Analysis and Design of Processes with Supercritical Fluids

The Group works on the development of processes using supercritical technology, mainly with CO2. Supercritical CO2 is a green solvent, the processes are fast, efficient and there is no solvent residue. It is mainly applied in processes of the pharmaceutical, cosmetic and food industry.

• Enrique Martínez de la Ossa:
• E-mail: enrique.martinezdelaossa@uca.es.
• ORCID: 0000-0001-5213-9686.

• Extraction of bioactive compounds from natural matrices and their impregnation in porous matrices such as polymers or dressings.
• Generation of nanoparticles from the previous extracts and their encapsulation in biocompatible polymers.
• Generation of scaffolds always using supercritical CO2.

Supercritical technology Nanoparticles Bioactive compounds Impregnation

• Principal Investigators:
  • Enrique José Martínez de la Ossa Fernández (PI).
• Investigators:
  • Clara Mª Pereyra López.
  • Casimiro Mantell Serrano.
  • Lourdes Casas Cardoso.
  • Antonio Montes Herrera.
• Postdoctoral Researchers:
  • Mª Teresa Fernández Ponce.
• Predoctoral Researchers:
  • Diego Valor López.

• Ministerio de Economía y Competitividad (MINECO); Programa Estatal de I+D+i Orientada a los Retos de la Sociedad CTQ2014-52427-R. PI: Casimiro Mantell Serrano: Impregnación supercrítica de extractos naturales en la preservación de alimentos perecederos.

1. Title: Production of submicron particles of the antioxidants of mango leaves/PVP by supercritical antisolvent extraction process. Journal: The Journal of Supercritical Fluids. Year: 2019. Volume: 143. Number:. First page: 294. Last page: 304. Authors: M.C. Guamán-Balcázar, A. Montes, C. Pereyra, E. Martínez de la Ossa. Impact index (ISI): 3.122. Impact index (SCImago): 1.015. Quartile (SCImago):Q1.
2. Title: Precipitation of powerful antioxidant nanoparticles from orange leaves by means of supercritical CO2. Journal: Journal of CO2 Utilization. Year: 2019. Volume: 31. Number:. First page: 235. Last page: 243. Authors: A. Montes, F. Hanke, D. Williamson, M.C. Guamán-Balcázar, D. Valor, C. Pereyra, U. Teipel, E. Martínez de la Ossa. Impact index (ISI): 5.503. Impact index (SCImago): 1.199. Quartile (SCImago): Q1.
3. Title: Selective fractionation and isolation of allelopathic compounds from Helianthus annuus L. leaves by means of high-pressure techniques. Journal: The Journal of Supercritical Fluids. Year: 2019. Volume: 143. Number:. First page: 32. Last page: 41. Authors: Fuentes-gandara, Fabio ; Torres-Martínez,Ascensión; Fernández-ponce, María Teresa; Casas-Cardoso, Lourdes; Mantell-Serrano, Casimiro; Varela-Montoya, Rosa Maria; Martinez de la Ossa Fernández,Enrique; Macias-Dominguez, Francisco Antonio. Impact index (ISI): 3.122. Impact index (SCImago): 1.015. Quartile (SCImago): Q1.

1. Title: Development of cotton fabric impregnated with antioxidant mango polyphenols by means of supercritical fluids. Journal: The Journal of Supercritical Fluids. Year: 2018. Volume: 140. Number:. First page: 310. Last page: 319. Authors: Fernández-ponce, María Teresa; Medina-ruiz,Esther; Casas-Cardoso, Lourdes; Mantell Serrano, Casimiro; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 3.122. Impact index (SCImago): 1,015. Quartile (SCImago): Q1.
2. Title: Characterization of olive leaf extract polyphenols loaded by supercritical solvent impregnation into PET/PP food packaging films. Journal: The Journal of Supercritical Fluids. Year: 2018. Volume: 140. Number:. First page: 196. Last page: 206. Authors: Cejudo, Cristina; Casas-Cardoso, Lourdes; Fernández-ponce, María Teresa; Mantell-Serrano, Casimiro; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 3.122. Impact index (SCImago): 1,015. Quartile (SCImago): Q1.
3. Title: Supercritical impregnation of antioxidantmango polyphenols into a multilayer PET/PP food-grade Journal: Journal of CO2 Utilization. Year: 2018. Volume: 25. Number:. First page: 56. Last page: 67. Authors: Belizón, María Luisa; Fernández-ponce, María Teresa; Casas-Cardoso, Lourdes; Mantell-Serrano, Casimiro; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 5.503. Impact index (SCImago): 1,199. Quartile (SCImago): Q1.
4. Title: Generation of potent antioxidant nanoparticles from mango leaves by supercritical antisolvent extraction. Journal: The Journal of Supercritical Fluids. Year: 2018. Volume: 138. Number: -. First page: 92. Last page: 101 Authors: Guamán-balcázar, María Del Cisne; Montes-Herrera, Antonio; Fernández-ponce, María Teresa; Casas-Cardoso, Lourdes; Mantell-Serrano, Casimiro; Pereyra-Lopez, Clara Maria; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 3.122. Impact index (SCImago): 1,015. Quartile (SCImago): Q1.
5. Title: New insight into formation process of silica submicron particles using CO2 as antisolvent. Journal: The Journal of Supercritical Fluids. Year: 2018. Volume: 133. Number:. First page: 218. Last page: 244. Authors: Montes-Herrera, Antonio; Williamson, D; Hanke, F; García, Ignacio; Pereyra-Lopez, Clara Maria; Martinez de la Ossa Fernández, Enrique; Teipel, Ulrich. Impact index (ISI): 3.122. Impact index (SCImago): 1,015. Quartile (SCImago): Q1.
6. Title: Production submicron particles of the antioxidants of mango leaves/PVP by supercritical antisolvent extraction process. Journal: The Journal of Supercritical Fluids. Year: 2018. Volume: 143. Number: -. First page: 294. Last page: 304. Authors: Guamán, Maria Del Cisne; Montes-Herrera, Antonio; Pereyra-Lopez, Clara Maria; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 3.122. Impact index (SCImago): 1,015. Quartile (SCImago): Q1.
7. Title: Impregnation of mesoporous silica with mangiferin using supercritical CO2. Journal: The Journal of Supercritical Fluids. Year: 2018. Volume: 140. Number:. First page: 129. Last page: 136. Authors: García, Ignacio; Montes-Herrera, Antonio; Valor, Diego; Pereyra-Lopez, Clara Maria; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 3.122. Impact index (SCImago): 1,015. Quartile (SCImago): Q1.
8. Title: Supercritical CO2 impregnation of silica microparticles with quercitin. Journal: The Journal of Supercritical Fluids. Year: 2018. Volume: 143. Number: -. First page: 157. Last page: 161. Authors: García, Ignacio; Crampon, Cristine; Montes-Herrera, Antonio; Pereyra-Lopez, Clara Maria; Martinezde la Ossa Fernández, Enrique; Badens, Elisabeth. Impact index (ISI): 3.122. Impact index (SCImago): 1,015. Quartile (SCImago): Q1.

1. Title: Selective antitumoural action of pressurized mango leaf extracts against minimally and highly invasive breast cancer. Journal: Food & Function. Year: 2017. Volume: 8. Number:. First page: 3610. Last page: 3620. Authors: Fernández-ponce, María Teresa; López, Luis Ángel; Sánchez-Quesada, Cristina; Casas-Cardoso, Lourdes; Mantell-Serrano, Casimiro; Gaforio-Martínez, José Juan; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 3.289. Impact index (SCImago): 1,209. Quartile (SCImago): Q1.
2. Title: Micronization of vanillin by rapid expansion of supercritical solutions process. Journal: Journal of CO2 Utilization. Year: 2017. Volume: 21. Number:. First page: 17. Last page: 32. Authors: Montes-Herrera, Antonio; Merino-vigo, Rafael; De Los Santos, Desiree; Pereyra-Lopez, Clara Maria; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 5.503. Impact index (SCImago): 1,199. Quartile (SCImago): Q1.
3. Title: Supercritical Impregnation of food packaging films to provide antioxidant properties. Journal: The Journal of Supercritical Fluids. Year: 2017. Volume: 128. Number:. First page: 200. Last page: 207. Authors: Cejudo, Cristina; Casas-Cardoso, Lourdes; Mantell-Serrano, Casimiro; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 3.122. Impact index (SCImago): 1,015. Quartile (SCImago): Q1.
4. Title: PRECIPITATION OF MANGO LEAVES ANTIOXIDANTS BY SUPERCRITICAL ANTISOLVENT PROCESS. Journal: The Journal of Supercritical Fluids. Year: 2017. Volume: 128. Number:. First page: 218. Last page: 226. Authors: Montes-Herrera, Antonio; Pereyra-Lopez, ClaraMaria; Martinez de la Ossa Fernández, Enrique; Guaman-balcazar, Ma Del Cisne Impact index (ISI): 3.122. Impact index (SCImago): 1,015. Quartile (SCImago): Q1.
5. Title: Impregnation of mango leaf extract into a polyester textile using supercritical carbon dioxide. Journal: The Journal of Supercritical Fluids. Year: 2017. Volume: 128. Number:. First page: 208. Last page: 217. Authors: Fernández-ponce, María Teresa; Casas-Cardoso, Lourdes; Mantell-Serrano, Casimiro; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 3.122. Impact index (SCImago): 1,015. Quartile (SCImago): Q1.
6. Title: Generation of quercetin/cellulose acetate phthalate systems for delivery by supercritical antisolvent process. Journal: European Journal Of Pharmaceutical Sciences. Year: 2017. Volume: 100. Number:. First page: 79. Last page: 86. Authors: García, Ignacio; Montes-Herrera, Antonio; Pereyra-Lopez, Clara Maria; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 3.466. Impact index (SCImago): 1,016. Quartile (SCImago): Q1.
7. Title: Co-precipitation of mangiferin with cellulose acetate phthalate by Supercritical antisolvent process. Journal: Journal of CO2 Utilization. Year: 2017. Volume: 22. Number:. First page: 197. Last page: 207. Authors: García, Ignacio; Montes-Herrera, Antonio; Pereyra-Lopez, Clara Maria; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 5.503. Impact index (SCImago): 1,199. Quartile (SCImago): Q1.

1. Title: Precipitation of submicron particles of rutin using supercriticalantisolvent process. Journal: The Journal of Supercritical Fluids. Year: 2016. Volume: 118. Number:. First page: 1. Last page: 10. Authors: Montes-Herrera, Antonio; Wehner, Lukas; Pereyra-Lopez, Clara Maria; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 2.991. Impact index (SCImago): 0,982. Quartile (SCImago): Q1.
2. Title: Generation of microparticles of ellagic acid by supercriticalantisolvent process. Journal: The Journal of Supercritical Fluids. Year: 2016. Volume: 116. Number:. First page: 101. Last page: 110. Authors: Montes-Herrera, Antonio; Wehner, Lukas; Pereyra-Lopez, Clara Maria; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 2.991. Impact index (SCImago): 0,982. Quartile (SCImago): Q1.
3. Title: Preparation of polyphenol fine particles potent antioxidants by a supercritical antisolvent process using different extracts of Olea europaea leaves.
4. Journal: Korean Journal of Chemical Engineering. Year: 2016. Volume: 33. Number: 2. First page: 594. Last page: 602. Authors: Chinnarasu, C.; Montes-Herrera, Antonio; Pereyra-Lopez, Clara Maria; Casas-Cardoso, Lourdes; Fernández-ponce, María Teresa; Mantell-Serrano, Casimiro; Pattabhi, S; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 2.007. Impact index (SCImago): 0,495. Quartile (SCImago): Q2.
5. Title: Mangiferin Nanoparticles Precipitation by Supercritical Antisolvent Process. Journal: Journal of Supercritical Fluids. Year: 2016. Volume: 112. Number:. First page: 44. Last page: 50. Authors: Montes-Herrera, Antonio; Wehner, Lukas; Pereyra-Lopez, Clara Maria; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 2.579. Impact index (SCImago): 0.904. Quartile (SCImago): Q1.
6. Title: Pilot-plant scale extraction of phenolic compounds from mango leaves using different green techniques: Kinetic and scale up study. Journal: Chemical Engineering Journal. Year: 2016. Volume: 299. Number:. First page: 420. Last page: 430. Authors: Fernández-ponce, María Teresa; Parjikolaei, Behnaz Razi ; Lari, Hamed Nasri ; Casas-Cardoso, Lourdes; Mantell-Serrano, Casimiro; Martinez de la Ossa. Fernández, Enrique. Impact index (ISI): 8.355. Impact index (SCImago):. Quartile (SCImago): Q1.

1. Title: Screening design of experiment applied to supercritical antisolvent precipitation of quercetin. Journal: The Journal of Supercritical Fluids. Year: 2015. Volume: 104. Number:. First page: 10. Last page: 18. Authors: Montes-Herrera, Antonio; Pereyra-Lopez, Clara Maria; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 2,579. Impact index (SCImago): 0,904. Quartile (SCImago): Q2.
2. Title: Particle design applied to quercetin using supercritical anti-solvent techniques. Journal: The Journal of Supercritical Fluids. Year: 2015. Volume: 105. Number:. First page: 119. Last page: 127. Authors: Fernández-ponce, María Teresa; Masmoudi,Yasmine; Djerafi, Rania; Casas-Cardoso, Lourdes; Mantell-Serrano, Casimiro; Martinez de la Ossa Fernández,Enrique; Badens, Elisabeth. Impact index (ISI): 2,579. Impact index (SCImago): 0,904. Quartile (SCImago): Q2.
3. Title: Use of high pressure techniques to produce Mangifera indica L. leaf extracts enriched in potent antioxidant phenolic compounds. Journal: Innovative Food Science and Emerging Technologies. Year: 2015. Volume: 29. Number:. First page: 94. Last page: 106. Authors: Fernández-ponce, María Teresa; Casas-Cardoso, Lourdes; Mantell-Serrano, Casimiro; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 2,997. Impact index (SCImago): 1,675. Quartile (SCImago): Q1.
4. Title: Green extraction of Antioxidants from different varieties of Red Grape Pomace. Journal: Molecules: A Journal of Synthetic Organic and Natural Product Chemistry. Year: 2015. Volume: 20. Number: 6. First page: 9686. Last page: 9702. Authors: Otero-pareja, María Jose; Casas-Cardoso,Lourdes; Fernández-ponce, María Teresa; Mantell-Serrano, Casimiro; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 2,465. Impact index (SCImago): 0,570. Quartile (SCImago): Q3.
5. Title: Precipitation of antioxidant fine particles from Olea europaea leaves using Supercritical Antisolvent process. Journal: The Journal of Supercritical Fluids. Year: 2015. Volume: 97. Number:. First page: 125. Last page: 132. Authors: Chinnarasu, Chandrasekar; Montes-Herrera, Antonio; Fernández-ponce, María Teresa; Casas-Cardoso, Lourdes; Mantell-Serrano, Casimiro; Pereyra-Lopez, Clara Maria; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 2,579. Impact index (SCImago): 0,904. Quartile (SCImago): Q2.
6. Title: Natural antioxidant fine particles recovery from Eucalyptus globulus leaves using supercritical carbon dioxide assisted processes. Journal: The Journal of Supercritical Fluids. Year: 2015. Volume: 101. Number:. First page: 161. Last page: 169. Authors: Chinnarasu, Chnadrasekar; Montes-Herrera, Antonio; Fernández-ponce, María Teresa; Casas-Cardoso, Lourdes; Mantell, Casimiro; Pereyra-Lopez, Clara Maria; Martinez de la Ossa Fernández, Enrique; Pattabhi, Sangma. Impact index (ISI): 2,579. Impact index (SCImago): 0,904. Quartile (SCImago): Q2.
7. Title: Isolation of Bioactive Compounds from Sunflower Leaves (Helianthus annuus L.) Extracted with Supercritical Carbon Dioxide. Journal: Journal of Agricultural and Food Chemistry. Year: 2015. Volume: 2015. Number: 63. First page: 6410. Last page: 6421. Authors: El Marsni-, Zouhir; Torres-Martínez, Ascensión; Varela-Montoya, Rosa Maria; Gonzalez-Molinillo, Jose Maria; Casas-Cardoso, Lourdes; Mantell, Casimiro;Martinez de la Ossa Fernández, Enrique; Macias-Dominguez, Francisco Antonio. Impact index (ISI): 2,857. Impact index (SCImago): 1,224. Quartile (SCImago): Q1.
8. Title: Helikaurolides A-D with a Diterpene-Sesquiterpene Skeleton from Supercritical FluidExtracts of Helianthus annuus L. var. Arianna. Journal: Organic Letters. Year: 2015. Volume: 17. Number:. First page: 4730. Last page: 4733. Authors: Torres-Martínez, Ascensión; Gonzalez-Molinillo, Jose Maria; Varela-Montoya, Rosa Maria; Casas-Cardoso, Lourdes; Mantell, Casimiro; Martinez de la Ossa Fernández, Enrique; Macias-Dominguez, Francisco Antonio. Impact index (ISI): 6,732. Impact index (SCImago): 3,005. Quartile (SCImago): Q1.
9. Title: Screening design of experiment applied to the SAS precipitation of Quercetin. Journal: The Journal of Supercritical Fluids. Year: 2015. Volume: 104. Number:. First page: 10. Last page: 18. Authors: Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 2,579. Impact index (SCImago): 0,904. Quartile (SCImago): Q2.

1. Title: effect of Supercritical Carbon Dioxide on the Enzymes Inactivation in Single-Strength Carrot Juice. Journal: International Journal of Food Sciences and Nutrition. Year: 2014. Volume: 4. Number: 4. First page: 106. Last page: 111. Authors: Di Giacomo, Gabriele; Taglieri, Luca; Scimia, Francesca; Trifiro, Antonio; Cocconi, Emanuela; Martinez de la Ossa Fernández, Enrique; Pereyra-Lopez, Clara Maria. Impact index (ISI): 1.206. Impact index (SCImago): 0,493. Quartile (SCImago): Q2.
2. Title: Fractionation of Mangifera indica Linn polyphenols by reverse phase supercritical fluid chromatography (RP-SFC) at pilot plant scale. Journal: The Journal of Supercritical Fluids. Year: 2014. Volume: 95. Number:. First page: 444. Last page: 456. Authors: Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 2.371. Impact index (SCImago): 1,128. Quartile (SCImago): Q1.
3. Title: Polymer-naproxen precipitation by supercritical antisolvent process. Journal: The Journal of Supercritical Fluids. Year: 2014. Volume: 89. Number:. First page: 58. Last page: 67 Authors: Montes-Herrera, Antonio; Kim, Natalia; Gordillo-Romero, Ma Dolores; Pereyra-Lopez, Clara Maria;Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 2.371. Impact index (SCImago): 1,128. Quartile (SCImago): Q1.
4. Title: New insight in the acrylic polymer precipitation by supercritical fluids. Journal: Chemical Engineering & Technology. Year: 2014. Volume: 37. Number:. First page: 1. Last page: 9. Authors: Montes-Herrera, Antonio; Gordillo-Romero, Ma Dolores; Pereyra-Lopez, Clara Maria; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 2.442. Impact index (SCImago): 0,702. Quartile (SCImago): Q2.
5. Title: Polymer encapsulation of amoxicillin microparticles by SAS process. Journal: Journal of Microencapsulation. Year: 2014. Volume: 31. Number: 1. First page: 16. Last page: 22. Authors: Montes-Herrera, Antonio; Gordillo-Romero, Ma Dolores; Pereyra-Lopez, Clara Maria; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 1.585. Impact index (SCImago): 0,574. Quartile (SCImago): Q2.
6. Title: Ibuprofen-Polymer Precipitation Using Supercritical CO2 At Low Temperature. Journal: The Journal of Supercritical Fluids. Year: 2014. Volume: 94. Number:. First page: 91. Last page: 101. Authors: Montes-Herrera, Antonio; Gordillo-Romero, Ma Dolores; De Los Santos-Martínez, Deseada María; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 2.371. Impact index (SCImago): 1,128. Quartile (SCImago): Q1.
7. Title: Exploring High Operating Conditions in the Ibuprofen Precipitation by RESS Process. Journal: Industrial & Engineering Chemistry Research. Year: 2014. Volume: 53. Number:. First page: 474. Last page: 480. Authors: Montes-Herrera, Antonio; Litwinowicz, Andrej; Gradl, Uwe; Gordillo-Romero, Ma Dolores; Pereyra-Lopez, Clara Maria; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 2.587. Impact index (SCImago): 1,009. Quartile (SCImago): Q1.
8. Title: Ibuprofen-polimer precipitation using supercritical CO2 at low temperature. Journal: The Journal of Supercritical Fluids. Year: 2014. Volume: 94. Number:. First page: 91. Last page: 101. Authors: Gordillo-Romero, Ma Dolores; Pereyra-Lopez, Clara Maria; De Los Santos-Martínez, Deseada María; Martinez de la Ossa Fernández, Enrique. Impact index (ISI): 2.371. Impact index (SCImago): 1,128. Quartile (SCImago): Q1.