CO10: Molecular Immunology and Gene and Cellular Immunotherapy

The group is dedicated to research in immunology, with a special focus on the development of chimeric antigen receptors (CARs) for cellular immunotherapy and on the study of early signaling mechanisms and the mechanisms involved in the induction of immune tolerance.

Responsible researcher

Francisco José García Cózar:
- E-mail: curro.garcia@uca.es
- ORCID: 0000-0003-3720-259x

Lines of research

Line 1: Molecular mechanisms of immune tolerance induction. Genomic and proteomic analysis of the mechanisms underlying basic immune tolerance and those responsible for the development of chronic infections.
Line 2: Gene and Cell Immunotherapy. Primarily based on the development of Chimeric Antigen Receptors (CARs), with applications in oncological and inflammatory diseases (cardiovascular, digestive, neurological, etc.) and in the rejection of transplanted organs.
Line 3: Nanomedicine. Development of nanoparticle-based contrast agents for the specific identification of molecules in vivo, for applications in diagnostic imaging.
Line 4: Early intracellular signaling in T and B lymphocytes. Implications for immune-mediated diseases.
Line 5: Transmembrane adapter proteins and their role as regulators of activation in lymphocytes.

Keywords

# T Cells
# Immunological Tolerance
# Intracellular signaling
# Membrane adapter proteins
# Cardiovascular Disease
# Gene Immunotherapy
# Cellular Immunotherapy
# Nanoparticles

CO10: Molecular Immunology and Gene and Cellular Immunotherapy

Responsible researcher

Francisco José García Cózar:

University Professor.

E-mail: curro.garcia@uca.es
ORCID: 0000-0003-3720-259x
Research ID: A-6212-2013

Members of the Team

Principal Investigators:
- Francisco José García Cózar (PI).
Researchers:
- Ana Diez Núñez.
- Auxiliadora Mazuecos Blanca.
- Juan Carlos Bohórquez Sierra.
- Carmen Mínguez Mañanes.
- Carmen María Pérez Alberca.
- Cristina Montes Durán.
- Encarnación García Domínguez.
- Federico Rodríguez-Rubio Cortadelas.
- Jesús García Serrano.
- Jesús Navarro Navarro.
- Juan Carlos Pérez Herrera.
- María Isabel Moreno García.
- Teresa María García Álvarez.
- Juan Pedro Muñoz Miranda.
- Ricardo Fernández Cisnal.
- Javier Álvarez Medialdea.
- Lucía Olvera Collantes.
- Sebastián Garzón López.
- María Victoria Verdugo Cabeza de Vaca.
- Noelia del Carmen Moares Fernández.
- Antonio Gabucio López.