Author's Name: Diana Gasca

🧬CAR therapies have made it possible to achieve cures for tumors that previously had no treatment options. However, limitations remain, such as toxicities, relapses mediated by antigenic escape, and challenges related to manufacturing, cost, and access. ⚙️To overcome these barriers, we present a modular system that separates a universal signaling module—responsible for activating the therapeutic cells—from one or more interchangeable recognition modules designed to identify tumors, allowing the specificity to be reoriented without having to reengineer the entire cell. 🧩The system allows for the targeted co-assembly of multiple targets with a single signaling scaffold, reducing the risk of antigenic escape by enabling the modification of recognition modules when changes occur in the tumors. The ability to modulate the presence of complete receptors by discontinuing the infusion of recognition modules will also allow for the control of toxicity and the depletion of therapeutic cells. 🌍The platform is also compatible with universal products, enabling the large-scale production of healthy donor cells with a common signaling module and the subsequent retrofitting of these cells with different recognition modules according to each patient’s needs. These universal CARs can be rapidly prepared for different tumor targets, with the ability to target multiple targets and fine-tune therapeutic activity to enhance the safety, efficacy, and accessibility of these therapies, enabling us to reach all patients in a timely manner. 🔬This innovation, which aims to improve safety (toxicity control), sustained efficacy (by mitigating antigenic escape and “fatigue” of therapeutic cells), and accessibility (standardized manufacturing of the signaling module and rapid “retrofitting” with recognition modules), is protected by a European patent pending, supplemented by Publications in two types of tumors—multiple myeloma and B-cell neoplasms—confirming the system’s versatility and its potential for patient-specific customization. 🔗 More information: Instagram

⏳ Twenty-five years ago, the University of Cádiz welcomed its first researchers from the Ramón y Cajal program, a national initiative created in 2000 to attract and retain scientific talent in Spain. Since then, the institution has seen 47 scientists pass through its doors who, thanks to this program, have been able to establish their professional careers and strengthen cutting-edge lines of basic and applied research. 🌟Among the pioneers is our colleague Carmen Castro, Principal Investigator (PI) of the “ CO5: r Neurogenesis and Neuroregeneration” Group at INiBICA and in the Department of Biomedicine, Biotechnology, and Public Health at the UCA. Her appointment in 2003 as one of the program’s first recipients not only provided an opportunity to stabilize her career but also gave a boost to biomedical research within the Cádiz-based institution. 🚀 The Ramón y Cajal program has been key to attracting talent back to Spain and creating a solid scientific foundation at Spanish universities, which has helped consolidate leading research groups and pave the way for new generations of scientists, demonstrating how commitment and excellence can transform the future of science within the university setting. 🔗 More information: UCA || Instagram

👨‍⚕️👩‍⚕️ On October 29, researchers María Jesús Viñolo and José Manuel Romero, from INiBICA’s EM14 Research Group on Languages, Processes, and Healthcare Management, led an in-person training session on “Prevention of Skin Injuries and Safe Transfers for Dependent Individuals” at the School of Nursing and Physical Therapy at the University of Cádiz. 🗣️🩹 During this session, they addressed topics such as the prevention of skin lesions and wounds resulting from dependency through the use of specific protocols, and provided theoretical and technical knowledge on the safe mobilization of dependent individuals, among other topics. 💙 This training is part of INiBICA’s commitment to the continuous improvement of care quality and safety in healthcare. 🔗 More information: Instagram

Conference on the " ISCIII " Platforms Supporting R&D&I in Biomedicine and Health Sciences at the Carlos III Health Institute (ITEMAS) 🎯 From October 27 to 29, more than 500 professionals gathered in Salamanca to share advances, challenges, and synergies within the framework of the ISCIII Platforms, which are key components for promoting excellence in biomedical research within the National Health System. 👩‍🔬🧑‍🔬 INiBICA was represented by María del Carmen García Montelongo, Biobank Technician, on behalf of the ISCIII Platform for Biomodels and Biobanks; Paula Castro Morales, Projects and Innovation Technician, on behalf of ITEMAS; and Julio M. Ríos de la Rosa, INiBICA Manager, on behalf of SCReN. 🌎 Over the course of three days, experiences and knowledge were shared with the Platform Isciii Biobanks and Biomodels and the Spanish Clinical Research Network (SCReN), at a gathering that brought together international experts and leaders from infrastructures such as BBMRI.it -ERIC, ECRIN (European Clinical Research Infrastructure Network), and Eatris. 🤝 A space for collaboration that reinforces the shared commitment to science that is more open, connected, and impact-oriented. 💙 Many thanks to IBSAL for the excellent organization and hospitality! 🔗 More information: Instagram

On November 20, 2025, at 9:30 a.m., we look forward to seeing you in the Auditorium of the School of Nursing and Physical Therapy – UCA – Cádiz and in Jerez (Avenida Ana de Viya, 52 – Cádiz) for the ConCIENCIA de Futuro Conference. 🎯 Objective: To familiarize early-career researchers (R1 –R2) with the principles of the European Charter for Researchers and the Code of Conduct, as well as with the HRS4R process and its impact on professional development. 🔍 STAY TUNED! ✍️ We’ll be publishing the final program and registration form very soon. 🚀 Don’t miss this key event to boost your research career! 🔗 More information: Instagram

We are very excited to share that Glucotypp—whose members include Dr. Felipe Monzo (Spanish College of Pharmacists, Trustee of the INiBICA Management Foundation) and Dr. Alfonso Lechuga (Pediatrician at Puerta del Mar Hospital and Responsible researcher member of INiBICA’s CO1 Group), has been selected as one of the top startups for the upcoming South Impact Cádiz 2025, an event that promotes innovation with a real impact on health and sustainability. 🌍✨ 🎯 Glucotypp’s mission is clear: to personalize nutrition through the glucotype, combining science, technology, and artificial intelligence to improve people’s metabolic health 🍎📊 🙌 Your vote can help us continue to grow and transform personalized nutrition. You can vote 👉 HERE 🔗 More information: South Impact || Instagram

🧬🔬 The INiBICA group CO1: INMOX (Inflammation, Nutrition, Metabolism and Oxidative Stress) participated in the 29th Human Genetics Congress of the Spanish Association of Human Genetics (AEGH), presenting an electronic poster on the analysis of biomolecular condensates as an experimental tool for the reclassification of variants of uncertain significance (VUS) in genes associated with RASopathies. 🔍 The study demonstrates the existence of a distinct cellular phenotype in patients with pathogenic variants in PTPN11, BRAF, and SOS1, supported by a high discrimination index. 🚀 These results reinforce the potential diagnostic value of condensate analysis and open new avenues for improving the functional interpretation of genetic variants in rare diseases. 🔗 More information: Instagram

🏃⏳🍏 Cádiz University will host the lecture “Influence of Training, Diet, Gender, and Age on Maximal Fat Oxidation: Is There a Link to Performance?”, presented by Jørn Wulff Helge, a professor at the University of Copenhagen. This session will offer an opportunity to explore in depth the influence of training, diet, gender, and age on maximal fat oxidation, as well as their possible relationship to physical performance. 🗣️ Speaker: Jørn Wulff Helge, Professor at the University of Copenhagen. 📅 Thursday, October 30, 2025 🕓 4:00–5:30 p.m. 📍 Alicia Plaza Conference Room, School of Education 💡 A key opportunity to understand the relationship between metabolism, training, and performance. 👉 Register here: UCA 🔗 More information: Instagram

🏅This recognition places the Cádiz-based institution among the Spanish universities with the greatest relative presence in this ranking, which evaluates the global scientific impact of researchers through the so-called c-score—an indicator that weighs citations, h-index, co-authorship, and leadership in scientific Publications . 🌟 The INiBICA researchers included in the World’s Top 2% Scientists are: José A. Moral-Muñoz, from the Department of Nursing and Physical Therapy; José Castro-Piñero, from the Department of Physical Education, Art, and Music Pedagogy; and Michele Alves-Bezerra, from the Department of Biomedicine, Biotechnology, and Public Health. 💜♀️In addition, Professor Michele Alves-Bezerra stands out as the only female researcher from the UCA included in the ranking—a recognition that highlights both her career in the fields of biomedicine and biotechnology and the growing contribution of women to research excellence. Her work focuses on the study of metabolic processes and molecular biology applied to health, a field with significant international impact. 🔗 More information: UCA || Elsevier || Instagram

We are pleased to announce that researchers from the A.G.S. Campo de Gibraltar Este— Andoni Carrión Jiménez , and Gorka Aitor Carrión Jiménez, from the University of Cádiz —have been honored at the Conference of the Professional Nursing Association of Cádiz (JOCOENFER) for their outstanding research: 🩺 Adjusting the Level of Therapeutic Effort in Patients with End-Stage Non-Oncological Medical Conditions at a Regional Hospital. AWARD FOR THE SECOND-BEST PRESENTATION IN THE CATEGORY OF DOCTORAL THESES AND ACTIVE RESEARCH PROJECTS ( Projects ). 📘 Learning Modules for Developing Competencies in Chronic Wound Care: An Innovative Proposal in Nursing Education. AWARD FOR THE BEST PRESENTATION IN THE CATEGORY OF BACHELOR’S THESES, MASTER’S THESES, DIPLOMA THESES, AND SPECIALTY THESES. Both are part of the project “Adjusting the Therapeutic Effort in Patients with Terminal Medical Illnesses at a Regional Hospital (PPI-AET Study),” an initiative that promotes the humanization of healthcare and shared decision-making at the end of life. This recognition highlights the importance of nursing research and our professionals’ commitment to more ethical, compassionate, and evidence-based care. 👏 Congratulations on this well-deserved recognition and for contributing to the advancement of research in nursing and bioethics!