ,  Vidaur L ,  Zaragoza R ,  Torres A ,  Rello J ;  Community-Acquired Pneumonia en la Unidad de Cuidados Intensivos II Study Investigators* . Decrease in mortality in severe community-acquired pneumococcal pneumonia: impact of improving antibiotic strategies (2000-2013). Chest. 2014;146:22-31.
  4. Rodriguez A, Póvoa P ,  Nseir S ,  Salluh J ,  Curcio D ,  Martín-Loeches I ;  TAVeM group investigators . Incidence and prognosis of ventilator-associated tracheobronchitis (TAVeM): a multicentre, prospective, observational study. Crit Care. 2014; 18:R32.
  5. Gustot T ,  Felleiter P ,  Pickkers P ,  Sakr Y ,  Rello J ,  Velissaris D ,  Pierrakos C ,  Taccone FS ,  Sevcik P ,  Moreno C ,  Vincent JL ;  EPIC II Group of Investigators . Impact of infection on the prognosis of critically ill cirrhotic patients: results from a large worldwide study. Liver Int 2014; 34:1496-503.
  6. De Waele JJ, Rello J, Anzueto A, Moreno R, Lipman J, Sakr Y, Pickkers P, Leone M, Ferguson A, Oud L, Vincent JL; EPIC II Investigators. Infections and use of antibiotics in patients admitted for severe acute pancreatitis: data from the EPIC II study. Surg Infect (Larchmt). 2014; 15:394-8.
  7. Hanberger H, Antonelli M, Holmbom M, Lipman J, Pickkers P, Leone M, Rello J, Sakr Y, Walther SM, Vanhems P, Vincent JL; EPIC II Group of Investigators. Infections, antibiotic treatment and mortality in patients admitted to ICUs in countries considered to have high levels of antibiotic resistance compared to those with low levels. BMC Infect Dis. 2014;14:513.
  8. Oteo J, Calbo E, Rodríguez-Baño J, Oliver A, Hornero A, Ruiz-Garbajosa P, Horcajada JP, Del Pozo JL, Riera M, Sierra R, Bou G, Salavert M. [The threat of the carbapenemase-producing enterobacteriaceae in Spain: Positioning report of the SEIMC study groups, GEIH and GEMARA.]. Enferm Infecc Microbiol Clin. 2014;32(10):666-70.
  9. Sierra R. Decontaminate inside and out: two is better than one. Crit Care Med. 2014 May;42(5):1296-7.