CO16: Intracellular signaling in lymphocytes and implications in immunologically based pathologies
CO16: Intracellular signaling in lymphocytes and implications in immunologically based pathologies
The group is led by an immunology specialist, and in recent years our group has been analyzing the regulatory functions of the LAT and NTAL membrane adaptors, as well as their relationship with Lck kinase in the transmission of intracellular signals associated with immune receptors. Our Lines of research deepen our understanding of the regulatory functions of intracellular signals in lymphocytes and analyze the implications in certain immune-based pathologies such as rheumatoid arthritis (RA).
Our Lines of research in vitro studies using tumor cell lines, work with mice, and analysis of lymphocytes from healthy donors and patients with immune-based diseases. We have ongoing international collaborations with groups in France (Drs. Bernard and Marie Malissen, CIML, Marseille, France), the United Kingdom (Dr. Michael Dustin, University of Oxford, UK), and Poland (Dr. Arkadiusz Miazek, University of Wroclaw, Poland). Our work may be useful not only for a better understanding of the molecular mechanisms governing T cell activation, but also for gaining insight into the altered immune mechanisms in RA and, potentially, other immune-based diseases.
Responsible researcher
- Enrique Aguado Vidal:
- E-mail: enrique.aguado@uca.es
- ORCID: 0000-0002-7232-2661
Lines of research
- Line 1: Early intracellular signaling in T and B lymphocytes. Implications in immunological pathologies.
- Line 2: Transmembrane adapter proteins and their role as regulators of activation in lymphocytes.
- Line 3: In vivo analysis of elements of the intracellular signaling cascade associated with immune receptors.
Keywords
- # TCR/CD3
- # Immunopathology
- # Intracellular signaling
- # Membrane adapters
CO16: Intracellular signaling in lymphocytes and implications in immunologically based pathologies
CO16: Intracellular signaling in lymphocytes and implications in immunologically based pathologies
Responsible researcher
Enrique Aguado Vidal:
University Professor.
- E-mail: enrique.aguado@uca.es
- ORCID: 0000-0002-7232-2661
- Research ID: L-4908-2014
Team Members
- Principal Investigators:
- Enrique Aguado Vidal (PI).
- Researchers:
- Maria Isabel Serrano Garcia.
- Alba Pérez Linaza.
- Luis Miguel Fernández Aguilar.
- José Luis Poveda Diaz.
- Maria Carmen Lopez Osuna.
- Raquel Muñoz Fernández.
- Isaac Narbona Sánchez.
- Manuel Carrasco Viñuela.
CO16: Intracellular signaling in lymphocytes and implications in immunologically based pathologies
CO16: Intracellular signaling in lymphocytes and implications in immunologically based pathologies
Production
Find all of the group's work (their Projects, Patents Publications) on the Andalusian Public Health System's I+Salud Portal:
